Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL20 Gene

Aliases for IL20 Gene

  • Interleukin 20 2 3 5
  • Cytokine Zcyto10 3 4
  • ZCYTO10 3 4
  • IL-20 3 4
  • Four Alpha Helix Cytokine 3
  • Interleukin-20 3
  • IL10D 3

External Ids for IL20 Gene

Previous GeneCards Identifiers for IL20 Gene

  • GC01P205699
  • GC01P202749
  • GC01P203682
  • GC01P204122
  • GC01P203427
  • GC01P205105
  • GC01P207038
  • GC01P177737

Summaries for IL20 Gene

Entrez Gene Summary for IL20 Gene

  • The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL20 Gene

IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.

UniProtKB/Swiss-Prot for IL20 Gene

  • Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.

Additional gene information for IL20 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL20 Gene

Genomics for IL20 Gene

GeneHancer (GH) Regulatory Elements for IL20 Gene

Promoters and enhancers for IL20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206864 Promoter/Enhancer 1.4 EPDnew ENCODE 650.7 -0.2 -188 1.1 PKNOX1 RB1 ARNT NFIB SIN3A RAD21 RFX5 ARID2 ZNF143 RCOR1 IL20 IL19 IL24 FCMR PIGR FCAMR IL10 LOC105372878
GH01J206863 Promoter 0.5 EPDnew 650.7 -1.8 -1808 0.1 IL20 IL24 FCMR PIGR FCAMR IL10 IL19 LOC105372878
GH01J206917 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +57.7 57717 12 HDGF PKNOX1 SMAD1 ARNT NEUROD1 YBX1 ZNF2 ZBTB7B IRF4 ZNF766 FCMR EIF2D CDCA4P4 MAPKAPK2 ENSG00000271680 CD46 PIGR FCAMR RPL7AP20 IL20
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +161.3 161314 18.4 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A C1orf116 EIF2D C4BPA CDCA4P4 C4BPB FCAMR PIGR FCMR RPL7AP20 IL20
GH01J206768 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -94.4 -94430 4.6 HDGF HDAC1 PKNOX1 SMAD1 STAT5A ZBTB40 BATF KLF5 IRF4 ZNF143 IL10 ENSG00000284486 IL19 MAPKAPK2 IL24 IL20 C4BPB RASSF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL20 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • STAT5A
  • Nkx2-5
  • Elk-1
  • AML1a
  • E4BP4

Genomic Locations for IL20 Gene

Genomic Locations for IL20 Gene
chr1:206,865,354-206,869,223
(GRCh38/hg38)
Size:
3,870 bases
Orientation:
Plus strand
chr1:207,038,699-207,042,568
(GRCh37/hg19)
Size:
3,870 bases
Orientation:
Plus strand

Genomic View for IL20 Gene

Genes around IL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL20 Gene

Proteins for IL20 Gene

  • Protein details for IL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYY1-IL20_HUMAN
    Recommended name:
    Interleukin-20
    Protein Accession:
    Q9NYY1
    Secondary Accessions:
    • Q17RB3
    • Q2THG6
    • Q96QZ6

    Protein attributes for IL20 Gene

    Size:
    176 amino acids
    Molecular mass:
    20072 Da
    Quaternary structure:
    • Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

    Three dimensional structures from OCA and Proteopedia for IL20 Gene

    Alternative splice isoforms for IL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL20 Gene

Post-translational modifications for IL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL20 Gene

No data available for DME Specific Peptides for IL20 Gene

Domains & Families for IL20 Gene

Gene Families for IL20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL20 Gene

Suggested Antigen Peptide Sequences for IL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYY1

UniProtKB/Swiss-Prot:

IL20_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL20: view

Function for IL20 Gene

Molecular function for IL20 Gene

UniProtKB/Swiss-Prot Function:
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-B irradiation in epithelial keratinocytes.

Phenotypes From GWAS Catalog for IL20 Gene

Gene Ontology (GO) - Molecular Function for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0045517 interleukin-20 receptor binding TAS 11470428
GO:0045518 interleukin-22 receptor binding IEA --
genes like me logo Genes that share ontologies with IL20: view
genes like me logo Genes that share phenotypes with IL20: view

Animal Models for IL20 Gene

MGI Knock Outs for IL20:

Animal Model Products

CRISPR Products

miRNA for IL20 Gene

miRTarBase miRNAs that target IL20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL20 Gene

Localization for IL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL20 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL20 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11470428
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL20: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL20 Gene

Pathways & Interactions for IL20 Gene

genes like me logo Genes that share pathways with IL20: view

SIGNOR curated interactions for IL20 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IBA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS 11470428
GO:0045606 positive regulation of epidermal cell differentiation TAS 11470428
genes like me logo Genes that share ontologies with IL20: view

Drugs & Compounds for IL20 Gene

(1) Drugs for IL20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL20: view

Transcripts for IL20 Gene

mRNA/cDNA for IL20 Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL20 Gene

Interleukin 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL20

Alternative Splicing Database (ASD) splice patterns (SP) for IL20 Gene

No ASD Table

Relevant External Links for IL20 Gene

GeneLoc Exon Structure for
IL20
ECgene alternative splicing isoforms for
IL20

Expression for IL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL20 Gene

mRNA differential expression in normal tissues according to GTEx for IL20 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x12.3), Adipose - Visceral (Omentum) (x9.9), and Skin - Sun Exposed (Lower leg) (x5.4).

Protein differential expression in normal tissues from HIPED for IL20 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL20 Gene



Protein tissue co-expression partners for IL20 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL20 Gene:

IL20

SOURCE GeneReport for Unigene cluster for IL20 Gene:

Hs.272373

mRNA Expression by UniProt/SwissProt for IL20 Gene:

Q9NYY1-IL20_HUMAN
Tissue specificity: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only.
genes like me logo Genes that share expression patterns with IL20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL20 Gene

Orthologs for IL20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL20 34 33
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL20 34 33
  • 87.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL20 34 33
  • 83.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il20 16 34 33
  • 82.38 (n)
rat
(Rattus norvegicus)
Mammalia Il20 33
  • 80.46 (n)
oppossum
(Monodelphis domestica)
Mammalia IL20 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL20 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL19 33
  • 54.67 (n)
zebrafish
(Danio rerio)
Actinopterygii il34 33
  • 52.63 (n)
il19l 34
  • 36 (a)
OneToMany
Species where no ortholog for IL20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL20 Gene

ENSEMBL:
Gene Tree for IL20 (if available)
TreeFam:
Gene Tree for IL20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL20: view image

Paralogs for IL20 Gene

Paralogs for IL20 Gene

(2) SIMAP similar genes for IL20 Gene using alignment to 2 proteins:

  • IL20_HUMAN
  • Q2THG6_HUMAN
genes like me logo Genes that share paralogs with IL20: view

Variants for IL20 Gene

Sequence variations from dbSNP and Humsavar for IL20 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000506836 -- 206,866,166(+) A/G intron_variant
rs1000558800 -- 206,865,752(+) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001140710 -- 206,864,822(+) A/T upstream_transcript_variant
rs1001443226 -- 206,865,229(+) GGGG/GGG upstream_transcript_variant
rs1002003744 -- 206,866,788(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL20 Gene

Variant ID Type Subtype PubMed ID
esv2660993 CNV deletion 23128226
esv3588662 CNV loss 21293372
nsv549070 CNV loss 21841781

Variation tolerance for IL20 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL20 Gene

Human Gene Mutation Database (HGMD)
IL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL20 Gene

Disorders for IL20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL20 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL20 Gene

Publications for IL20 Gene

  1. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T … Kõks S (BMC medical genetics 2008) 3 22 44 58
  2. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K … Silm H (The British journal of dermatology 2007) 3 22 44 58
  3. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk TK … Smith MW (Genes and immunity 2005) 3 22 44 58
  4. Interleukin 20: discovery, receptor identification, and role in epidermal function. (PMID: 11163236) Blumberg H … Chandrasekher YA (Cell 2001) 2 3 4 58
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58

Products for IL20 Gene

Sources for IL20 Gene

Content
Loading form....