The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favor... See more...

Aliases for IL25 Gene

Aliases for IL25 Gene

  • Interleukin 25 2 3 5
  • Interleukin-17E 3 4
  • Interleukin-25 3 4
  • IL17E 3 4
  • Interleukin 17E 2
  • IL-17E 4
  • IL-25 4

External Ids for IL25 Gene

Previous HGNC Symbols for IL25 Gene

  • IL17E

Previous GeneCards Identifiers for IL25 Gene

  • GC14P022912
  • GC14P023843
  • GC14P003958
  • GC14P023857
  • GC14P023467
  • GC14P023500
  • GC14P024491
  • GC14P024612
  • GC14P024730
  • GC14P023649
  • GC14P023682
  • GC14P023867
  • GC14P023928
  • GC14P024039
  • GC14P024154
  • GC14P024265
  • GC14P024376

Summaries for IL25 Gene

Entrez Gene Summary for IL25 Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for IL25 Gene

IL25 (Interleukin 25) is a Protein Coding gene. Diseases associated with IL25 include Nail Disease and Chronic Mucocutaneous Candidiasis. Among its related pathways are Development and heterogeneity of the ILC family and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-17E receptor binding. An important paralog of this gene is IL17C.

UniProtKB/Swiss-Prot Summary for IL25 Gene

  • Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

Gene Wiki entry for IL25 Gene

Additional gene information for IL25 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL25 Gene

Genomics for IL25 Gene

GeneHancer (GH) Regulatory Elements for IL25 Gene

Promoters and enhancers for IL25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023442 Enhancer 1.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.8 +70.3 70319 3.1 ZNF341 ZNF282 E4F1 GABPA ZNF395 HDAC2 ZNF175 PHB2 IKZF1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 piR-36756-027
GH14J023145 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -225.4 -225434 4.5 PHB2 ZBTB11 AFF1 TRIM28 REST HES1 USF2 NR3C1 TOE1 MYC ENSG00000259321 RNF212B SLC7A8 CEBPE ACIN1 AP1G2 SLC22A17 CMTM5 IL25 C14orf93
GH14J023140 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -230.6 -230614 3.2 USF1 RFX1 ZNF316 CEBPB RCOR1 GTF2F1 GATA3 ZNF335 MAX MXI1 SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 CMTM5 IL25 DHRS4-AS1 piR-43105-157
GH14J023453 Enhancer 1.1 Ensembl ENCODE 9.8 +81.6 81622 1.9 PHB2 AFF1 MYC CTBP1 MXI1 ZSCAN9 NCOR1 TRIM25 NFIC ARNT MYH6 MIR208B SLC22A17 MIR208A ZFHX2-AS1 ZFHX2 BCL2L2 CMTM5 IL25 HOMEZ
GH14J023328 Enhancer 0.9 Ensembl ENCODE 10.6 -44.6 -44582 0.9 CTCF POLR2G NCOR1 POLR2A REST RAD21 TRIM22 ZKSCAN8 SMC3 ZSCAN9 SLC22A17 EFS CMTM5 BCL2L2 HOMEZ PPP1R3E MIR208A IL25 MYH6 MIR208B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL25

Top Transcription factor binding sites by QIAGEN in the IL25 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • p53

Genomic Locations for IL25 Gene

Genomic Locations for IL25 Gene
chr14:23,372,809-23,376,403
(GRCh38/hg38)
Size:
3,595 bases
Orientation:
Plus strand
chr14:23,842,018-23,845,612
(GRCh37/hg19)
Size:
3,595 bases
Orientation:
Plus strand

Genomic View for IL25 Gene

Genes around IL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL25 Gene

Proteins for IL25 Gene

  • Protein details for IL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H293-IL25_HUMAN
    Recommended name:
    Interleukin-25
    Protein Accession:
    Q9H293
    Secondary Accessions:
    • Q2M3F0
    • Q8IZV3
    • Q8WXB0

    Protein attributes for IL25 Gene

    Size:
    177 amino acids
    Molecular mass:
    20330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL25 Gene

Post-translational modifications for IL25 Gene

  • Glycosylation at Asn136
  • Modification sites at PhosphoSitePlus

Other Protein References for IL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL25 Gene

Domains & Families for IL25 Gene

Gene Families for IL25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL25 Gene

Blocks:
  • Interleukin-17
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL25 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-17E (IL25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H293

UniProtKB/Swiss-Prot:

IL25_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL25: view

Function for IL25 Gene

Molecular function for IL25 Gene

UniProtKB/Swiss-Prot Function:
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

Phenotypes From GWAS Catalog for IL25 Gene

Gene Ontology (GO) - Molecular Function for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0030380 interleukin-17E receptor binding TAS 11058597
genes like me logo Genes that share ontologies with IL25: view
genes like me logo Genes that share phenotypes with IL25: view

Animal Models for IL25 Gene

MGI Knock Outs for IL25:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL25

CRISPR Products

miRNA for IL25 Gene

miRTarBase miRNAs that target IL25

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL25 Gene

Localization for IL25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL25 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL25 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL25 Gene

Pathways & Interactions for IL25 Gene

genes like me logo Genes that share pathways with IL25: view

Gene Ontology (GO) - Biological Process for IL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0006954 inflammatory response IEA --
GO:0008150 biological_process ND --
GO:0009620 response to fungus IEA --
GO:0009624 response to nematode IEA --
genes like me logo Genes that share ontologies with IL25: view

No data available for SIGNOR curated interactions for IL25 Gene

Drugs & Compounds for IL25 Gene

(1) Drugs for IL25 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vidofludimus Investigational Pharma inhibitor DHODH inhibitor 0
genes like me logo Genes that share compounds with IL25: view

Transcripts for IL25 Gene

mRNA/cDNA for IL25 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for IL25 Gene

GeneLoc Exon Structure for
IL25

Expression for IL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL25 Gene

mRNA differential expression in normal tissues according to GTEx for IL25 Gene

This gene is overexpressed in Testis (x7.0) and Heart - Atrial Appendage (x5.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL25

SOURCE GeneReport for Unigene cluster for IL25 Gene:

Hs.302036

mRNA Expression by UniProt/SwissProt for IL25 Gene:

Q9H293-IL25_HUMAN
Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Evidence on tissue expression from TISSUES for IL25 Gene

  • Lung(2)
genes like me logo Genes that share expression patterns with IL25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL25 Gene

Orthologs for IL25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL25 31 30
  • 98.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL25 31 30
  • 84.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il25 17 31 30
  • 84.06 (n)
dog
(Canis familiaris)
Mammalia IL25 31 30
  • 83.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il25 30
  • 81.57 (n)
oppossum
(Monodelphis domestica)
Mammalia IL25 31
  • 52 (a)
OneToOne
Species where no ortholog for IL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL25 Gene

ENSEMBL:
Gene Tree for IL25 (if available)
TreeFam:
Gene Tree for IL25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL25: view image

Paralogs for IL25 Gene

Paralogs for IL25 Gene

genes like me logo Genes that share paralogs with IL25: view

Variants for IL25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL25 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
775101 Benign: not provided 23,375,770(+) C/T MISSENSE_VARIANT
791055 Likely Benign: not provided 23,375,867(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IL25 Gene

Variation tolerance for IL25 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL25 Gene

Disorders for IL25 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL25 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nail disease
  • nail anomaly
chronic mucocutaneous candidiasis
  • cmc
inflammatory bowel disease
  • inflammatory bowel diseases
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search IL25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL25 Gene

Publications for IL25 Gene

  1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PMID: 11058597) Lee J … Gurney AL (The Journal of biological chemistry 2001) 2 3 4 54
  2. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. (PMID: 11754819) Fort MM … Rennick DM (Immunity 2001) 2 3 4 54
  3. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 41 54
  4. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. (PMID: 19129540) Caruso R … Monteleone G (Blood 2009) 3 23 54
  5. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. (PMID: 17635955) Wang YH … Liu YJ (The Journal of experimental medicine 2007) 3 23 54

Products for IL25 Gene

Sources for IL25 Gene