This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018] See more...

Aliases for IL22 Gene

Aliases for IL22 Gene

  • Interleukin 22 2 3 5
  • IL-10-Related T-Cell-Derived Inducible Factor 2 3
  • Cytokine Zcyto18 3 4
  • Interleukin-22 3 4
  • IL-TIF 3 4
  • IL-22 3 4
  • ILTIF 3 4
  • IL-10-Related T-Cell-Derived-Inducible Factor 4
  • TIFIL-23 3
  • IL-D110 3
  • Zcyto18 3
  • ZCYTO18 4
  • IL-21 3
  • TIFa 3

External Ids for IL22 Gene

Previous GeneCards Identifiers for IL22 Gene

  • GC12M068157
  • GC12M068446
  • GC12M068358
  • GC12M066928
  • GC12M068642
  • GC12M065693

Summaries for IL22 Gene

Entrez Gene Summary for IL22 Gene

  • This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

GeneCards Summary for IL22 Gene

IL22 (Interleukin 22) is a Protein Coding gene. Diseases associated with IL22 include Scleritis and Inflammatory Bowel Disease. Among its related pathways are Th1 Differentiation Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-22 receptor binding.

UniProtKB/Swiss-Prot Summary for IL22 Gene

Gene Wiki entry for IL22 Gene

Additional gene information for IL22 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL22 Gene

Genomics for IL22 Gene

GeneHancer (GH) Regulatory Elements for IL22 Gene

Promoters and enhancers for IL22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J068253 Promoter 0.6 EPDnew 500.7 0.0 -20 0.1 ZNF316 EMSY CBX8 IL22 lnc-MDM1-2 lnc-NUP107-26 LOC105369818
GH12J068277 Enhancer 1 Ensembl ENCODE 12.5 -23.8 -23797 2.4 RXRA SP1 EP300 OSR2 BCL11A TCF12 CBFB ARNT MEF2B NFE2 MDM1 IL22 IL26 LINC02384 LINC02421 piR-56497-032 lnc-NUP107-26 piR-59907-008 LOC105369818
GH12J068224 Enhancer 0.8 FANTOM5 12.8 +30.0 29991 0.3 ZNF217 CTCF MYC RBM25 SIN3A KLF9 SMC3 YY1 KLF13 CHD1 MDM1 IL22 NUP107 IL26 LOC105369818 IFNG-AS1
GH12J068223 Enhancer 0.9 ENCODE 11 +30.3 30298 0.2 ZNF217 CTCF TRIM28 REST RFX1 RAD21 CTBP1 MYC TRIM22 GATAD2B IL22 MDM1 LINC02384 LINC02421 IL26 LOC105369818 IFNG-AS1
GH12J068279 Enhancer 0.8 Ensembl 11.7 -25.9 -25897 0.2 ZNF639 TRIM28 ZEB1 OSR2 MYNN NFIC ZBTB17 GATA3 BMI1 CEBPG IL22 IL26 MDM1 LINC02384 piR-56497-032 lnc-NUP107-26 piR-59907-008 LOC105369818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL22 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL22

Top Transcription factor binding sites by QIAGEN in the IL22 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • Brachyury
  • c-Jun
  • CUTL1
  • Evi-1
  • STAT3
  • STAT5A

Genomic Locations for IL22 Gene

Genomic Locations for IL22 Gene
chr12:68,248,242-68,253,604
(GRCh38/hg38)
Size:
5,363 bases
Orientation:
Minus strand
chr12:68,642,022-68,647,387
(GRCh37/hg19)
Size:
5,366 bases
Orientation:
Minus strand

Genomic View for IL22 Gene

Genes around IL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22 Gene

Proteins for IL22 Gene

  • Protein details for IL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZX6-IL22_HUMAN
    Recommended name:
    Interleukin-22
    Protein Accession:
    Q9GZX6

    Protein attributes for IL22 Gene

    Size:
    179 amino acids
    Molecular mass:
    20011 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL22 Gene

neXtProt entry for IL22 Gene

Post-translational modifications for IL22 Gene

  • Glycosylation at Asn54, Asn68, and Asn97
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL22

Protein Products

  • Abcam proteins for IL22

No data available for DME Specific Peptides for IL22 Gene

Domains & Families for IL22 Gene

Gene Families for IL22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL22 Gene

Suggested Antigen Peptide Sequences for IL22 Gene

GenScript: Design optimal peptide antigens:
  • IL-10-related T-cell-derived-inducible factor (IL22_HUMAN)
  • Interleukin 22 (Q6NWP4_HUMAN)
  • Interleukin 22 (Q6NZ83_HUMAN)
  • Interleukin 22 (Q6NZ84_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZX6

UniProtKB/Swiss-Prot:

IL22_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL22: view

Function for IL22 Gene

Molecular function for IL22 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that contributes to the inflammatory response in vivo.

Phenotypes From GWAS Catalog for IL22 Gene

Gene Ontology (GO) - Molecular Function for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 12513909
GO:0045518 interleukin-22 receptor binding NAS 10875937
genes like me logo Genes that share ontologies with IL22: view
genes like me logo Genes that share phenotypes with IL22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22

CRISPR Products

miRNA for IL22 Gene

miRTarBase miRNAs that target IL22

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL22 Gene

Localization for IL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL22 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL22 Gene

Pathways & Interactions for IL22 Gene

PathCards logo

SuperPathways for IL22 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.40
3 Th17 cell differentiation
.36
.01
4 Akt Signaling
.60
.60
.55
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with IL22: view

Pathways by source for IL22 Gene

2 GeneGo (Thomson Reuters) pathways for IL22 Gene
  • Immune response IL-22 signaling pathway
  • Immune response IL-9 signaling pathway
25 Qiagen pathways for IL22 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

SIGNOR curated interactions for IL22 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response NAS 11481447
GO:0006954 inflammatory response NAS 10954742
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with IL22: view

Drugs & Compounds for IL22 Gene

(1) Drugs for IL22 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL22: view

Transcripts for IL22 Gene

mRNA/cDNA for IL22 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL22

Alternative Splicing Database (ASD) splice patterns (SP) for IL22 Gene

No ASD Table

Relevant External Links for IL22 Gene

GeneLoc Exon Structure for
IL22

Expression for IL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL22 Gene

mRNA differential expression in normal tissues according to GTEx for IL22 Gene

This gene is overexpressed in Minor Salivary Gland (x21.4) and Esophagus - Mucosa (x6.8).

Protein differential expression in normal tissues from HIPED for IL22 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL22 Gene



Protein tissue co-expression partners for IL22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL22

SOURCE GeneReport for Unigene cluster for IL22 Gene:

Hs.287369

Evidence on tissue expression from TISSUES for IL22 Gene

  • Blood(4.5)
genes like me logo Genes that share expression patterns with IL22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL22 Gene

Orthologs for IL22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL22 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL22 31 30
  • 91.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il22 31 30
  • 80.82 (n)
OneToMany
Iltifb 17 31
  • 78 (a)
cow
(Bos Taurus)
Mammalia IL22 30
  • 79.78 (n)
IL-22 31
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il22 30
  • 78.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL22 31
  • 38 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL22 31
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL22 31 30
  • 58.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL22 31
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il22 30
  • 51.8 (n)
Species where no ortholog for IL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22 Gene

ENSEMBL:
Gene Tree for IL22 (if available)
TreeFam:
Gene Tree for IL22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL22: view image

Paralogs for IL22 Gene

No data available for Paralogs for IL22 Gene

Variants for IL22 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL22 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
709289 Benign: not provided 68,248,867(-) T/C MISSENSE_VARIANT
rs2227507 - p.Ser158Gly

Additional dbSNP identifiers (rs#s) for IL22 Gene

Variation tolerance for IL22 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL22 Gene

Human Gene Mutation Database (HGMD)
IL22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22 Gene

Disorders for IL22 Gene

MalaCards: The human disease database

(25) MalaCards diseases for IL22 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
scleritis
inflammatory bowel disease
  • inflammatory bowel diseases
chronic mucocutaneous candidiasis
  • cmc
autoimmune polyendocrine syndrome
  • autoimmune polyendocrinopathy
autoimmune uveitis
- elite association - COSMIC cancer census association via MalaCards
Search IL22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL22 Gene

Publications for IL22 Gene

  1. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie MH … Gurney AL (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. (PMID: 10954742) Dumoutier L … Renauld JC (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 23 54
  3. Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis. (PMID: 19469905) Weger W … Salmhofer W (Experimental dermatology 2009) 3 23 41 54
  4. Structure of IL-22 bound to its high-affinity IL-22R1 chain. (PMID: 18599299) Jones BC … Walter MR (Structure (London, England : 1993) 2008) 3 4 23 54
  5. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PMID: 17845543) Hennig BJ … Hill AV (Liver international : official journal of the International Association for the Study of the Liver 2007) 3 23 41 54

Products for IL22 Gene

Sources for IL22 Gene