IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009] See more...

Aliases for IL20RB Gene

Aliases for IL20RB Gene

  • Interleukin 20 Receptor Subunit Beta 2 3 5
  • Fibronectin Type III Domain Containing 6 2 3 4
  • IL-20R2 2 3 4
  • DIRS1 2 3 4
  • Interleukin 20 Receptor Beta Subunit 2 3
  • Interleukin-20 Receptor Subunit Beta 3 4
  • IL-20 Receptor Subunit Beta 3 4
  • IL-20R-Beta 3 4
  • IL-20RB 3 4
  • FNDC6 3 4
  • Interleukin 20 Receptor Beta 2
  • Interleukin-20 Receptor II 3
  • MGC34923 2
  • IL20RB 5

External Ids for IL20RB Gene

Previous HGNC Symbols for IL20RB Gene

  • FNDC6

Previous GeneCards Identifiers for IL20RB Gene

  • GC00U990739
  • GC03P138161
  • GC03P136665
  • GC03P134052

Summaries for IL20RB Gene

Entrez Gene Summary for IL20RB Gene

  • IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

GeneCards Summary for IL20RB Gene

IL20RB (Interleukin 20 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL20RB include 46,Xy Sex Reversal 8. Among its related pathways are Cytokine Signaling in Immune system and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-20 binding. An important paralog of this gene is IFNLR1.

UniProtKB/Swiss-Prot Summary for IL20RB Gene

  • The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Gene Wiki entry for IL20RB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL20RB Gene

Genomics for IL20RB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL20RB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20RB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL20RB

Top Transcription factor binding sites by QIAGEN in the IL20RB gene promoter:
  • AhR
  • AML1a
  • Arnt
  • CP2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-2
  • Pax-2a
  • YY1

Genomic Locations for IL20RB Gene

Latest Assembly
chr3:136,946,230-137,011,085
(GRCh38/hg38)
Size:
64,856 bases
Orientation:
Plus strand

Previous Assembly
chr3:136,676,825-136,729,927
(GRCh37/hg19 by Entrez Gene)
Size:
53,103 bases
Orientation:
Plus strand

chr3:136,665,072-136,729,927
(GRCh37/hg19 by Ensembl)
Size:
64,856 bases
Orientation:
Plus strand

Genomic View for IL20RB Gene

Genes around IL20RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20RB Gene

Proteins for IL20RB Gene

  • Protein details for IL20RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXL0-I20RB_HUMAN
    Recommended name:
    Interleukin-20 receptor subunit beta
    Protein Accession:
    Q6UXL0
    Secondary Accessions:
    • B4DL40
    • Q6P438
    • Q8IYY5
    • Q8TAJ7

    Protein attributes for IL20RB Gene

    Size:
    311 amino acids
    Molecular mass:
    35076 Da
    Quaternary structure:
    • Heterodimer with IL20RA and heterodimer with IL22RA1.

    Three dimensional structures from OCA and Proteopedia for IL20RB Gene

    Alternative splice isoforms for IL20RB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20RB Gene

Post-translational modifications for IL20RB Gene

  • Glycosylation at Asn40 and Asn134

Protein products for research

  • Abcam proteins for IL20RB

No data available for DME Specific Peptides for IL20RB Gene

Domains & Families for IL20RB Gene

Protein Domains for IL20RB Gene

Suggested Antigen Peptide Sequences for IL20RB Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78983, highly similar to Interleukin-20 receptor beta chain (B4DL40_HUMAN)
  • IL-20R2 (I20RB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXL0

UniProtKB/Swiss-Prot:

I20RB_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL20RB: view

Function for IL20RB Gene

Molecular function for IL20RB Gene

UniProtKB/Swiss-Prot Function:
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Phenotypes From GWAS Catalog for IL20RB Gene

Gene Ontology (GO) - Molecular Function for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0005515 protein binding IPI 22802649
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL20RB: view
genes like me logo Genes that share phenotypes with IL20RB: view

Animal Models for IL20RB Gene

MGI Knock Outs for IL20RB:

Animal Models for research

  • Taconic Biosciences Mouse Models for IL20RB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20RB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20RB Gene

Localization for IL20RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20RB Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20RB gene
Compartment Confidence
plasma membrane 4
nucleus 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with IL20RB: view

Pathways & Interactions for IL20RB Gene

genes like me logo Genes that share pathways with IL20RB: view

SIGNOR curated interactions for IL20RB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001808 negative regulation of type IV hypersensitivity IEA --
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0002765 immune response-inhibiting signal transduction IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032689 negative regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL20RB: view

Drugs & Compounds for IL20RB Gene

No Compound Related Data Available

Transcripts for IL20RB Gene

mRNA/cDNA for IL20RB Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20RB

Alternative Splicing Database (ASD) splice patterns (SP) for IL20RB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - -
SP3: - -

Relevant External Links for IL20RB Gene

GeneLoc Exon Structure for
IL20RB

Expression for IL20RB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL20RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL20RB Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x13.8), Skin - Sun Exposed (Lower leg) (x13.1), Esophagus - Mucosa (x10.5), and Vagina (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL20RB

SOURCE GeneReport for Unigene cluster for IL20RB Gene:

Hs.61232

mRNA Expression by UniProt/SwissProt for IL20RB Gene:

Q6UXL0-I20RB_HUMAN
Tissue specificity: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.

Evidence on tissue expression from TISSUES for IL20RB Gene

  • Skin(4.6)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IL20RB: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20RB Gene

Orthologs for IL20RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20RB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL20RB 29 30
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL20RB 29 30
  • 88.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL20RB 29 30
  • 84.26 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il20rb 29 16 30
  • 82.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il20rb 29
  • 80.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL20RB 30
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL20RB 30
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL20RB 29 30
  • 63.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL20RB 30
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia il20rb 29
  • 50.45 (n)
Zebrafish
(Danio rerio)
Actinopterygii crfb16 30
  • 22 (a)
OneToOne
Species where no ortholog for IL20RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL20RB Gene

ENSEMBL:
Gene Tree for IL20RB (if available)
TreeFam:
Gene Tree for IL20RB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL20RB: view image
Alliance of Genome Resources:
Additional Orthologs for IL20RB

Paralogs for IL20RB Gene

genes like me logo Genes that share paralogs with IL20RB: view

Variants for IL20RB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL20RB Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs244405 Benign: not provided 136,989,562(+) C/G
NM_144717.4(IL20RB):c.528C>G (p.Ala176=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL20RB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL20RB Gene

Variant ID Type Subtype PubMed ID
esv3597894 CNV gain 21293372
esv3597895 CNV gain 21293372
nsv524856 CNV loss 19592680

Variation tolerance for IL20RB Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20RB Gene

Human Gene Mutation Database (HGMD)
IL20RB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL20RB
Leiden Open Variation Database (LOVD)
IL20RB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20RB Gene

Disorders for IL20RB Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20RB Gene - From: COP

Disorder Aliases PubMed IDs
46,xy sex reversal 8
  • srxy8
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL20RB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL20RB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20RB Gene

Publications for IL20RB Gene

  1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4
  2. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. (PMID: 22802649) Logsdon NJ … Walter MR (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
  3. Association analysis of IL20RA and IL20RB genes in psoriasis. (PMID: 18480827) Kingo K … Kõks S (Genes and immunity 2008) 3 40
  4. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PMID: 19043545) Gieger C … Suhre K (PLoS genetics 2008) 3 40
  5. IL-20: biological functions and clinical implications. (PMID: 16703417) Wei CC … Chang MS (Journal of biomedical science 2006) 2 3

Products for IL20RB Gene

Sources for IL20RB Gene