Aliases for IL23R Gene
External Ids for IL23R Gene
Previous GeneCards Identifiers for IL23R Gene
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL23R Gene
IL23R (Interleukin 23 Receptor) is a Protein Coding gene. Diseases associated with IL23R include Inflammatory Bowel Disease 17 and Psoriasis 7. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Cytokine production by Th17 cells in CF (Mouse model). Gene Ontology (GO) annotations related to this gene include interleukin-12 receptor binding and interleukin-23 receptor activity. An important paralog of this gene is IL6ST.
UniProtKB/Swiss-Prot Summary for IL23R Gene
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.