Aliases for IL25 Gene
External Ids for IL25 Gene
Previous HGNC Symbols for IL25 Gene
Previous GeneCards Identifiers for IL25 Gene
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for IL25 Gene
IL25 (Interleukin 25) is a Protein Coding gene. Diseases associated with IL25 include Nail Disease and Chronic Mucocutaneous Candidiasis. Among its related pathways are Development and heterogeneity of the ILC family and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-17E receptor binding. An important paralog of this gene is IL17C.
UniProtKB/Swiss-Prot Summary for IL25 Gene
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.