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Aliases for IL22 Gene

Aliases for IL22 Gene

  • Interleukin 22 2 3 5
  • IL-10-Related T-Cell-Derived Inducible Factor 2 3
  • Cytokine Zcyto18 3 4
  • IL-TIF 3 4
  • IL-22 3 4
  • ILTIF 3 4
  • IL-10-Related T-Cell-Derived-Inducible Factor 4
  • Interleukin-22 3
  • TIFIL-23 3
  • IL-D110 3
  • Zcyto18 3
  • ZCYTO18 4
  • IL-21 3
  • TIFa 3

External Ids for IL22 Gene

Previous GeneCards Identifiers for IL22 Gene

  • GC12M068157
  • GC12M068446
  • GC12M068358
  • GC12M066928
  • GC12M068642
  • GC12M065693

Summaries for IL22 Gene

GeneCards Summary for IL22 Gene

IL22 (Interleukin 22) is a Protein Coding gene. Diseases associated with IL22 include Scleritis and Acute Generalized Exanthematous Pustulosis. Among its related pathways are Akt Signaling and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-22 receptor binding.

UniProtKB/Swiss-Prot for IL22 Gene

  • Cytokine that contributes to the inflammatory response in vivo.

Gene Wiki entry for IL22 Gene

Additional gene information for IL22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL22 Gene

Genomics for IL22 Gene

GeneHancer (GH) Regulatory Elements for IL22 Gene

Promoters and enhancers for IL22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J068253 Promoter 0.7 EPDnew 650.7 0.0 -17 0.1 ZNF316 EMSY IL22 LOC105369818 GC12M068294
GH12J068223 Enhancer 1.3 FANTOM5 Ensembl ENCODE 12.7 +30.2 30231 0.8 PKNOX1 ATF1 ARID4B SIN3A ZNF2 IRF4 ARID2 ZNF207 ZNF143 ATF7 MDM1 IL22 LINC02384 NUP107 LINC02421 IL26 GC12P068213 LOC105369818 IFNG-AS1
GH12J068277 Enhancer 0.7 ENCODE 11.7 -24.4 -24369 0.2 STAT5A EBF1 BMI1 BATF IRF4 ZFHX2 NFATC1 EED ATF7 ETV6 IL22 IL26 MDM1 LINC02384 GC12M068294 LOC105369818
GH12J068309 Enhancer 0.4 ENCODE 10.8 -56.9 -56903 1.2 JUND JUN FOS IL26 MDM1 LINC02384 IL22 MDM2 LOC100130075 GC12M068294 LOC105369818
GH12J068404 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -152.4 -152441 2.8 CTCF FOXA2 MAX RAD21 YY1 GATA3 POLR2A EGR1 ZNF548 RXRA NUP107 CPSF6 KRT8P39 MDM2 MDM1 IL22 SLC35E3 RAP1B GC12P068422 LINC02384
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL22 gene promoter:
  • STAT3
  • STAT5A
  • AP-1
  • c-Jun
  • ATF-2
  • Brachyury
  • Evi-1
  • CUTL1
  • AREB6

Genomic Locations for IL22 Gene

Genomic Locations for IL22 Gene
5,366 bases
Minus strand
5,366 bases
Minus strand

Genomic View for IL22 Gene

Genes around IL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22 Gene

Proteins for IL22 Gene

  • Protein details for IL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for IL22 Gene

    179 amino acids
    Molecular mass:
    20011 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL22 Gene

neXtProt entry for IL22 Gene

Post-translational modifications for IL22 Gene

  • Glycosylation at Asn97, isoforms=68, and isoforms=54
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay Products

  • Boster Bio ELISA Kits for IL22
  • Abcam assays for IL22

No data available for DME Specific Peptides for IL22 Gene

Domains & Families for IL22 Gene

Gene Families for IL22 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL22 Gene

Suggested Antigen Peptide Sequences for IL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-10 family.
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL22: view

Function for IL22 Gene

Molecular function for IL22 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that contributes to the inflammatory response in vivo.

Phenotypes From GWAS Catalog for IL22 Gene

Gene Ontology (GO) - Molecular Function for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 12513909
GO:0045518 interleukin-22 receptor binding NAS 10875937
genes like me logo Genes that share ontologies with IL22: view
genes like me logo Genes that share phenotypes with IL22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22

CRISPR Products

miRNA for IL22 Gene

miRTarBase miRNAs that target IL22

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL22 Gene

Localization for IL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL22 gene
Compartment Confidence
extracellular 5
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL22 Gene

Pathways & Interactions for IL22 Gene

genes like me logo Genes that share pathways with IL22: view

SIGNOR curated interactions for IL22 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002360 T cell lineage commitment IBA --
GO:0006953 acute-phase response NAS 11481447
GO:0006954 inflammatory response NAS 10954742
GO:0010469 regulation of signaling receptor activity IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL22: view

Drugs & Compounds for IL22 Gene

(1) Drugs for IL22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL22: view

Transcripts for IL22 Gene

mRNA/cDNA for IL22 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL22 Gene

Interleukin 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL22

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL22 Gene

No ASD Table

Relevant External Links for IL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL22 Gene

mRNA differential expression in normal tissues according to GTEx for IL22 Gene

This gene is overexpressed in Minor Salivary Gland (x21.4) and Esophagus - Mucosa (x6.8).

Protein differential expression in normal tissues from HIPED for IL22 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL22 Gene

Protein tissue co-expression partners for IL22 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL22 Gene:


SOURCE GeneReport for Unigene cluster for IL22 Gene:


Evidence on tissue expression from TISSUES for IL22 Gene

  • Blood(4.5)
genes like me logo Genes that share expression patterns with IL22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL22 Gene

Orthologs for IL22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL22 34 33
  • 99.63 (n)
(Canis familiaris)
Mammalia IL22 34 33
  • 91.43 (n)
(Mus musculus)
Mammalia Il22 34 33
  • 80.82 (n)
Iltifb 16 34
  • 78 (a)
(Bos Taurus)
Mammalia IL22 33
  • 79.78 (n)
IL-22 34
  • 65 (a)
(Rattus norvegicus)
Mammalia Il22 33
  • 78.96 (n)
(Ornithorhynchus anatinus)
Mammalia IL22 34
  • 38 (a)
(Monodelphis domestica)
Mammalia IL22 34
  • 35 (a)
(Gallus gallus)
Aves IL22 34 33
  • 58.11 (n)
(Anolis carolinensis)
Reptilia IL22 34
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il22 33
  • 51.8 (n)
Species where no ortholog for IL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22 Gene

Gene Tree for IL22 (if available)
Gene Tree for IL22 (if available)
Evolutionary constrained regions (ECRs) for IL22: view image

Paralogs for IL22 Gene

No data available for Paralogs for IL22 Gene

Variants for IL22 Gene

Sequence variations from dbSNP and Humsavar for IL22 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000297653 -- 68,254,262(-) C/T upstream_transcript_variant
rs1000691546 -- 68,249,905(-) C/T intron_variant
rs1000802859 -- 68,254,820(-) G/A upstream_transcript_variant
rs1001517336 -- 68,253,254(-) G/A/T intron_variant
rs1001645220 -- 68,250,371(-) C/T intron_variant

Variation tolerance for IL22 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22 Gene

Disorders for IL22 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IL22 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute generalized exanthematous pustulosis
  • agep
chronic mucocutaneous candidiasis
  • cmc
autoimmune polyendocrine syndrome
  • autoimmune polyendocrinopathy
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards
Search IL22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL22

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL22 Gene

Publications for IL22 Gene

  1. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie MH … Gurney AL (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. (PMID: 10954742) Dumoutier L … Renauld JC (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 22 58
  3. Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis. (PMID: 19469905) Weger W … Salmhofer W (Experimental dermatology 2009) 3 22 44 58
  4. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PMID: 18599299) Jones BC … Walter MR (Structure (London, England : 1993) 2008) 3 4 22 58
  5. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PMID: 17845543) Hennig BJ … Hill AV (Liver international : official journal of the International Association for the Study of the Liver 2007) 3 22 44 58

Products for IL22 Gene

Sources for IL22 Gene

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