Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL20RA Gene

Aliases for IL20RA Gene

  • Interleukin 20 Receptor Subunit Alpha 2 3 5
  • Interleukin 20 Receptor Alpha Subunit 2 3
  • Cytokine Receptor Family 2 Member 8 3 4
  • Interleukin 20 Receptor, Alpha 2 3
  • IL-20R-Alpha 3 4
  • IL-20R1 3 4
  • IL-20RA 3 4
  • CRF2-8 3 4
  • Interleukin-20 Receptor Subunit Alpha 3
  • Cytokine Receptor Class-II Member 8 4
  • Class II Cytokine Receptor ZCYTOR7 3
  • IL-20 Receptor Subunit Alpha 4
  • Interleukin-20 Receptor I 3
  • ZcytoR7 4

External Ids for IL20RA Gene

Previous GeneCards Identifiers for IL20RA Gene

  • GC06M136944
  • GC06M137168
  • GC06M137301
  • GC06M137362
  • GC06M134884
  • GC06M137321

Summaries for IL20RA Gene

Entrez Gene Summary for IL20RA Gene

  • This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL20RA Gene

IL20RA (Interleukin 20 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL20RA include Psoriasis. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-20 binding. An important paralog of this gene is IL22RA1.

UniProtKB/Swiss-Prot for IL20RA Gene

  • The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Gene Wiki entry for IL20RA Gene

Additional gene information for IL20RA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20RA Gene

Genomics for IL20RA Gene

GeneHancer (GH) Regulatory Elements for IL20RA Gene

Promoters and enhancers for IL20RA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J137043 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 657.9 +0.8 787 1.6 MZF1 BMI1 ZNF335 ZNF202 ZNF362 ZNF398 ZFP69B CBX8 SMARCA4 ZNF524 IL20RA BCLAF1 GC06P137009
GH06J137024 Enhancer 0.8 ENCODE 18.3 +19.2 19211 4.1 HDGF FOXA2 BATF YY1 ATF7 FOS IKZF2 RUNX3 RXRA CEBPB IL20RA ENSG00000235399 NHEG1 GC06P137009
GH06J136989 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.5 +55.5 55547 1.5 KLF17 BACH1 ZIC2 ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 IL20RA SLC35D3 NHEG1 RPL35AP3
GH06J137094 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 5.9 -50.4 -50432 1.8 PKNOX1 SMAD1 STAT5A BMI1 BATF RAD21 IRF4 ZNF143 ATF7 ETV6 IL22RA2 IL20RA GC06P137115
GH06J136920 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 4.2 +122.9 122918 3.4 ZNF2 RFX5 ZNF335 GLIS2 SCRT2 IKZF2 EGR2 ZNF202 ZBTB11 ZNF398 SLC35D3 GC06M136918 BCLAF1 PEX7 IL20RA ENSG00000207247
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20RA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL20RA gene promoter:
  • STAT3
  • AREB6
  • Cart-1
  • Nkx2-5
  • POU2F1a
  • POU2F1
  • STAT1beta
  • STAT1alpha
  • STAT1

Genomic Locations for IL20RA Gene

Genomic Locations for IL20RA Gene
45,396 bases
Minus strand
45,191 bases
Minus strand

Genomic View for IL20RA Gene

Genes around IL20RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20RA Gene

Proteins for IL20RA Gene

  • Protein details for IL20RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-20 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • B4DLR5
    • F5H675
    • Q14CW2
    • Q6UWA9
    • Q96SH8

    Protein attributes for IL20RA Gene

    553 amino acids
    Molecular mass:
    62485 Da
    Quaternary structure:
    • Heterodimer with IL20RB and heterodimer with IL10RB.

    Three dimensional structures from OCA and Proteopedia for IL20RA Gene

    Alternative splice isoforms for IL20RA Gene


neXtProt entry for IL20RA Gene

Post-translational modifications for IL20RA Gene

  • Glycosylation at isoforms=2, 3200, Asn191, Asn182, Asn91, isoforms=383, and Asn42

No data available for DME Specific Peptides for IL20RA Gene

Domains & Families for IL20RA Gene

Gene Families for IL20RA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL20RA Gene

Suggested Antigen Peptide Sequences for IL20RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type II cytokine receptor family.
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL20RA: view

Function for IL20RA Gene

Molecular function for IL20RA Gene

UniProtKB/Swiss-Prot Function:
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Phenotypes From GWAS Catalog for IL20RA Gene

Gene Ontology (GO) - Molecular Function for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0005515 protein binding IPI 22802649
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL20RA: view
genes like me logo Genes that share phenotypes with IL20RA: view

Animal Models for IL20RA Gene

MGI Knock Outs for IL20RA:

Animal Model Products

miRNA for IL20RA Gene

miRTarBase miRNAs that target IL20RA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20RA Gene

Localization for IL20RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20RA gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL20RA: view

Pathways & Interactions for IL20RA Gene

genes like me logo Genes that share pathways with IL20RA: view

SIGNOR curated interactions for IL20RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045124 regulation of bone resorption IEA --
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with IL20RA: view

Drugs & Compounds for IL20RA Gene

No Compound Related Data Available

Transcripts for IL20RA Gene

Unigene Clusters for IL20RA Gene

Interleukin 20 receptor, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL20RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP7: -

Relevant External Links for IL20RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL20RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL20RA Gene

mRNA differential expression in normal tissues according to GTEx for IL20RA Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.5) and Skin - Sun Exposed (Lower leg) (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of IL20RA Gene:


SOURCE GeneReport for Unigene cluster for IL20RA Gene:


mRNA Expression by UniProt/SwissProt for IL20RA Gene:

Tissue specificity: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.

Evidence on tissue expression from TISSUES for IL20RA Gene

  • Nervous system(4.1)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with IL20RA: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20RA Gene

Orthologs for IL20RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20RA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL20RA 34 33
  • 99.28 (n)
(Bos Taurus)
Mammalia IL20RA 34 33
  • 82.41 (n)
(Canis familiaris)
Mammalia IL20RA 34 33
  • 80.69 (n)
(Mus musculus)
Mammalia Il20ra 16 34 33
  • 74.47 (n)
(Rattus norvegicus)
Mammalia Il20ra 33
  • 73.41 (n)
(Monodelphis domestica)
Mammalia IL20RA 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia IL20RA 34
  • 56 (a)
(Gallus gallus)
Aves IL20RA 34 33
  • 55.49 (n)
(Danio rerio)
Actinopterygii crfb8 34 33
  • 45.25 (n)
Species where no ortholog for IL20RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20RA Gene

Gene Tree for IL20RA (if available)
Gene Tree for IL20RA (if available)
Evolutionary constrained regions (ECRs) for IL20RA: view image

Paralogs for IL20RA Gene

Paralogs for IL20RA Gene

genes like me logo Genes that share paralogs with IL20RA: view

Variants for IL20RA Gene

Sequence variations from dbSNP and Humsavar for IL20RA Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000117513 -- 137,033,086(-) C/T intron_variant
rs1000179133 -- 137,022,205(-) C/G intron_variant
rs1000199418 -- 137,002,404(-) A/C intron_variant
rs1000312850 -- 137,028,870(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL20RA Gene

Variant ID Type Subtype PubMed ID
nsv349973 CNV deletion 16902084

Variation tolerance for IL20RA Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20RA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20RA Gene

Disorders for IL20RA Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20RA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL20RA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL20RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20RA Gene

Publications for IL20RA Gene

  1. Association analysis of IL20RA and IL20RB genes in psoriasis. (PMID: 18480827) Kingo K … Kõks S (Genes and immunity 2008) 3 22 44 58
  2. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F … Kotenko SV (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
  3. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4 58
  4. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. (PMID: 22802649) Logsdon NJ … Walter MR (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 58
  5. Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis. (PMID: 19926456) Kingo K … Kõks S (Journal of dermatological science 2010) 3 44 58

Products for IL20RA Gene

Sources for IL20RA Gene

Loading form....