Aliases for IL24 Gene
External Ids for IL24 Gene
Previous HGNC Symbols for IL24 Gene
Previous GeneCards Identifiers for IL24 Gene
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL24 Gene
IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include Melanoma and Lower Gum Cancer. Among its related pathways are ERK Signaling and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL19.
UniProtKB/Swiss-Prot Summary for IL24 Gene
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.