Aliases for IL21R Gene
External Ids for IL21R Gene
Previous GeneCards Identifiers for IL21R Gene
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
GeneCards Summary for IL21R Gene
IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic. Among its related pathways are IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Cytokine production by Th17 cells in CF (Mouse model). Gene Ontology (GO) annotations related to this gene include interleukin-21 receptor activity. An important paralog of this gene is IL2RB.
UniProtKB/Swiss-Prot Summary for IL21R Gene
This is a receptor for interleukin-21.