Aliases for IL2RB Gene
External Ids for IL2RB Gene
Previous HGNC Symbols for IL2RB Gene
Previous GeneCards Identifiers for IL2RB Gene
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
GeneCards Summary for IL2RB Gene
IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis. Among its related pathways are Transcriptional misregulation in cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding. An important paralog of this gene is CSF2RB.
UniProtKB/Swiss-Prot Summary for IL2RB Gene
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185).