Aliases for IL1RL2 Gene
External Ids for IL1RL2 Gene
Previous GeneCards Identifiers for IL1RL2 Gene
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL2 Gene
IL1RL2 (Interleukin 1 Receptor Like 2) is a Protein Coding gene. Diseases associated with IL1RL2 include Familial Cold Autoinflammatory Syndrome 2 and Pustulosis Of Palm And Sole. Among its related pathways are Innate Immune System and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, type I, activating receptor activity. An important paralog of this gene is IL1R1.
UniProtKB/Swiss-Prot Summary for IL1RL2 Gene
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.