The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurolog... See more...

Aliases for IL3 Gene

Aliases for IL3 Gene

  • Interleukin 3 2 3 5
  • Hematopoietic Growth Factor 2 3 4
  • IL-3 2 3 4
  • MCGF 2 3 4
  • Multipotential Colony-Stimulating Factor 3 4
  • Multilineage-Colony-Stimulating Factor 2 3
  • Colony-Stimulating Factor, Multiple 2 3
  • P-Cell Stimulating Factor 2 3
  • Mast-Cell Growth Factor 2 3
  • Interleukin-3 3 4
  • MULTI-CSF 2 3
  • Interleukin 3 (Colony-Stimulating Factor, Multiple) 2
  • P-Cell-Stimulating Factor 4
  • Mast Cell Growth Factor 4
  • MGC79398 2
  • MGC79399 2
  • IL3 5

External Ids for IL3 Gene

Previous GeneCards Identifiers for IL3 Gene

  • GC05U990034
  • GC05P131843
  • GC05P131427
  • GC05P131472
  • GC05P131424
  • GC05P131396
  • GC05P126588

Summaries for IL3 Gene

Entrez Gene Summary for IL3 Gene

  • The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL3 Gene

IL3 (Interleukin 3) is a Protein Coding gene. Diseases associated with IL3 include Neutropenia and Thrombocytosis. Among its related pathways are RET signaling and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-3 receptor binding.

UniProtKB/Swiss-Prot Summary for IL3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
  • This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Gene Wiki entry for IL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL3 Gene

Genomics for IL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J132057 Enhancer 0.5 Ensembl 250.7 -1.0 -954 1 MAFF ZNF316 MAFK MAFG EMSY IL3 RAPGEF6 HSALNG0044807 LOC105379174 ACSL6 lnc-ACSL6-2
GH05J132060 Promoter 0.3 EPDnew 250.7 0.0 -18 0.1 IL3 MEIKIN HSALNG0044807 LOC105379174 ACSL6 lnc-ACSL6-2
GH05J132061 Enhancer 0.2 Ensembl 250.7 +0.2 246 0.2 HSALNG0044807 IL3 LOC105379174 CSF2
GH05J132110 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 45.9 +50.0 50045 2.2 CEBPA FOXA2 SRF ZSCAN4 RUNX3 FOXA3 IL3 CSF2 IL5 P4HA2 ENSG00000253067 ENSG00000224015 P4HA2-AS1 RAD50 RAPGEF6 piR-56883-151
GH05J132069 Enhancer 1.2 FANTOM5 Ensembl ENCODE 24.9 +9.5 9545 2.4 MYC IKZF1 ZNF592 MBD2 ZNF316 RELA PTBP1 PRDM10 ATF1 CBX1 CSF2 IL3 P4HA2 ENSG00000224015 P4HA2-AS1 PDLIM4 IL5 MEIKIN FNIP1 RAPGEF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL3

Top Transcription factor binding sites by QIAGEN in the IL3 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for IL3 Gene

Latest Assembly
chr5:132,060,655-132,063,204
(GRCh38/hg38)
Size:
2,550 bases
Orientation:
Plus strand

Previous Assembly
chr5:131,396,348-131,398,897
(GRCh37/hg19 by Entrez Gene)
Size:
2,550 bases
Orientation:
Plus strand

chr5:131,396,222-131,398,897
(GRCh37/hg19 by Ensembl)
Size:
2,676 bases
Orientation:
Plus strand

Genomic View for IL3 Gene

Genes around IL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL3 Gene

Proteins for IL3 Gene

  • Protein details for IL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08700-IL3_HUMAN
    Recommended name:
    Interleukin-3
    Protein Accession:
    P08700
    Secondary Accessions:
    • Q6GS87

    Protein attributes for IL3 Gene

    Size:
    152 amino acids
    Molecular mass:
    17233 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for IL3 Gene

neXtProt entry for IL3 Gene

Post-translational modifications for IL3 Gene

  • Glycosylation at Asn34 and Asn89

Other Protein References for IL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for IL3

No data available for DME Specific Peptides for IL3 Gene

Domains & Families for IL3 Gene

Gene Families for IL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL3 Gene

InterPro:
Blocks:
  • Interleukin-3 signature

Suggested Antigen Peptide Sequences for IL3 Gene

GenScript: Design optimal peptide antigens:
  • P-cell-stimulating factor (IL3_HUMAN)
  • Interleukin 3 (Colony-stimulating factor, multiple) (Q6NZ78_HUMAN)
  • Interleukin 3 (Colony-stimulating factor, multiple) (Q6NZ79_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08700

UniProtKB/Swiss-Prot:

IL3_HUMAN :
  • Belongs to the IL-3 family.
Family:
  • Belongs to the IL-3 family.
genes like me logo Genes that share domains with IL3: view

Function for IL3 Gene

Molecular function for IL3 Gene

UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
UniProtKB/Swiss-Prot Function:
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
GENATLAS Biochemistry:
interleukin 3,17.2kDa,colony-stimulating factor (multilineage),survival factor inducing phosphorylation of BAD through the activation of the protein kinases (AKT1,AKT2)

LifeMap Function Summary for IL3 Gene

Phenotypes From GWAS Catalog for IL3 Gene

Gene Ontology (GO) - Molecular Function for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005135 interleukin-3 receptor binding TAS 2544122
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL3: view
genes like me logo Genes that share phenotypes with IL3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL3 Gene

Localization for IL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 3
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
genes like me logo Genes that share ontologies with IL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL3 Gene

Pathways & Interactions for IL3 Gene

PathCards logo

SuperPathways for IL3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
3 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
4 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
5 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
genes like me logo Genes that share pathways with IL3: view

Pathways by source for IL3 Gene

69 Qiagen pathways for IL3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
1 Cell Signaling Technology pathway for IL3 Gene

SIGNOR curated interactions for IL3 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway TAS --
GO:0006955 immune response IEA --
GO:0007267 cell-cell signaling TAS 3497400
GO:0007399 nervous system development TAS 9736740
genes like me logo Genes that share ontologies with IL3: view

Drugs & Compounds for IL3 Gene

(91) Drugs for IL3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amlexanox Approved, Investigational, Withdrawn Pharma Target, antagonist Inhibitor of TBK1 and IKKepsilon; antiallergic agent 3
Tacrolimus Approved, Investigational Pharma 1328
Zinc Approved, Investigational Pharma Target 1706
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target, binder 0

(51) Additional Compounds for IL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL3: view

Transcripts for IL3 Gene

mRNA/cDNA for IL3 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL3

Alternative Splicing Database (ASD) splice patterns (SP) for IL3 Gene

No ASD Table

Relevant External Links for IL3 Gene

GeneLoc Exon Structure for
IL3

Expression for IL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL3 Gene



Protein tissue co-expression partners for IL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL3

SOURCE GeneReport for Unigene cluster for IL3 Gene:

Hs.694

mRNA Expression by UniProt/SwissProt for IL3 Gene:

P08700-IL3_HUMAN
Tissue specificity: Activated T-cells, mast cells, natural killer cells.

Evidence on tissue expression from TISSUES for IL3 Gene

  • Blood(3.2)
  • Bone marrow(3.2)
  • Spleen(2.8)
  • Lymph node(2.5)
  • Bone(2.4)
  • Liver(2.4)
  • Skin(2.3)
  • Heart(2.3)
  • Kidney(2.3)
  • Nervous system(2.2)
  • Lung(2.2)
  • Intestine(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with IL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL3 Gene

Orthologs for IL3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL3 29 30
  • 99.34 (n)
OneToOne
Species where no ortholog for IL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL3 Gene

ENSEMBL:
Gene Tree for IL3 (if available)
TreeFam:
Gene Tree for IL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL3: view image
Alliance of Genome Resources:
Additional Orthologs for IL3

Paralogs for IL3 Gene

No data available for Paralogs for IL3 Gene

Variants for IL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs35415145 Benign: not provided 132,060,713(+) C/Tp.Arg3Cys
NM_000588.4(IL3):c.7C>T (p.Arg3Cys)
MISSENSE
rs35482671 Likely Benign: not provided 132,060,983(+) A/Gp.Asn60Ser
NM_000588.4(IL3):c.179A>G (p.Asn60Ser)
MISSENSE
rs55698209 Benign: not provided 132,060,993(+) C/T
NM_000588.4(IL3):c.189C>T (p.Asp63=)
SYNONYMOUS
rs60211209 Benign: not provided 132,062,410(+) A/T
NM_000588.4(IL3):c.294+9A>T
INTRON
rs2069787 -- p.Arg15His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL3 Gene

Variant ID Type Subtype PubMed ID
esv25745 CNV gain 19812545
esv3606803 CNV loss 21293372
nsv1024604 CNV gain 25217958

Variation tolerance for IL3 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL3 Gene

Human Gene Mutation Database (HGMD)
IL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL3
Leiden Open Variation Database (LOVD)
IL3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL3 Gene

Disorders for IL3 Gene

MalaCards: The human disease database

(94) MalaCards diseases for IL3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
neutropenia
  • leukopenia
thrombocytosis
  • thrombocythaemia
eosinophilic pneumonia
  • pneumonia, eosinophilic
allergic disease
  • allergic hypersensitivity disease
hypereosinophilic syndrome
  • eosinophilia
- elite association - COSMIC cancer census association via MalaCards
Search IL3 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IL3 Gene

leukemia,acute,lymphoblastic,preB cell,with translocation t(5;14)(q31;q32)

Additional Disease Information for IL3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL3: view

No data available for UniProtKB/Swiss-Prot for IL3 Gene

Publications for IL3 Gene

  1. Interleukin 3 and schizophrenia: the impact of sex and family history. (PMID: 17179997) Chen X … Kendler KS (Molecular psychiatry 2007) 3 22 40
  2. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PMID: 17362254) Kabesch M … Nickel R (Allergy 2007) 3 22 40
  3. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (PMID: 15372320) Park BL … Shin HD (Journal of human genetics 2004) 3 22 40
  4. A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand. (PMID: 14551608) Ohashi J … Tokunaga K (Genes and immunity 2003) 3 22 40
  5. Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. (PMID: 3489530) Yang YC … Wong GG (Cell 1986) 2 3 4

Products for IL3 Gene

  • Addgene plasmids for IL3

Sources for IL3 Gene