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The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for ... See more...
Aliases for IL2 Gene
Aliases for IL2 Gene
External Ids for IL2 Gene
- HGNC: 6001
- Entrez Gene: 3558
- Ensembl: ENSG00000109471
- OMIM: 147680
- UniProtKB: P60568
Previous GeneCards Identifiers for IL2 Gene
- GC04M124285
- GC04M123652
- GC04M123765
- GC04M123831
- GC04M123730
- GC04M123592
- GC04M123372
- GC04M119099
Summaries for IL2 Gene
-
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL2 Gene
IL2 (Interleukin 2) is a Protein Coding gene. Diseases associated with IL2 include Capillary Leak Syndrome and Tropical Spastic Paraparesis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and growth factor activity.
UniProtKB/Swiss-Prot Summary for IL2 Gene
-
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL2 Gene
- HGNC(6001)
- Entrez Gene(3558)
- Ensembl(ENSG00000109471)
- OMIM(147680)
- UniProtKB(P60568)
- Open Targets Platform(ENSG00000109471)
- Monarch Initiative
- Search for IL2 at DataMed
- Search for IL2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL2 Gene
Genomics for IL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J122458 | Promoter/Enhancer | 0.8 | Ensembl ENCODE | 600.7 | -2.0 | -1976 | 1 | HMBOX1 MNT IRF2 MAX ZNF148 | IL2 piR-57195-166 IL21 | |
| GH04J122456 | Promoter | 0.3 | EPDnew | 600.7 | +0.2 | 213 | 0.1 | IL2 lnc-IL21-2 ADAD1 | ||
| GH04J122150 | Promoter/Enhancer | 2 | FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 6.3 | +304.7 | 304660 | 3.9 | SP1 CREB1 TEAD4 PRDM10 ZNF629 NFKBIZ POLR2A BACH1 FOXA1 ZIC2 | KIAA1109 lnc-TRPC3-4 lnc-KIAA1109-1 IL2 IL21 piR-34822-252 TRPC3 | |
| GH04J122503 | Enhancer | 0.5 | Ensembl | 11 | -46.6 | -46576 | 0.6 | SOX6 ZNF589 ETV1 ATF1 MEIS2 TEAD4 | IL2 piR-32461-132 IL21-AS1 IL21 | |
| GH04J122531 | Enhancer | 0.3 | Ensembl | 11.1 | -75.0 | -74976 | 1 | NFE2 | IL2 IL21-AS1 piR-32461-132 IL21 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL2
- Top Transcription factor binding sites by QIAGEN in the IL2 gene promoter:
-
- AML1a
Genomic Locations for IL2 Gene
Genomic Locations for IL2 Gene
- chr4:122,451,470-122,456,725
- (GRCh38/hg38)
- Size:
- 5,256 bases
- Orientation:
- Minus strand
- chr4:123,372,625-123,377,880
- (GRCh37/hg19)
- Size:
- 5,256 bases
- Orientation:
- Minus strand
Genomic View for IL2 Gene
Genes around IL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q27 by HGNC
- 4q27 by Entrez Gene
- 4q27 by Ensembl
IL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL2 Gene
Proteins for IL2 Gene
-
Protein details for IL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60568-IL2_HUMAN
- Recommended name:
- Interleukin-2
- Protein Accession:
- P60568
- P01585
Protein attributes for IL2 Gene
- Size:
- 153 amino acids
- Molecular mass:
- 17628 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA59140.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Post-translational modifications for IL2 Gene
Other Protein References for IL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IL2 Antibody and Immunotag™ Interleukin 2 Antibody
- NSJ Bioreagents IL-2 Antibody
-
BioLegend
- IL-2 Antibody (500302)
- IL-2 Antibody (500306)
- IL-2 Antibody (500307)
- IL-2 Antibody (500309)
- IL-2 Antibody (500310)
- IL-2 Antibody (500304)
- IL-2 Antibody (500305)
- IL-2 Antibody (500301)
- IL-2 Antibody (500311)
- IL-2 Antibody (500315)
- IL-2 Antibody (500314)
- IL-2 Antibody (500319)
- IL-2 Antibody (500320)
- PerCP/Cyanine5.5 IL-2 Antibody (500321)
- PerCP/Cyanine5.5 IL-2 Antibody (500322)
- IL-2 Antibody (500324)
- IL-2 Antibody (500325)
- IL-2 Antibody (500326)
- IL-2 Antibody (500327)
- IL-2 Antibody (500328)
- IL-2 Antibody (500331)
- IL-2 Antibody (500333)
- IL-2 Antibody (500337)
- IL-2 Antibody (500338)
- IL-2 (MaxPar(R) Ready) Antibody
- APC/Cyanine7 IL-2 Antibody (500341)
- APC/Cyanine7 IL-2 Antibody (500342)
- IL-2 Antibody (500343)
- IL-2 Antibody (517605)
- IL-2 Antibody (500334)
- IL-2 Antibody (500344)
- IL-2 Antibody (500332)
- IL-2 Antibody (500348)
- IL-2 Antibody (500347)
- IL-2 Antibody (500346)
- IL-2 Antibody (500345)
- IL-2 Antibody (500350)
- IL-2 Antibody (500349)
- GeneTex Anti-IL2 antibody [14-0] and Anti-IL2 antibody
-
Custom Antibody ServicesOriGene Antibodies for IL2
- AM00961AF-N
- AM05018PU-N
- AM06310SU-N
- AM09170PU-N
- AM09171PU-N
- AM09172PU-N
- AM09173PU-N
- AM09174PU-N
- AM09175PU-N
- AM20812PU-L
- AM20812PU-N
- AM20812PU-S
- AM31260AF-N
- AM31260FC-N
- AM31260RP-N
- AM39037PU-N
- AM39037RP-N
- AP01137BT-N
- AP01137BT-S
- AP01137PU-N
- AP01137PU-S
- AP02017SU-N
- AP02017SU-S
- AP05798AF-N
- AP17501PU-N
- AP20657PU-N
- CF810724
- PM1000A
- PP009B1
- PP009B2
- PP009P1
- PP009P2
- PP1024B1
- PP1024B2
- PP1024P1
- PP1024P2
- SM100F
- SM100P
- SM100R
- SM1540A
- SM1698P
- SM2088F
- SM2088P
- SM2088R
- TA319036
- TA319037
- TA319283
- TA319284
- TA326824
- TA328204
- TA328205
- TA328206
- TA328207
- TA328480
- TA328481
- TA328566
- TA328567
- TA347867
- TA352735
- TA352751
- TA352775
- TA352776
- TA352777
- TA810724
- TA810724S
- TA810802
- TA810802S
- Novus Biologicals Antibodies for IL2
-
Abcam antibodies for IL2
- Invitrogen Antibodies for IL2 (AFLGC-IL2)
- antibodies-online: Show 577 available IL2 Antibodies ranked by validation data
- Compare Top IL2 Antibodies
-
Recommended
- 207 WB Antibodies (anti-human)
- 76 FACS Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 7 EIA Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 84 WB Antibodies (anti-mouse)
- 76 FACS Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 Inhibition Antibody (anti-mouse)
- 1 BR Antibody (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 St Antibody (anti-mouse)
- 73 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL2
- Sino Biological Antibodies for IL2
Protein Products
-
G Biosciences
- Search Origene for MassSpec and Protein Over-expression Lysates for IL2
- Origene Custom Protein Services for IL2
- Sino Biological Recombinant Proteins for IL2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IL2
-
ProSci Proteins for IL2
- interleukin 2 [40-599]
- interleukin 2 [92-521]
- interleukin 2 [90-293]
- interleukin 2 [40-243]
- interleukin 2 [90-464]
- interleukin 2 [90-465]
- interleukin 2 [90-466]
- interleukin 2 [90-467]
- interleukin 2 [90-468]
- interleukin 2 [90-469]
- interleukin 2 [90-470]
- interleukin 2 [90-471]
- interleukin 2 [91-937]
- interleukin 2 [40-431]
- interleukin 2 [40-462]
- interleukin 2 [91-011]
-
Abcam proteins for IL2
Assay Products
- RayBiotech Human IL-2 ELISA and Human IL-2 ELISA (For Lysates)
-
Custom Assay ServicesOriGene ELISA Kits for IL2
- EA100017
- EA100018
- EA100119
- EA100120
- EA100159
- EA100160
- EA100268
- EA100269
- EA100270
- EA101241
- EA101242
- EA101243
- EA101277
- EA101278
- EA101279
- EA101280
- EA101281
- EA101412
- EA101413
- EA101414
- EA101415
- EA101416
- EA101417
- EA101418
- EA101419
- EA101420
- EA101421
- EA101422
- EA101423
- EA101424
- EA101425
- EA101426
- EA101427
- EA101428
- EA101684
- EA101685
- EA101686
- EA101708
- EA101709
- EA101710
- EA101711
- EA101712
- EA101733
- EA101734
- EA101735
- EA101736
- EA101737
- EA101738
- EA101739
- EA101740
- EA101741
- EA101742
- EA101743
- EA101744
- EA101745
- EA101746
- EA101747
- EA101748
- EA101749
- EA101810
- EA102139
- EA102140
- EA102141
- EA102894
- Novus Biologicals ELISA Kits for IL2
- antibodies-online: Show 316 available IL2 Elisa Kits ranked by validation data
- Compare Top IL2 Elisa Kits
-
Quality Products:
- ABIN6730879
- ABIN6574106
- ABIN6720516
- ABIN411295
- ABIN1115643
- ABIN625022
- ABIN414882
- ABIN365161
- ABIN2690564
- ABIN2472116
- ABIN411296
- ABIN625143
- ABIN1115642
- ABIN415510
- ABIN365173
- ABIN2691021
- ABIN2472098
- ABIN491776
- ABIN3032815
- ABIN924816
- ABIN921062
- ABIN1115644
- ABIN416247
- ABIN625202
- ABIN365194
- ABIN2684654
- ABIN2472109
- ABIN5676188
- ABIN491777
- ABIN924837
- ABIN413926
- ABIN364624
- ABIN5563458
- ABIN1979412
- ABIN1028983
- ABIN455564
- ABIN5520867
- ABIN5592207
- ABIN6384610
- ABIN993231
-
Abcam assays for IL2
- Sino Biological Assays for IL2
No data available for DME Specific Peptides for IL2 Gene
Domains & Families for IL2 Gene
Gene Families for IL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for IL2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL2 Gene
- GenScript: Design optimal peptide antigens:
-
- T-cell growth factor (IL2_HUMAN)
- IL-2 protein (O95974_HUMAN)
- Interleukin-2 (Q0GK43_HUMAN)
- Interleukin 2 (Q13169_HUMAN)
- IL-2 protein (Q16334_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P60568- Family:
-
- Belongs to the IL-2 family.
Function for IL2 Gene
Molecular function for IL2 Gene
- UniProtKB/Swiss-Prot Function:
- Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
- GENATLAS Biochemistry:
- interleukin 2,30-35kDa,involved in activation and proliferation of T cell
Phenotypes From GWAS Catalog for IL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 1830926 |
| GO:0005134 | interleukin-2 receptor binding | IDA,TAS | 3925347 |
| GO:0005515 | protein binding | IPI | 16477002 |
| GO:0008083 | growth factor activity | TAS | 8476561 |
| GO:0019209 | kinase activator activity | TAS | 8476561 |
Phenotypes for IL2 Gene
- MGI mutant phenotypes for IL2:
-
inferred from 5 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for IL2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased viability with MLN4924 (a NAE inhibitor)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Model Products
-
Taconic Biosciences Mouse Models for IL2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL2 - Select products 50% OFF >
- * IL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2
miRNA for IL2 Gene
- miRTarBase miRNAs that target IL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2
- Browse OriGene Inhibitory RNA Products For IL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2
Clone Products
- Applied Biological Materials (abm): Clones for IL2 - Select products 50% OFF >
- * IL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL2
- Addgene plasmids for IL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2
Cell Line Products
-
Horizon Cell Lines for IL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL2 Gene
Localization for IL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| cytosol | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS | 6608729 |
| GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL2 Gene
Pathways & Interactions for IL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 3 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 4 | Allograft rejection |
THC Differentiation Pathway
.39
|
|
| 5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
Pathways by source for IL2 Gene
1 Sino Biological pathway for IL2 Gene
25 BioSystems pathways for IL2 Gene
52 Reactome pathways for IL2 Gene
1 PharmGKB pathway for IL2 Gene
6 GeneGo (Thomson Reuters) pathways for IL2 Gene
- Apoptosis and survival Lymphotoxin-beta receptor signaling
- Immune response CD16 signaling in NK cells
- Immune response Function of MEF2 in T lymphocytes
- Immune response IL-2 activation and signaling pathway
- Immune response IL-22 signaling pathway
9 R&D Systems pathways for IL2 Gene
3 Tocris pathways for IL2 Gene
72 Qiagen pathways for IL2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 Cell Signaling Technology pathway for IL2 Gene
Interacting Proteins for IL2 Gene
Selected Interacting proteins:
P60568-IL2_HUMAN
ENSP00000226730
for IL2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002366 | leukocyte activation involved in immune response | IDA | 16204630 |
Drugs & Compounds for IL2 Gene
(115) Drugs for IL2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dacarbazine | Approved, Investigational | Pharma | 193 | |||
| rituximab | Approved | Pharma | Therapeutic Antibodies | 2024 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 429 | ||
| Cefazolin | Approved | Pharma | Target, inhibitor | 163 | ||
| keyhole limpet hemocyanin | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AS 101 |
|
106566-58-9 |
|
|||
| GIT 27 |
|
6501-72-0 |
|
|
(4) Tocris Compounds for IL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
(1) ApexBio Compounds for IL2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Triptolide | IL-2/MMP-3/MMP7/MMP19 inhibitor | 38748-32-2 |
Transcripts for IL2 Gene
mRNA/cDNA for IL2 Gene
- 1 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000226730 1029 nts (view in UCSC)
- ENST00000477645 586 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL2 - Select products 50% OFF >
- * IL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL2
- Browse OriGene Inhibitory RNA Products For IL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL2
Clone Products
- Applied Biological Materials (abm): Clones for IL2 - Select products 50% OFF >
- * IL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL2
- Addgene plasmids for IL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: |
Relevant External Links for IL2 Gene
- GeneLoc Exon Structure for
- IL2
Expression for IL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IL2 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x9.9) and Bladder (x4.9).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL2
SOURCE GeneReport for Unigene cluster for IL2 Gene:
Hs.89679Evidence on tissue expression from TISSUES for IL2 Gene
- Blood(4.8)
- Spleen(3.9)
- Lymph node(3.8)
- Skin(3.5)
- Bone marrow(3.4)
- Intestine(3.3)
- Kidney(3.3)
- Liver(3.3)
- Nervous system(3.2)
- Lung(3.1)
- Heart(3)
- Muscle(3)
- Pancreas(2.8)
- Thyroid gland(2.7)
- Stomach(2.7)
- Adrenal gland(2.6)
- Bone(2.6)
- Urine(2.4)
- Eye(2.3)
- Saliva(2.2)
Primer Products
-
OriGene qPCR primer pairs for IL2
-
OriGene qPCR primer pairs and template standards for IL2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL2 Gene
Orthologs for IL2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Il2 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL2 31 |
|
OneToOne |
- Species where no ortholog for IL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL2 Gene
- ENSEMBL:
- Gene Tree for IL2 (if available)
- TreeFam:
- Gene Tree for IL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL2: view image
Paralogs for IL2 Gene
(1) SIMAP similar genes for IL2 Gene using alignment to 5 proteins:
- IL2_HUMAN
- Q0GK43_HUMAN
- Q13169_HUMAN
- Q6NZ91_HUMAN
- Q6NZ93_HUMAN
No data available for Paralogs for IL2 Gene
Variants for IL2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3894021 | CNV | loss | 25118596 |
Residual Variation Intolerance Score:
44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.22;
4.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL2 Gene
Disorders for IL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| capillary leak syndrome |
|
|
| tropical spastic paraparesis |
|
|
| smallpox |
|
|
| graft-versus-host disease |
|
|
| lepromatous leprosy |
|
Search IL2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL2_HUMAN- Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. {ECO:0000269 PubMed:1396583}.
Genatlas disease for IL2 Gene
immunodeficiency,severe,combined
Additional Disease Information for IL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for IL2 Gene
- The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. (PMID: 20060205) Czerny B … Pawlik A (European journal of obstetrics, gynecology, and reproductive biology 2010) 3 23 41
- Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (PMID: 19951419) Carr EJ … Smith KG (BMC medical genetics 2009) 3 23 41
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 23 41
- IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma. (PMID: 18972297) Movahedi M … Amirzargar AA (The Journal of asthma : official journal of the Association for the Care of Asthma 2008) 3 23 41
- Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population. (PMID: 18574615) Watanabe Y … Someya T (European archives of psychiatry and clinical neuroscience 2008) 3 23 41
ExternalLinks
Products for IL2 Gene
- View all 98 R&D Systems IL2 (IL-2) Products
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- AP02017SU-N
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- AP05798AF-N
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- PP009B1
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- SM100F
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- Sino Biological Human cDNA Clone for IL2
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- Browse Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for IL2
- Novus Biologicals proteins and lysates for IL2
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IL2
- Abcam proteins for IL2
- Abcam assays for IL2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IL2
- Taconic Biosciences Mouse Models for IL2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IL2 (AFLGC-IL2)
- ApexBio compounds for IL2
- VectorBuilder Custom and pre-made DNA vectors for IL2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IL2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IL2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
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- Addgene plasmids for IL2
- antibodies-online: Show 577 available IL2 Antibodies ranked by validation data
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- Recommended
- 207 WB Antibodies (anti-human)
- 76 FACS Antibodies (anti-human)
- 21 IF (p) Antibodies (anti-human)
- 7 EIA Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 84 WB Antibodies (anti-mouse)
- 76 FACS Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 7 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 Inhibition Antibody (anti-mouse)
- 1 BR Antibody (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 St Antibody (anti-mouse)
- 73 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 316 available IL2 Elisa Kits ranked by validation data
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- ABIN5520867
- ABIN5592207
- ABIN6384610
- ABIN993231
- antibodies-online: Show 213 available IL2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL2
- Search Santa Cruz Biotechnology (SCBT) for IL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL2
- Search for IL2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for IL2
- interleukin 2 [40-599]
- interleukin 2 [92-521]
- interleukin 2 [90-293]
- interleukin 2 [40-243]
- interleukin 2 [90-464]
- interleukin 2 [90-465]
- interleukin 2 [90-466]
- interleukin 2 [90-467]
- interleukin 2 [90-468]
- interleukin 2 [90-469]
- interleukin 2 [90-470]
- interleukin 2 [90-471]
- interleukin 2 [91-937]
- interleukin 2 [40-431]
- interleukin 2 [40-462]
- interleukin 2 [91-011]
- Horizon Cell Lines for IL2
- Browse GeneCopoeia Cell Lines
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Sources for IL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4)