Aliases for IL23A Gene
External Ids for IL23A Gene
Previous GeneCards Identifiers for IL23A Gene
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL23A Gene
IL23A (Interleukin 23 Subunit Alpha) is a Protein Coding gene. Diseases associated with IL23A include Autoimmune Cholangitis and Multiple Sclerosis. Among its related pathways are Rheumatoid arthritis and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-23 receptor binding.
UniProtKB/Swiss-Prot Summary for IL23A Gene
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.