Aliases for IL1RAP Gene
Aliases for IL1RAP Gene
External Ids for IL1RAP Gene
- HGNC: 5995
- Entrez Gene: 3556
- Ensembl: ENSG00000196083
- OMIM: 602626
- UniProtKB: Q9NPH3
Previous GeneCards Identifiers for IL1RAP Gene
- GC03P187234
- GC03P191494
- GC03P191633
- GC03P191552
- GC03P191714
- GC03P190231
- GC03P187631
Summaries for IL1RAP Gene
-
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
GeneCards Summary for IL1RAP Gene
IL1RAP (Interleukin 1 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL1RAP include Chromosome Xp21 Deletion Syndrome and Stromal Keratitis. Among its related pathways are Bacterial infections in CF airways and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot for IL1RAP Gene
-
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
-
Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
-
Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
Additional gene information for IL1RAP Gene
- Monarch Initiative
- Search for IL1RAP at DataMed
- Search for IL1RAP at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RAP Gene
Genomics for IL1RAP Gene
GeneHancer (GH) Regulatory Elements for IL1RAP Gene
Promoters and enhancers for IL1RAP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J190512 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +1.6 | 1567 | 5.5 | FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 FOS | IL1RAP TMEM207 CCDC50 GC03P190507 GCNT1P3 | |
| GH03J190616 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 23.4 | +103.7 | 103710 | 3.3 | CTCF ELF3 PKNOX1 MXI1 FOXA2 SAP130 CEBPG BMI1 ZNF644 TEAD3 | IL1RAP GCNT1P3 | |
| GH03J190565 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 11.4 | +52.8 | 52822 | 3.1 | FOXA2 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 | IL1RAP GCNT1P3 | |
| GH03J190590 | Enhancer | 0.6 | ENCODE | 19.9 | +77.5 | 77452 | 2 | SMARCE1 FOXA2 CLOCK RXRA DPF2 MNT FOXA1 SP1 JUND GATA3 | IL1RAP GCNT1P3 | |
| GH03J190701 | Enhancer | 0.9 | ENCODE | 11.3 | +187.2 | 187176 | 0.1 | FOXA2 ARID4B YY1 NFKBIZ RXRA ZHX2 MIER2 REST PPARG KAT8 | LINC02013 IL1RAP CCT6P4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1RAP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL1RAP gene promoter:
-
- LHX3b
- Lhx3a
- Egr-4
- MRF-2
- Tal-1beta
- ITF-2
- FOXJ2 (long isoform)
- FOXJ2
- AML1a
- FOXO1a
Regulatory Element Products
Genomic Locations for IL1RAP Gene
Genomic Locations for IL1RAP Gene
- chr3:190,514,051-190,659,750
- (GRCh38/hg38)
- Size:
- 145,700 bases
- Orientation:
- Plus strand
- chr3:190,231,840-190,375,843
- (GRCh37/hg19)
- Size:
- 144,004 bases
- Orientation:
- Plus strand
Genomic View for IL1RAP Gene
Genes around IL1RAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q28 by Entrez Gene
- 3q28 by HGNC
- 3q28 by Ensembl
IL1RAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1RAP Gene
Proteins for IL1RAP Gene
-
Protein details for IL1RAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPH3-IL1AP_HUMAN
- Recommended name:
- Interleukin-1 receptor accessory protein
- Protein Accession:
- Q9NPH3
- B1NLD0
- D3DNW0
- O14915
- Q86WJ7
Protein attributes for IL1RAP Gene
- Size:
- 570 amino acids
- Molecular mass:
- 65418 Da
- Quaternary structure:
-
- The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Isoform 4 interacts with IL1R1 in a interleukin-1-dependent manner. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).
Protein Expression for IL1RAP Gene
Post-translational modifications for IL1RAP Gene
Other Protein References for IL1RAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL1RAP (IL-1 RAcP/IL-1 R3)
- Novus Biologicals Antibodies for IL1RAP
-
Abcam antibodies for IL1RAP
- Invitrogen Antibodies for IL1RAP
- GeneTex IL1RAP Antibody for IL1RAP
-
Custom Antibody ServicesProSci Antibodies for IL1RAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1RAP
- Sino Biological Antibodies for IL1RAP
Protein Products
- R&D Systems Proteins and Enzymes for IL1RAP (IL-1 RAcP/IL-1 R3)
-
OriGene Purified Proteins for IL1RAP
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1RAP
- Origene Custom Protein Services for IL1RAP
- Sino Biological Recombinant Proteins for IL1RAP
- Sino Biological Cell Lysates for IL1RAP
- Search GeneTex for Proteins for IL1RAP
-
Abcam proteins for IL1RAP
Assay Products
- R&D Systems ELISAs and other biochemical assays for IL1RAP (IL-1 RAcP/IL-1 R3)
- antibodies-online: Search results for 27 available IL1RAP Elisa Kits ranked by validation data
- Compare Top IL1RAP Elisa Kits
-
Recommended
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
No data available for DME Specific Peptides for IL1RAP Gene
Domains & Families for IL1RAP Gene
Gene Families for IL1RAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL1RAP Gene
Suggested Antigen Peptide Sequences for IL1RAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NPH3- Family:
-
- Belongs to the interleukin-1 receptor family.
Function for IL1RAP Gene
Molecular function for IL1RAP Gene
- UniProtKB/Swiss-Prot Function:
- Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.
- GENATLAS Biochemistry:
- interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptor complex,after induction by IL1A or IL1B
Phenotypes From GWAS Catalog for IL1RAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002114 | interleukin-33 receptor activity | IEA | -- |
| GO:0004871 | obsolete signal transducer activity | TAS | -- |
| GO:0004908 | interleukin-1 receptor activity | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:1990782 | protein tyrosine kinase binding | IEA | -- |
Phenotypes for IL1RAP Gene
- MGI mutant phenotypes for IL1RAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL1RAP:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance
- Decreased viability
- no effect
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Decreased caspase 3/7 activity
Animal Models for IL1RAP Gene
- MGI Knock Outs for IL1RAP:
-
- Il1rap Il1rap<tm1Roml>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL1RAP
-
CRISPR Products
-
OriGene CRISPR knockouts for IL1RAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RAP
- genomics-online: gRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- Applied Biological Materials CRISPR for IL1RAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RAP
- GenScript: Design CRISPR guide RNA sequences for IL1RAP
miRNA for IL1RAP Gene
- miRTarBase miRNAs that target IL1RAP
-
- hsa-mir-204-5p (MIRT005831)
- hsa-mir-375 (MIRT020058)
- hsa-mir-215-5p (MIRT024630)
- hsa-mir-192-5p (MIRT026944)
- hsa-mir-1228-3p (MIRT036392)
- hsa-mir-146a-5p (MIRT437619)
- hsa-mir-146b-5p (MIRT437625)
- hsa-mir-510-3p (MIRT448176)
- hsa-mir-494-3p (MIRT448177)
- hsa-mir-4635 (MIRT448178)
- hsa-mir-548c-3p (MIRT448179)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL1RAP
- Browse OriGene Inhibitory RNA Products For IL1RAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RAP
- genomics-online: shRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
Clone Products
-
OriGene ORF clones in human for IL1RAP
- RC230294L1V
- RC230294L2V
- RC230295L1V
- RC230295L2V
- RC229933L1V
- RC229933L2V
- RC230427L1V
- RC230427L2V
- RC211970L1V
- RC211970L2V
- RC208786L1V
- RC208786L2V
- RC230294
- RC230294L1
- RC230294L2
- RG230294
- RC230295
- RC230295L1
- RC230295L2
- RG230295
- RC229933
- RC229933L1
- RC229933L2
- RG229933
- RC230427
- RC230427L1
- RC230427L2
- RG230427
- RC211970
- RC211970L1
- RC211970L2
- RG211970
- RC208786
- RC208786L1
- RC208786L2
- RG208786
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RAP
- VectorBuilder custom plasmid, inducible vectors for IL1RAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1RAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RAP
- Applied Biological Materials Clones for IL1RAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL1RAP (IL-1 RAcP/IL-1 R3)
Cell Line Products
-
Horizon Cell Lines for IL1RAP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RAP Gene
Localization for IL1RAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1RAP Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
- Isoform 3: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 7775431 |
| GO:0016020 | membrane | HDA,IEA | 19946888 |
Pathways & Interactions for IL1RAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-1 signaling pathway | ||
| 2 | Bacterial infections in CF airways | ||
| 3 | IL-1 Family Signaling Pathways | ||
| 4 | Cytokine Signaling in Immune system | ||
| 5 | PEDF Induced Signaling | ||
Pathways by source for IL1RAP Gene
2 BioSystems pathways for IL1RAP Gene
4 Reactome pathways for IL1RAP Gene
4 KEGG pathways for IL1RAP Gene
5 GeneGo (Thomson Reuters) pathways for IL1RAP Gene
2 R&D Systems pathways for IL1RAP Gene
1 Qiagen pathway for IL1RAP Gene
Interacting Proteins for IL1RAP Gene
Selected Interacting proteins:
ENSP00000314807
Q9NPH3-IL1AP_HUMAN
for IL1RAP Gene via
STRING
IID
MINT
GPS-Prot Interaction Network for IL1RAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006954 | inflammatory response | TAS,IEA | -- |
| GO:0006955 | immune response | TAS | 9065432 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Drugs & Compounds for IL1RAP Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for IL1RAP Gene
mRNA/cDNA for IL1RAP Gene
- (9) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (116) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000072516 4697 bps (uc003fso.2)
- ENST00000439062 2244 bps (uc010hzg.3)
- ENST00000447382 4769 bps (uc003fsm.3)
- ENST00000422625 534 bps (uc062rjv.1)
- ENST00000465496 646 bps (uc062rjw.1)
Unigene Clusters for IL1RAP Gene
- Interleukin 1 receptor accessory protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IL1RAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RAP
- genomics-online: gRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- Applied Biological Materials CRISPR for IL1RAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RAP
- GenScript: Design CRISPR guide RNA sequences for IL1RAP
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL1RAP
- Browse OriGene Inhibitory RNA Products For IL1RAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RAP
- genomics-online: shRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
Clone Products
-
OriGene ORF clones in human for IL1RAP
- RC230294L1V
- RC230294L2V
- RC230295L1V
- RC230295L2V
- RC229933L1V
- RC229933L2V
- RC230427L1V
- RC230427L2V
- RC211970L1V
- RC211970L2V
- RC208786L1V
- RC208786L2V
- RC230294
- RC230294L1
- RC230294L2
- RG230294
- RC230295
- RC230295L1
- RC230295L2
- RG230295
- RC229933
- RC229933L1
- RC229933L2
- RG229933
- RC230427
- RC230427L1
- RC230427L2
- RG230427
- RC211970
- RC211970L1
- RC211970L2
- RG211970
- RC208786
- RC208786L1
- RC208786L2
- RG208786
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RAP
- VectorBuilder custom plasmid, inducible vectors for IL1RAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1RAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RAP
- Applied Biological Materials Clones for IL1RAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL1RAP (IL-1 RAcP/IL-1 R3)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Expression for IL1RAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Oligodendrocyte progenitor cells(Najm FJ et. al. 2011)
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Spinal Cord (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
- NULL (Integumentary System)
- Uncategorized
- Oligodendrocytes (Nervous System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for IL1RAP Gene
This gene is overexpressed in Whole Blood (x10.3) and Liver (x8.4).
This gene is overexpressed in Serum (57.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL1RAP Gene
NURSA nuclear receptor signaling pathways regulating expression of IL1RAP Gene:
IL1RAPSOURCE GeneReport for Unigene cluster for IL1RAP Gene:
Hs.478673mRNA Expression by UniProt/SwissProt for IL1RAP Gene:
Q9NPH3-IL1AP_HUMAN
Tissue specificity:
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpresed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD).
Evidence on tissue expression from TISSUES for IL1RAP Gene
- Liver(4.5)
- Nervous system(4.4)
- Skin(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for IL1RAP
-
OriGene qPCR primer pairs for IL1RAP
- genomics-online: primer clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RAP Gene
Orthologs for IL1RAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL1RAP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL1RAP 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IL1RAP 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Il1rap 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il1rap 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL1RAP 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IL1RAP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL1RAP 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IL1RAP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il1rap 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01068246.1 34 |
|
OneToOne |
- Species where no ortholog for IL1RAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IL1RAP Gene
- ENSEMBL:
- Gene Tree for IL1RAP (if available)
- TreeFam:
- Gene Tree for IL1RAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1RAP: view image
Paralogs for IL1RAP Gene
Variants for IL1RAP Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012012 | -- | 190,570,438(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000049580 | -- | 190,519,288(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000055429 | -- | 190,587,238(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000085682 | -- | 190,606,263(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000116308 | -- | 190,593,351(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv131n6 | CNV | deletion | 16902084 |
| dgv2661n106 | CNV | deletion | 24896259 |
| esv1000745 | CNV | deletion | 20482838 |
| esv1433093 | CNV | deletion | 17803354 |
| esv1980229 | CNV | deletion | 18987734 |
| esv2440806 | CNV | deletion | 19546169 |
| esv2667728 | CNV | deletion | 23128226 |
| esv2677697 | CNV | deletion | 23128226 |
| esv2726382 | CNV | deletion | 23290073 |
| esv2726383 | CNV | deletion | 23290073 |
| esv3302996 | CNV | tandem duplication | 20981092 |
| esv34194 | CNV | loss | 18971310 |
| esv3563082 | CNV | deletion | 23714750 |
| esv3893843 | CNV | gain | 25118596 |
| esv4162 | CNV | loss | 18987735 |
| esv4944 | CNV | loss | 18987735 |
| esv6677 | CNV | gain | 19470904 |
| nsv1149600 | CNV | deletion | 26484159 |
| nsv829820 | CNV | gain | 17160897 |
| nsv956268 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.81;
47.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1RAP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IL1RAP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAP Gene
Disorders for IL1RAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome xp21 deletion syndrome |
|
|
| stromal keratitis |
|
|
Search IL1RAP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1RAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAP Gene
Publications for IL1RAP Gene
- The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PMID: 9479509) Dale M … Nicklin MJ (Genomics 1998) 2 3 4 22 58
- A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687. (PMID: 17949817) Lu HL … Ting LP (Molecular immunology 2008) 3 4 22 58
- The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PMID: 12530978) Smith DE … Sims JE (Immunity 2003) 3 4 22 58
- Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PMID: 12781872) Jensen LE … Whitehead AS (Cellular signalling 2003) 3 4 22 58
- IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PMID: 10799889) Jensen LE … Whitehead AS (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
Products for IL1RAP Gene
- R&D Systems Antibodies for IL1RAP (IL-1 RAcP/IL-1 R3)
- R&D Systems Proteins and Enzymes for IL1RAP (IL-1 RAcP/IL-1 R3)
- R&D Systems ELISAs and other biochemical assays for IL1RAP (IL-1 RAcP/IL-1 R3)
- R&D Systems cDNA Clones for IL1RAP (IL-1 RAcP/IL-1 R3)
- Browse Human Proteins and Enzymes
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IL1RAP
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1RAP
- Origene Custom Protein Services for IL1RAP
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL1RAP
- Browse OriGene Inhibitory RNA Products For IL1RAP
- OriGene qPCR primer pairs and template standards for IL1RAP
- OriGene qPCR primer pairs for IL1RAP
- OriGene CRISPR knockouts for IL1RAP
- OriGene ORF clones in human for IL1RAP
- RC230294L1V
- RC230294L2V
- RC230295L1V
- RC230295L2V
- RC229933L1V
- RC229933L2V
- RC230427L1V
- RC230427L2V
- RC211970L1V
- RC211970L2V
- RC208786L1V
- RC208786L2V
- RC230294
- RC230294L1
- RC230294L2
- RG230294
- RC230295
- RC230295L1
- RC230295L2
- RG230295
- RC229933
- RC229933L1
- RC229933L2
- RG229933
- RC230427
- RC230427L1
- RC230427L2
- RG230427
- RC211970
- RC211970L1
- RC211970L2
- RG211970
- RC208786
- RC208786L1
- RC208786L2
- RG208786
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL1RAP
- GenScript: Next-day shipping of latest version cDNA ORF clones for IL1RAP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IL1RAP
- GenScript Custom Assay Services for IL1RAP
- GenScript Custom overexpressing Cell Line Services for IL1RAP
- GenScript: Design CRISPR guide RNA sequences for IL1RAP
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL1RAP
- Sino Biological Human cDNA Clone for IL1RAP
- Sino Biological Recombinant Proteins for IL1RAP
- Sino Biological Cell Lysates for IL1RAP
- Sino Biological Antibodies for IL1RAP
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL1RAP
- Novus Biologicals proteins and lysates for IL1RAP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IL1RAP
- Abcam proteins for IL1RAP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder custom plasmid, inducible vectors for IL1RAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL1RAP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 78 available IL1RAP Antibodies ranked by validation data
- Compare Top IL1RAP Antibodies
- antibodies-online: Search results for 27 available IL1RAP Elisa Kits ranked by validation data
- Compare Top IL1RAP Elisa Kits
- Recommended
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 1 Guinea Pig ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 27 available IL1RAP Proteins ranked by validation data
- Compare Top IL1RAP Proteins
- GeneTex IL1RAP Antibody for IL1RAP
- Search GeneTex for Proteins for IL1RAP
- Santa Cruz Biotechnology (SCBT) Antibodies for IL1RAP
- Search Santa Cruz Biotechnology (SCBT) for IL1RAP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL1RAP
- Custom Antibody ServicesProSci Antibodies for IL1RAP
- Horizon Cell Lines for IL1RAP
- genomics-online: cdna clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- orf clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- genomics-online: gRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- genomics-online: primer clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- genomics-online: shRNA clones - Search results for 174 available IL1RAP gene related products
- Overview of 174 available IL1RAP gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RAP
- GeneCopoeia miRNA 3'UTR Target clone products for IL1RAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RAP
Sources for IL1RAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt