This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed i... See more...

Aliases for IL20RA Gene

Aliases for IL20RA Gene

  • Interleukin 20 Receptor Subunit Alpha 2 3 5
  • IL-20R1 2 3 4
  • Interleukin 20 Receptor Alpha Subunit 2 3
  • Interleukin-20 Receptor Subunit Alpha 3 4
  • Cytokine Receptor Family 2 Member 8 3 4
  • Interleukin 20 Receptor, Alpha 2 3
  • IL-20R-Alpha 3 4
  • IL-20RA 3 4
  • CRF2-8 3 4
  • Cytokine Receptor Class-II Member 8 4
  • Class II Cytokine Receptor ZCYTOR7 3
  • IL-20 Receptor Subunit Alpha 4
  • Interleukin-20 Receptor I 3
  • ZCYTOR7 2
  • ZcytoR7 4
  • IL20RA 5

External Ids for IL20RA Gene

Previous GeneCards Identifiers for IL20RA Gene

  • GC06M136944
  • GC06M137168
  • GC06M137301
  • GC06M137362
  • GC06M134884
  • GC06M137321

Summaries for IL20RA Gene

Entrez Gene Summary for IL20RA Gene

  • This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL20RA Gene

IL20RA (Interleukin 20 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL20RA include Psoriasis. Among its related pathways are Akt Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-20 binding. An important paralog of this gene is IL22RA1.

UniProtKB/Swiss-Prot Summary for IL20RA Gene

  • The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Gene Wiki entry for IL20RA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL20RA Gene

Genomics for IL20RA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL20RA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J137043 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 257.8 +0.9 879 2.2 ZBTB10 CHD2 REST SIN3A SMARCA4 CBX2 BMI1 ZNF362 ZNF398 ZNF18 IL20RA lnc-IL22RA2-2 BCLAF1 lnc-IL22RA2-1 SLC35D3
GH06J137024 Enhancer 0.9 Ensembl ENCODE 18.3 +19.1 19057 4.2 ATF3 JUND YY1 BCL11A CEBPB TRIM22 ZNF217 EP300 ELF1 CTBP1 IL20RA NHEG1 ENSG00000235399 lnc-IL22RA2-1 lnc-IL22RA2-2 SLC35D3
GH06J136989 Promoter/Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas 9.5 +55.4 55361 1.5 ZNF600 ZIC2 POLR2A ZNF610 TARDBP KLF16 ZBTB48 ZNF2 ZNF189 ZFP37 IL20RA SLC35D3 HSALNG0053737 NHEG1 ENSG00000235399
GH06J137013 Enhancer 0.7 Ensembl ENCODE 12.2 +31.8 31762 2 ZNF654 CEBPB CTCF RAD21 SMC3 JUND ZNF26 ZBTB12 POLR2A TRIM22 BCLAF1 IL20RA OLIG3 lnc-IL22RA2-1 NHEG1 lnc-IL22RA2-2 SLC35D3
GH06J136969 Enhancer 1 Ensembl ENCODE 8.5 +75.9 75863 2.6 BCLAF1 ZNF654 NFIC REST CEBPB KLF11 TRIM22 CTCF MAX EP300 NHEG1 IL20RA ENSG00000235399 piR-56133-202 SLC35D3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20RA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL20RA

Top Transcription factor binding sites by QIAGEN in the IL20RA gene promoter:
  • AREB6
  • Cart-1
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for IL20RA Gene

Latest Assembly
chr6:136,999,971-137,045,180
(GRCh38/hg38)
Size:
45,210 bases
Orientation:
Minus strand

Previous Assembly
chr6:137,321,108-137,366,317
(GRCh37/hg19 by Entrez Gene)
Size:
45,210 bases
Orientation:
Minus strand

chr6:137,321,108-137,366,298
(GRCh37/hg19 by Ensembl)
Size:
45,191 bases
Orientation:
Minus strand

Genomic View for IL20RA Gene

Genes around IL20RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20RA Gene

Proteins for IL20RA Gene

  • Protein details for IL20RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF4-I20RA_HUMAN
    Recommended name:
    Interleukin-20 receptor subunit alpha
    Protein Accession:
    Q9UHF4
    Secondary Accessions:
    • B4DLR5
    • F5H675
    • Q14CW2
    • Q6UWA9
    • Q96SH8

    Protein attributes for IL20RA Gene

    Size:
    553 amino acids
    Molecular mass:
    62485 Da
    Quaternary structure:
    • Heterodimer with IL20RB and heterodimer with IL10RB.

    Three dimensional structures from OCA and Proteopedia for IL20RA Gene

    Alternative splice isoforms for IL20RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20RA Gene

Post-translational modifications for IL20RA Gene

  • Glycosylation at Asn83, Asn42, Asn91, Asn182, Asn191, and Asn200

No data available for DME Specific Peptides for IL20RA Gene

Domains & Families for IL20RA Gene

Gene Families for IL20RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL20RA Gene

Suggested Antigen Peptide Sequences for IL20RA Gene

GenScript: Design optimal peptide antigens:
  • ZcytoR7 (I20RA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHF4

UniProtKB/Swiss-Prot:

I20RA_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL20RA: view

Function for IL20RA Gene

Molecular function for IL20RA Gene

UniProtKB/Swiss-Prot Function:
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Phenotypes From GWAS Catalog for IL20RA Gene

Gene Ontology (GO) - Molecular Function for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0005515 protein binding IEA,IPI 22802649
GO:0042015 interleukin-20 binding IBA 21873635
genes like me logo Genes that share ontologies with IL20RA: view
genes like me logo Genes that share phenotypes with IL20RA: view

Animal Models for IL20RA Gene

MGI Knock Outs for IL20RA:

miRNA for IL20RA Gene

miRTarBase miRNAs that target IL20RA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20RA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20RA Gene

Localization for IL20RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20RA Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20RA gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with IL20RA: view

Pathways & Interactions for IL20RA Gene

genes like me logo Genes that share pathways with IL20RA: view

Pathways by source for IL20RA Gene

7 Qiagen pathways for IL20RA Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • MAPK Family Pathway
  • Molecular Mechanisms of Cancer
  • p38 Signaling

SIGNOR curated interactions for IL20RA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL20RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045124 regulation of bone resorption IEA --
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with IL20RA: view

Drugs & Compounds for IL20RA Gene

No Compound Related Data Available

Transcripts for IL20RA Gene

mRNA/cDNA for IL20RA Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20RA

Alternative Splicing Database (ASD) splice patterns (SP) for IL20RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for IL20RA Gene

GeneLoc Exon Structure for
IL20RA

Expression for IL20RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL20RA Gene

mRNA differential expression in normal tissues according to GTEx for IL20RA Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.5) and Skin - Sun Exposed (Lower leg) (x6.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL20RA

SOURCE GeneReport for Unigene cluster for IL20RA Gene:

Hs.445868

mRNA Expression by UniProt/SwissProt for IL20RA Gene:

Q9UHF4-I20RA_HUMAN
Tissue specificity: Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.

Evidence on tissue expression from TISSUES for IL20RA Gene

  • Nervous system(4.3)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with IL20RA: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20RA Gene

Orthologs for IL20RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20RA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL20RA 29 30
  • 99.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL20RA 29 30
  • 82.41 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL20RA 29 30
  • 80.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il20ra 29 16 30
  • 74.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il20ra 29
  • 73.41 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL20RA 30
  • 57 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL20RA 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL20RA 29 30
  • 55.49 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii crfb8 29 30
  • 45.25 (n)
OneToOne
Species where no ortholog for IL20RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL20RA Gene

ENSEMBL:
Gene Tree for IL20RA (if available)
TreeFam:
Gene Tree for IL20RA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL20RA: view image
Alliance of Genome Resources:
Additional Orthologs for IL20RA

Paralogs for IL20RA Gene

genes like me logo Genes that share paralogs with IL20RA: view

Variants for IL20RA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL20RA Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs5880323 Benign: not specified. Benign: not specified 137,004,764(-) TA/TTAA/T
NM_014432.3(IL20RA):c.725-5del
INTRON
rs1342642 -- p.Leu382Phe
rs1555498 -- p.Val259Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL20RA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL20RA Gene

Variant ID Type Subtype PubMed ID
nsv349973 CNV deletion 16902084

Variation tolerance for IL20RA Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20RA Gene

Human Gene Mutation Database (HGMD)
IL20RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL20RA
Leiden Open Variation Database (LOVD)
IL20RA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20RA Gene

Disorders for IL20RA Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20RA Gene - From: COP and GCD

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL20RA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL20RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20RA Gene

Publications for IL20RA Gene

  1. Association analysis of IL20RA and IL20RB genes in psoriasis. (PMID: 18480827) Kingo K … Kõks S (Genes and immunity 2008) 3 22 40
  2. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. (PMID: 14764663) Sheikh F … Kotenko SV (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22
  3. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4
  4. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. (PMID: 22802649) Logsdon NJ … Walter MR (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 40

Products for IL20RA Gene

Sources for IL20RA Gene