This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008] See more...

Aliases for IL26 Gene

Aliases for IL26 Gene

  • Interleukin 26 2 3 5
  • AK155 2 3 4
  • IL-26 2 3 4
  • Interleukin-26 3 4
  • Protein AK155 4
  • IL26 5

External Ids for IL26 Gene

Previous GeneCards Identifiers for IL26 Gene

  • GC12M068110
  • GC12M068399
  • GC12M068311
  • GC12M066881
  • GC12M068595
  • GC12M065646

Summaries for IL26 Gene

Entrez Gene Summary for IL26 Gene

  • This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL26 Gene

IL26 (Interleukin 26) is a Protein Coding gene. Diseases associated with IL26 include Crohn's Disease and Inflammatory Bowel Disease. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL10.

UniProtKB/Swiss-Prot Summary for IL26 Gene

  • May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

Gene Wiki entry for IL26 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL26 Gene

Genomics for IL26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J068225 Promoter 0.4 EPDnew 600.7 -0.1 -82 0.1 PKNOX1 IL26 LOC105369818 IL22 lnc-MDM1-2 IFNG-AS1
GH12J068227 Enhancer 0.3 Ensembl 600.7 +0.7 721 0.6 FOXA1 IL26 MDM1 LOC105369818 IFNG IFNG-AS1
GH12J068264 Enhancer 0.9 FANTOM5 Ensembl ENCODE 19.6 -43.0 -42991 10.4 PRDM10 ZNF24 CEBPB FOS ATF2 EP300 CEBPG SPI1 STAT3 BATF piR-56497-031 IL26 MDM1 LINC02384 IL22 lnc-NUP107-26 piR-56497-032 LOC105369818
GH12J068319 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 -94.5 -94463 0.9 IKZF1 JUND ZNF600 NFE2 ZNF316 NR2C2 MAFG MAFK SMARCA4 MAFF IL26 RPL7P42 ENSG00000247363 NUP107 RPL10P12 SNORA70G MN309480 MN309481 MDM1 piR-59907-008
GH12J068290 Enhancer 1 Ensembl ENCODE 11.1 -64.6 -64590 0.8 SP1 BACH1 STAT3 JUND TCF12 IKZF2 RCOR1 TRIM22 PKNOX1 EED IL26 MDM1 LINC02384 piR-56497-032 MN309480 lnc-NUP107-26 IL22 LOC105369818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL26

Top Transcription factor binding sites by QIAGEN in the IL26 gene promoter:
  • AML1a
  • C/EBPalpha
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for IL26 Gene

Genomic Locations for IL26 Gene
chr12:68,201,349-68,225,810
(GRCh38/hg38)
Size:
24,462 bases
Orientation:
Minus strand
chr12:68,595,129-68,619,601
(GRCh37/hg19)
Size:
24,473 bases
Orientation:
Minus strand

Genomic View for IL26 Gene

Genes around IL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL26 Gene

Proteins for IL26 Gene

  • Protein details for IL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH9-IL26_HUMAN
    Recommended name:
    Interleukin-26
    Protein Accession:
    Q9NPH9

    Protein attributes for IL26 Gene

    Size:
    171 amino acids
    Molecular mass:
    19843 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for IL26 Gene

Post-translational modifications for IL26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL26 Gene

Domains & Families for IL26 Gene

Gene Families for IL26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL26 Gene

Suggested Antigen Peptide Sequences for IL26 Gene

GenScript: Design optimal peptide antigens:
  • Protein AK155 (IL26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPH9

UniProtKB/Swiss-Prot:

IL26_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL26: view

Function for IL26 Gene

Molecular function for IL26 Gene

UniProtKB/Swiss-Prot Function:
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
UniProtKB/Swiss-Prot Induction:
By Herpesvirus saimiri infection.

Phenotypes From GWAS Catalog for IL26 Gene

Gene Ontology (GO) - Molecular Function for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IDA 18483078
genes like me logo Genes that share ontologies with IL26: view
genes like me logo Genes that share phenotypes with IL26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL26 Gene

Localization for IL26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL26 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL26 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 18483078
GO:0005829 cytosol IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL26 Gene

Pathways & Interactions for IL26 Gene

PathCards logo

SuperPathways for IL26 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.41
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with IL26: view

Pathways by source for IL26 Gene

1 KEGG pathway for IL26 Gene
1 R&D Systems pathway for IL26 Gene
24 Qiagen pathways for IL26 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

Interacting Proteins for IL26 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 6)
STRING Interaction Network
Selected Interacting proteins: ENSP00000229134 Q9NPH9-IL26_HUMAN for IL26 Gene via STRING IID

SIGNOR curated interactions for IL26 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 10729163
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032874 positive regulation of stress-activated MAPK cascade IDA 18483078
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 18483078
GO:0046427 positive regulation of JAK-STAT cascade IDA 18483078
genes like me logo Genes that share ontologies with IL26: view

Drugs & Compounds for IL26 Gene

No Compound Related Data Available

Transcripts for IL26 Gene

mRNA/cDNA for IL26 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL26

Alternative Splicing Database (ASD) splice patterns (SP) for IL26 Gene

No ASD Table

Relevant External Links for IL26 Gene

GeneLoc Exon Structure for
IL26

Expression for IL26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL26 Gene

mRNA differential expression in normal tissues according to GTEx for IL26 Gene

This gene is overexpressed in Colon - Sigmoid (x6.0), Esophagus - Mucosa (x4.5), and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for IL26 Gene

This gene is overexpressed in Heart (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL26 Gene



Protein tissue co-expression partners for IL26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL26

SOURCE GeneReport for Unigene cluster for IL26 Gene:

Hs.272350

mRNA Expression by UniProt/SwissProt for IL26 Gene:

Q9NPH9-IL26_HUMAN
Tissue specificity: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).

Evidence on tissue expression from TISSUES for IL26 Gene

  • Blood(2.4)
  • Spleen(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with IL26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL26 Gene

Orthologs for IL26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL26 30 31
  • 99.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL26 30
  • 89.35 (n)
Dog
(Canis familiaris)
Mammalia IL26 30 31
  • 86.59 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL26 31
  • 50 (a)
OneToOne
Species where no ortholog for IL26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL26 Gene

ENSEMBL:
Gene Tree for IL26 (if available)
TreeFam:
Gene Tree for IL26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL26: view image

Paralogs for IL26 Gene

Paralogs for IL26 Gene

genes like me logo Genes that share paralogs with IL26: view

Variants for IL26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL26 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
776730 Benign: not provided 68,225,670(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IL26 Gene

Variation tolerance for IL26 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL26 Gene

Disorders for IL26 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL26 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
crohn's disease
  • ileitis
inflammatory bowel disease
  • inflammatory bowel diseases
psoriasis 12
  • psoriasis 12, susceptibility to
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards
Search IL26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL26 Gene

Publications for IL26 Gene

  1. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. (PMID: 18483078) Dambacher J … Brand S (Gut 2009) 3 4 23
  2. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. (PMID: 15178681) Hör S … Fickenscher H (The Journal of biological chemistry 2004) 3 4 23
  3. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F … Kotenko SV (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 23
  4. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. (PMID: 14558082) Vandenbroeck K … Rooney M (Arthritis and rheumatism 2003) 3 23 41
  5. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. (PMID: 10729163) Knappe A … Fickenscher H (Journal of virology 2000) 2 3 4

Products for IL26 Gene

  • Biorbyt antibodies for IL26

Sources for IL26 Gene