Aliases for IL26 Gene
External Ids for IL26 Gene
Previous GeneCards Identifiers for IL26 Gene
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL26 Gene
IL26 (Interleukin 26) is a Protein Coding gene. Diseases associated with IL26 include Crohn's Disease and Hidradenitis Suppurativa. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL10.
UniProtKB/Swiss-Prot Summary for IL26 Gene
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.