Aliases for IL22RA2 Gene
External Ids for IL22RA2 Gene
Previous GeneCards Identifiers for IL22RA2 Gene
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for IL22RA2 Gene
IL22RA2 (Interleukin 22 Receptor Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Th17 cell differentiation and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include interleukin-22 binding and interleukin-22 receptor activity. An important paralog of this gene is IL20RA.
UniProtKB/Swiss-Prot Summary for IL22RA2 Gene
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.