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The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005125 | cytokine activity | IEA | -- |
GO:0045517 | interleukin-20 receptor binding | TAS | 11470428 |
GO:0045518 | interleukin-22 receptor binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | 11470428 |
GO:0005615 | extracellular space | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
5 | JAK-STAT signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | TAS | 11470428 |
GO:0045606 | positive regulation of epidermal cell differentiation | TAS | 11470428 |
GO:0045618 | positive regulation of keratinocyte differentiation | TAS | 11470428 |
GO:0045672 | positive regulation of osteoclast differentiation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL20 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL20 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL20 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il20 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il20 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IL20 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL20 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL19 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il34 30 |
|
||
il19l 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35856950 | - | p.Arg107Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660993 | CNV | deletion | 23128226 |
esv3588662 | CNV | loss | 21293372 |
nsv549070 | CNV | loss | 21841781 |