Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL20RB Gene

Aliases for IL20RB Gene

  • Interleukin 20 Receptor Subunit Beta 2 3 5
  • Fibronectin Type III Domain Containing 6 2 3 4
  • Interleukin 20 Receptor Beta Subunit 2 3
  • IL-20 Receptor Subunit Beta 3 4
  • IL-20R-Beta 3 4
  • IL-20R2 3 4
  • IL-20RB 3 4
  • FNDC6 3 4
  • DIRS1 3 4
  • Interleukin-20 Receptor Subunit Beta 3
  • Interleukin 20 Receptor Beta 2
  • Interleukin-20 Receptor II 3

External Ids for IL20RB Gene

Previous HGNC Symbols for IL20RB Gene

  • FNDC6

Previous GeneCards Identifiers for IL20RB Gene

  • GC00U990739
  • GC03P138161
  • GC03P136665
  • GC03P134052

Summaries for IL20RB Gene

Entrez Gene Summary for IL20RB Gene

  • IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

GeneCards Summary for IL20RB Gene

IL20RB (Interleukin 20 Receptor Subunit Beta) is a Protein Coding gene. Among its related pathways are Jak-Stat Signaling Pathway (sino) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-20 binding.

UniProtKB/Swiss-Prot for IL20RB Gene

  • The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Gene Wiki entry for IL20RB Gene

Additional gene information for IL20RB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20RB Gene

Genomics for IL20RB Gene

GeneHancer (GH) Regulatory Elements for IL20RB Gene

Promoters and enhancers for IL20RB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J136954 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 688.8 +12.3 12250 7.9 FOXA2 ARNT BRCA1 POLR2B FOS ATF7 RXRA ATF4 MIER3 STAT3 IL20RB IL20RB-AS1 SLC35G2 ENSG00000242968 GC03P136873
GH03J136860 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 33.4 -84.1 -84089 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 NCK1 NCK1-DT STAG1 IL20RB MSL2 SLC35G2 ENSG00000273486 ENSG00000242968
GH03J136748 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21 -194.4 -194394 6.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 STAG1 ENSG00000261758 MSL2 IL20RB SLC35G2 NCK1 ENSG00000242968 ENSG00000273486 PCCB LOC100421438
GH03J136248 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.5 -696.0 -696032 4.2 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 PCCB MSL2 IL20RB NCK1 STAG1 RPL31P23
GH03J136918 Enhancer 1.1 Ensembl ENCODE dbSUPER 34.3 -25.4 -25429 4.8 JUN PAX8 EBF1 BATF FOSL1 ZNF316 MAFK SOX6 RXRA DPF2 IL20RB ENSG00000273486 NCK1 IL20RB-AS1 RAD51AP1P1 GC03P136873
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20RB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL20RB gene promoter:
  • YY1
  • AhR
  • Meis-1b
  • Meis-1a
  • Meis-1
  • Arnt
  • Pax-2
  • Pax-2a
  • AML1a
  • CP2

Genomic Locations for IL20RB Gene

Genomic Locations for IL20RB Gene
64,856 bases
Plus strand
64,856 bases
Plus strand

Genomic View for IL20RB Gene

Genes around IL20RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20RB Gene

Proteins for IL20RB Gene

  • Protein details for IL20RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-20 receptor subunit beta
    Protein Accession:
    Secondary Accessions:
    • B4DL40
    • Q6P438
    • Q8IYY5
    • Q8TAJ7

    Protein attributes for IL20RB Gene

    311 amino acids
    Molecular mass:
    35076 Da
    Quaternary structure:
    • Heterodimer with IL20RA and heterodimer with IL22RA1.

    Three dimensional structures from OCA and Proteopedia for IL20RB Gene

    Alternative splice isoforms for IL20RB Gene


neXtProt entry for IL20RB Gene

Post-translational modifications for IL20RB Gene

  • Glycosylation at Asn134 and Asn40

Other Protein References for IL20RB Gene

No data available for DME Specific Peptides for IL20RB Gene

Domains & Families for IL20RB Gene

Protein Domains for IL20RB Gene

Suggested Antigen Peptide Sequences for IL20RB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type II cytokine receptor family.
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL20RB: view

Function for IL20RB Gene

Molecular function for IL20RB Gene

UniProtKB/Swiss-Prot Function:
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Phenotypes From GWAS Catalog for IL20RB Gene

Gene Ontology (GO) - Molecular Function for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0004920 interleukin-10 receptor activity IBA --
GO:0005515 protein binding IPI 22802649
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL20RB: view
genes like me logo Genes that share phenotypes with IL20RB: view

Animal Models for IL20RB Gene

MGI Knock Outs for IL20RB:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL20RB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20RB Gene

Localization for IL20RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20RB gene
Compartment Confidence
plasma membrane 5
nucleus 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with IL20RB: view

Pathways & Interactions for IL20RB Gene

genes like me logo Genes that share pathways with IL20RB: view

Pathways by source for IL20RB Gene

SIGNOR curated interactions for IL20RB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL20RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001808 negative regulation of type IV hypersensitivity IEA --
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0002765 immune response-inhibiting signal transduction IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032689 negative regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL20RB: view

Drugs & Compounds for IL20RB Gene

No Compound Related Data Available

Transcripts for IL20RB Gene

mRNA/cDNA for IL20RB Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL20RB Gene

Interleukin 20 receptor beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL20RB Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: - -
SP3: - -

Relevant External Links for IL20RB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL20RB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL20RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL20RB Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x13.8), Skin - Sun Exposed (Lower leg) (x13.1), Esophagus - Mucosa (x10.5), and Vagina (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of IL20RB Gene:


SOURCE GeneReport for Unigene cluster for IL20RB Gene:


mRNA Expression by UniProt/SwissProt for IL20RB Gene:

Tissue specificity: Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin.

Evidence on tissue expression from TISSUES for IL20RB Gene

  • Skin(4.6)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with IL20RB: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20RB Gene

Orthologs for IL20RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20RB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL20RB 34 33
  • 99.78 (n)
(Canis familiaris)
Mammalia IL20RB 34 33
  • 88.03 (n)
(Bos Taurus)
Mammalia IL20RB 34 33
  • 84.26 (n)
(Mus musculus)
Mammalia Il20rb 16 34 33
  • 82.24 (n)
(Rattus norvegicus)
Mammalia Il20rb 33
  • 80.61 (n)
(Monodelphis domestica)
Mammalia IL20RB 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia IL20RB 34
  • 46 (a)
(Gallus gallus)
Aves IL20RB 34 33
  • 63.83 (n)
(Anolis carolinensis)
Reptilia IL20RB 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il20rb 33
  • 50.45 (n)
(Danio rerio)
Actinopterygii crfb16 34
  • 22 (a)
Species where no ortholog for IL20RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20RB Gene

Gene Tree for IL20RB (if available)
Gene Tree for IL20RB (if available)
Evolutionary constrained regions (ECRs) for IL20RB: view image

Paralogs for IL20RB Gene

No data available for Paralogs for IL20RB Gene

Variants for IL20RB Gene

Sequence variations from dbSNP and Humsavar for IL20RB Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000084834 -- 137,004,742(+) G/A intron_variant
rs1000140701 -- 137,007,505(+) C/T intron_variant
rs1000191817 -- 137,007,753(+) G/A intron_variant
rs1000207122 -- 136,992,969(+) A/G intron_variant
rs1000251920 -- 136,971,323(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL20RB Gene

Variant ID Type Subtype PubMed ID
esv3597894 CNV gain 21293372
esv3597895 CNV gain 21293372
nsv524856 CNV loss 19592680

Variation tolerance for IL20RB Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20RB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20RB Gene

Disorders for IL20RB Gene

Additional Disease Information for IL20RB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IL20RB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL20RB Gene

Publications for IL20RB Gene

  1. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4 58
  2. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. (PMID: 22802649) Logsdon NJ … Walter MR (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 58
  3. Association analysis of IL20RA and IL20RB genes in psoriasis. (PMID: 18480827) Kingo K … Kõks S (Genes and immunity 2008) 3 44 58
  4. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PMID: 19043545) Gieger C … Suhre K (PLoS genetics 2008) 3 44 58
  5. IL-20: biological functions and clinical implications. (PMID: 16703417) Wei CC … Chang MS (Journal of biomedical science 2006) 2 3 58

Products for IL20RB Gene

Sources for IL20RB Gene

Loading form....