This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the... See more...

Aliases for IL22RA2 Gene

Aliases for IL22RA2 Gene

  • Interleukin 22 Receptor Subunit Alpha 2 2 3 5
  • Cytokine Receptor Family Type 2, Soluble 1 3 4
  • Interleukin-22 Receptor Subunit Alpha-2 3 4
  • Cytokine Receptor Class-II Member 10 3 4
  • Interleukin 22 Receptor, Alpha 2 2 3
  • IL-22R-Alpha-2 3 4
  • IL-22RA2 3 4
  • CRF2-10 3 4
  • CRF2-S1 3 4
  • IL-22BP 3 4
  • Cytokine Receptor Family 2 Member 10 4
  • Interleukin 22-Binding Protein 3
  • IL-22 Receptor Subunit Alpha-2 4
  • Interleukin-22-Binding Protein 4
  • ZCYTOR16 3
  • ZcytoR16 4
  • IL22BP 4
  • CRF2X 3

External Ids for IL22RA2 Gene

Previous GeneCards Identifiers for IL22RA2 Gene

  • GC06M137088
  • GC06M137312
  • GC06M137445
  • GC06M137506
  • GC06M135028
  • GC06M137464

Summaries for IL22RA2 Gene

Entrez Gene Summary for IL22RA2 Gene

  • This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL22RA2 Gene

IL22RA2 (Interleukin 22 Receptor Subunit Alpha 2) is a Protein Coding gene. Among its related pathways are Th17 cell differentiation and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include interleukin-22 binding and interleukin-22 receptor activity. An important paralog of this gene is IL20RA.

UniProtKB/Swiss-Prot Summary for IL22RA2 Gene

  • Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
  • Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Additional gene information for IL22RA2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL22RA2 Gene

Genomics for IL22RA2 Gene

GeneHancer (GH) Regulatory Elements for IL22RA2 Gene

Promoters and enhancers for IL22RA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J137169 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 500.7 +1.7 1746 4.2 EP300 ZBTB11 RELA CUX1 TOE1 HINFP GATAD2B CTBP1 RBM25 BCL11A IL22RA2 BCLAF1 IFNGR1 piR-51635
GH06J137174 Enhancer 0.6 Ensembl 500.7 -1.6 -1553 0.4 ZNF263 PBX2 MEIS2 ARID1B CBFA2T2 ZNF316 PKNOX1 HDAC1 FOXJ2 CBFA2T3 IL22RA2 lnc-IFNGR1-1
GH06J137161 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.4 +11.9 11867 0.1 IL22RA2 IFNGR1 piR-51635
GH06J137093 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +73.0 73010 14.6 ZBTB40 CTCF USF1 SP1 EP300 JUND REST RELA MEF2C RCOR1 IL22RA2 IFNGR1 OLIG3 IL20RA RF00017-5799 piR-35674-458
GH06J137240 Enhancer 1 ENCODE dbSUPER 11.4 -67.8 -67806 2.5 EP300 ZBTB40 TCF12 NCOR1 TCF7 SKI TEAD1 FOXA2 ZSCAN9 CEBPB IFNGR1 IL22RA2 OLIG3 piR-46847-233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL22RA2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL22RA2

Top Transcription factor binding sites by QIAGEN in the IL22RA2 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SRF
  • SRF (504 AA)

Genomic Locations for IL22RA2 Gene

Genomic Locations for IL22RA2 Gene
chr6:137,143,820-137,173,648
(GRCh38/hg38)
Size:
29,829 bases
Orientation:
Minus strand
chr6:137,464,957-137,494,785
(GRCh37/hg19)
Size:
29,829 bases
Orientation:
Minus strand

Genomic View for IL22RA2 Gene

Genes around IL22RA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22RA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22RA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22RA2 Gene

Proteins for IL22RA2 Gene

  • Protein details for IL22RA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J5-I22R2_HUMAN
    Recommended name:
    Interleukin-22 receptor subunit alpha-2
    Protein Accession:
    Q969J5
    Secondary Accessions:
    • Q08AH7
    • Q6UWM1
    • Q96A41
    • Q96QR0

    Protein attributes for IL22RA2 Gene

    Size:
    263 amino acids
    Molecular mass:
    30550 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL22RA2 Gene

    Alternative splice isoforms for IL22RA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL22RA2 Gene

Post-translational modifications for IL22RA2 Gene

  • Glycosylation at Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22RA2 Gene

No data available for DME Specific Peptides for IL22RA2 Gene

Domains & Families for IL22RA2 Gene

Gene Families for IL22RA2 Gene

Protein Domains for IL22RA2 Gene

Suggested Antigen Peptide Sequences for IL22RA2 Gene

GenScript: Design optimal peptide antigens:
  • ZcytoR16 (I22R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969J5

UniProtKB/Swiss-Prot:

I22R2_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL22RA2: view

Function for IL22RA2 Gene

Molecular function for IL22RA2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
UniProtKB/Swiss-Prot Function:
Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Phenotypes From GWAS Catalog for IL22RA2 Gene

Gene Ontology (GO) - Molecular Function for IL22RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0005515 protein binding IEA --
GO:0042017 interleukin-22 binding IDA 11390453
GO:0042018 interleukin-22 receptor activity IDA,IBA 11390454
genes like me logo Genes that share ontologies with IL22RA2: view
genes like me logo Genes that share phenotypes with IL22RA2: view

Animal Models for IL22RA2 Gene

MGI Knock Outs for IL22RA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22RA2

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL22RA2 Gene

Localization for IL22RA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22RA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL22RA2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL22RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 11390453
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with IL22RA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL22RA2 Gene

Pathways & Interactions for IL22RA2 Gene

PathCards logo

SuperPathways for IL22RA2 Gene

genes like me logo Genes that share pathways with IL22RA2: view

Pathways by source for IL22RA2 Gene

1 GeneGo (Thomson Reuters) pathway for IL22RA2 Gene
  • Immune response IL-22 signaling pathway
2 Qiagen pathways for IL22RA2 Gene
  • IL-22 Pathway
  • MAPK Family Pathway

SIGNOR curated interactions for IL22RA2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL22RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0042509 regulation of tyrosine phosphorylation of STAT protein ISS --
GO:0050728 negative regulation of inflammatory response IEA --
genes like me logo Genes that share ontologies with IL22RA2: view

Drugs & Compounds for IL22RA2 Gene

(1) Drugs for IL22RA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL22RA2: view

Transcripts for IL22RA2 Gene

mRNA/cDNA for IL22RA2 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3: - -

Relevant External Links for IL22RA2 Gene

GeneLoc Exon Structure for
IL22RA2

Expression for IL22RA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL22RA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL22RA2 Gene

This gene is overexpressed in Spleen (x9.2), Breast - Mammary Tissue (x9.2), Skin - Not Sun Exposed (Suprapubic) (x6.2), Small Intestine - Terminal Ileum (x5.4), and Skin - Sun Exposed (Lower leg) (x4.8).

Protein differential expression in normal tissues from HIPED for IL22RA2 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL22RA2 Gene



Protein tissue co-expression partners for IL22RA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL22RA2

SOURCE GeneReport for Unigene cluster for IL22RA2 Gene:

Hs.126891

mRNA Expression by UniProt/SwissProt for IL22RA2 Gene:

Q969J5-I22R2_HUMAN
Tissue specificity: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
genes like me logo Genes that share expression patterns with IL22RA2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL22RA2 Gene

Orthologs for IL22RA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22RA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL22RA2 31 30
  • 98.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL22RA2 31 30
  • 87.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL22RA2 31 30
  • 80 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il22ra2 30
  • 78.89 (n)
mouse
(Mus musculus)
Mammalia Il22ra2 17 31 30
  • 77.97 (n)
oppossum
(Monodelphis domestica)
Mammalia IL22RA2 31
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL22RA2 31
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL22RA2 31 30
  • 59.67 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crfb9 31 30
  • 49.92 (n)
OneToOne
Species where no ortholog for IL22RA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL22RA2 Gene

ENSEMBL:
Gene Tree for IL22RA2 (if available)
TreeFam:
Gene Tree for IL22RA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL22RA2: view image

Paralogs for IL22RA2 Gene

genes like me logo Genes that share paralogs with IL22RA2: view

Variants for IL22RA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL22RA2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs28362173 - p.Glu190Lys
rs28385692 - p.Leu16Pro

Additional dbSNP identifiers (rs#s) for IL22RA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL22RA2 Gene

Variant ID Type Subtype PubMed ID
esv2759473 CNV loss 17122850
nsv470863 CNV loss 18288195

Variation tolerance for IL22RA2 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL22RA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL22RA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL22RA2 Gene

Disorders for IL22RA2 Gene

Additional Disease Information for IL22RA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IL22RA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL22RA2 Gene

Publications for IL22RA2 Gene

  1. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. (PMID: 11390454) Kotenko SV … Pestka S (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23 54
  2. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. (PMID: 11481447) Xu W … Foster DC (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 23 54
  3. Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. (PMID: 19285080) de Moura PR … Polikarpov I (FEBS letters 2009) 3 4 23 54
  4. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. (PMID: 15201862) Weiss B … Sabat R (Genes and immunity 2004) 3 4 23 54
  5. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. (PMID: 11390453) Dumoutier L … Renauld JC (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23 54

Products for IL22RA2 Gene

Sources for IL22RA2 Gene