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The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2)... See more...
Aliases for IL1RL1 Gene
Aliases for IL1RL1 Gene
External Ids for IL1RL1 Gene
- HGNC: 5998
- NCBI Entrez Gene: 9173
- Ensembl: ENSG00000115602
- OMIM®: 601203
- UniProtKB/Swiss-Prot: Q01638
Previous GeneCards Identifiers for IL1RL1 Gene
- GC02P100792
- GC02P101380
- GC02P102532
- GC02P102549
- GC02P102386
- GC02P102927
- GC02P096692
Summaries for IL1RL1 Gene
-
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL1 Gene
IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include Loeffler Syndrome and Allergic Disease. Among its related pathways are Innate Immune System and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot Summary for IL1RL1 Gene
-
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
-
[Isoform B]: Inhibits IL-33 signaling.
Additional gene information for IL1RL1 Gene
- HGNC (5998)
- NCBI Entrez Gene (9173)
- Ensembl (ENSG00000115602)
- OMIM® (601203)
- UniProtKB/Swiss-Prot (Q01638)
- Open Targets Platform(ENSG00000115602)
- Monarch Initiative
- Search for IL1RL1 at DataMed
- Search for IL1RL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1RL1 Gene
Genomics for IL1RL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL1RL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1RL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1RL1
- Top Transcription factor binding sites by QIAGEN in the IL1RL1 gene promoter:
-
- aMEF-2
- FOXD3
- HNF-1
- HNF-1A
- MEF-2
- MEF-2A
- p53
- STAT5A
- YY1
Genomic Locations for IL1RL1 Gene
Latest Assembly
- chr2:102,311,502-102,352,367
- (GRCh38/hg38)
- Size:
- 40,866 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:102,928,023-102,968,497
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 40,475 bases
- Orientation:
- Plus strand
- chr2:102,927,962-102,968,497
- (GRCh37/hg19 by Ensembl)
- Size:
- 40,536 bases
- Orientation:
- Plus strand
Genomic View for IL1RL1 Gene
Genes around IL1RL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q12.1 by HGNC
- 2q12.1 by Entrez Gene
- 2q12.1 by Ensembl
IL1RL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1RL1 Gene
Proteins for IL1RL1 Gene
-
Protein details for IL1RL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01638-ILRL1_HUMAN
- Recommended name:
- Interleukin-1 receptor-like 1
- Protein Accession:
- Q01638
- A8K6B3
- B4E0I3
- Q53TU7
- Q8NEJ3
- Q9ULV7
- Q9UQ44
Protein attributes for IL1RL1 Gene
- Size:
- 556 amino acids
- Molecular mass:
- 63358 Da
- Quaternary structure:
-
- Interacts with MYD88, IRAK1, IRAK4, and TRAF6. Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.
- Miscellaneous:
-
- [Isoform C]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for IL1RL1 Gene
Post-translational modifications for IL1RL1 Gene
Other Protein References for IL1RL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ IL1RL1 Antibody
- GeneTex Anti-ST2 antibody [N1C1]
- Novus Biologicals Antibodies for IL1RL1
-
Abcam antibodies for IL1RL1
- Invitrogen Antibodies for IL1RL1 (AFLGC-IL1RL1)
-
Boster Bio Antibodies for IL1RL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1RL1
- Sino Biological Antibodies for IL1RL1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1RL1
- Origene Custom Protein Services for IL1RL1
- Novus Biologicals proteins for IL1RL1
- Sino Biological Recombinant Proteins for IL1RL1
- Sino Biological Cell Lysates for IL1RL1
- ProSpec Recombinant Proteins for IL1RL1
-
ProSci Proteins for IL1RL1
- interleukin 1 receptor like 1 [90-054]
- interleukin 1 receptor like 1 [90-531]
- interleukin 1 receptor-like 1 [90-532]
- interleukin 1 receptor-like 1 [92-583]
- interleukin 1 receptor-like 1 [92-589]
- interleukin 1 receptor-like 1 [96-427]
- interleukin 1 receptor-like 1 [96-428]
- interleukin 1 receptor like 1 [92-389]
-
Abcam proteins for IL1RL1
Assay products for research
- RayBiotech Human IL-1 R4 ELISA
- Novus Biologicals ELISA Kits for IL1RL1
- antibodies-online: Show 34 available IL1RL1 Elisa Kits ranked by validation data
- Compare Top IL1RL1 Elisa Kits
-
Quality Products:
-
Abcam assays for IL1RL1
- Sino Biological Assays for IL1RL1
No data available for DME Specific Peptides for IL1RL1 Gene
Domains & Families for IL1RL1 Gene
Gene Families for IL1RL1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL1RL1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-2 type
- Interleukin-1 receptor type I and type II family signature
- Interleukin-1 receptor type I family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for IL1RL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin 1 receptor-like 1 isoform 2 (A8VPW9_HUMAN)
- Interleukin 1 receptor-like 1 isoform 1 (A8VPX0_HUMAN)
- Protein ST2 (ILRL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q01638UniProtKB/Swiss-Prot:
ILRL1_HUMAN :- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Belongs to the interleukin-1 receptor family.
- Domain:
-
- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Family:
-
- Belongs to the interleukin-1 receptor family.
Function for IL1RL1 Gene
Molecular function for IL1RL1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
- UniProtKB/Swiss-Prot Function:
- [Isoform B]: Inhibits IL-33 signaling.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};.
- GENATLAS Biochemistry:
- interleukin 1receptor-like 1
Enzyme Numbers (IUBMB) for IL1RL1 Gene
Phenotypes From GWAS Catalog for IL1RL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002113 | interleukin-33 binding | IBA | 21873635 |
| GO:0002114 | interleukin-33 receptor activity | IBA | 21873635 |
| GO:0004896 | cytokine receptor activity | TAS | 10191101 |
| GO:0004908 | interleukin-1 receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 8621446 |
Phenotypes for IL1RL1 Gene
- MGI mutant phenotypes for IL1RL1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for IL1RL1:
Animal Models for IL1RL1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RL1 - Starting at $85 >
- * IL1RL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL1
miRNA for IL1RL1 Gene
- miRTarBase miRNAs that target IL1RL1
-
- hsa-miR-26b-5p (MIRT029172)
- mmu-miR-1199-5p (MIRT578474)
- mmu-miR-3089-5p (MIRT578475)
- mmu-miR-1195 (MIRT578476)
- mmu-miR-5135 (MIRT578477)
- mmu-miR-804 (MIRT578478)
- mmu-miR-706 (MIRT593470)
- mmu-miR-10a-5p (MIRT593471)
- mmu-miR-10b-5p (MIRT593472)
- mmu-miR-339-5p (MIRT593473)
- mmu-miR-292a-5p (MIRT593474)
- mmu-miR-290a-5p (MIRT593475)
- mmu-miR-3087-3p (MIRT602162)
- mmu-miR-3471 (MIRT602163)
- mmu-miR-5125 (MIRT602164)
- mmu-miR-3110-5p (MIRT602165)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RL1
- Browse OriGene Inhibitory RNA Products For IL1RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RL1
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RL1 - Starting at $45 >
- * IL1RL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205016
- MG227098
- MR205016
- MR205016L3
- MR205016L4
- MR227098
- MR227098L3
- MR227098L4
- MR229321
- RC205916
- RC205916L1
- RC205916L2
- RC205916L3
- RC205916L4
- RC217503
- RC217503L1
- RC217503L2
- RC217503L3
- RC217503L4
- RC236595
- RG205916
- RG217503
- RR200410
- RR200410L3
- RR200410L4
- RR200411
- RR200411L3
- RR200411L4
- MR205016L3V
- MR205016L4V
- MR227098L3V
- MR227098L4V
- RC205916L1V
- RC205916L2V
- RC205916L3V
- RC205916L4V
- RC217503L1V
- RC217503L2V
- RC217503L3V
- RC217503L4V
- RR200410L3V
- RR200410L4V
- RR200411L3V
- RR200411L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RL1
Cell Lines for research
-
Horizon Cell Lines for IL1RL1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RL1 Gene
Localization for IL1RL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1RL1 Gene
- [Isoform C]: Cell membrane.
- [Isoform B]: Secreted.
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Cytosol (2)
- Focal adhesion sites (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | IDA | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
Pathways & Interactions for IL1RL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | PEDF Induced Signaling | ||
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | Innate Lymphoid Cell Differentiation Pathways | ||
| 5 | Th2 Differentiation Pathway | ||
Pathways by source for IL1RL1 Gene
3 Reactome pathways for IL1RL1 Gene
1 KEGG pathway for IL1RL1 Gene
3 R&D Systems pathways for IL1RL1 Gene
1 Qiagen pathway for IL1RL1 Gene
- Toll-Like Receptors Pathway
Interacting Proteins for IL1RL1 Gene
Selected Interacting proteins:
Q01638-ILRL1_HUMAN
ENSP00000233954
for IL1RL1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL1RL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002826 | negative regulation of T-helper 1 type immune response | IEA | -- |
| GO:0006955 | immune response | NAS | 10527832 |
| GO:0007165 | signal transduction | TAS | 1482686 |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | -- |
| GO:0032689 | negative regulation of interferon-gamma production | IEA | -- |
No data available for SIGNOR curated interactions for IL1RL1 Gene
Transcripts for IL1RL1 Gene
mRNA/cDNA for IL1RL1 Gene
- 4 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000233954 1997 nts (view in UCSC)
- ENST00000311734 3994 nts (view in UCSC)
- ENST00000404917 3571 nts (view in UCSC)
- ENST00000409584 2693 nts (view in UCSC)
- ENST00000427077 1680 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RL1 - Starting at $85 >
- * IL1RL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RL1
- Browse OriGene Inhibitory RNA Products For IL1RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RL1
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RL1 - Starting at $45 >
- * IL1RL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205016
- MG227098
- MR205016
- MR205016L3
- MR205016L4
- MR227098
- MR227098L3
- MR227098L4
- MR229321
- RC205916
- RC205916L1
- RC205916L2
- RC205916L3
- RC205916L4
- RC217503
- RC217503L1
- RC217503L2
- RC217503L3
- RC217503L4
- RC236595
- RG205916
- RG217503
- RR200410
- RR200410L3
- RR200410L4
- RR200411
- RR200411L3
- RR200411L4
- MR205016L3V
- MR205016L4V
- MR227098L3V
- MR227098L4V
- RC205916L1V
- RC205916L2V
- RC205916L3V
- RC205916L4V
- RC217503L1V
- RC217503L2V
- RC217503L3V
- RC217503L4V
- RR200410L3V
- RR200410L4V
- RR200411L3V
- RR200411L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RL1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for IL1RL1 Gene
- GeneLoc Exon Structure for
- IL1RL1
Expression for IL1RL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Mast cell progenitor cells Hematopoietic Bone Marrow
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
- Alveolar type II cells(Wade KC et. al. 2006)
- Endothelium (Cardiovascular System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for IL1RL1 Gene
This gene is overexpressed in Lung (x13.8) and Kidney - Cortex (x8.5).
This gene is overexpressed in Breast (68.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1RL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1RL1
SOURCE GeneReport for Unigene cluster for IL1RL1 Gene:
Hs.66mRNA Expression by UniProt/SwissProt for IL1RL1 Gene:
Q01638-ILRL1_HUMAN
Tissue specificity:
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Evidence on tissue expression from TISSUES for IL1RL1 Gene
- Blood(4.5)
- Bone marrow(4.4)
- Lung(3.2)
- Heart(2.8)
- Spleen(2.4)
- Kidney(2.4)
- Intestine(2.3)
- Lymph node(2.3)
- Liver(2.2)
- Nervous system(2.1)
- Muscle(2.1)
Primer products for research
-
OriGene qPCR primer pairs for IL1RL1
-
OriGene qPCR primer pairs and template standards for IL1RL1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RL1 Gene
Orthologs for IL1RL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC749266 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | IL1RL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL1RL1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il1rl1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il1rl1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IL1RL1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1RL1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL1RL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IL1RL1 31 |
|
OneToOne |
- Species where no ortholog for IL1RL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL1RL1 Gene
- ENSEMBL:
- Gene Tree for IL1RL1 (if available)
- TreeFam:
- Gene Tree for IL1RL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1RL1: view image
Paralogs for IL1RL1 Gene
Paralogs for IL1RL1 Gene
(2) SIMAP similar genes for IL1RL1 Gene using alignment to 6 proteins:
- ILRL1_HUMAN
- A8VPW9_HUMAN
- A8VPX0_HUMAN
- B4E0I3_HUMAN
- C9JSY6_HUMAN
- E9PC41_HUMAN
Variants for IL1RL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1RL1 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs111942110 | Benign: not provided | 102,351,579(+) |
G/A NM_016232.5(IL1RL1):c.1329G>A (p.Arg443=) |
SYNONYMOUS | |
| rs111970215 | Benign: not provided | 102,342,258(+) |
G/A NM_016232.5(IL1RL1):c.646G>A (p.Ala216Thr) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs112595294 | Benign: not provided | 102,347,959(+) |
A/G NM_016232.5(IL1RL1):c.985A>G (p.Ile329Val) |
MISSENSE | |
| rs113360315 | Benign: not provided | 102,351,783(+) |
G/A NM_016232.5(IL1RL1):c.1533G>A (p.Lys511=) |
SYNONYMOUS | |
| rs114797672 | Benign: not provided | 102,340,676(+) |
C/T NM_016232.5(IL1RL1):c.458C>T (p.Ala153Val) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1258097 | CNV | deletion | 17803354 |
| esv2585327 | CNV | deletion | 19546169 |
| esv2673990 | CNV | deletion | 23128226 |
| esv3591787 | CNV | loss | 21293372 |
| esv3591788 | CNV | gain | 21293372 |
| esv3591789 | CNV | loss | 21293372 |
| nsv1160830 | CNV | deletion | 26073780 |
| nsv820800 | CNV | duplication | 20802225 |
| nsv829585 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
20.34;
99.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1RL1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL1 Gene
Disorders for IL1RL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| loeffler syndrome |
|
|
| allergic disease |
|
|
| allergic conjunctivitis |
|
|
| conjunctivitis |
|
|
| thoracic cancer |
|
|
Search IL1RL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1RL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RL1 Gene
Publications for IL1RL1 Gene
- Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. (PMID: 19671251) Castano R … Desrosiers M (American journal of rhinology & allergy 2009) 3 23 41
- IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (PMID: 16286016) Schmitz J … Kastelein RA (Immunity 2005) 2 3 4
- Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. (PMID: 11478810) Tago K … Tominaga S (Biochemical and biophysical research communications 2001) 3 4 23
- The cloning and nucleotide sequence of human ST2L cDNA. (PMID: 10936050) Li H … Yanagisawa K (Genomics 2000) 3 4 23
- Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM. (PMID: 10527832) Tominaga Si … Komatsu N (Biochemical and biophysical research communications 1999) 3 4 23
ExternalLinks
Products for IL1RL1 Gene
- View all 45 R&D Systems IL1RL1 (ST2/IL-33R) Products
- View all R&D Systems IL1RL1 (ST2/IL-33R) Proteins and Enzymes
- View all 37 R&D Systems IL1RL1 (ST2/IL-33R) Primary Antibodies
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- MG205016
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- antibodies-online: Show 34 available IL1RL1 Antibodies ranked by validation data
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- antibodies-online: Show 30 available IL1RL1 Proteins ranked by validation data
- Compare Top IL1RL1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IL1RL1
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- Santa Cruz Biotechnology (SCBT) CRISPR for IL1RL1
- Custom Antibody ServicesProSci Antibodies for IL1RL1
- ProSci Proteins for IL1RL1
- interleukin 1 receptor like 1 [90-054]
- interleukin 1 receptor like 1 [90-531]
- interleukin 1 receptor-like 1 [90-532]
- interleukin 1 receptor-like 1 [92-583]
- interleukin 1 receptor-like 1 [92-589]
- interleukin 1 receptor-like 1 [96-427]
- interleukin 1 receptor-like 1 [96-428]
- interleukin 1 receptor like 1 [92-389]
- Horizon Cell Lines for IL1RL1
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Sources for IL1RL1 Gene
- (1) GeneCards
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