The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008] See more...

Aliases for IL23R Gene

Aliases for IL23R Gene

  • Interleukin 23 Receptor 2 3 5
  • Interleukin-23 Receptor 3 4
  • IL-23 Receptor 3 4
  • IL-23R 2 4
  • IL23R 5

External Ids for IL23R Gene

Previous GeneCards Identifiers for IL23R Gene

  • GC01P066563
  • GC01P066989
  • GC01P067002
  • GC01P067344
  • GC01P067632
  • GC01P065740

Summaries for IL23R Gene

Entrez Gene Summary for IL23R Gene

  • The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL23R Gene

IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17 and Psoriasis 7. Among its related pathways are Immune response IL-23 signaling pathway and AKT Siganaling Pathway. Gene Ontology (GO) annotations related to this gene include interleukin-12 receptor binding and interleukin-23 receptor activity. An important paralog of this gene is IL6ST.

UniProtKB/Swiss-Prot Summary for IL23R Gene

  • Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene Wiki entry for IL23R Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL23R Gene

Genomics for IL23R Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL23R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J067170 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.3 +33.1 33062 3 GATAD2A IKZF2 ZNF740 SP1 YY1 CEBPA EED ARID3A ZNF766 HMBOX1 IL23R C1orf141 RNU6-586P ENSG00000252433 SLC35D1 piR-39341-005 piR-32810-001
GH01J067165 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.3 +28.1 28113 2.3 SP1 BACH1 STAT3 RELA TCF12 IKZF2 TRIM22 YY1 PKNOX1 EED IL23R C1orf141 SLC35D1 piR-39341-005 piR-32810-001
GH01J067207 Promoter 0.9 EPDnew 600.2 +69.0 68958 0.1 ARHGAP35 IKZF1 ZNF24 HDAC1 SOX6 MGA NKRF ZNF766 POLR2A MTA3 IL23R RF00026-047 RNU6-586P C1orf141 NONHSAG001750.2
GH01J067137 Enhancer 0.7 Ensembl ENCODE 600.7 -0.2 -152 2.9 RAD51 USF1 USF2 HNF4A PRDM10 TOE1 HLF MNT L3MBTL2 CBFA2T2 IL23R C1orf141 ENSG00000252433 RNU6-586P SLC35D1 lnc-SLC35D1-9
GH01J067194 Enhancer 1.1 FANTOM5 Ensembl ENCODE 5.9 +56.0 55985 2 RFX1 BACH1 STAT3 PKNOX1 TCF12 IKZF2 TRIM22 ARID3A DPF2 RELB RF00026-047 RNU6-586P C1orf141 IL23R SLC35D1 DNAI4 IL12RB2 MIER1 INSL5 NONHSAG001750.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL23R on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL23R

Top Transcription factor binding sites by QIAGEN in the IL23R gene promoter:
  • aMEF-2
  • AP-1
  • Bach1
  • GATA-1
  • IRF-2
  • MEF-2A
  • MRF-2
  • Nkx6-1
  • PPAR-alpha

Genomic Locations for IL23R Gene

Genomic Locations for IL23R Gene
chr1:67,138,639-67,259,979
(GRCh38/hg38)
Size:
121,341 bases
Orientation:
Plus strand
chr1:67,632,083-67,725,662
(GRCh37/hg19)
Size:
93,580 bases
Orientation:
Plus strand

Genomic View for IL23R Gene

Genes around IL23R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL23R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL23R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL23R Gene

Proteins for IL23R Gene

  • Protein details for IL23R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWK5-IL23R_HUMAN
    Recommended name:
    Interleukin-23 receptor
    Protein Accession:
    Q5VWK5
    Secondary Accessions:
    • C9JGX4
    • Q4VGP1
    • Q4VGP2
    • Q4VGP3
    • Q4VGP4
    • Q4VGP5
    • Q4VGP6
    • Q5VWK7
    • Q8IW84
    • Q8NFQ9
    • Q96AS1

    Protein attributes for IL23R Gene

    Size:
    629 amino acids
    Molecular mass:
    71722 Da
    Quaternary structure:
    • Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.
    SequenceCaution:
    • Sequence=AAH16829.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Produced by translation in an alternate frame of the cDNA encoding isoform 4.
    • [Isoform 3]: Produced by translation in an alternate frame of the cDNA encoding isoform 5.
    • [Isoform 4]: Produced by translation in an alternate frame of the cDNA encoding isoform 2.
    • [Isoform 5]: Produced by translation in an alternate frame of the cDNA encoding isoform 3.

    Three dimensional structures from OCA and Proteopedia for IL23R Gene

    Alternative splice isoforms for IL23R Gene

neXtProt entry for IL23R Gene

Post-translational modifications for IL23R Gene

  • Phosphorylated in response to IL23.
  • Glycosylation at Asn262, Asn273, Asn29, Asn47, Asn81, Asn141, Asn180, and Asn232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL23R Gene

Domains & Families for IL23R Gene

Gene Families for IL23R Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL23R Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL23R Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 23 receptor (B6HY67_HUMAN)
  • Interleukin 23 receptor (B6HY68_HUMAN)
  • Interleukin 23 receptor (B6HY69_HUMAN)
  • Interleukin 23 receptor (B6HY70_HUMAN)
  • Interleukin 23 receptor (B6HY71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VWK5

UniProtKB/Swiss-Prot:

IL23R_HUMAN :
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL23R: view

Function for IL23R Gene

Molecular function for IL23R Gene

UniProtKB/Swiss-Prot Function:
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Phenotypes From GWAS Catalog for IL23R Gene

Gene Ontology (GO) - Molecular Function for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0005143 contributes_to interleukin-12 receptor binding IBA,IPI 12023369
GO:0005515 protein binding IPI 12023369
GO:0019955 cytokine binding IBA 21873635
GO:0042019 contributes_to interleukin-23 binding IBA,IPI 12023369
genes like me logo Genes that share ontologies with IL23R: view
genes like me logo Genes that share phenotypes with IL23R: view

Human Phenotype Ontology for IL23R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL23R Gene

MGI Knock Outs for IL23R:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL23R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL23R Gene

Localization for IL23R Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL23R Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL23R gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with IL23R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL23R Gene

Pathways & Interactions for IL23R Gene

genes like me logo Genes that share pathways with IL23R: view

Pathways by source for IL23R Gene

3 GeneGo (Thomson Reuters) pathways for IL23R Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Immune response IL-23 signaling pathway
6 Qiagen pathways for IL23R Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • STAT3 Pathway

SIGNOR curated interactions for IL23R Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL23R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002230 positive regulation of defense response to virus by host ISS --
GO:0002376 immune system process IEA --
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with IL23R: view

Drugs & Compounds for IL23R Gene

(2) Drugs for IL23R Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Celecoxib Approved, Investigational Pharma Inhibitor, Inhibition Selective cyclooxygenase-2 (COX-2) inhibitor 536
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with IL23R: view

Transcripts for IL23R Gene

mRNA/cDNA for IL23R Gene

1 REFSEQ mRNAs :
40 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL23R

Alternative Splicing Database (ASD) splice patterns (SP) for IL23R Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for IL23R Gene

GeneLoc Exon Structure for
IL23R

Expression for IL23R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL23R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL23R Gene

This gene is overexpressed in Testis (x6.6) and Adrenal Gland (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL23R Gene



Protein tissue co-expression partners for IL23R Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL23R

SOURCE GeneReport for Unigene cluster for IL23R Gene:

Hs.677426

mRNA Expression by UniProt/SwissProt for IL23R Gene:

Q5VWK5-IL23R_HUMAN
Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

Evidence on tissue expression from TISSUES for IL23R Gene

  • Blood(4.6)
  • Skin(4.4)
  • Bone marrow(4.4)
  • Intestine(2.8)
  • Spleen(2.6)
  • Lymph node(2.6)
  • Nervous system(2.3)
  • Lung(2.1)
  • Liver(2.1)
  • Heart(2.1)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL23R Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • penis
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with IL23R: view

No data available for Protein differential expression in normal tissues for IL23R Gene

Orthologs for IL23R Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL23R Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL23R 30 31
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL23R 30 31
  • 89.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL23R 30 31
  • 87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il23r 30 17 31
  • 78.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il23r 30
  • 76.02 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 60 (a)
OneToMany
-- 31
  • 27 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia IL23R 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL23R 30 31
  • 48.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL23R 31
  • 33 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii il23r 31
  • 10 (a)
OneToOne
Species where no ortholog for IL23R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL23R Gene

ENSEMBL:
Gene Tree for IL23R (if available)
TreeFam:
Gene Tree for IL23R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL23R: view image

Paralogs for IL23R Gene

(1) SIMAP similar genes for IL23R Gene using alignment to 25 proteins:

  • IL23R_HUMAN
  • B6HY67_HUMAN
  • B6HY68_HUMAN
  • B6HY69_HUMAN
  • B6HY70_HUMAN
  • B6HY71_HUMAN
  • B6HY72_HUMAN
  • B6HY73_HUMAN
  • B6HY74_HUMAN
  • B6HY75_HUMAN
  • B6HY76_HUMAN
  • B6HY77_HUMAN
  • B6HY78_HUMAN
  • B6HY79_HUMAN
  • B6HY80_HUMAN
  • B6HY85_HUMAN
  • B6HY86_HUMAN
  • B6HY89_HUMAN
  • B6VNT3_HUMAN
  • B6VNT4_HUMAN
  • B6VNT5_HUMAN
  • B6VNT6_HUMAN
  • B6VNT7_HUMAN
  • D9N2T9_HUMAN
  • H7BZ42_HUMAN
genes like me logo Genes that share paralogs with IL23R: view

Variants for IL23R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL23R Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
716831 Benign: not provided 67,206,917(+) T/A SYNONYMOUS_VARIANT
718308 Benign: not provided 67,206,980(+) T/C SYNONYMOUS_VARIANT
726485 Likely Benign: not provided 67,206,906(+) C/A INTRON_VARIANT
728416 Benign: not provided 67,182,942(+) C/T SYNONYMOUS_VARIANT
733253 Likely Benign: not provided 67,206,911(+) G/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IL23R Gene

Structural Variations from Database of Genomic Variants (DGV) for IL23R Gene

Variant ID Type Subtype PubMed ID
nsv1113131 CNV deletion 24896259
nsv1243 CNV deletion 18451855
nsv461751 CNV loss 19166990
nsv461762 CNV gain 19166990
nsv546445 CNV loss 21841781
nsv546446 CNV gain 21841781

Variation tolerance for IL23R Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL23R Gene

Human Gene Mutation Database (HGMD)
IL23R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL23R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL23R Gene

Disorders for IL23R Gene

MalaCards: The human disease database

(29) MalaCards diseases for IL23R Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 17
  • ibd17
psoriasis 7
  • pv
ulcerative colitis
  • left-sided ulcerative colitis
crohn's disease
  • ileitis
behcet syndrome
  • behcet disease; bd
- elite association - COSMIC cancer census association via MalaCards
Search IL23R in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL23R_HUMAN
  • Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17068223, ECO:0000269 PubMed:17804789}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for IL23R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL23R: view

No data available for Genatlas for IL23R Gene

Publications for IL23R Gene

  1. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PMID: 17587057) Capon F … Nestle FO (Human genetics 2007) 3 4 23 41
  2. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr RH … Cho JH (Science (New York, N.Y.) 2006) 3 4 23 41
  3. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. (PMID: 20380008) Gazouli M … Roma-Giannikou E (World journal of gastroenterology 2010) 3 23 41
  4. Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn's disease patients. (PMID: 20066736) Csöngei V … Melegh B (World journal of gastroenterology 2010) 3 23 41
  5. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. (PMID: 20485703) Cotterill L … Newman WG (Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2010) 3 23 41

Products for IL23R Gene

Sources for IL23R Gene