Aliases for IL2RA Gene
Aliases for IL2RA Gene
External Ids for IL2RA Gene
- HGNC: 6008
- Entrez Gene: 3559
- Ensembl: ENSG00000134460
- OMIM: 147730
- UniProtKB: P01589
Previous HGNC Symbols for IL2RA Gene
- IL2R
- IDDM10
Previous GeneCards Identifiers for IL2RA Gene
- GC10M005997
- GC10M006203
- GC10M006058
- GC10M006059
- GC10M006093
- GC10M006041
Summaries for IL2RA Gene
-
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
GeneCards Summary for IL2RA Gene
IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Diabetes Mellitus, Insulin-Dependent, 10. Among its related pathways are Akt Signaling and MAPK Pathway. Gene Ontology (GO) annotations related to this gene include drug binding and interleukin-2 binding.
UniProtKB/Swiss-Prot for IL2RA Gene
-
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL2RA Gene
- Monarch Initiative
- Search for IL2RA at DataMed
- Search for IL2RA at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL2RA Gene
Genomics for IL2RA Gene
GeneHancer (GH) Regulatory Elements for IL2RA Gene
Promoters and enhancers for IL2RA Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J006061 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.1 | 63 | 1.1 | SRF EED IKZF1 JUNB RUNX3 | GC10P006063 IL2RA GC10M006044 GC10M006043 | |
| GH10J006062 | Enhancer | 0.8 | FANTOM5 dbSUPER | 659.3 | +1.5 | 1537 | 0.2 | JUNB NFE2 BATF SPI1 | IL2RA PFKFB3 IL15RA RBM17 GDI2 GC10M006044 GC10M006043 | |
| GH10J006063 | Enhancer | 0.6 | ENCODE dbSUPER | 650.7 | +1.3 | 1297 | 0.2 | NFE2 MLLT1 SPI1 | IL2RA GC10M006043 GC10M006044 | |
| GH10J006060 | Enhancer | 0.4 | Ensembl dbSUPER | 650.7 | +1.9 | 1869 | 0.2 | IL2RA GC10M006043 GC10M006044 | ||
| GH10J006086 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 31.6 | -24.3 | -24250 | 1.2 | PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 ZNF416 | IL2RA ANKRD16 LOC105376384 FBH1 CALML3-AS1 RBM17 PFKFB3 IL15RA RPL32P23 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL2RA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL2RA gene promoter:
-
- STAT3
- p53
- NF-kappaB1
- NF-kappaB
- IRF-7A
- STAT5A
- STAT6
- STAT1
- STAT1alpha
Regulatory Element Products
Genomic Locations for IL2RA Gene
Genomic Locations for IL2RA Gene
- chr10:6,010,689-6,062,370
- (GRCh38/hg38)
- Size:
- 51,682 bases
- Orientation:
- Minus strand
- chr10:6,052,652-6,104,333
- (GRCh37/hg19)
- Size:
- 51,682 bases
- Orientation:
- Minus strand
Genomic View for IL2RA Gene
Genes around IL2RA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.1 by Entrez Gene
- 10p15.1 by HGNC
- 10p15.1 by Ensembl
IL2RA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL2RA Gene
Proteins for IL2RA Gene
-
Protein details for IL2RA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01589-IL2RA_HUMAN
- Recommended name:
- Interleukin-2 receptor subunit alpha
- Protein Accession:
- P01589
- Q5W007
Protein attributes for IL2RA Gene
- Size:
- 272 amino acids
- Molecular mass:
- 30819 Da
- Quaternary structure:
-
- Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
Protein Expression for IL2RA Gene
Post-translational modifications for IL2RA Gene
Other Protein References for IL2RA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL2RA (CD25/IL-2 R alpha)
-
Custom Antibody ServicesOriGene Antibodies for IL2RA
- AM00962PU-N
- AM01310FC-N
- AM01310RP-N
- AM01360PU-N
- AM05184AC-N
- AM05184BT-N
- AM05184FC-N
- AM05184PU-N
- AM05184RP-N
- AM05864PU-N
- AM08035AC-N
- AM08035BT-N
- AM08035FC-N
- AM08035FC-S
- AM08035LE-N
- AM08035PU-N
- AM08035RC7-N
- AM08035RP-N
- AM08035RP-S
- AM08036AC-N
- AM08036BT-N
- AM08036FC-N
- AM08036LE-N
- AM08036PU-N
- AM08036RC7-N
- AM08036RP-N
- AM08036RP-S
- AM26037BT-L
- AM26037BT-N
- AM26037FC-L
- AM26037FC-S
- AM26037LE-M
- AM26037PU-M
- AM26037RP-L
- AM26037RP-S
- AM26037SU-N
- AM26760BT-N
- AM31169AF-N
- AM31169BT-N
- AM31169RP-N
- AM31170AF-N
- AM31170FC-N
- AM31170PU-N
- AM31170PU-S
- AM31171AF-N
- AM31299AF-N
- AM31300BT-N
- AM32321FC-N
- AM32321RP-N
- AP20309PU-N
- AP33330SU-N
- AP33330SU-S
- DM254
- DM254-05
- SM2097F
- SM265LE
- SM265P
- SM265PS
- SM265PXS
- SM265R
- SM266A
- SM266P
- SM266PS
- SM3015APC
- SM3015B
- SM3015F
- SM3015P
- SM3015PP
- SM3015R
- SM3015RD5
- SM3151B
- SM3151P
- TA310265
- TA314066
- TA320368
- TA323668
- TA323669
- TA354176
- Novus Biologicals Antibodies for IL2RA
-
Abcam antibodies for IL2RA
- Invitrogen Antibodies for IL2RA (AFLGC-IL2RA)
- antibodies-online: Search results for 1159 available CD25 Antibodies ranked by validation data
- Compare Top CD25 Antibodies
-
Recommended
- 293 FACS Antibodies (anti-human)
- 141 WB Antibodies (anti-human)
- 40 IHC Antibodies (anti-human)
- 29 IF Antibodies (anti-human)
- 20 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 5 IF/ICC Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IC Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 59 WB Antibodies (anti-rat)
- 49 FACS Antibodies (anti-rat)
- 16 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 7 IP Antibodies (anti-rat)
- 5 IHC (fro) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 232 FACS Antibodies (anti-mouse)
- 74 IP Antibodies (anti-mouse)
- 56 WB Antibodies (anti-mouse)
- 29 IHC (p) Antibodies (anti-mouse)
- 28 IHC Antibodies (anti-mouse)
- 17 ICFC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Func Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 in vivo Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 ELISPOT (Detection) Antibody (anti-mouse)
- 293 FACS Antibodies (anti-human)
- 141 WB Antibodies (anti-human)
- 40 IHC Antibodies (anti-human)
- 29 IF Antibodies (anti-human)
- 20 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 5 IF/ICC Antibodies (anti-human)
- 4 BCA Antibodies (anti-human)
- 4 Neut Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IC Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 59 WB Antibodies (anti-rat)
- 49 FACS Antibodies (anti-rat)
- 16 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 7 IP Antibodies (anti-rat)
- 5 IHC (fro) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 232 FACS Antibodies (anti-mouse)
- 74 IP Antibodies (anti-mouse)
- 56 WB Antibodies (anti-mouse)
- 29 IHC (p) Antibodies (anti-mouse)
- 28 IHC Antibodies (anti-mouse)
- 17 ICFC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Func Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 in vivo Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 ELISPOT (Detection) Antibody (anti-mouse)
- GeneTex Il2ra Antibody for IL2RA
-
CrownBio Antibodies for IL2RA
-
Boster Bio Antibodies for IL2RA
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL2RA
- Sino Biological Antibodies for IL2RA
Protein Products
- R&D Systems Proteins and Enzymes for IL2RA (CD25/IL-2 R alpha)
-
OriGene Purified Proteins for IL2RA
- Search Origene for MassSpec and Protein Over-expression Lysates for IL2RA
- Origene Custom Protein Services for IL2RA
- Novus Biologicals proteins for IL2RA
- Sino Biological Recombinant Proteins for IL2RA
- Sino Biological Cell Lysates for IL2RA
- ProSpec Recombinant Proteins for IL2RA
- Search GeneTex for Proteins for IL2RA
-
Abcam proteins for IL2RA
Assay Products
- R&D Systems Cell Selection and Detection Kits, ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IL2RA (CD25/IL-2 R alpha)
- Novus Biologicals ELISA Kits for IL2RA
- antibodies-online: Search results for 84 available CD25 Elisa Kits ranked by validation data
- Compare Top CD25 Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 42 Human ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Chicken ELISA Kit
- 5 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 42 Human ELISA Kits
- 13 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
-
Abcam assays for IL2RA
No data available for DME Specific Peptides for IL2RA Gene
Domains & Families for IL2RA Gene
Gene Families for IL2RA Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IL2RA Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL2RA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IL2RA Gene
Function for IL2RA Gene
Molecular function for IL2RA Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
- GENATLAS Biochemistry:
- interleukin 2,low affinity receptor,alpha chain 45kDa,expressed in T cell,B lymphoblast lines,peripheral blood monocyte
Phenotypes From GWAS Catalog for IL2RA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004911 | interleukin-2 receptor activity | IEA,IBA | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16477002 |
| GO:0008144 | drug binding | IEA | -- |
| GO:0019976 | interleukin-2 binding | IBA,IEA | -- |
Phenotypes for IL2RA Gene
- MGI mutant phenotypes for IL2RA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL2RA:
-
- Decreased BPV1 E2 protein expression
- Increased HPV18 LCR reporter activity
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for IL2RA Gene
- MGI Knock Outs for IL2RA:
-
- Il2ra Il2ra<tm1Dw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL2RA
-
CRISPR Products
-
OriGene CRISPR knockouts for IL2RA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2RA
- genomics-online: gRNA clones - Search results for 131 available CD25 gene related products
- Overview of 131 available CD25 gene related products
- Applied Biological Materials CRISPR for IL2RA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2RA
miRNA for IL2RA Gene
- miRTarBase miRNAs that target IL2RA
-
- hsa-mir-5698 (MIRT631396)
- hsa-mir-744-3p (MIRT631397)
- hsa-mir-4423-5p (MIRT631398)
- hsa-mir-6501-5p (MIRT631399)
- hsa-mir-143-5p (MIRT631400)
- hsa-mir-4430 (MIRT631401)
- hsa-mir-3652 (MIRT631402)
- hsa-mir-122-5p (MIRT631403)
- hsa-mir-504-3p (MIRT631404)
- hsa-mir-3135b (MIRT631405)
- hsa-mir-6499-3p (MIRT631406)
- hsa-mir-367-5p (MIRT631407)
- hsa-mir-1267 (MIRT631408)
- hsa-mir-6805-3p (MIRT644978)
- hsa-mir-5691 (MIRT644979)
- hsa-mir-3194-3p (MIRT644980)
- hsa-mir-629-3p (MIRT662558)
- hsa-mir-6808-3p (MIRT662559)
- hsa-mir-6867-3p (MIRT662560)
- hsa-mir-4713-5p (MIRT662561)
- hsa-mir-6868-3p (MIRT662562)
- hsa-mir-642a-5p (MIRT662563)
- hsa-mir-7973 (MIRT662564)
- hsa-mir-6821-3p (MIRT662565)
- hsa-mir-6790-3p (MIRT662566)
- hsa-mir-3124-3p (MIRT662567)
- hsa-mir-6837-3p (MIRT662568)
- hsa-mir-6754-3p (MIRT662569)
- hsa-mir-412-3p (MIRT662570)
- hsa-mir-6515-3p (MIRT662571)
- hsa-mir-4685-3p (MIRT662572)
- hsa-mir-4287 (MIRT662573)
- hsa-mir-7113-3p (MIRT662574)
- hsa-mir-4469 (MIRT662575)
- hsa-mir-1248 (MIRT662576)
- hsa-mir-1237-3p (MIRT662577)
- hsa-mir-3667-3p (MIRT662578)
- hsa-mir-6734-3p (MIRT662579)
- hsa-mir-877-3p (MIRT662580)
- hsa-mir-5088-3p (MIRT662581)
- hsa-mir-2276-5p (MIRT662582)
- hsa-mir-6892-3p (MIRT662583)
- hsa-mir-4302 (MIRT662584)
- hsa-mir-6866-3p (MIRT662585)
- hsa-mir-188-5p (MIRT662586)
- hsa-mir-4439 (MIRT671560)
- hsa-mir-3136-5p (MIRT671561)
- hsa-mir-6857-3p (MIRT671562)
- hsa-mir-4513 (MIRT671563)
- hsa-mir-6855-3p (MIRT671564)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2RA
- Browse OriGene Inhibitory RNA Products For IL2RA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2RA
- genomics-online: shRNA clones - Search results for 131 available CD25 gene related products
- Overview of 131 available CD25 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IL2RA
- Addgene plasmids for IL2RA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2RA
- Applied Biological Materials Clones for IL2RA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL2RA (CD25/IL-2 R alpha)
Cell Line Products
-
Horizon Cell Lines for IL2RA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL2RA Gene
Localization for IL2RA Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL2RA Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL2RA Gene
Pathways & Interactions for IL2RA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
| 3 | PEDF Induced Signaling |
.47
|
|
| 4 | TGF-Beta Pathway |
.60
|
.57
.51
|
| 5 | Th17 cell differentiation | ||
Pathways by source for IL2RA Gene
2 Sino Biological pathways for IL2RA Gene
14 BioSystems pathways for IL2RA Gene
52 Reactome pathways for IL2RA Gene
10 KEGG pathways for IL2RA Gene
3 GeneGo (Thomson Reuters) pathways for IL2RA Gene
5 R&D Systems pathways for IL2RA Gene
3 Tocris pathways for IL2RA Gene
38 Qiagen pathways for IL2RA Gene
1 Cell Signaling Technology pathway for IL2RA Gene
Interacting Proteins for IL2RA Gene
Selected Interacting proteins:
ENSP00000369293
P01589-IL2RA_HUMAN
for IL2RA Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for IL2RA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002437 | inflammatory response to antigenic stimulus | IEA | -- |
| GO:0002664 | regulation of T cell tolerance induction | IMP | 23416241 |
| GO:0006915 | apoptotic process | TAS | 9096364 |
Drugs & Compounds for IL2RA Gene
(92) Drugs for IL2RA Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Denileukin diftitox | Approved, Investigational | Pharma | binder, Target | 47 | ||
| Basiliximab | Approved, Investigational | Pharma | antibody, Target | 140 | ||
| Aldesleukin | Approved | Pharma | inhibitor, modulator, Target, agonist | 419 | ||
| Proleukin | Approved January 1998 | Pharma | 0 | |||
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 65 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AS 101 |
|
106566-58-9 |
|
|||
| GIT 27 |
|
6501-72-0 |
|
|
(4) Tocris Compounds for IL2RA Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
Drug Products
Transcripts for IL2RA Gene
mRNA/cDNA for IL2RA Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000379959 3176 bps (uc001iiz.3)
- ENST00000379954 1562 bps (uc009xih.3)
- ENST00000256876 1006 bps (uc057rme.1)
- ENST00000447847 326 bps (uc057rmg.1)
- ENST00000644262 622 bps
Unigene Clusters for IL2RA Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL2RA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2RA
- genomics-online: gRNA clones - Search results for 131 available CD25 gene related products
- Overview of 131 available CD25 gene related products
- Applied Biological Materials CRISPR for IL2RA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2RA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2RA
- Browse OriGene Inhibitory RNA Products For IL2RA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2RA
- genomics-online: shRNA clones - Search results for 131 available CD25 gene related products
- Overview of 131 available CD25 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IL2RA
- Addgene plasmids for IL2RA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2RA
- Applied Biological Materials Clones for IL2RA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL2RA (CD25/IL-2 R alpha)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: |
Expression for IL2RA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- T Helper Cells Peripheral Blood
- T-Regulatory Cells Peripheral Blood
- Large Pre B-Cells Hematopoietic Bone Marrow
- Immature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Double Negative 3 Thymocytes Thymus
- T-Regulatory Cells Thymus
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Endothelium (Cardiovascular System)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IL2RA Gene
This gene is overexpressed in Spleen (x9.3), Small Intestine - Terminal Ileum (x6.2), and Whole Blood (x4.3).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL2RA Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IL2RA Gene:
IL2RASOURCE GeneReport for Unigene cluster for IL2RA Gene:
Hs.231367Evidence on tissue expression from TISSUES for IL2RA Gene
- Blood(3.1)
- Spleen(3.1)
- Lymph node(2.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL2RA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- skull
- tooth
Abdomen:
- intestine
- large intestine
- liver
- small intestine
- spleen
Pelvis:
- anus
- rectum
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- bone marrow
- hair
- lymph node
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IL2RA
-
OriGene qPCR primer pairs and template standards for IL2RA
- genomics-online: primer clones - Search results for 131 available CD25 gene related products
- Overview of 131 available CD25 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for IL2RA Gene
Orthologs for IL2RA Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL2RA 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL2RA 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Il2ra 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il2ra 33 |
|
||
| cow (Bos Taurus) |
Mammalia | IL2RA 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL2RA 34 |
|
OneToOne |
- Species where no ortholog for IL2RA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IL2RA Gene
- ENSEMBL:
- Gene Tree for IL2RA (if available)
- TreeFam:
- Gene Tree for IL2RA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL2RA: view image
Paralogs for IL2RA Gene
(1) SIMAP similar genes for IL2RA Gene using alignment to 4 proteins:
- IL2RA_HUMAN
- H0Y5Z0_HUMAN
- Q5W005_HUMAN
- Q5W006_HUMAN
No data available for Paralogs for IL2RA Gene
Variants for IL2RA Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1005252344 | uncertain-significance, Interleukin 2 receptor, alpha, deficiency of | 6,011,297(-) | C/A/T | 3_prime_UTR_variant | |
| rs1015746287 | uncertain-significance, Interleukin 2 receptor, alpha, deficiency of | 6,011,298(-) | G/A | 3_prime_UTR_variant | |
| rs11256354 | benign, conflicting-interpretations-of-pathogenicity, not specified, Interleukin 2 receptor, alpha, deficiency of | 6,019,444(-) | T/C/G | coding_sequence_variant, synonymous_variant | |
| rs11256369 | benign, Interleukin 2 receptor, alpha, deficiency of, not specified | 6,024,237(-) | C/G | intron_variant | |
| rs12244380 | benign, Interleukin 2 receptor, alpha, deficiency of | 6,011,411(-) | A/G | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1e49 | CNV | loss | 18971310 |
| dgv352n106 | CNV | deletion | 24896259 |
| esv1000739 | CNV | deletion | 20482838 |
| esv1011098 | CNV | deletion | 20482838 |
| esv1592945 | CNV | deletion | 17803354 |
| esv2014648 | CNV | deletion | 18987734 |
| esv2516054 | CNV | deletion | 19546169 |
| esv2731873 | CNV | deletion | 23290073 |
| esv2731884 | CNV | deletion | 23290073 |
| esv2731895 | CNV | deletion | 23290073 |
| esv3132533 | CNV | deletion | 24192839 |
| esv3264829 | CNV | deletion | 24192839 |
| esv3349435 | CNV | duplication | 20981092 |
| esv3545834 | CNV | deletion | 23714750 |
| esv3545835 | CNV | deletion | 23714750 |
| esv4965 | CNV | loss | 18987735 |
| esv5272 | CNV | loss | 18987735 |
| esv9342 | CNV | loss | 19470904 |
| nsv1068274 | CNV | deletion | 25765185 |
| nsv1073083 | CNV | deletion | 25765185 |
| nsv1148973 | CNV | deletion | 26484159 |
| nsv525927 | CNV | loss | 19592680 |
| nsv956342 | CNV | deletion | 24416366 |
| nsv958561 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL2RA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RA Gene
Disorders for IL2RA Gene
(81) MalaCards diseases for IL2RA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 41 with lymphoproliferation and autoimmunity |
|
|
| diabetes mellitus, insulin-dependent, 10 |
|
|
| intermediate uveitis |
|
|
| autoimmune enteropathy |
|
|
| adult t-cell leukemia |
|
Search IL2RA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL2RA_HUMAN- Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:17676041}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41) [MIM:606367]: A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions. {ECO:0000269 PubMed:23416241, ECO:0000269 PubMed:24116927}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for IL2RA Gene
immunodeficiency,severe combined with absence of CD1 and of IL2RA expression on cortical thymocyte
Additional Disease Information for IL2RA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for IL2RA Gene
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PMID: 17676041) Lowe CE … Todd JA (Nature genetics 2007) 2 3 4 44 58
- Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. (PMID: 19106270) Kawasaki E … Japanese Study Group on Type 1 Diabetes Genetics (The Journal of clinical endocrinology and metabolism 2009) 3 22 44 58
- Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity. (PMID: 23416241) Goudy K … Bacchetta R (Clinical immunology (Orlando, Fla.) 2013) 3 4 58
- 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. (PMID: 22293688) Huang J … Li Y (European journal of human genetics : EJHG 2012) 3 44 58
- A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 44 58
Products for IL2RA Gene
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- AM32321FC-N
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- AP20309PU-N
- AP33330SU-N
- AP33330SU-S
- DM254
- DM254-05
- SM2097F
- SM265LE
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- TA310265
- TA314066
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- TA323669
- TA354176
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