Aliases for IL1RL2 Gene
External Ids for IL1RL2 Gene
Previous GeneCards Identifiers for IL1RL2 Gene
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL2 Gene
IL1RL2 (Interleukin 1 Receptor Like 2) is a Protein Coding gene. Diseases associated with IL1RL2 include Geographic Tongue and Impetigo Herpetiformis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include interleukin-1 receptor activity and interleukin-1, type I, activating receptor activity. An important paralog of this gene is IL1R1.
UniProtKB/Swiss-Prot Summary for IL1RL2 Gene
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.