The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (... See more...

Aliases for IL22RA1 Gene

Aliases for IL22RA1 Gene

  • Interleukin 22 Receptor Subunit Alpha 1 2 3 5
  • Interleukin-22 Receptor Subunit Alpha-1 3 4
  • Cytokine Receptor Class-II Member 9 3 4
  • Cytokine Receptor Family 2 Member 9 3 4
  • Interleukin 22 Receptor, Alpha 1 2 3
  • IL-22 Receptor Subunit Alpha-1 3 4
  • IL-22R-Alpha-1 3 4
  • ZcytoR11 3 4
  • IL-22RA1 3 4
  • CRF2-9 3 4
  • IL22R 3 4
  • Interleukin 22 Receptor 2
  • IL22R1 3

External Ids for IL22RA1 Gene

Previous HGNC Symbols for IL22RA1 Gene

  • IL22R

Previous GeneCards Identifiers for IL22RA1 Gene

  • GC01M023516
  • GC01M023797
  • GC01M024191
  • GC01M024318
  • GC01M024446
  • GC01M022699

Summaries for IL22RA1 Gene

Entrez Gene Summary for IL22RA1 Gene

  • The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL22RA1 Gene

IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL22RA1 include Spondyloarthropathy and Intestinal Tuberculosis. Among its related pathways are ERK Signaling and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interferon receptor activity. An important paralog of this gene is IFNLR1.

UniProtKB/Swiss-Prot Summary for IL22RA1 Gene

  • Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Additional gene information for IL22RA1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL22RA1 Gene

Genomics for IL22RA1 Gene

GeneHancer (GH) Regulatory Elements for IL22RA1 Gene

Promoters and enhancers for IL22RA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J024140 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 518.1 +0.5 462 4 POLR2G NCOR1 SKI CEBPB SAP130 FOSL1 JUND FOXP1 IRF1 SMAD4 IL22RA1 lnc-IL22RA1-2 ASAP3 piR-57133-010
GH01J024115 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.7 +24.2 24168 6.2 EP300 NCOR1 KDM6A TCF7 ZBTB25 TGIF2 TEAD1 ZBTB26 ZSCAN9 KMT2B MYOM3 IL22RA1 ENSG00000232298 GRHL3 NCMAP IFNLR1 PNRC2 piR-57133-010 lnc-IL22RA1-2
GH01J024091 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.3 +40.8 40763 21.4 EP300 CTCF NRF1 FOS ZIC2 KDM6A ZNF263 ZNF423 ZNF623 REST MYOM3 SRRM1 LINC01355 SRSF10 ELOA IL22RA1 LOC105376864
GH01J024183 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.9 -45.3 -45321 9.8 ZSCAN5C POLR2G USF1 SP1 GTF2E2 FOS ZNF10 ZIC2 ZNF423 ZBTB26 IFNLR1 LINC02800 GRHL3 IL22RA1 PNRC2 HSALNG0001696
GH01J024125 Enhancer 0.8 Ensembl dbSUPER 16.4 +17.5 17485 2.8 CTBP1 ZNF341 RBM25 MAX FOSL1 JUND BATF BHLHE40 ZNF768 MITF IL22RA1 NCMAP piR-57133-010 lnc-IL22RA1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL22RA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL22RA1

Top Transcription factor binding sites by QIAGEN in the IL22RA1 gene promoter:
  • E47
  • GATA-2
  • HEN1
  • MyoD
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • STAT3
  • STAT5A

Genomic Locations for IL22RA1 Gene

Genomic Locations for IL22RA1 Gene
chr1:24,119,771-24,143,285
(GRCh38/hg38)
Size:
23,515 bases
Orientation:
Minus strand
chr1:24,446,261-24,469,775
(GRCh37/hg19)
Size:
23,515 bases
Orientation:
Minus strand

Genomic View for IL22RA1 Gene

Genes around IL22RA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22RA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22RA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22RA1 Gene

Proteins for IL22RA1 Gene

  • Protein details for IL22RA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6P7-I22R1_HUMAN
    Recommended name:
    Interleukin-22 receptor subunit alpha-1
    Protein Accession:
    Q8N6P7
    Secondary Accessions:
    • A8K839
    • B2R9Y9
    • Q9HB22

    Protein attributes for IL22RA1 Gene

    Size:
    574 amino acids
    Molecular mass:
    63077 Da
    Quaternary structure:
    • Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.
    Miscellaneous:
    • Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

    Three dimensional structures from OCA and Proteopedia for IL22RA1 Gene

neXtProt entry for IL22RA1 Gene

Post-translational modifications for IL22RA1 Gene

  • Glycosylation at Asn80 and Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22RA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL22RA1 Gene

Domains & Families for IL22RA1 Gene

Gene Families for IL22RA1 Gene

Protein Domains for IL22RA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL22RA1 Gene

GenScript: Design optimal peptide antigens:
  • ZcytoR11 (I22R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6P7

UniProtKB/Swiss-Prot:

I22R1_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL22RA1: view

Function for IL22RA1 Gene

Molecular function for IL22RA1 Gene

UniProtKB/Swiss-Prot Function:
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in keratinocytes.

Phenotypes From GWAS Catalog for IL22RA1 Gene

Gene Ontology (GO) - Molecular Function for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0004904 interferon receptor activity TAS 10875937
GO:0005515 protein binding IEA,IPI 12513909
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL22RA1: view
genes like me logo Genes that share phenotypes with IL22RA1: view

Animal Models for IL22RA1 Gene

MGI Knock Outs for IL22RA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22RA1

miRNA for IL22RA1 Gene

miRTarBase miRNAs that target IL22RA1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL22RA1 Gene

Localization for IL22RA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22RA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL22RA1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL22RA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL22RA1 Gene

Pathways & Interactions for IL22RA1 Gene

PathCards logo

SuperPathways for IL22RA1 Gene

SuperPathway Contained pathways
1 Akt Signaling
.60
.60
.55
2 PEDF Induced Signaling
.47
3 JAK-STAT signaling pathway (KEGG)
4 Th17 cell differentiation
.36
.01
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with IL22RA1: view

Pathways by source for IL22RA1 Gene

1 GeneGo (Thomson Reuters) pathway for IL22RA1 Gene
  • Immune response IL-22 signaling pathway
8 Qiagen pathways for IL22RA1 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • IL-22 Pathway
  • MAPK Family Pathway
  • Molecular Mechanisms of Cancer

SIGNOR curated interactions for IL22RA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0050829 defense response to Gram-negative bacterium IEA --
genes like me logo Genes that share ontologies with IL22RA1: view

Drugs & Compounds for IL22RA1 Gene

No Compound Related Data Available

Transcripts for IL22RA1 Gene

mRNA/cDNA for IL22RA1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for IL22RA1 Gene

GeneLoc Exon Structure for
IL22RA1

Expression for IL22RA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL22RA1 Gene

mRNA differential expression in normal tissues according to GTEx for IL22RA1 Gene

This gene is overexpressed in Pancreas (x30.8), Skin - Sun Exposed (Lower leg) (x5.7), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

Protein differential expression in normal tissues from HIPED for IL22RA1 Gene

This gene is overexpressed in Adipocyte (55.2) and Pancreas (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL22RA1 Gene



Protein tissue co-expression partners for IL22RA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL22RA1

SOURCE GeneReport for Unigene cluster for IL22RA1 Gene:

Hs.110915

mRNA Expression by UniProt/SwissProt for IL22RA1 Gene:

Q8N6P7-I22R1_HUMAN
Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.

Evidence on tissue expression from TISSUES for IL22RA1 Gene

  • Liver(4.3)
  • Adrenal gland(4)
  • Skin(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with IL22RA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL22RA1 Gene

Orthologs for IL22RA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22RA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL22RA1 31 30
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL22RA1 31 30
  • 84.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL22RA1 31 30
  • 81.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il22ra1 17 31 30
  • 78.4 (n)
rat
(Rattus norvegicus)
Mammalia Il22ra1 30
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia IL22RA1 31
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL22RA1 31
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL22RA1 31 30
  • 47.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL22RA1 31
  • 35 (a)
OneToOne
Species where no ortholog for IL22RA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22RA1 Gene

ENSEMBL:
Gene Tree for IL22RA1 (if available)
TreeFam:
Gene Tree for IL22RA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL22RA1: view image

Paralogs for IL22RA1 Gene

genes like me logo Genes that share paralogs with IL22RA1: view

Variants for IL22RA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL22RA1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711820 Benign: not provided 24,134,354(-) A/G MISSENSE_VARIANT
711835 Benign: not provided 24,121,342(-) C/T SYNONYMOUS_VARIANT
775524 Benign: not provided 24,121,311(-) T/C MISSENSE_VARIANT
rs16829204 - p.Val205Ile
rs34379702 - p.Ala209Ser

Additional dbSNP identifiers (rs#s) for IL22RA1 Gene

Variation tolerance for IL22RA1 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.95; 96.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL22RA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL22RA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22RA1 Gene

Disorders for IL22RA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IL22RA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spondyloarthropathy
  • spondarthropathy
intestinal tuberculosis
  • tuberculosis of intestine
autoimmune uveitis
rheumatoid arthritis
  • ra
gastrointestinal anthrax
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL22RA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL22RA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL22RA1 Gene

Publications for IL22RA1 Gene

  1. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. (PMID: 19393422) Endam LM … Desrosiers M (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2009) 3 23 41 54
  2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie MH … Gurney AL (The Journal of biological chemistry 2000) 2 3 4 54
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  4. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. (PMID: 18675809) Bleicher L … Polikarpov I (FEBS letters 2008) 3 4 54
  5. Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor. (PMID: 17906500) Ramanathan M … Lane AP (The Laryngoscope 2007) 3 4 54

Products for IL22RA1 Gene

Sources for IL22RA1 Gene