Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]
IL27 (Interleukin 27) is a Protein Coding gene. Diseases associated with IL27 include Visceral Leishmaniasis and Posterior Uveitis. Among its related pathways are PEDF Induced Signaling and IL27-mediated signaling events. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and interleukin-27 receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA,ISS | -- |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005515 | protein binding | IPI | 19933857 |
GO:0045523 | interleukin-27 receptor binding | IBA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA,ISS | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL27-mediated signaling events | ||
2 | Cytokine Signaling in Immune system | ||
3 | Interleukin-6 family signaling | ||
4 | PEDF Induced Signaling | ||
5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002230 | positive regulation of defense response to virus by host | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
GO:0009617 | response to bacterium | IEA | -- |
GO:0042129 | regulation of T cell proliferation | ISS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL27 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il27 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il27 30 |
|
||
Cow (Bos Taurus) |
Mammalia | IL27 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL27 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL27 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL27 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17855750 | - | p.Ser59Ala | |||
rs181206 | - | p.Leu119Pro |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758640 | CNV | gain+loss | 17122850 |
nsv1059555 | CNV | gain | 25217958 |
nsv509608 | CNV | insertion | 20534489 |
nsv833180 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
visceral leishmaniasis |
|
|
posterior uveitis |
|
|
autoimmune disease of eyes, ear, nose and throat |
|
|
middle cerebral artery infarction |
|
|
granulomatosis with polyangiitis |
|
|