The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/... See more...

Aliases for IL2RB Gene

Aliases for IL2RB Gene

  • Interleukin 2 Receptor Subunit Beta 2 3 5
  • High Affinity IL-2 Receptor Subunit Beta 3 4
  • Interleukin-15 Receptor Subunit Beta 3 4
  • Interleukin-2 Receptor Subunit Beta 3 4
  • Interleukin 15 Receptor, Beta 2 3
  • Interleukin 2 Receptor, Beta 2 3
  • IL-2 Receptor Subunit Beta 3 4
  • IL-2R Subunit Beta 3 4
  • CD122 Antigen 3 4
  • P70-75 3 4
  • IL15RB 3 4
  • IL-2RB 3 4
  • P75 3 4
  • High Affinity IL-2 Receptor Beta Subunit 3
  • CD122 3
  • IMD63 3

External Ids for IL2RB Gene

Previous HGNC Symbols for IL2RB Gene

  • IL15RB

Previous GeneCards Identifiers for IL2RB Gene

  • GC22M034136
  • GC22M035764
  • GC22M035846
  • GC22M037515
  • GC22M020487

Summaries for IL2RB Gene

Entrez Gene Summary for IL2RB Gene

  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

CIViC Summary for IL2RB Gene

GeneCards Summary for IL2RB Gene

IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding. An important paralog of this gene is CSF2RB.

UniProtKB/Swiss-Prot Summary for IL2RB Gene

  • Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).

Gene Wiki entry for IL2RB Gene

Additional gene information for IL2RB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL2RB Gene

Genomics for IL2RB Gene

GeneHancer (GH) Regulatory Elements for IL2RB Gene

Promoters and enhancers for IL2RB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL2RB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL2RB

Top Transcription factor binding sites by QIAGEN in the IL2RB gene promoter:
  • Elk-1
  • GATA-1
  • GATA-2
  • GATA-3
  • STAT5A

Genomic Locations for IL2RB Gene

Genomic Locations for IL2RB Gene
chr22:37,125,838-37,175,054
(GRCh38/hg38)
Size:
49,217 bases
Orientation:
Minus strand
chr22:37,521,878-37,571,094
(GRCh37/hg19)
Size:
49,217 bases
Orientation:
Minus strand

Genomic View for IL2RB Gene

Genes around IL2RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL2RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL2RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL2RB Gene

Proteins for IL2RB Gene

  • Protein details for IL2RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14784-IL2RB_HUMAN
    Recommended name:
    Interleukin-2 receptor subunit beta
    Protein Accession:
    P14784
    Secondary Accessions:
    • B2R765

    Protein attributes for IL2RB Gene

    Size:
    551 amino acids
    Molecular mass:
    61117 Da
    Quaternary structure:
    • Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.
    • (Microbial infection) Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for IL2RB Gene

neXtProt entry for IL2RB Gene

Post-translational modifications for IL2RB Gene

  • Glycosylation at Asn29, Asn43, Asn71, and Asn149
  • Modification sites at PhosphoSitePlus

Other Protein References for IL2RB Gene

Antibody Products

No data available for DME Specific Peptides for IL2RB Gene

Domains & Families for IL2RB Gene

Gene Families for IL2RB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for IL2RB Gene

Blocks:
  • Short hematopoietin receptor, family 1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL2RB Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 2 receptor, beta (B0QYB9_HUMAN)
  • Interleukin 2 receptor, beta (B7ZB96_HUMAN)
  • p70-75 (IL2RB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14784

UniProtKB/Swiss-Prot:

IL2RB_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with IL2RB: view

Function for IL2RB Gene

Molecular function for IL2RB Gene

UniProtKB/Swiss-Prot Function:
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
GENATLAS Biochemistry:
interleukin 2,high affinity receptor,beta chain 70-75kDa,hematopoietic receptor family,expressed in various tissues

Phenotypes From GWAS Catalog for IL2RB Gene

Gene Ontology (GO) - Molecular Function for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IEA --
GO:0004911 contributes_to interleukin-2 receptor activity IMP,IDA 2467293
GO:0005515 protein binding IPI,IEA 16477002
GO:0019976 interleukin-2 binding IEA,ISS --
GO:0042010 interleukin-15 receptor activity IDA 15123770
genes like me logo Genes that share ontologies with IL2RB: view
genes like me logo Genes that share phenotypes with IL2RB: view

Human Phenotype Ontology for IL2RB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL2RB Gene

MGI Knock Outs for IL2RB:
  • Il2rb Il2rb<tm1Mak>
  • Il2rb Il2rb<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL2RB Gene

Localization for IL2RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL2RB Gene

Cell membrane; Single-pass type I membrane protein. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL2RB gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 4
extracellular 3
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8514792
GO:0005893 interleukin-2 receptor complex TAS 2467293
genes like me logo Genes that share ontologies with IL2RB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL2RB Gene

Pathways & Interactions for IL2RB Gene

PathCards logo

SuperPathways for IL2RB Gene

SuperPathway Contained pathways
1 RET signaling
2 PEDF Induced Signaling
.57
.51
.47
.43
3 TGF-Beta Pathway
.60
.60
.57
.51
4 Th17 cell differentiation
.36
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with IL2RB: view

Pathways by source for IL2RB Gene

2 GeneGo (Thomson Reuters) pathways for IL2RB Gene
  • Immune response IL-2 activation and signaling pathway
  • Immune response IL-22 signaling pathway
15 Qiagen pathways for IL2RB Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Glucocorticoid Receptor Signaling
  • ICos-ICosL Pathway in T-Helper Cell
  • IL-2 Pathway
2 Cell Signaling Technology pathways for IL2RB Gene

SIGNOR curated interactions for IL2RB Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for IL2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction TAS 2785715
GO:0016032 viral process IEA --
GO:0019221 cytokine-mediated signaling pathway TAS,IDA --
GO:0035723 interleukin-15-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL2RB: view

Drugs & Compounds for IL2RB Gene

(75) Drugs for IL2RB Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Denileukin diftitox Approved, Investigational Pharma Target, agonist, binder 46
Aldesleukin Approved Pharma Target, agonist, modulator, inhibitor 449
Basiliximab Approved, Investigational Pharma Target, antibody 146
Daclizumab Investigational, Withdrawn Pharma Target, antibody 98
IL-2 Pharma 0

(48) Additional Compounds for IL2RB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL2RB: view

Transcripts for IL2RB Gene

mRNA/cDNA for IL2RB Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL2RB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: -
SP4:

Relevant External Links for IL2RB Gene

GeneLoc Exon Structure for
IL2RB

Expression for IL2RB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL2RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL2RB Gene

This gene is overexpressed in Whole Blood (x18.3) and Spleen (x6.8).

Protein differential expression in normal tissues from HIPED for IL2RB Gene

This gene is overexpressed in NK cells (34.4), Monocytes (26.9), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL2RB Gene



Protein tissue co-expression partners for IL2RB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL2RB

SOURCE GeneReport for Unigene cluster for IL2RB Gene:

Hs.474787

Evidence on tissue expression from TISSUES for IL2RB Gene

  • Lung(4.3)
  • Blood(2.8)
  • Spleen(2.7)
  • Lymph node(2.3)
  • Bone marrow(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL2RB Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
  • skeleton
Regions:
Head and neck:
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • skull
  • tooth
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with IL2RB: view

No data available for mRNA Expression by UniProt/SwissProt for IL2RB Gene

Orthologs for IL2RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL2RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL2RB 31 30
  • 98.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL2RB 31 30
  • 79.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC510185 30
  • 76.48 (n)
IL2RB 31
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il2rb 17 31 30
  • 71.04 (n)
rat
(Rattus norvegicus)
Mammalia Il2rb 30
  • 70.17 (n)
oppossum
(Monodelphis domestica)
Mammalia IL2RB 31
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL2RB 31
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL2RB 31
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL2RB 31
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il2rb 31
  • 21 (a)
OneToOne
Species where no ortholog for IL2RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL2RB Gene

ENSEMBL:
Gene Tree for IL2RB (if available)
TreeFam:
Gene Tree for IL2RB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL2RB: view image

Paralogs for IL2RB Gene

Paralogs for IL2RB Gene

genes like me logo Genes that share paralogs with IL2RB: view

Variants for IL2RB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL2RB Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
635832 Pathogenic: IMMUNODEFICIENCY 63 WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY 37,136,257(-) TGGCTCCAGG/T INFRAME_DELETION
711744 Likely Benign: not provided 37,128,804(-) G/A SYNONYMOUS_VARIANT
719309 Benign: not provided 37,142,481(-) C/T MISSENSE_VARIANT
727903 Likely Benign: not provided 37,128,792(-) A/C SYNONYMOUS_VARIANT
730177 Benign: not provided 37,128,348(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IL2RB Gene

Structural Variations from Database of Genomic Variants (DGV) for IL2RB Gene

Variant ID Type Subtype PubMed ID
esv34015 CNV loss 18971310
nsv459882 CNV gain 19166990
nsv588984 CNV gain 21841781
nsv588986 CNV gain 21841781
nsv829203 CNV loss 20364138
nsv834187 CNV loss 17160897

Variation tolerance for IL2RB Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL2RB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL2RB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RB Gene

Disorders for IL2RB Gene

MalaCards: The human disease database

(46) MalaCards diseases for IL2RB Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 63 with lymphoproliferation and autoimmunity
  • imd63
ichthyosis
  • ichthyoses
oligoarticular juvenile idiopathic arthritis
  • pauciarticular chronic arthritis
rheumatoid factor-negative juvenile idiopathic arthritis
  • juvenile rheumatoid factor-negative polyarthritis
diphtheria
  • corynebacterium infection
- elite association - COSMIC cancer census association via MalaCards
Search IL2RB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL2RB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL2RB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL2RB Gene

Publications for IL2RB Gene

  1. Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis. (PMID: 17108990) Bucheton B … Dessein AJ (Genes and immunity 2007) 3 23 41 54
  2. IL-2 gene C/T polymorphism is associated with prostate cancer. (PMID: 17115417) Wu HC … Chen WC (Journal of clinical laboratory analysis 2006) 3 23 41 54
  3. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. (PMID: 12200137) Lindholm CK (Biochemical and biophysical research communications 2002) 3 4 23 54
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 41 54
  5. Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways. (PMID: 21653640) Eleftherohorinou H … Coin LJ (Human molecular genetics 2011) 3 41 54

Products for IL2RB Gene