The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 rec... See more...

Aliases for IL1RL2 Gene

Aliases for IL1RL2 Gene

  • Interleukin 1 Receptor Like 2 2 3 5
  • Interleukin-1 Receptor-Related Protein 2 3 4
  • Interleukin-1 Receptor-Like 2 3 4
  • IL-36 Receptor 3 4
  • IL-1Rrp2 3 4
  • IL1R-Rp2 3 4
  • IL1RRP2 3 4
  • IL-36R 3 4
  • IL-1 Receptor-Related Protein 2 3

External Ids for IL1RL2 Gene

Previous GeneCards Identifiers for IL1RL2 Gene

  • GC02P100667
  • GC02P101256
  • GC02P102408
  • GC02P102424
  • GC02P102261
  • GC02P102803
  • GC02P096567

Summaries for IL1RL2 Gene

Entrez Gene Summary for IL1RL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL2 Gene

IL1RL2 (Interleukin 1 Receptor Like 2) is a Protein Coding gene. Diseases associated with IL1RL2 include Geographic Tongue and Impetigo Herpetiformis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, type I, activating receptor activity. An important paralog of this gene is IL1R1.

UniProtKB/Swiss-Prot Summary for IL1RL2 Gene

  • Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Wiki entry for IL1RL2 Gene

Additional gene information for IL1RL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1RL2 Gene

Genomics for IL1RL2 Gene

GeneHancer (GH) Regulatory Elements for IL1RL2 Gene

Promoters and enhancers for IL1RL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102186 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 510 +1.4 1444 1.6 CTCF JUND RAD21 MAX REST EZH2 MYC EGR1 IL1RL2 ENSG00000234389 HSALNG0017407
GH02J102238 Enhancer 1.5 FANTOM5 Ensembl ENCODE 20.3 +53.8 53844 5.2 ZBTB40 ZNF217 CTCF TCF12 EP300 REST KDM6A RELA ZBTB25 TGIF2 HSALNG0017407 IL1RL2 IL1R2 IL1R1-AS1 ENSG00000234389 IL18R1 IL1R1 IL18RAP HSALNG0017409 lnc-MFSD9-11
GH02J102226 Enhancer 1.4 FANTOM5 ENCODE 17.1 +41.9 41880 3.7 FOXK2 ZNF217 TCF12 POLR2G JUND FOS ZNF10 ZIC2 REST POLR2A IL1RL2 IL1R1-AS1 IL1R2 IL1R1 IL18RAP HSALNG0017407
GH02J102033 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -152.2 -152150 2.6 SIN3A TCF12 POLR2G NCOR1 CTCF CUX1 ZBTB25 TGIF2 ZBTB7A SKI IL1R2 IL1R1 IL1RL2 IL1R1-AS1 IL18RAP TBC1D8 MAP4K4 IL18R1 ENSG00000287771 HSALNG0017394
GH02J102158 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 16.8 -26.8 -26835 1.8 ZNF623 CTCF TEAD3 ZNF316 IL1RL2 IL1R1-AS1 IL18RAP IL1R1 MAP4K4 RF00017-3286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL1RL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1RL2

Top Transcription factor binding sites by QIAGEN in the IL1RL2 gene promoter:
  • CREB
  • deltaCREB
  • GATA-1
  • Gfi-1
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • TBP

Genomic Locations for IL1RL2 Gene

Genomic Locations for IL1RL2 Gene
chr2:102,186,157-102,240,002
(GRCh38/hg38)
Size:
53,846 bases
Orientation:
Plus strand
chr2:102,803,433-102,856,462
(GRCh37/hg19)
Size:
53,030 bases
Orientation:
Plus strand

Genomic View for IL1RL2 Gene

Genes around IL1RL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1RL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL2 Gene

Proteins for IL1RL2 Gene

  • Protein details for IL1RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB29-ILRL2_HUMAN
    Recommended name:
    Interleukin-1 receptor-like 2
    Protein Accession:
    Q9HB29
    Secondary Accessions:
    • A4FU63
    • Q13525
    • Q45H74
    • Q53TU8
    • Q587I8

    Protein attributes for IL1RL2 Gene

    Size:
    575 amino acids
    Molecular mass:
    65405 Da
    Quaternary structure:
    • Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).
    SequenceCaution:
    • Sequence=AAB53237.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for IL1RL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RL2 Gene

Post-translational modifications for IL1RL2 Gene

  • Glycosylation at Asn41, Asn59, Asn184, Asn109, Asn234, Asn127, Asn250, Asn266, and Asn299
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL1RL2 Gene

Domains & Families for IL1RL2 Gene

Gene Families for IL1RL2 Gene

Protein Domains for IL1RL2 Gene

Blocks:
  • Immunoglobulin subtype
  • Interleukin-1 receptor type I family signature
  • TIR domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL1RL2 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-1 receptor-related protein 2 (ILRL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HB29

UniProtKB/Swiss-Prot:

ILRL2_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL2: view

Function for IL1RL2 Gene

Molecular function for IL1RL2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
GENATLAS Biochemistry:
interleukin 1 receptor related protein 2,not binding IL1

Phenotypes From GWAS Catalog for IL1RL2 Gene

Gene Ontology (GO) - Molecular Function for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 1833184
GO:0004909 interleukin-1, type I, activating receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with IL1RL2: view
genes like me logo Genes that share phenotypes with IL1RL2: view

Animal Models for IL1RL2 Gene

MGI Knock Outs for IL1RL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1RL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL2 Gene

Localization for IL1RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1RL2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1833184
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL1RL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1RL2 Gene

Pathways & Interactions for IL1RL2 Gene

genes like me logo Genes that share pathways with IL1RL2: view

Pathways by source for IL1RL2 Gene

1 R&D Systems pathway for IL1RL2 Gene

Gene Ontology (GO) - Biological Process for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006968 cellular defense response TAS 8332913
GO:0007165 signal transduction TAS 1833184
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with IL1RL2: view

No data available for SIGNOR curated interactions for IL1RL2 Gene

Drugs & Compounds for IL1RL2 Gene

No Compound Related Data Available

Transcripts for IL1RL2 Gene

mRNA/cDNA for IL1RL2 Gene

6 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2: - -

Relevant External Links for IL1RL2 Gene

GeneLoc Exon Structure for
IL1RL2

Expression for IL1RL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL1RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.7), Skin - Not Sun Exposed (Suprapubic) (x6.5), and Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1RL2 Gene



Protein tissue co-expression partners for IL1RL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1RL2

SOURCE GeneReport for Unigene cluster for IL1RL2 Gene:

Hs.659863

mRNA Expression by UniProt/SwissProt for IL1RL2 Gene:

Q9HB29-ILRL2_HUMAN
Tissue specificity: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

Evidence on tissue expression from TISSUES for IL1RL2 Gene

  • Skin(2.4)
genes like me logo Genes that share expression patterns with IL1RL2: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RL2 Gene

Orthologs for IL1RL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RL2 31 30
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL1RL2 30
  • 81.16 (n)
-- 31
  • 77 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia IL1RL2 31 30
  • 77.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il1rl2 17 31 30
  • 74.82 (n)
rat
(Rattus norvegicus)
Mammalia Il1rl2 30
  • 74.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RL2 31
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1RL2 31
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1R1 31
  • 40 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC799279 30
  • 47.36 (n)
CABZ01054962.1 31
  • 24 (a)
ManyToMany
CABZ01054965.1 31
  • 22 (a)
ManyToMany
Species where no ortholog for IL1RL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RL2 Gene

ENSEMBL:
Gene Tree for IL1RL2 (if available)
TreeFam:
Gene Tree for IL1RL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL1RL2: view image

Paralogs for IL1RL2 Gene

(1) SIMAP similar genes for IL1RL2 Gene using alignment to 3 proteins:

  • ILRL2_HUMAN
  • A4FU63_HUMAN
  • C9K0I8_HUMAN
genes like me logo Genes that share paralogs with IL1RL2: view

Variants for IL1RL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1RL2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
708748 Likely Benign: not provided 102,235,264(+) C/T SYNONYMOUS_VARIANT
736632 Likely Benign: not provided 102,235,210(+) G/T SYNONYMOUS_VARIANT
786485 Benign: not provided 102,225,960(+) G/A MISSENSE_VARIANT
787240 Benign: not provided 102,212,160(+) T/C MISSENSE_VARIANT,INTRON_VARIANT
rs13405631 - p.Ile237Thr

Additional dbSNP identifiers (rs#s) for IL1RL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL1RL2 Gene

Variant ID Type Subtype PubMed ID
esv2564673 CNV deletion 19546169
esv2720460 CNV deletion 23290073
esv2720462 CNV deletion 23290073
esv3559865 CNV deletion 23714750
esv3583991 CNV loss 25503493
nsv1138823 CNV deletion 24896259
nsv582555 CNV gain 21841781
nsv582556 CNV loss 21841781

Variation tolerance for IL1RL2 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL1RL2 Gene

Human Gene Mutation Database (HGMD)
IL1RL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1RL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL2 Gene

Disorders for IL1RL2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL1RL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
geographic tongue
  • benign migratory glossitis
impetigo herpetiformis
pustulosis of palm and sole
  • generalized pustular psoriasis
atrophic glossitis
  • atrophy of tongue papillae
pityriasis rubra pilaris
  • prp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL1RL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL1RL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RL2 Gene

Publications for IL1RL2 Gene

  1. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R … Kastelein RA (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23 54
  2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). (PMID: 8898719) Lovenberg TW … Maki RA (Journal of neuroimmunology 1996) 2 3 4 23 54
  3. Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. (PMID: 19684156) Solovieva S … Leino-Arjas P (The Journal of rheumatology 2009) 3 23 41 54
  4. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M … Nicklin MJ (Genomics 1999) 2 3 23 54
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54

Products for IL1RL2 Gene

Sources for IL1RL2 Gene