Aliases for IL20 Gene
External Ids for IL20 Gene
Previous GeneCards Identifiers for IL20 Gene
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL20 Gene
IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are Cytokine Signaling in Immune system and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.
UniProtKB/Swiss-Prot Summary for IL20 Gene
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.