IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubM... See more...

Aliases for IL31 Gene

Aliases for IL31 Gene

  • Interleukin 31 2 3 5
  • IL-31 2 3 4
  • Interleukin-31 3 4
  • IL31 5

External Ids for IL31 Gene

Previous GeneCards Identifiers for IL31 Gene

  • GC00U914001
  • GC12U900495
  • GC12M121222
  • GC12M122656
  • GC12M119617

Summaries for IL31 Gene

Entrez Gene Summary for IL31 Gene

  • IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IL31 Gene

IL31 (Interleukin 31) is a Protein Coding gene. Diseases associated with IL31 include Allergic Contact Dermatitis and Contact Dermatitis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot Summary for IL31 Gene

  • Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).

Gene Wiki entry for IL31 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL31 Gene

Genomics for IL31 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J122116 Enhancer 1 Ensembl ENCODE dbSUPER 12.9 +56.8 56820 2.8 HNRNPL ZBTB33 JUND REST ZNF600 CTCF FOXA2 YY1 FOSL1 MAFG MLXIP LRRC43 IL31 BCL7A ENSG00000255856 DIABLO HPD PSMD9 ENSG00000256950 AB372616
GH12J122104 Enhancer 1 ENCODE dbSUPER 12.3 +64.4 64374 10.2 CREB1 PRDM10 FOXA1 ZIC2 SP1 CEBPA ATF7 SOX13 CEBPB SMARCA5 MLXIP ENSG00000256546 LRRC43 IL31 B3GNT4 RNU7-170P PSMD9 ENSG00000256950 HPD piR-42694-043
GH12J122182 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 0.4 -9.0 -8980 1.2 EZH2 EED RFX3 YY1 SIN3A SAP130 POLR2A GABPB1 ARID4B ZNF143 HSALNG0094635 LRRC43 ENSG00000256546 IL31 piR-53177-010 B3GNT4
GH12J122197 Enhancer 1 FANTOM5 Ensembl 0.4 -22.9 -22892 0.6 LEF1 IKZF1 DDX20 PKNOX1 ZNF24 BRD9 HDAC1 ELK1 TCF12 EP300 piR-53177-010 B3GNT4 HSALNG0094635 IL31 LRRC43
GH12J122190 Enhancer 0.7 ENCODE 0.4 -16.8 -16848 0.2 CREB1 CTCF JUND ZNF143 REST RAD21 TRIM22 SCRT2 SMARCA5 CTBP1 HSALNG0094635 piR-53177-010 B3GNT4 IL31 LRRC43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL31 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL31

Top Transcription factor binding sites by QIAGEN in the IL31 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXJ2
  • HFH-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3
  • STAT5A

Genomic Locations for IL31 Gene

Genomic Locations for IL31 Gene
chr12:122,172,029-122,174,221
(GRCh38/hg38)
Size:
2,193 bases
Orientation:
Minus strand
chr12:122,656,577-122,658,746
(GRCh37/hg19)
Size:
2,170 bases
Orientation:
Minus strand

Genomic View for IL31 Gene

Genes around IL31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL31 Gene

Proteins for IL31 Gene

  • Protein details for IL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EBC2-IL31_HUMAN
    Recommended name:
    Interleukin-31
    Protein Accession:
    Q6EBC2
    Secondary Accessions:
    • A2RUQ1

    Protein attributes for IL31 Gene

    Size:
    164 amino acids
    Molecular mass:
    18205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL31 Gene

Post-translational modifications for IL31 Gene

  • Glycosylation at Asn67 and Asn100

Other Protein References for IL31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL31 Gene

Domains & Families for IL31 Gene

Gene Families for IL31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL31 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL31 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-31 (IL31_HUMAN)
genes like me logo Genes that share domains with IL31: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL31 Gene

Function for IL31 Gene

Molecular function for IL31 Gene

UniProtKB/Swiss-Prot Function:
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).

Phenotypes From GWAS Catalog for IL31 Gene

Gene Ontology (GO) - Molecular Function for IL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IL31: view
genes like me logo Genes that share phenotypes with IL31: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL31

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL31 Gene

Localization for IL31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL31 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL31 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 21182835
genes like me logo Genes that share ontologies with IL31: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL31 Gene

Pathways & Interactions for IL31 Gene

genes like me logo Genes that share pathways with IL31: view

Pathways by source for IL31 Gene

1 R&D Systems pathway for IL31 Gene

Interacting Proteins for IL31 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q6EBC2-IL31_HUMAN ENSP00000366234 for IL31 Gene via UniProtKB STRING IID

SIGNOR curated interactions for IL31 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL31: view

Drugs & Compounds for IL31 Gene

(1) Drugs for IL31 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL31 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL31: view

Transcripts for IL31 Gene

mRNA/cDNA for IL31 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL31

Alternative Splicing Database (ASD) splice patterns (SP) for IL31 Gene

No ASD Table

Relevant External Links for IL31 Gene

GeneLoc Exon Structure for
IL31

Expression for IL31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL31 Gene

mRNA differential expression in normal tissues according to GTEx for IL31 Gene

This gene is overexpressed in Testis (x38.2), Muscle - Skeletal (x9.3), and Brain - Hypothalamus (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL31

SOURCE GeneReport for Unigene cluster for IL31 Gene:

Hs.569071

mRNA Expression by UniProt/SwissProt for IL31 Gene:

Q6EBC2-IL31_HUMAN
Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.

Evidence on tissue expression from TISSUES for IL31 Gene

  • Blood(4.5)
  • Spleen(2.7)
  • Skin(2.6)
  • Lymph node(2.4)
  • Bone marrow(2.4)
  • Nervous system(2.4)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with IL31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL31 Gene

Orthologs for IL31 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL31 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL31 30 31
  • 98.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL31 30
  • 69.83 (n)
IL-31 31
  • 55 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Il31 31
  • 28 (a)
OneToOne
Species where no ortholog for IL31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL31 Gene

ENSEMBL:
Gene Tree for IL31 (if available)
TreeFam:
Gene Tree for IL31 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL31: view image

Paralogs for IL31 Gene

No data available for Paralogs for IL31 Gene

Variants for IL31 Gene

Additional dbSNP identifiers (rs#s) for IL31 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL31 Gene

Variant ID Type Subtype PubMed ID
nsv1038827 CNV loss 25217958

Variation tolerance for IL31 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL31 Gene

Human Gene Mutation Database (HGMD)
IL31
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL31

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL31 Gene

Disorders for IL31 Gene

MalaCards: The human disease database

(23) MalaCards diseases for IL31 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic contact dermatitis
  • contact dermatitis, allergic
contact dermatitis
  • contact dermatitis/eczema
dermatitis
  • eczema
primary cutaneous amyloidosis
  • pca
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search IL31 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL31

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL31 Gene

Publications for IL31 Gene

  1. A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. (PMID: 17900679) Schulz F … Lee YA (The Journal of allergy and clinical immunology 2007) 3 23 41
  2. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. (PMID: 16461143) Bilsborough J … Gross JA (The Journal of allergy and clinical immunology 2006) 3 4 23
  3. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. (PMID: 17030248) Neis MM … Hermanns HM (The Journal of allergy and clinical immunology 2006) 3 4 23
  4. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. (PMID: 15184896) Dillon SR … Gross JA (Nature immunology 2004) 2 3 4
  5. Common IL-31 gene haplotype associated with non-atopic eczema is not implicated in epidermolysis bullosa pruriginosa. (PMID: 21057749) Nagy N … McGrath JA (Acta dermato-venereologica 2010) 3 41

Products for IL31 Gene

Sources for IL31 Gene