Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 rec... See more...
Aliases for IL1RL2 Gene
Aliases for IL1RL2 Gene
External Ids for IL1RL2 Gene
- HGNC: 5999
- NCBI Entrez Gene: 8808
- Ensembl: ENSG00000115598
- OMIM®: 604512
- UniProtKB/Swiss-Prot: Q9HB29
Previous GeneCards Identifiers for IL1RL2 Gene
- GC02P100667
- GC02P101256
- GC02P102408
- GC02P102424
- GC02P102261
- GC02P102803
- GC02P096567
Summaries for IL1RL2 Gene
-
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL2 Gene
IL1RL2 (Interleukin 1 Receptor Like 2) is a Protein Coding gene. Diseases associated with IL1RL2 include Familial Cold Autoinflammatory Syndrome 2 and Pustulosis Of Palm And Sole. Among its related pathways are Innate Immune System and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, type I, activating receptor activity. An important paralog of this gene is IL1R1.
UniProtKB/Swiss-Prot Summary for IL1RL2 Gene
-
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Additional gene information for IL1RL2 Gene
- HGNC (5999)
- NCBI Entrez Gene (8808)
- Ensembl (ENSG00000115598)
- OMIM® (604512)
- UniProtKB/Swiss-Prot (Q9HB29)
- Open Targets Platform(ENSG00000115598)
- Search for IL1RL2 at DataMed
- Search for IL1RL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1RL2 Gene
Genomics for IL1RL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL1RL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1RL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1RL2
- Top Transcription factor binding sites by QIAGEN in the IL1RL2 gene promoter:
-
- CREB
- deltaCREB
- GATA-1
- Gfi-1
- POU2F1
- POU2F1a
- PPAR-gamma1
- PPAR-gamma2
- RORalpha1
- TBP
Genomic Locations for IL1RL2 Gene
Latest Assembly
- chr2:102,186,973-102,242,910
- (GRCh38/hg38)
- Size:
- 55,938 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:102,803,433-102,856,462
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 53,030 bases
- Orientation:
- Plus strand
- chr2:102,803,433-102,856,462
- (GRCh37/hg19 by Ensembl)
- Size:
- 53,030 bases
- Orientation:
- Plus strand
Genomic View for IL1RL2 Gene
Genes around IL1RL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q12.1 by HGNC
- 2q12.1 by Entrez Gene
- 2q12.1 by Ensembl
IL1RL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1RL2 Gene
Proteins for IL1RL2 Gene
-
Protein details for IL1RL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HB29-ILRL2_HUMAN
- Recommended name:
- Interleukin-1 receptor-like 2
- Protein Accession:
- Q9HB29
- A4FU63
- Q13525
- Q45H74
- Q53TU8
- Q587I8
Protein attributes for IL1RL2 Gene
- Size:
- 575 amino acids
- Molecular mass:
- 65405 Da
- Quaternary structure:
-
- Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).
- SequenceCaution:
-
- Sequence=AAB53237.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for IL1RL2 Gene
Post-translational modifications for IL1RL2 Gene
Other Protein References for IL1RL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IL1RL2 Antibody (LS-B9085) and IL1RL2 Antibody (LS-B10135)
- G Biosciences Immunotag™ ILRL2 Antibody
- Novus Biologicals Antibodies for IL1RL2
-
Abcam antibodies for IL1RL2
- Invitrogen Antibodies for IL1RL2 (AFLGC-IL1RL2)
-
Custom Antibody ServicesProSci Antibodies for IL1RL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1RL2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IL1RL2
- Origene Custom Protein Services for IL1RL2
- Novus Biologicals proteins for IL1RL2
- Sino Biological Recombinant Proteins for IL1RL2
- Sino Biological Cell Lysates for IL1RL2
- antibodies-online: Show 14 available IL1RL2 Proteins ranked by validation data
- Compare Top IL1RL2 Proteins
-
Quality Products:
-
ProSci Proteins for IL1RL2
-
Abcam proteins for IL1RL2
Assay products for research
- RayBiotech Human IL-1 R6 ELISA
- antibodies-online: Show 11 available IL1RL2 Elisa Kits ranked by validation data
- Compare Top IL1RL2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for IL1RL2 Gene
Domains & Families for IL1RL2 Gene
Gene Families for IL1RL2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IL1RL2 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
- TIR domain
- Interleukin-1 receptor type I family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for IL1RL2 Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin-1 receptor-related protein 2 (ILRL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HB29UniProtKB/Swiss-Prot:
ILRL2_HUMAN :- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Belongs to the interleukin-1 receptor family.
- Domain:
-
- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Family:
-
- Belongs to the interleukin-1 receptor family.
Function for IL1RL2 Gene
Molecular function for IL1RL2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};.
- GENATLAS Biochemistry:
- interleukin 1 receptor related protein 2,not binding IL1
Enzyme Numbers (IUBMB) for IL1RL2 Gene
Phenotypes From GWAS Catalog for IL1RL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004908 | interleukin-1 receptor activity | TAS | 1833184 |
| GO:0004909 | interleukin-1, type I, activating receptor activity | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0050135 | NAD(P)+ nucleosidase activity | IEA | -- |
Phenotypes for IL1RL2 Gene
- MGI mutant phenotypes for IL1RL2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL1RL2:
Animal Models for IL1RL2 Gene
- MGI Knock Outs for IL1RL2:
-
- Il1rl2 Il1rl2<tm1Hblu>
Animal Models for research
-
Taconic Biosciences Mouse Models for IL1RL2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RL2 - Starting at $85 >
- * IL1RL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL2
miRNA for IL1RL2 Gene
- miRTarBase miRNAs that target IL1RL2
-
- hsa-miR-146a-5p (MIRT437620)
- hsa-miR-146b-5p (MIRT437626)
- hsa-miR-1229-3p (MIRT570131)
- hsa-miR-591 (MIRT570132)
- hsa-miR-6862-3p (MIRT570133)
- hsa-miR-6784-3p (MIRT570134)
- hsa-miR-6511b-3p (MIRT570135)
- hsa-miR-6511a-3p (MIRT570136)
- hsa-miR-361-3p (MIRT570137)
- hsa-miR-4301 (MIRT570138)
- hsa-miR-4267 (MIRT570139)
- hsa-miR-500b-3p (MIRT570140)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RL2
- Browse OriGene Inhibitory RNA Products For IL1RL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RL2
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RL2 - Starting at $45 >
- * IL1RL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IL1RL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RL2
Cell Lines for research
-
Horizon Cell Lines for IL1RL2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL2 Gene
Localization for IL1RL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1RL2 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1833184 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1RL2 Gene
Pathways & Interactions for IL1RL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | PEDF Induced Signaling | ||
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | Innate Immune System |
.61
|
|
Pathways by source for IL1RL2 Gene
3 Reactome pathways for IL1RL2 Gene
1 KEGG pathway for IL1RL2 Gene
1 R&D Systems pathway for IL1RL2 Gene
Interacting Proteins for IL1RL2 Gene
GPS-Prot Interaction Network for IL1RL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0006968 | cellular defense response | TAS | 8332913 |
| GO:0007165 | signal transduction | TAS | 1833184 |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
No data available for SIGNOR curated interactions for IL1RL2 Gene
Transcripts for IL1RL2 Gene
mRNA/cDNA for IL1RL2 Gene
- 6 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264257 2565 nts (view in UCSC)
- ENST00000421464 557 nts (view in UCSC)
- ENST00000441515 1484 nts (view in UCSC)
- ENST00000481806 1487 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RL2 - Starting at $85 >
- * IL1RL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RL2
- Browse OriGene Inhibitory RNA Products For IL1RL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RL2
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RL2 - Starting at $45 >
- * IL1RL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IL1RL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||
| SP2: | - | - |
Relevant External Links for IL1RL2 Gene
- GeneLoc Exon Structure for
- IL1RL2
Expression for IL1RL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for IL1RL2 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.7), Skin - Not Sun Exposed (Suprapubic) (x6.5), and Esophagus - Mucosa (x5.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1RL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1RL2
SOURCE GeneReport for Unigene cluster for IL1RL2 Gene:
Hs.659863mRNA Expression by UniProt/SwissProt for IL1RL2 Gene:
Q9HB29-ILRL2_HUMAN
Tissue specificity:
Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Evidence on tissue expression from TISSUES for IL1RL2 Gene
- Skin(2.5)
- Lymph node(2.4)
- Blood(2.2)
- Nervous system(2.1)
- Spleen(2.1)
Primer products for research
-
OriGene qPCR primer pairs for IL1RL2
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RL2 Gene
Orthologs for IL1RL2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL1RL2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL1RL2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | IL1RL2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il1rl2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il1rl2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1RL2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL1RL2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL1R1 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC799279 30 |
|
||
| CABZ01054962.1 31 |
|
ManyToMany | |||
| CABZ01054965.1 31 |
|
ManyToMany |
- Species where no ortholog for IL1RL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL1RL2 Gene
- ENSEMBL:
- Gene Tree for IL1RL2 (if available)
- TreeFam:
- Gene Tree for IL1RL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1RL2: view image
Paralogs for IL1RL2 Gene
Variants for IL1RL2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1RL2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs13405631 | Benign: not provided. - | 102,212,160(+) |
T/Cp.Ile237Thr NM_003854.4(IL1RL2):c.710T>C (p.Ile237Thr) |
MISSENSE_VARIANT,INTRON | |
| rs139406977 | Likely Benign: not provided | 102,235,264(+) |
C/T NM_003854.4(IL1RL2):c.1665C>T (p.Cys555=) |
SYNONYMOUS | |
| rs141789680 | Likely Benign: not provided | 102,235,210(+) |
G/T NM_003854.4(IL1RL2):c.1611G>T (p.Pro537=) |
SYNONYMOUS | |
| rs33946385 | Benign: not provided. - | 102,225,960(+) |
G/Ap.Val352Ile NM_003854.4(IL1RL2):c.1054G>A (p.Val352Ile) |
MISSENSE | |
| rs2302612 | - |
p.Leu550Pro |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2564673 | CNV | deletion | 19546169 |
| esv2720460 | CNV | deletion | 23290073 |
| esv2720462 | CNV | deletion | 23290073 |
| esv3559865 | CNV | deletion | 23714750 |
| esv3583991 | CNV | loss | 25503493 |
| nsv1138823 | CNV | deletion | 24896259 |
| nsv582555 | CNV | gain | 21841781 |
| nsv582556 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.17;
69.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1RL2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL2 Gene
Disorders for IL1RL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial cold autoinflammatory syndrome 2 |
|
|
| pustulosis of palm and sole |
|
|
| psoriasis 14, pustular |
|
|
| geographic tongue |
|
|
| lateral sinus thrombosis |
|
|
Search IL1RL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1RL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RL2 Gene
Publications for IL1RL2 Gene
- Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R … Kastelein RA (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23
- Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). (PMID: 8898719) Lovenberg TW … Maki RA (Journal of neuroimmunology 1996) 2 3 4 23
- Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. (PMID: 19684156) Solovieva S … Leino-Arjas P (The Journal of rheumatology 2009) 3 23 41
- Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M … Nicklin MJ (Genomics 1999) 2 3 23
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 41
ExternalLinks
Products for IL1RL2 Gene
- View all 9 R&D Systems IL1RL2 (IL-1Rrp2/IL-1R6) Products
- View all R&D Systems IL1RL2 (IL-1Rrp2/IL-1R6) Proteins and Enzymes
- View all 7 R&D Systems IL1RL2 (IL-1Rrp2/IL-1R6) Primary Antibodies
- View all R&D Systems IL1RL2 (IL-1Rrp2/IL-1R6) cDNA Clones
- Learn more about R&D Systems custom IL1RL2 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IL1RL2
- Origene Custom Protein Services for IL1RL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RL2
- Browse OriGene Inhibitory RNA Products For IL1RL2
- OriGene qPCR primer pairs for IL1RL2
- OriGene CRISPR knockouts for IL1RL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL1RL2
- Sino Biological Human cDNA Clone for IL1RL2
- Sino Biological Recombinant Proteins for IL1RL2
- Sino Biological Cell Lysates for IL1RL2
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL1RL2
- Novus Biologicals proteins for IL1RL2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IL1RL2
- Abcam proteins for IL1RL2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for IL1RL2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IL1RL2 (AFLGC-IL1RL2)
- VectorBuilder Custom and pre-made DNA vectors for IL1RL2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL1RL2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IL1RL2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IL1RL2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IL1RL2
- antibodies-online: Show 12 available IL1RL2 Antibodies ranked by validation data
- Compare Top IL1RL2 Antibodies
- antibodies-online: Show 11 available IL1RL2 Elisa Kits ranked by validation data
- Compare Top IL1RL2 Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available IL1RL2 Proteins ranked by validation data
- Compare Top IL1RL2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for IL1RL2
- Search Santa Cruz Biotechnology (SCBT) for IL1RL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL2
- Custom Antibody ServicesProSci Antibodies for IL1RL2
- ProSci Proteins for IL1RL2
- Horizon Cell Lines for IL1RL2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IL1RL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RL2
Sources for IL1RL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB