IL20 Gene (Protein Coding)

Interleukin 20

GC01P206866
GIFtS:
40
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this pr... See more...

Aliases for IL20 Gene

Aliases for IL20 Gene

  • Interleukin 20 2 3 5
  • ZCYTO10 2 3 4
  • IL-20 2 3 4
  • Cytokine Zcyto10 3 4
  • Interleukin-20 3 4
  • IL10D 2 3
  • Four Alpha Helix Cytokine 3
  • IL20 5

External Ids for IL20 Gene

Previous GeneCards Identifiers for IL20 Gene

  • GC01P205699
  • GC01P202749
  • GC01P203682
  • GC01P204122
  • GC01P203427
  • GC01P205105
  • GC01P207038
  • GC01P177737

Summaries for IL20 Gene

Entrez Gene Summary for IL20 Gene

  • The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL20 Gene

IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot Summary for IL20 Gene

  • Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

Additional gene information for IL20 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL20 Gene

Genomics for IL20 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL20 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J206864 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 250.7 +1.6 1601 1.1 ZNF654 MYC NFIC NONO CTCF REST CEBPB DEK TRIM22 MAX IL20 IL19 IL24 FCMR PIGR FCAMR IL10 HSALNG0010052
GH01J206863 Promoter 0.3 EPDnew 250.7 0.0 -19 0.1 IL20 IL24 FCMR PIGR FCAMR IL10 IL19 LOC105372878
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +163.1 163103 18.4 IKZF1 MYC NCOR1 JUND ZNF592 ATF2 CEBPA BRCA1 POLR2A NFIC C1orf116 HSALNG0010068 EIF2D C4BPA CDCA4P4 C4BPB FCAMR PIGR FCMR RPL7AP20
GH01J206917 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +59.5 59506 12 BCLAF1 SP1 ZNF207 IKZF1 POLR2A ZSCAN16 BCL11A REST CEBPB ZNF592 FCMR HSALNG0010058 lnc-FCMR-1 lnc-PIGR-3 CDCA4P4 MAPKAPK2 EIF2D ENSG00000271680 PIGR FCAMR
GH01J206768 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -92.6 -92645 4.5 BCLAF1 SP1 IKZF1 POLR2A NFIC BCL11A SIN3A TRIM22 MAFF IRF4 IL10 IL19 lnc-IL10-5 MAPKAPK2 IL24 IL20 C4BPB RASSF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL20

Top Transcription factor binding sites by QIAGEN in the IL20 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • E4BP4
  • Elk-1
  • Nkx2-5
  • STAT5A

Genomic Locations for IL20 Gene

Latest Assembly
chr1:206,863,565-206,869,223
(GRCh38/hg38)
Size:
5,659 bases
Orientation:
Plus strand

Previous Assembly
chr1:207,036,910-207,042,568
(GRCh37/hg19 by Entrez Gene)
Size:
5,659 bases
Orientation:
Plus strand

chr1:207,038,699-207,042,568
(GRCh37/hg19 by Ensembl)
Size:
3,870 bases
Orientation:
Plus strand

Genomic View for IL20 Gene

Genes around IL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL20 Gene

Proteins for IL20 Gene

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  • Protein details for IL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY1-IL20_HUMAN
    Recommended name:
    Interleukin-20
    Protein Accession:
    Q9NYY1
    Secondary Accessions:
    • Q17RB3
    • Q2THG6
    • Q96QZ6

    Protein attributes for IL20 Gene

    Size:
    176 amino acids
    Molecular mass:
    20072 Da
    Quaternary structure:
    • Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.
    Miscellaneous:
    • [Isoform 2]: Lung-specific.

    Three dimensional structures from OCA and Proteopedia for IL20 Gene

    Alternative splice isoforms for IL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20 Gene

Protein Expression for IL20 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL20 Gene

Domains & Families for IL20 Gene

Gene Families for IL20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL20 Gene

InterPro:
Blocks:
  • Interleukin-10

Suggested Antigen Peptide Sequences for IL20 Gene

GenScript: Design optimal peptide antigens:
  • Cytokine Zcyto10 (IL20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYY1

UniProtKB/Swiss-Prot:

IL20_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL20: view

Function for IL20 Gene

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  6. Cell Lines for research

Molecular function for IL20 Gene

UniProtKB/Swiss-Prot Function:
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-B irradiation in epithelial keratinocytes.

Phenotypes From GWAS Catalog for IL20 Gene

Gene Ontology (GO) - Molecular Function for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005125 cytokine activity IEA --
GO:0045517 interleukin-20 receptor binding TAS 11470428
GO:0045518 interleukin-22 receptor binding IEA --
genes like me logo Genes that share ontologies with IL20: view
genes like me logo Genes that share phenotypes with IL20: view

Animal Models for IL20 Gene

MGI Knock Outs for IL20:
  • Il20 Il20<tm1.1(KOMP)Vlcg>
  • Il20 Il20<tm1Lex>

Animal Models for research

miRNA for IL20 Gene

miRTarBase miRNAs that target IL20

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20 Gene

Localization for IL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11470428
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL20 Gene

Pathways & Interactions for IL20 Gene

PathCards logo

SuperPathways for IL20 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
3 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
4 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
5 JAK-STAT signaling pathway
JAK-STAT signaling pathway
.30
Interleukin-19, 20, 22, 24
.01
genes like me logo Genes that share pathways with IL20: view

Pathways by source for IL20 Gene

24 Qiagen pathways for IL20 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

SIGNOR curated interactions for IL20 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS 11470428
GO:0045606 positive regulation of epidermal cell differentiation TAS 11470428
GO:0045618 positive regulation of keratinocyte differentiation TAS 11470428
GO:0045672 positive regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with IL20: view

Drugs & Compounds for IL20 Gene

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  1. Drug products for research

(1) Drugs for IL20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL20: view

Transcripts for IL20 Gene

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mRNA/cDNA for IL20 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20

Alternative Splicing Database (ASD) splice patterns (SP) for IL20 Gene

No ASD Table

Relevant External Links for IL20 Gene

GeneLoc Exon Structure for
IL20

Expression for IL20 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL20 Gene

mRNA expression in normal human tissues for IL20 Gene
mRNA expression by GTEx for IL20 Gene

mRNA differential expression in normal tissues according to GTEx for IL20 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x12.3), Adipose - Visceral (Omentum) (x9.9), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for IL20 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL20 Gene



Protein tissue co-expression partners for IL20 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL20

SOURCE GeneReport for Unigene cluster for IL20 Gene:

Hs.272373

mRNA Expression by UniProt/SwissProt for IL20 Gene:

Q9NYY1-IL20_HUMAN
Tissue specificity: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
genes like me logo Genes that share expression patterns with IL20: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20 Gene

Orthologs for IL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL20 29 30
  • 99.62 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL20 29 30
  • 87.88 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia IL20 29 30
  • 83.9 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Il20 29 16 30
  • 82.38 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il20 29
  • 80.46 (n)
Oppossum
(Monodelphis domestica)
 Mammalia IL20 30
  • 68 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia IL20 30
  • 58 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves IL19 29
  • 54.67 (n)
Zebrafish
(Danio rerio)
 Actinopterygii il34 29
  • 52.63 (n)
il19l 30
  • 36 (a)
 OneToMany
Species where no ortholog for IL20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL20 Gene

ENSEMBL:
Gene Tree for IL20 (if available)
TreeFam:
Gene Tree for IL20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL20: view image
Alliance of Genome Resources:
Additional Orthologs for IL20

Paralogs for IL20 Gene

Paralogs for IL20 Gene

(2) SIMAP similar genes for IL20 Gene using alignment to 2 proteins:

  • IL20_HUMAN
  • Q2THG6_HUMAN
genes like me logo Genes that share paralogs with IL20: view

Variants for IL20 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL20 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs35856950 -- p.Arg107Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL20 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL20 Gene

Variant ID Type Subtype PubMed ID
esv2660993 CNV deletion 23128226
esv3588662 CNV loss 21293372
nsv549070 CNV loss 21841781

Variation tolerance for IL20 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20 Gene

Human Gene Mutation Database (HGMD)
IL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL20
Leiden Open Variation Database (LOVD)
IL20

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20 Gene

Disorders for IL20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20 Gene - From: GCD

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL20

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20 Gene

Publications for IL20 Gene

  1. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T … Kõks S (BMC medical genetics 2008) 3 22 40
  2. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K … Silm H (The British journal of dermatology 2007) 3 22 40
  3. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk TK … Smith MW (Genes and immunity 2005) 3 22 40
  4. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40

ExternalLinks

View latest publications for IL20 gene in Mastermind

Products for IL20 Gene

Sources for IL20 Gene