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Aliases for IL27 Gene

Aliases for IL27 Gene

  • Interleukin 27 2 3 5
  • Interleukin-27 Subunit Alpha 3 4
  • IL-27 Subunit Alpha 3 4
  • Interleukin-30 3 4
  • IL-27-A 3 4
  • IL27-A 3 4
  • IL27A 3 4
  • IL30 3 4
  • P28 3 4
  • IL-27 P28 Subunit 3
  • Interleukin 30 2
  • IL27p28 3
  • IL-27A 3
  • IL-27 3

External Ids for IL27 Gene

Previous HGNC Symbols for IL27 Gene

  • IL30

Previous GeneCards Identifiers for IL27 Gene

  • GC16P028586
  • GC16M028418
  • GC16M026536

Summaries for IL27 Gene

Entrez Gene Summary for IL27 Gene

  • The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

GeneCards Summary for IL27 Gene

IL27 (Interleukin 27) is a Protein Coding gene. Diseases associated with IL27 include Eosinophilic Granulomatosis With Polyangiitis and Visceral Leishmaniasis. Among its related pathways are Innate Immune System and Th1 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and interleukin-27 receptor binding.

UniProtKB/Swiss-Prot for IL27 Gene

  • Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.

Additional gene information for IL27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL27 Gene

Genomics for IL27 Gene

GeneHancer (GH) Regulatory Elements for IL27 Gene

Promoters and enhancers for IL27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028503 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.3 +20.3 20285 5 ZNF652 ELF3 CTCF NKRF CEBPG RERE MYC TFE3 RELA SP1 IL27 SGF29 TUFM SULT1A2 CDC37P1 GC16P028499 PIR49782
GH16J028525 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 600.7 -1.3 -1349 4.5 ZNF652 ELF3 CEBPG RERE TFE3 SP1 PPARG SP5 ZNF384 ZNF644 IL27 SULT1A2 TUFM CLN3 APOBR NPIPB7 SGF29 ENSG00000251417 PIR42560
GH16J028524 Enhancer 0.9 Ensembl ENCODE 600.7 +1.8 1798 1.6 NFIB MAFK SP1 RXRA NFE2L2 REST ZNF341 ZNF316 CTCF NFE2 IL27 SULT1A2 APOBR CLN3 ENSG00000251417 PIR49782 GC16P028499
GH16J028531 Enhancer 1.1 FANTOM5 ENCODE 10.8 -7.3 -7257 3.7 CC2D1A SP1 HNF1A PPARG SP5 ZNF644 RXRA IKZF1 ZNF512 CEBPA PIR42560 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1
GH16J028617 Enhancer 0.9 FANTOM5 ENCODE 7 -91.4 -91432 1.2 ELF3 CEBPG ZNF384 KAT8 SOX13 CEBPA GATAD2A RXRB GABPA TCF7 TUFM IL27 SBK1 PIR38771 SULT1A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL27 gene promoter:
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • C/EBPbeta
  • IRF-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for IL27 Gene

Genomic Locations for IL27 Gene
chr16:28,499,069-28,526,399
(GRCh38/hg38)
Size:
27,331 bases
Orientation:
Minus strand
chr16:28,510,683-28,523,372
(GRCh37/hg19)
Size:
12,690 bases
Orientation:
Minus strand

Genomic View for IL27 Gene

Genes around IL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL27 Gene

Proteins for IL27 Gene

  • Protein details for IL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV9-IL27A_HUMAN
    Recommended name:
    Interleukin-27 subunit alpha
    Protein Accession:
    Q8NEV9
    Secondary Accessions:
    • A0N0L2
    • Q6P676

    Protein attributes for IL27 Gene

    Size:
    243 amino acids
    Molecular mass:
    27493 Da
    Quaternary structure:
    • Heterodimer with EBI3; not disulfide-linked. This heterodimer is known as interleukin IL-27.

neXtProt entry for IL27 Gene

Post-translational modifications for IL27 Gene

Other Protein References for IL27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL27 Gene

Domains & Families for IL27 Gene

Gene Families for IL27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL27 Gene

GenScript: Design optimal peptide antigens:
  • p28 (IL27A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEV9

UniProtKB/Swiss-Prot:

IL27A_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL27: view

Function for IL27 Gene

Molecular function for IL27 Gene

UniProtKB/Swiss-Prot Function:
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.
UniProtKB/Swiss-Prot Induction:
Transiently induced by bacterial lipopolysaccharides (LPS) stimulation in monocytes.

Phenotypes From GWAS Catalog for IL27 Gene

Gene Ontology (GO) - Molecular Function for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding ISS,IEA --
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 20974977
GO:0045523 interleukin-27 receptor binding ISS --
genes like me logo Genes that share ontologies with IL27: view
genes like me logo Genes that share phenotypes with IL27: view

Animal Models for IL27 Gene

MGI Knock Outs for IL27:
  • Il27 Il27<tm1b(EUCOMM)Wtsi>
  • Il27 Il27<tm1Lex>
  • Il27 Il27<tm1Cua>

Animal Model Products

  • Taconic Biosciences Mouse Models for IL27

CRISPR Products

miRNA for IL27 Gene

miRTarBase miRNAs that target IL27

Clone Products

  • Applied Biological Materials (abm): Clones for IL27 - Now 50% OFF >
  • * IL27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IL27 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL27 Gene

Localization for IL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL27 Gene

Secreted. Note=Does not seem to be secreted without coexpression of EBI3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL27 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 4
plasma membrane 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS,IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IL27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL27 Gene

Pathways & Interactions for IL27 Gene

genes like me logo Genes that share pathways with IL27: view

Pathways by source for IL27 Gene

SIGNOR curated interactions for IL27 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IEA --
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0009617 response to bacterium IEA --
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with IL27: view

Drugs & Compounds for IL27 Gene

No Compound Related Data Available

Transcripts for IL27 Gene

mRNA/cDNA for IL27 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for IL27 Gene

Interleukin 27:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for IL27 - Now 50% OFF >
  • * IL27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IL27 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for IL27 Gene

No ASD Table

Relevant External Links for IL27 Gene

GeneLoc Exon Structure for
IL27
ECgene alternative splicing isoforms for
IL27

Expression for IL27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL27 Gene

mRNA differential expression in normal tissues according to GTEx for IL27 Gene

This gene is overexpressed in Liver (x26.4) and Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for IL27 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL27 Gene



Protein tissue co-expression partners for IL27 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL27 Gene:

IL27

SOURCE GeneReport for Unigene cluster for IL27 Gene:

Hs.528111

mRNA Expression by UniProt/SwissProt for IL27 Gene:

Q8NEV9-IL27A_HUMAN
Tissue specificity: Expressed in monocytes and in placenta.

Evidence on tissue expression from TISSUES for IL27 Gene

  • Lung(4)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with IL27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL27 Gene

Orthologs for IL27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL27 35 34
  • 99.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il27 17 35 34
  • 82.35 (n)
rat
(Rattus norvegicus)
Mammalia Il27 34
  • 80.69 (n)
cow
(Bos Taurus)
Mammalia IL27 35 34
  • 79.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL27 35 34
  • 77.78 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL27 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL27 35
  • 51 (a)
OneToOne
Species where no ortholog for IL27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL27 Gene

ENSEMBL:
Gene Tree for IL27 (if available)
TreeFam:
Gene Tree for IL27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL27: view image

Paralogs for IL27 Gene

No data available for Paralogs for IL27 Gene

Variants for IL27 Gene

Sequence variations from dbSNP and Humsavar for IL27 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000008119 -- 28,511,608(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000024692 -- 28,523,152(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000325951 -- 28,503,889(-) C/T coding_sequence_variant, missense_variant
rs1000444768 -- 28,511,166(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000480983 -- 28,522,872(-) G/A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL27 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1059555 CNV gain 25217958
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897

Variation tolerance for IL27 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL27
Human Gene Mutation Database (HGMD)
IL27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL27 Gene

Disorders for IL27 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL27 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic granulomatosis with polyangiitis
  • css
visceral leishmaniasis
  • infection by visceral leishmaniasis
granulomatosis with polyangiitis
  • gpa
- elite association - COSMIC cancer census association via MalaCards
Search IL27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL27 Gene

Publications for IL27 Gene

  1. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. (PMID: 17318299) Chae SC … Chung HT (Journal of human genetics 2007) 3 4 23 45 58
  2. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. (PMID: 19686419) Li CS … Chae SC (Journal of gastroenterology and hepatology 2009) 3 23 45 58
  3. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. (PMID: 12121660) Pflanz S … Kastelein RA (Immunity 2002) 2 3 4 58
  4. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 45 58
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 45 58

Products for IL27 Gene

Sources for IL27 Gene

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