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The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and dete... See more...
Aliases for IL2RA Gene
Aliases for IL2RA Gene
External Ids for IL2RA Gene
- HGNC: 6008
- NCBI Entrez Gene: 3559
- Ensembl: ENSG00000134460
- OMIM®: 147730
- UniProtKB/Swiss-Prot: P01589
Previous HGNC Symbols for IL2RA Gene
- IL2R
- IDDM10
Previous GeneCards Identifiers for IL2RA Gene
- GC10M005997
- GC10M006203
- GC10M006058
- GC10M006059
- GC10M006093
- GC10M006041
Summaries for IL2RA Gene
-
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
GeneCards Summary for IL2RA Gene
IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10. Among its related pathways are RET signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include drug binding and interleukin-2 binding.
UniProtKB/Swiss-Prot Summary for IL2RA Gene
-
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL2RA Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL2RA Gene
Genomics for IL2RA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL2RA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL2RA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL2RA
- Top Transcription factor binding sites by QIAGEN in the IL2RA gene promoter:
-
- IRF-7A
- NF-kappaB
- NF-kappaB1
- p53
- STAT1
- STAT1alpha
- STAT3
- STAT5A
- STAT6
Genomic Locations for IL2RA Gene
Latest Assembly
- chr10:6,010,689-6,062,370
- (GRCh38/hg38)
- Size:
- 51,682 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:6,052,652-6,104,330
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 51,679 bases
- Orientation:
- Minus strand
Genomic View for IL2RA Gene
Genes around IL2RA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.1 by HGNC
- 10p15.1 by Entrez Gene
- 10p15.1 by Ensembl
IL2RA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL2RA Gene
Proteins for IL2RA Gene
-
Protein details for IL2RA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01589-IL2RA_HUMAN
- Recommended name:
- Interleukin-2 receptor subunit alpha
- Protein Accession:
- P01589
- Q5W007
Protein attributes for IL2RA Gene
- Size:
- 272 amino acids
- Molecular mass:
- 30819 Da
- Quaternary structure:
-
- Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
Protein Expression for IL2RA Gene
Post-translational modifications for IL2RA Gene
Other Protein References for IL2RA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IL2RA / CD25 Monoclonal Antibody
- G Biosciences Immunotag™ IL2RA Antibody
- NSJ Bioreagents IL2RA Antibody
-
BioLegend
- CD25 Antibody (302603)
- CD25 Antibody (302612)
- APC/Cyanine7 CD25 Antibody (302614)
- CD25 Antibody (302605)
- APC/Cyanine7 CD25 Antibody (302613)
- CD25 Antibody (302607)
- CD25 Antibody (302609)
- CD25 Antibody (302602)
- CD25 Antibody (302611)
- CD25 Antibody (302610)
- CD25 Antibody (302604)
- CD25 Antibody (302608)
- CD25 Antibody (302606)
- CD25 Antibody (302617)
- CD25 Antibody (302616)
- CD25 Antibody (302620)
- CD25 Antibody (302622)
- CD25 Antibody (302615)
- CD25 Antibody (302621)
- CD25 Antibody (302618)
- CD25 Antibody (302624)
- PerCP/Cyanine5.5 CD25 Antibody (302625)
- PerCP/Cyanine5.5 CD25 Antibody (302626)
- CD25 Antibody (302627)
- CD25 Antibody (302629)
- CD25 Antibody (302630)
- CD25 Antibody (302631)
- CD25 Antibody (302633)
- CD25 Antibody (302632)
- CD25 Antibody (302637)
- CD25 Antibody (302635)
- CD25 Antibody (356102)
- CD25 Antibody (356106)
- CD25 Antibody (356104)
- CD25 Antibody (356101)
- CD25 Antibody (356105)
- CD25 Antibody (356103)
- CD25 Antibody (356114)
- CD25 Antibody (356109)
- APC/Cyanine7 CD25 Antibody (356122)
- APC/Cyanine7 CD25 Antibody (356121)
- CD25 Antibody (356119)
- CD25 Antibody (356107)
- PerCP/Cyanine5.5 CD25 Antibody (356111)
- CD25 Antibody (356113)
- PerCP/Cyanine5.5 CD25 Antibody (356112)
- CD25 Antibody (356110)
- CD25 Antibody (356118)
- CD25 Antibody (356108)
- CD25 Antibody (356117)
- CD25 Antibody (356115)
- CD25 Antibody (356116)
- CD25 Antibody (302636)
- CD25 Antibody (356126)
- CD25 Antibody (356125)
- CD25 Antibody (356124)
- CD25 Antibody (356123)
- CD25 Antibody (356129)
- CD25 Antibody (356127)
- CD25 Antibody (356132)
- CD25 Antibody (356131)
- CD25 Antibody (356128)
- CD25 Antibody (356130)
- CD25 Antibody (302634)
- CD25 Antibody (356134)
- CD25 Antibody (356120)
- CD25 Antibody (302638)
- APC/Fire(TM) 750 CD25 Antibody (356135)
- APC/Fire(TM) 750 CD25 Antibody (356136)
- CD25 Antibody (302639)
- CD25 Antibody (302640)
- CD25 Antibody (356138)
- CD25 Antibody (356137)
- APC/Fire(TM) 750 CD25 Antibody (302641)
- APC/Fire(TM) 750 CD25 Antibody (302642)
- CD25 Antibody (154202)
- CD25 Antibody (302645)
- CD25 Antibody (302646)
- TotalSeq(TM)-A0085 CD25 Antibody
- CD25 Antibody (356139)
- CD25 Antibody (356140)
-
Custom Antibody ServicesOriGene Antibodies for IL2RA
- AM00962PU-N
- AM01310FC-N
- AM01310RP-N
- AM01360PU-N
- AM05184AC-N
- AM05864PU-N
- AM08035AC-N
- AM08035BT-N
- AM08035FC-N
- AM08035FC-S
- AM08035LE-N
- AM08035PU-N
- AM08035RC7-N
- AM08035RP-N
- AM08035RP-S
- AM08036AC-N
- AM08036BT-N
- AM08036FC-N
- AM08036LE-N
- AM08036PU-N
- AM08036RC7-N
- AM08036RP-N
- AM08036RP-S
- AM26037BT-L
- AM26037BT-N
- AM26037FC-L
- AM26037FC-S
- AM26037LE-M
- AM26037PU-M
- AM26037RP-L
- AM26037RP-S
- AM26037SU-N
- AM26760BT-N
- AM31169AF-N
- AM31169BT-N
- AM31169RP-N
- AM31170AF-N
- AM31170FC-N
- AM31170PU-N
- AM31171AF-N
- AM32321FC-N
- AM32321RP-N
- AP20309PU-N
- AP33330SU-N
- AP33330SU-S
- SM2097F
- SM265P
- SM265PS
- SM265PXS
- SM265R
- SM266A
- SM266PS
- SM3015APC
- SM3015F
- SM3015P
- SM3015PP
- SM3015R
- SM3015RD5
- SM3151B
- SM3151P
- TA310265
- TA314066
- TA320368
- TA323668
- TA323669
- TA354176
- Novus Biologicals Antibodies for IL2RA
-
Abcam antibodies for IL2RA
- Invitrogen Antibodies for IL2RA (AFLGC-IL2RA)
-
Boster Bio Antibodies for IL2RA
-
Custom Antibody ServicesProSci Antibodies for IL2RA
- interleukin 2 receptor, alpha [18-894]
- interleukin 2 receptor, alpha [38-230]
- interleukin 2 receptor, alpha [43-525]
- interleukin 2 receptor, alpha [76-499]
- interleukin 2 receptor, alpha [76-500]
- interleukin 2 receptor, alpha [76-501]
- interleukin 2 receptor, alpha [76-502]
- interleukin 2 receptor, alpha [76-503]
- interleukin 2 receptor, alpha [76-504]
- interleukin 2 receptor, alpha [76-505]
- interleukin 2 receptor, alpha chain [76-506]
- interleukin 2 receptor, alpha chain [76-507]
- interleukin 2 receptor, alpha chain [76-508]
- interleukin 2 receptor, alpha chain [76-509]
- interleukin 2 receptor, alpha chain [76-510]
- interleukin 2 receptor, alpha chain [76-511]
- interleukin 2 receptor, alpha chain [76-512]
- interleukin 2 receptor, alpha chain [76-513]
- interleukin 2 receptor, alpha chain [76-514]
- interleukin 2 receptor, alpha chain [76-515]
- interleukin 2 receptor, alpha chain [76-516]
- interleukin 2 receptor, alpha chain [76-517]
- interleukin 2 receptor, alpha chain [76-518]
- interleukin 2 receptor, alpha chain [76-519]
- interleukin 2 receptor, alpha chain [76-520]
- interleukin 2 receptor, alpha [70-308]
- interleukin 2 receptor, alpha chain [98-697]
- interleukin 2 receptor, alpha chain [98-698]
- interleukin 2 receptor, alpha chain [98-699]
- interleukin 2 receptor, alpha chain [98-700]
- interleukin 2 receptor, alpha chain [98-701]
- interleukin 2 receptor, alpha chain [98-702]
- interleukin 2 receptor, alpha chain [98-703]
- interleukin 2 receptor, alpha chain [98-704]
- interleukin 2 receptor, alpha chain [98-705]
- interleukin 2 receptor, alpha chain [98-706]
- interleukin 2 receptor, alpha chain [98-707]
- interleukin 2 receptor, alpha chain [98-708]
- interleukin 2 receptor, alpha chain [98-709]
- interleukin 2 receptor, alpha chain [98-710]
- interleukin 2 receptor, alpha chain [98-711]
- interleukin 2 receptor, alpha chain [98-712]
- interleukin 2 receptor, alpha [99-502]
- interleukin 2 receptor, alpha [99-503]
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL2RA
- Sino Biological Antibodies for IL2RA
Protein products for research
- RayBiotech Recombinant Human IL-2 R alpha
- Search Origene for MassSpec and Protein Over-expression Lysates for IL2RA
- Origene Custom Protein Services for IL2RA
- Novus Biologicals proteins for IL2RA
- Sino Biological Recombinant Proteins for IL2RA
- Sino Biological Cell Lysates for IL2RA
- ProSpec Recombinant Proteins for IL2RA
-
ProSci Proteins for IL2RA
-
Abcam proteins for IL2RA
Assay products for research
- RayBiotech Human IL-2 R alpha ELISA
- Novus Biologicals ELISA Kits for IL2RA
- antibodies-online: Show 98 available CD25 Elisa Kits ranked by validation data
- Compare Top CD25 Elisa Kits
-
Quality Products:
- ABIN1115648
- ABIN365801
- ABIN417245
- ABIN625322
- ABIN5520142
- ABIN2684679
- ABIN2472085
- ABIN1672737
- ABIN4993127
- ABIN1029824
- ABIN425137
- ABIN1672833
- ABIN5563446
- ABIN1029825
- ABIN625409
- ABIN2708455
- ABIN6719931
- ABIN2684684
- ABIN366354
- ABIN6384350
- ABIN6730938
- ABIN1115692
- ABIN366483
- ABIN416235
- ABIN1570723
- ABIN5520144
- ABIN5670393
- ABIN5591798
- ABIN2748239
- ABIN6384348
- ABIN841976
- ABIN649216
- ABIN455614
- ABIN5655878
- ABIN2535483
- ABIN4970419
- ABIN6202551
-
Abcam assays for IL2RA
No data available for DME Specific Peptides for IL2RA Gene
Domains & Families for IL2RA Gene
Gene Families for IL2RA Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IL2RA Gene
- InterPro:
- Blocks:
-
- Sushi domain/SCR domain/CCP module
Suggested Antigen Peptide Sequences for IL2RA Gene
- GenScript: Design optimal peptide antigens:
-
- IL2R protein (A2N4P8_HUMAN)
- p55 (IL2RA_HUMAN)
- Interleukin-2 receptor (O15163_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL2RA Gene
Function for IL2RA Gene
Molecular function for IL2RA Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
- GENATLAS Biochemistry:
- interleukin 2,low affinity receptor,alpha chain 45kDa,expressed in T cell,B lymphoblast lines,peripheral blood monocyte
Phenotypes From GWAS Catalog for IL2RA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004911 | contributes_to interleukin-2 receptor activity | IEA,IMP | 2467293 |
| GO:0005515 | protein binding | IPI | 16477002 |
| GO:0019976 | interleukin-2 binding | IEA,IBA | 21873635 |
Phenotypes for IL2RA Gene
- MGI mutant phenotypes for IL2RA:
-
inferred from 3 alleles
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- GenomeRNAi human phenotypes for IL2RA:
-
- Decreased NF-kappaB reporter expression
- Decreased viability
- Reduced mammosphere formation
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability (cell death)
- No cells
- Increased HPV18 LCR reporter activity
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased BPV1 E2 protein expression
Animal Models for IL2RA Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL2RA - Starting at $85 >
- * IL2RA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL2RA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2RA
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2RA
miRNA for IL2RA Gene
- miRTarBase miRNAs that target IL2RA
-
- hsa-miR-5698 (MIRT631396)
- hsa-miR-744-3p (MIRT631397)
- hsa-miR-4423-5p (MIRT631398)
- hsa-miR-6501-5p (MIRT631399)
- hsa-miR-143-5p (MIRT631400)
- hsa-miR-4430 (MIRT631401)
- hsa-miR-3652 (MIRT631402)
- hsa-miR-122-5p (MIRT631403)
- hsa-miR-504-3p (MIRT631404)
- hsa-miR-3135b (MIRT631405)
- hsa-miR-6499-3p (MIRT631406)
- hsa-miR-367-5p (MIRT631407)
- hsa-miR-1267 (MIRT631408)
- hsa-miR-6805-3p (MIRT644978)
- hsa-miR-5691 (MIRT644979)
- hsa-miR-3194-3p (MIRT644980)
- hsa-miR-629-3p (MIRT662558)
- hsa-miR-6808-3p (MIRT662559)
- hsa-miR-6867-3p (MIRT662560)
- hsa-miR-4713-5p (MIRT662561)
- hsa-miR-6868-3p (MIRT662562)
- hsa-miR-642a-5p (MIRT662563)
- hsa-miR-7973 (MIRT662564)
- hsa-miR-6821-3p (MIRT662565)
- hsa-miR-6790-3p (MIRT662566)
- hsa-miR-3124-3p (MIRT662567)
- hsa-miR-6837-3p (MIRT662568)
- hsa-miR-6754-3p (MIRT662569)
- hsa-miR-412-3p (MIRT662570)
- hsa-miR-6515-3p (MIRT662571)
- hsa-miR-4685-3p (MIRT662572)
- hsa-miR-4287 (MIRT662573)
- hsa-miR-7113-3p (MIRT662574)
- hsa-miR-4469 (MIRT662575)
- hsa-miR-1248 (MIRT662576)
- hsa-miR-1237-3p (MIRT662577)
- hsa-miR-3667-3p (MIRT662578)
- hsa-miR-6734-3p (MIRT662579)
- hsa-miR-877-3p (MIRT662580)
- hsa-miR-5088-3p (MIRT662581)
- hsa-miR-2276-5p (MIRT662582)
- hsa-miR-6892-3p (MIRT662583)
- hsa-miR-4302 (MIRT662584)
- hsa-miR-6866-3p (MIRT662585)
- hsa-miR-188-5p (MIRT662586)
- hsa-miR-4439 (MIRT671560)
- hsa-miR-3136-5p (MIRT671561)
- hsa-miR-6857-3p (MIRT671562)
- hsa-miR-4513 (MIRT671563)
- hsa-miR-6855-3p (MIRT671564)
- mmu-miR-210-3p (MIRT732828)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2RA
- Browse OriGene Inhibitory RNA Products For IL2RA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2RA
Clone products for research
- Applied Biological Materials (abm): Clones for IL2RA - Starting at $45 >
- * IL2RA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IL2RA
- Addgene plasmids for IL2RA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2RA
Cell Lines for research
-
Horizon Cell Lines for IL2RA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL2RA Gene
Localization for IL2RA Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL2RA Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005893 | interleukin-2 receptor complex | TAS | 2467293 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL2RA Gene
Pathways & Interactions for IL2RA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
|
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PEDF Induced Signaling |
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
| 4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
| 5 | Th17 cell differentiation |
Immune response IL-22 signaling pathway
.36
|
|
Pathways by source for IL2RA Gene
3 Sino Biological pathways for IL2RA Gene
14 BioSystems pathways for IL2RA Gene
52 Reactome pathways for IL2RA Gene
11 KEGG pathways for IL2RA Gene
3 GeneGo (Thomson Reuters) pathways for IL2RA Gene
- Immune response IL-2 activation and signaling pathway
- Immune response IL-22 signaling pathway
- Immune response_IL-12 signaling pathway
8 R&D Systems pathways for IL2RA Gene
- Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers
- IgA-Producing B Cells in the Intestine
- IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
- IL-2 Signaling Pathways
- IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types
3 Tocris pathways for IL2RA Gene
38 Qiagen pathways for IL2RA Gene
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- Akt Signaling
- Antioxidant Action of Vitamin-C
- Apoptotic Pathways in Synovial Fibroblasts
1 Cell Signaling Technology pathway for IL2RA Gene
Interacting Proteins for IL2RA Gene
Selected Interacting proteins:
P01589-IL2RA_HUMAN
ENSP00000369293
for IL2RA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IL2RA
SIGNOR curated interactions for IL2RA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002437 | inflammatory response to antigenic stimulus | IEA | -- |
| GO:0002664 | regulation of T cell tolerance induction | IMP | 23416241 |
| GO:0006915 | apoptotic process | TAS | 9096364 |
Drugs & Compounds for IL2RA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Denileukin diftitox | Approved, Investigational | Pharma | Target, binder | 46 | ||
| Basiliximab | Approved, Investigational | Pharma | Target, antibody | 151 | ||
| Aldesleukin | Approved | Pharma | Target, agonist, modulator, inhibitor | 465 | ||
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 92 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 440 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AS 101 |
|
106566-58-9 |
|
|||
| GIT 27 |
|
6501-72-0 |
|
|
(4) Tocris Compounds for IL2RA Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
(1) ApexBio Compounds for IL2RA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Dexamethasone Sodium Phosphate | 55203-24-2 |
Transcripts for IL2RA Gene
mRNA/cDNA for IL2RA Gene
- 3 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256876 1006 nts (view in UCSC)
- ENST00000379954 1562 nts (view in UCSC)
- ENST00000379959 3218 nts (view in UCSC)
- ENST00000447847 326 nts (view in UCSC)
- ENST00000644262 622 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL2RA - Starting at $85 >
- * IL2RA CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL2RA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2RA
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2RA
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2RA
- Browse OriGene Inhibitory RNA Products For IL2RA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2RA
Clone products for research
- Applied Biological Materials (abm): Clones for IL2RA - Starting at $45 >
- * IL2RA as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IL2RA
- Addgene plasmids for IL2RA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2RA
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: |
Relevant External Links for IL2RA Gene
- GeneLoc Exon Structure for
- IL2RA
Expression for IL2RA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- T Helper Cells Peripheral Blood
- T-Regulatory Cells Peripheral Blood
- Large Pre B-Cells Hematopoietic Bone Marrow
- Immature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Double Negative 3 Thymocytes Thymus
- T-Regulatory Cells Thymus
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Endothelium (Cardiovascular System)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IL2RA Gene
This gene is overexpressed in Spleen (x9.3), Small Intestine - Terminal Ileum (x6.2), and Whole Blood (x4.3).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL2RA Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL2RA
SOURCE GeneReport for Unigene cluster for IL2RA Gene:
Hs.231367Evidence on tissue expression from TISSUES for IL2RA Gene
- Spleen(3.4)
- Lymph node(3.2)
- Blood(3)
- Bone marrow(2.5)
- Intestine(2.5)
- Skin(2.2)
- Lung(2.1)
- Heart(2.1)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL2RA Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- skull
- tooth
Abdomen:
- intestine
- large intestine
- liver
- small intestine
- spleen
Pelvis:
- anus
- rectum
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- bone marrow
- hair
- lymph node
- red blood cell
- skin
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for IL2RA
-
OriGene qPCR primer pairs and template standards for IL2RA
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt for IL2RA Gene
Orthologs for IL2RA Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL2RA 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL2RA 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il2ra 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il2ra 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | IL2RA 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL2RA 30 |
|
OneToOne |
- Species where no ortholog for IL2RA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL2RA Gene
- ENSEMBL:
- Gene Tree for IL2RA (if available)
- TreeFam:
- Gene Tree for IL2RA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL2RA: view image
- Alliance of Genome Resources:
- Additional Orthologs for IL2RA
Paralogs for IL2RA Gene
(1) SIMAP similar genes for IL2RA Gene using alignment to 4 proteins:
- IL2RA_HUMAN
- H0Y5Z0_HUMAN
- Q5W005_HUMAN
- Q5W006_HUMAN
No data available for Paralogs for IL2RA Gene
Variants for IL2RA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL2RA Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1005381 | Uncertain Significance: Interleukin 2 receptor, alpha, deficiency of | 6,021,634(-) |
C/A NM_000417.3(IL2RA):c.427G>T (p.Val143Leu) |
MISSENSE_VARIANT,INTRON | |
| 1005899 | Uncertain Significance: Interleukin 2 receptor, alpha, deficiency of | 6,021,607(-) |
A/G NM_000417.3(IL2RA):c.454T>C (p.Cys152Arg) |
MISSENSE_VARIANT,INTRON | |
| 1011504 | Uncertain Significance: Interleukin 2 receptor, alpha, deficiency of | 6,026,004(-) |
G/A NM_000417.3(IL2RA):c.86C>T (p.Pro29Leu) |
MISSENSE | |
| 1015319 | Uncertain Significance: Interleukin 2 receptor, alpha, deficiency of | 6,025,869(-) |
G/A NM_000417.3(IL2RA):c.221C>T (p.Ser74Leu) |
MISSENSE | |
| 1019241 | Uncertain Significance: Interleukin 2 receptor, alpha, deficiency of | 6,026,014(-) |
C/T NM_000417.3(IL2RA):c.76G>A (p.Asp26Asn) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1e49 | CNV | loss | 18971310 |
| dgv352n106 | CNV | deletion | 24896259 |
| esv1000739 | CNV | deletion | 20482838 |
| esv1011098 | CNV | deletion | 20482838 |
| esv1592945 | CNV | deletion | 17803354 |
| esv2014648 | CNV | deletion | 18987734 |
| esv2516054 | CNV | deletion | 19546169 |
| esv2731873 | CNV | deletion | 23290073 |
| esv2731884 | CNV | deletion | 23290073 |
| esv2731895 | CNV | deletion | 23290073 |
| esv3132533 | CNV | deletion | 24192839 |
| esv3264829 | CNV | deletion | 24192839 |
| esv3349435 | CNV | duplication | 20981092 |
| esv3545834 | CNV | deletion | 23714750 |
| esv3545835 | CNV | deletion | 23714750 |
| esv4965 | CNV | loss | 18987735 |
| esv5272 | CNV | loss | 18987735 |
| esv9342 | CNV | loss | 19470904 |
| nsv1068274 | CNV | deletion | 25765185 |
| nsv1073083 | CNV | deletion | 25765185 |
| nsv1148973 | CNV | deletion | 26484159 |
| nsv525927 | CNV | loss | 19592680 |
| nsv956342 | CNV | deletion | 24416366 |
| nsv958561 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL2RA Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL2RA Gene
Disorders for IL2RA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 41 with lymphoproliferation and autoimmunity |
|
|
| type 1 diabetes mellitus 10 |
|
|
| intermediate uveitis |
|
|
| posterior uveitis |
|
|
| oligoarticular juvenile idiopathic arthritis |
|
Search IL2RA in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL2RA_HUMAN- Diabetes mellitus, insulin-dependent, 10 (IDDM10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:17676041}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
- Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41) [MIM:606367]: A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions. {ECO:0000269 PubMed:23416241, ECO:0000269 PubMed:24116927}. Note=The disease is caused by variants affecting the gene represented in this entry.
Genatlas disease for IL2RA Gene
immunodeficiency,severe combined with absence of CD1 and of IL2RA expression on cortical thymocyte
Additional Disease Information for IL2RA
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
Publications for IL2RA Gene
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. (PMID: 17676041) Lowe CE … Todd JA (Nature genetics 2007) 2 3 4 40 72
- Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population. (PMID: 19106270) Kawasaki E … Japanese Study Group on Type 1 Diabetes Genetics (The Journal of clinical endocrinology and metabolism 2009) 3 22 40
- Risk alleles for multiple sclerosis identified by a genomewide study. (PMID: 17660530) International Multiple Sclerosis Genetics Consortium … Hauser SL (The New England journal of medicine 2007) 3 22 40
- Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity. (PMID: 23416241) Goudy K … Bacchetta R (Clinical immunology (Orlando, Fla.) 2013) 3 4
- A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S … Arnett DK (Pharmacogenetics and genomics 2012) 3 40
ExternalLinks
Products for IL2RA Gene
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- AM00962PU-N
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- AP20309PU-N
- AP33330SU-N
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- SM2097F
- SM265P
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- SM266A
- SM266PS
- SM3015APC
- SM3015F
- SM3015P
- SM3015PP
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