Aliases for IL1RL1 Gene
External Ids for IL1RL1 Gene
Previous GeneCards Identifiers for IL1RL1 Gene
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1RL1 Gene
IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include Loeffler Syndrome and Allergic Disease. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot Summary for IL1RL1 Gene
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
[Isoform B]: Inhibits IL-33 signaling.