Aliases for IL22RA1 Gene
External Ids for IL22RA1 Gene
Previous HGNC Symbols for IL22RA1 Gene
Previous GeneCards Identifiers for IL22RA1 Gene
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL22RA1 Gene
IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL22RA1 include Spondyloarthropathy and Intestinal Tuberculosis. Among its related pathways are ERK Signaling and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interferon receptor activity. An important paralog of this gene is IFNLR1.
UniProtKB/Swiss-Prot Summary for IL22RA1 Gene
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.