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The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008] See more...
Aliases for IL23R Gene
Aliases for IL23R Gene
External Ids for IL23R Gene
- HGNC: 19100
- Entrez Gene: 149233
- Ensembl: ENSG00000162594
- OMIM: 607562
- UniProtKB: Q5VWK5
Previous GeneCards Identifiers for IL23R Gene
- GC01P066563
- GC01P066989
- GC01P067002
- GC01P067344
- GC01P067632
- GC01P065740
Summaries for IL23R Gene
-
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL23R Gene
IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17 and Psoriasis 7. Among its related pathways are Immune response IL-23 signaling pathway and AKT Siganaling Pathway. Gene Ontology (GO) annotations related to this gene include interleukin-12 receptor binding and interleukin-23 receptor activity. An important paralog of this gene is IL6ST.
UniProtKB/Swiss-Prot Summary for IL23R Gene
-
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Additional gene information for IL23R Gene
- HGNC(19100)
- Entrez Gene(149233)
- Ensembl(ENSG00000162594)
- OMIM(607562)
- UniProtKB(Q5VWK5)
- Open Targets Platform(ENSG00000162594)
- Monarch Initiative
- Search for IL23R at DataMed
- Search for IL23R at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL23R Gene
Genomics for IL23R Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL23R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL23R on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL23R
- Top Transcription factor binding sites by QIAGEN in the IL23R gene promoter:
-
- aMEF-2
- AP-1
- Bach1
- GATA-1
- IRF-2
- MEF-2A
- MRF-2
- Nkx6-1
- PPAR-alpha
Genomic Locations for IL23R Gene
Genomic Locations for IL23R Gene
- chr1:67,138,639-67,259,979
- (GRCh38/hg38)
- Size:
- 121,341 bases
- Orientation:
- Plus strand
- chr1:67,632,083-67,725,662
- (GRCh37/hg19)
- Size:
- 93,580 bases
- Orientation:
- Plus strand
Genomic View for IL23R Gene
Genes around IL23R on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
IL23R Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL23R Gene
Proteins for IL23R Gene
-
Protein details for IL23R Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VWK5-IL23R_HUMAN
- Recommended name:
- Interleukin-23 receptor
- Protein Accession:
- Q5VWK5
- C9JGX4
- Q4VGP1
- Q4VGP2
- Q4VGP3
- Q4VGP4
- Q4VGP5
- Q4VGP6
- Q5VWK7
- Q8IW84
- Q8NFQ9
- Q96AS1
Protein attributes for IL23R Gene
- Size:
- 629 amino acids
- Molecular mass:
- 71722 Da
- Quaternary structure:
-
- Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.
- SequenceCaution:
-
- Sequence=AAH16829.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: Produced by translation in an alternate frame of the cDNA encoding isoform 4.
- [Isoform 3]: Produced by translation in an alternate frame of the cDNA encoding isoform 5.
- [Isoform 4]: Produced by translation in an alternate frame of the cDNA encoding isoform 2.
- [Isoform 5]: Produced by translation in an alternate frame of the cDNA encoding isoform 3.
Protein Expression for IL23R Gene
Post-translational modifications for IL23R Gene
- Phosphorylated in response to IL23.
-
Glycosylation at Asn262, Asn273, Asn29, Asn47, Asn81, Asn141, Asn180, and Asn232
- NX_Q5VWK5 (NX_Q5VWK5-1)
- Modification sites at PhosphoSitePlus
Other Protein References for IL23R Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IL23R Antibody
- Novus Biologicals Antibodies for IL23R
- Invitrogen Antibodies for IL23R (AFLGC-Il23r)
- antibodies-online: Show 21 available IL23R Antibodies ranked by validation data
- Compare Top IL23R Antibodies
-
Recommended
- 77 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 25 WB Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL23R
Protein Products
-
OriGene Purified Proteins for IL23R
- Search Origene for MassSpec and Protein Over-expression Lysates for IL23R
- Origene Custom Protein Services for IL23R
- Novus Biologicals lysates for IL23R
- Sino Biological Cell Lysates for IL23R
- Sino Biological Recombinant Proteins for IL23R
- ProSpec Recombinant Proteins for IL23R
-
Abcam proteins for IL23R
No data available for DME Specific Peptides for IL23R Gene
Domains & Families for IL23R Gene
Gene Families for IL23R Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IL23R Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL23R Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin 23 receptor (B6HY67_HUMAN)
- Interleukin 23 receptor (B6HY68_HUMAN)
- Interleukin 23 receptor (B6HY69_HUMAN)
- Interleukin 23 receptor (B6HY70_HUMAN)
- Interleukin 23 receptor (B6HY71_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5VWK5UniProtKB/Swiss-Prot:
IL23R_HUMAN :- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL23R Gene
Molecular function for IL23R Gene
- UniProtKB/Swiss-Prot Function:
- Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Phenotypes From GWAS Catalog for IL23R Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0005143 | contributes_to interleukin-12 receptor binding | IBA,IPI | 12023369 |
| GO:0005515 | protein binding | IPI | 12023369 |
| GO:0019955 | cytokine binding | IBA | 21873635 |
| GO:0042019 | contributes_to interleukin-23 binding | IBA,IPI | 12023369 |
Phenotypes for IL23R Gene
- MGI mutant phenotypes for IL23R:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for IL23R:
Animal Models for IL23R Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL23R - Select products 50% OFF >
- * IL23R CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL23R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL23R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL23R
miRNA for IL23R Gene
- miRTarBase miRNAs that target IL23R
-
- hsa-miR-640 (MIRT626111)
- hsa-miR-378a-5p (MIRT626112)
- hsa-miR-4777-3p (MIRT626113)
- hsa-miR-6821-3p (MIRT626114)
- hsa-miR-6790-3p (MIRT626115)
- hsa-miR-3653-5p (MIRT626116)
- hsa-miR-3934-5p (MIRT626117)
- hsa-miR-764 (MIRT626118)
- hsa-miR-125a-3p (MIRT626119)
- hsa-miR-6787-3p (MIRT646773)
- hsa-miR-152-3p (MIRT646774)
- hsa-miR-148b-3p (MIRT646775)
- hsa-miR-148a-3p (MIRT646776)
- hsa-miR-6736-3p (MIRT646777)
- hsa-miR-454-3p (MIRT646778)
- hsa-miR-3666 (MIRT646779)
- hsa-miR-4295 (MIRT646780)
- hsa-miR-301b-3p (MIRT646781)
- hsa-miR-301a-3p (MIRT646782)
- hsa-miR-130b-3p (MIRT646783)
- hsa-miR-6854-5p (MIRT646784)
- hsa-miR-130a-3p (MIRT646785)
- hsa-miR-216a-5p (MIRT646786)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL23R
- Browse OriGene Inhibitory RNA Products For IL23R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL23R
Clone Products
- Applied Biological Materials (abm): Clones for IL23R - Select products 50% OFF >
- * IL23R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL23R
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL23R
Cell Line Products
-
Horizon Cell Lines for IL23R
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL23R Gene
Localization for IL23R Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL23R Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043235 | receptor complex | IDA | 23382219 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL23R Gene
Pathways & Interactions for IL23R Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 2 | PEDF Induced Signaling |
STAT3 Pathway
.47
|
|
| 3 | Th17 cell differentiation | ||
| 4 | Th17 Differentiation | ||
| 5 | Cytokine Signaling in Immune system | ||
Pathways by source for IL23R Gene
4 Sino Biological pathways for IL23R Gene
1 BioSystems pathway for IL23R Gene
4 Reactome pathways for IL23R Gene
5 KEGG pathways for IL23R Gene
3 GeneGo (Thomson Reuters) pathways for IL23R Gene
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Immune response IL-23 signaling pathway
3 R&D Systems pathways for IL23R Gene
6 Qiagen pathways for IL23R Gene
- Akt Signaling
- Antioxidant Action of Vitamin-C
- Molecular Mechanisms of Cancer
- p38 Signaling
- STAT3 Pathway
Interacting Proteins for IL23R Gene
Selected Interacting proteins:
Q5VWK5-IL23R_HUMAN
ENSP00000321345
for IL23R Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL23R
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | ISS | -- |
| GO:0002230 | positive regulation of defense response to virus by host | ISS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002827 | positive regulation of T-helper 1 type immune response | ISS | -- |
| GO:0006954 | inflammatory response | IEA | -- |
Transcripts for IL23R Gene
mRNA/cDNA for IL23R Gene
- 1 REFSEQ mRNAs :
- 40 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000347310 2858 nts (view in UCSC)
- ENST00000395227 1459 nts (view in UCSC)
- ENST00000425614 1295 nts (view in UCSC)
- ENST00000473881 1507 nts (view in UCSC)
- ENST00000637002 2208 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL23R - Select products 50% OFF >
- * IL23R CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL23R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL23R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL23R
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL23R
- Browse OriGene Inhibitory RNA Products For IL23R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL23R
Clone Products
- Applied Biological Materials (abm): Clones for IL23R - Select products 50% OFF >
- * IL23R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL23R
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL23R
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for IL23R Gene
- GeneLoc Exon Structure for
- IL23R
Expression for IL23R Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IL23R Gene
This gene is overexpressed in Testis (x6.6) and Adrenal Gland (x5.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL23R Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL23R
SOURCE GeneReport for Unigene cluster for IL23R Gene:
Hs.677426mRNA Expression by UniProt/SwissProt for IL23R Gene:
Q5VWK5-IL23R_HUMAN
Tissue specificity:
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Evidence on tissue expression from TISSUES for IL23R Gene
- Blood(4.6)
- Skin(4.4)
- Bone marrow(4.4)
- Intestine(2.8)
- Spleen(2.6)
- Lymph node(2.6)
- Nervous system(2.3)
- Lung(2.1)
- Liver(2.1)
- Heart(2.1)
- Kidney(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL23R Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- face
- head
- meninges
- mouth
- neck
Thorax:
- esophagus
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- penis
- testicle
- vagina
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IL23R
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues for IL23R Gene
Orthologs for IL23R Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL23R 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL23R 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL23R 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il23r 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il23r 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | IL23R 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL23R 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IL23R 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | il23r 31 |
|
OneToOne |
- Species where no ortholog for IL23R was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL23R Gene
- ENSEMBL:
- Gene Tree for IL23R (if available)
- TreeFam:
- Gene Tree for IL23R (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL23R: view image
Paralogs for IL23R Gene
Paralogs for IL23R Gene
(1) SIMAP similar genes for IL23R Gene using alignment to 25 proteins:
- IL23R_HUMAN
- B6HY67_HUMAN
- B6HY68_HUMAN
- B6HY69_HUMAN
- B6HY70_HUMAN
- B6HY71_HUMAN
- B6HY72_HUMAN
- B6HY73_HUMAN
- B6HY74_HUMAN
- B6HY75_HUMAN
- B6HY76_HUMAN
- B6HY77_HUMAN
- B6HY78_HUMAN
- B6HY79_HUMAN
- B6HY80_HUMAN
- B6HY85_HUMAN
- B6HY86_HUMAN
- B6HY89_HUMAN
- B6VNT3_HUMAN
- B6VNT4_HUMAN
- B6VNT5_HUMAN
- B6VNT6_HUMAN
- B6VNT7_HUMAN
- D9N2T9_HUMAN
- H7BZ42_HUMAN
Variants for IL23R Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL23R Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716831 | Benign: not provided | 67,206,917(+) | T/A | SYNONYMOUS_VARIANT | |
| 718308 | Benign: not provided | 67,206,980(+) | T/C | SYNONYMOUS_VARIANT | |
| 726485 | Likely Benign: not provided | 67,206,906(+) | C/A | INTRON_VARIANT | |
| 728416 | Benign: not provided | 67,182,942(+) | C/T | SYNONYMOUS_VARIANT | |
| 733253 | Likely Benign: not provided | 67,206,911(+) | G/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.57;
56.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL23R Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL23R Gene
Disorders for IL23R Gene
(29) MalaCards diseases for IL23R Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory bowel disease 17 |
|
|
| psoriasis 7 |
|
|
| ulcerative colitis |
|
|
| crohn's disease |
|
|
| behcet syndrome |
|
|
Search IL23R in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL23R_HUMAN- Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17068223, ECO:0000269 PubMed:17804789}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for IL23R
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
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No data available for Genatlas for IL23R Gene
Publications for IL23R Gene
- Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PMID: 17587057) Capon F … Nestle FO (Human genetics 2007) 3 4 23 41
- A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr RH … Cho JH (Science (New York, N.Y.) 2006) 3 4 23 41
- NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. (PMID: 20380008) Gazouli M … Roma-Giannikou E (World journal of gastroenterology 2010) 3 23 41
- Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients. (PMID: 20066736) Csöngei V … Melegh B (World journal of gastroenterology 2010) 3 23 41
- Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. (PMID: 20485703) Cotterill L … Newman WG (Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2010) 3 23 41
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Products for IL23R Gene
- View all 25 R&D Systems IL23R (IL-23R) Products
- View all R&D Systems IL23R (IL-23R) Proteins and Enzymes
- View all 22 R&D Systems IL23R (IL-23R) Primary Antibodies
- View all R&D Systems IL23R (IL-23R) ELISAs
- View all R&D Systems IL23R (IL-23R) cDNA Clones
- Learn more about R&D Systems custom IL23R antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IL23R
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- OriGene Purified Proteins for IL23R
- Search Origene for MassSpec and Protein Over-expression Lysates for IL23R
- Origene Custom Protein Services for IL23R
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL23R
- Browse OriGene Inhibitory RNA Products For IL23R
- OriGene qPCR primer pairs for IL23R
- OriGene CRISPR knockouts for IL23R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL23R
- Sino Biological Human cDNA Clone for IL23R
- Sino Biological Cell Lysates for IL23R
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- VectorBuilder Custom and pre-made DNA vectors for IL23R (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL23R (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IL23R (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IL23R CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IL23R
- antibodies-online: Show 21 available IL23R Antibodies ranked by validation data
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- 77 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 25 WB Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 20 available IL23R Elisa Kits ranked by validation data
- Compare Top IL23R Elisa Kits
- antibodies-online: Show 27 available IL23R Proteins ranked by validation data
- Compare Top IL23R Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IL23R
- Search Santa Cruz Biotechnology (SCBT) for IL23R siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL23R
- Horizon Cell Lines for IL23R
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL23R
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL23R
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IL23R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL23R
Sources for IL23R Gene
- (1) GeneCards
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