This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The p... See more...

Aliases for IL24 Gene

Aliases for IL24 Gene

  • Interleukin 24 2 3 5
  • Suppression Of Tumorigenicity 16 (Melanoma Differentiation) 2 3
  • Melanoma Differentiation-Associated Gene 7 Protein 3 4
  • IL-4-Induced Secreted Protein 2 3
  • Interleukin-24 3 4
  • IL10B 2 3
  • IL-24 2 4
  • C49A 2 3
  • FISP 2 3
  • MDA7 3 4
  • ST16 3 4
  • Melanoma Differentiation Association Protein 7 2
  • Suppression Of Tumorigenicity 16 Protein 4
  • Melanocyte-Associated Mda-7 3
  • Mda-7 2
  • Mob-5 2
  • MDA-7 4
  • MOB5 3
  • IL24 5

External Ids for IL24 Gene

Previous HGNC Symbols for IL24 Gene

  • ST16

Previous GeneCards Identifiers for IL24 Gene

  • GC01P205730
  • GC01P202781
  • GC01P203714
  • GC01P204154
  • GC01P203459
  • GC01P205137
  • GC01P207070
  • GC01P177769

Summaries for IL24 Gene

Entrez Gene Summary for IL24 Gene

  • This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL24 Gene

IL24 (Interleukin 24) is a Protein Coding gene. Diseases associated with IL24 include Melanoma and Chronic Spontaneous Urticaria. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot Summary for IL24 Gene

  • Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Gene Wiki entry for IL24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL24 Gene

Genomics for IL24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206889 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 252.6 -3.1 -3082 10.3 JUND BRCA1 ZNF217 CEBPB ELK1 HES1 BHLHE40 FEZF1 MAX EP300 IL24 LOC105372879 ENSG00000271680 RASSF5 CD55 MAPKAPK2 DYRK3 HSALNG0010055 lnc-FCMR-2 IL20
GH01J206768 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -126.5 -126484 4.5 BCLAF1 SP1 IKZF1 POLR2A NFIC BCL11A SIN3A TRIM22 MAFF IRF4 IL10 IL19 lnc-IL10-5 MAPKAPK2 IL24 IL20 C4BPB RASSF5
GH01J206864 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.8 -32.2 -32238 1.1 ZNF654 MYC NFIC NONO CTCF REST CEBPB DEK TRIM22 MAX IL20 IL19 IL24 FCMR PIGR FCAMR IL10 HSALNG0010052
GH01J206722 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -173.7 -173716 2.2 ATF3 BRCA1 ZIC2 YY1 CEBPB DEK MAX ZNF513 EP300 RXRA MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 HSALNG0010045
GH01J206830 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 11.3 -64.9 -64903 8.6 CEBPB REST MAX ZNF316 EBF1 CTCF SPI1 MAFG MAFF MEIS2 IL19 IL20 IL24 FCMR PIGR FCAMR IL10 MAPKAPK2 C1orf147 CD46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL24

Top Transcription factor binding sites by QIAGEN in the IL24 gene promoter:
  • AML1a
  • ATF-2
  • c-Jun

Genomic Locations for IL24 Gene

Latest Assembly
chr1:206,897,404-206,904,139
(GRCh38/hg38)
Size:
6,736 bases
Orientation:
Plus strand

Previous Assembly
chr1:207,070,788-207,077,484
(GRCh37/hg19 by Entrez Gene)
Size:
6,697 bases
Orientation:
Plus strand

chr1:207,070,788-207,077,484
(GRCh37/hg19 by Ensembl)
Size:
6,697 bases
Orientation:
Plus strand

Genomic View for IL24 Gene

Genes around IL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL24 Gene

Proteins for IL24 Gene

  • Protein details for IL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13007-IL24_HUMAN
    Recommended name:
    Interleukin-24
    Protein Accession:
    Q13007
    Secondary Accessions:
    • Q2YHE5
    • Q53XZ7
    • Q5YLN8
    • Q96DB0
    • Q96KG4

    Protein attributes for IL24 Gene

    Size:
    206 amino acids
    Molecular mass:
    23825 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL24 Gene

    Alternative splice isoforms for IL24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL24 Gene

Post-translational modifications for IL24 Gene

  • Ubiquitination at Lys-122 promotes proteasomal degradation.
  • Glycosylation at Asn85, Asn99, and Asn126
  • Ubiquitination at Lys122
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL24 Gene

Domains & Families for IL24 Gene

Gene Families for IL24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL24 Gene

InterPro:
Blocks:
  • Interleukin-10

Suggested Antigen Peptide Sequences for IL24 Gene

GenScript: Design optimal peptide antigens:
  • Suppression of tumorigenicity 16 protein (IL24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13007

UniProtKB/Swiss-Prot:

IL24_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL24: view

Function for IL24 Gene

Molecular function for IL24 Gene

UniProtKB/Swiss-Prot Function:
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Phenotypes From GWAS Catalog for IL24 Gene

Gene Ontology (GO) - Molecular Function for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25640309
genes like me logo Genes that share ontologies with IL24: view
genes like me logo Genes that share phenotypes with IL24: view

Animal Models for IL24 Gene

MGI Knock Outs for IL24:
  • Il24 Il24<tm1Dnax>
  • Il24 Il24<tm1.1(KOMP)Vlcg>

Animal Models for research

  • Taconic Biosciences Mouse Models for IL24

miRNA for IL24 Gene

miRTarBase miRNAs that target IL24

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL24

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL24 Gene

Localization for IL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL24 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL24 gene
Compartment Confidence
extracellular 5
mitochondrion 3
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL24 Gene

Pathways & Interactions for IL24 Gene

PathCards logo

SuperPathways for IL24 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 JAK-STAT signaling pathway
genes like me logo Genes that share pathways with IL24: view

Pathways by source for IL24 Gene

24 Qiagen pathways for IL24 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

Gene Ontology (GO) - Biological Process for IL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0030336 negative regulation of cell migration IEA --
genes like me logo Genes that share ontologies with IL24: view

No data available for SIGNOR curated interactions for IL24 Gene

Drugs & Compounds for IL24 Gene

(3) Drugs for IL24 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
INGN 242 Pharma 0

(3) Additional Compounds for IL24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL24: view

Transcripts for IL24 Gene

mRNA/cDNA for IL24 Gene

5 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL24

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for IL24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for IL24 Gene

GeneLoc Exon Structure for
IL24

Expression for IL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL24 Gene

mRNA differential expression in normal tissues according to GTEx for IL24 Gene

This gene is overexpressed in Spleen (x11.8), Whole Blood (x10.0), and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for IL24 Gene

This gene is overexpressed in Platelet (62.6) and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL24 Gene



Protein tissue co-expression partners for IL24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL24

SOURCE GeneReport for Unigene cluster for IL24 Gene:

Hs.58831

mRNA Expression by UniProt/SwissProt for IL24 Gene:

Q13007-IL24_HUMAN
Tissue specificity: Up-regulated in melanoma cells induced to terminally differentiate.

Evidence on tissue expression from TISSUES for IL24 Gene

  • Lung(4.5)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Intestine(2.3)
  • Skin(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with IL24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL24 Gene

Orthologs for IL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL24 29 30
  • 99.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il24 29
  • 79.24 (n)
Dog
(Canis familiaris)
Mammalia IL24 29 30
  • 78.01 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il24 29 16 30
  • 75.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL24 30
  • 63 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IL24 30
  • 46 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL24 30
  • 33 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL24 30
  • 31 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii il19l 30
  • 26 (a)
OneToMany
Species where no ortholog for IL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL24 Gene

ENSEMBL:
Gene Tree for IL24 (if available)
TreeFam:
Gene Tree for IL24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL24: view image
Alliance of Genome Resources:
Additional Orthologs for IL24

Paralogs for IL24 Gene

Paralogs for IL24 Gene

(1) SIMAP similar genes for IL24 Gene using alignment to 3 proteins:

  • IL24_HUMAN
  • E7ER64_HUMAN
  • E7ETP6_HUMAN
genes like me logo Genes that share paralogs with IL24: view

Variants for IL24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL24 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs115008149 Benign: not provided 206,900,364(+) A/G
NM_006850.3(IL24):c.303+7A>G
INTRON
rs141593545 Benign: not provided 206,897,862(+) G/T
NM_006850.3(IL24):c.30G>T (p.Leu10=)
SYNONYMOUS
rs150080259 Benign: not provided 206,902,976(+) T/G
NM_006850.3(IL24):c.538T>G (p.Leu180Val)
MISSENSE
rs75762018 Benign: not provided 206,897,861(+) T/C
NM_006850.3(IL24):c.29T>C (p.Leu10Pro)
MISSENSE
rs1150258 -- p.Tyr124His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL24 Gene

Variant ID Type Subtype PubMed ID
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv549071 CNV loss 21841781

Variation tolerance for IL24 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL24
Leiden Open Variation Database (LOVD)
IL24

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL24 Gene

Disorders for IL24 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL24 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
chronic spontaneous urticaria
  • chronic idiopathic urticaria
pancreatic cancer
  • pancreatic carcinoma
psoriasis
spondyloarthropathy
  • spondarthropathy
- elite association - COSMIC cancer census association via MalaCards
Search IL24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL24

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL24 Gene

Publications for IL24 Gene

  1. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. (PMID: 8545104) Jiang H … Fisher PB (Oncogene 1995) 2 3 4 22
  2. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T … Kõks S (BMC medical genetics 2008) 3 22 40
  3. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K … Silm H (The British journal of dermatology 2007) 3 22 40
  4. Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5. (PMID: 16313301) Allen M … Lucas T (International journal of immunogenetics 2005) 3 4 22
  5. Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma. (PMID: 15304100) Allen M … Lucas T (The Journal of investigative dermatology 2004) 3 4 22

Products for IL24 Gene

Sources for IL24 Gene