Aliases for IL20 Gene
External Ids for IL20 Gene
Previous GeneCards Identifiers for IL20 Gene
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL20 Gene
IL20 (Interleukin 20) is a Protein Coding gene. Diseases associated with IL20 include Psoriasis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-20 receptor binding. An important paralog of this gene is IL19.
UniProtKB/Swiss-Prot Summary for IL20 Gene
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3.