Aliases for IL27RA Gene
External Ids for IL27RA Gene
Previous GeneCards Identifiers for IL27RA Gene
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL27RA Gene
IL27RA (Interleukin 27 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL27RA include Crisponi/Cold-Induced Sweating Syndrome 2. Among its related pathways are Interleukin-6 family signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and interleukin-27 receptor activity. An important paralog of this gene is IL12RB2.
UniProtKB/Swiss-Prot Summary for IL27RA Gene
Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.