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This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [prov... See more...
Aliases for IL1RAP Gene
Aliases for IL1RAP Gene
External Ids for IL1RAP Gene
- HGNC: 5995
- NCBI Entrez Gene: 3556
- Ensembl: ENSG00000196083
- OMIM®: 602626
- UniProtKB/Swiss-Prot: Q9NPH3
Previous GeneCards Identifiers for IL1RAP Gene
- GC03P187234
- GC03P191494
- GC03P191633
- GC03P191552
- GC03P191714
- GC03P190231
- GC03P187631
Summaries for IL1RAP Gene
-
This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]
GeneCards Summary for IL1RAP Gene
IL1RAP (Interleukin 1 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL1RAP include Marginal Corneal Ulcer and Indolent Plasma Cell Myeloma. Among its related pathways are Toll Comparative Pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.
UniProtKB/Swiss-Prot Summary for IL1RAP Gene
-
Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).
-
[Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
-
[Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
Additional gene information for IL1RAP Gene
- HGNC (5995)
- NCBI Entrez Gene (3556)
- Ensembl (ENSG00000196083)
- OMIM® (602626)
- UniProtKB/Swiss-Prot (Q9NPH3)
- Open Targets Platform(ENSG00000196083)
- Monarch Initiative
- Alliance of Genome Resources
- Search for IL1RAP at DataMed
- Search for IL1RAP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1RAP Gene
Genomics for IL1RAP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL1RAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1RAP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1RAP
- Top Transcription factor binding sites by QIAGEN in the IL1RAP gene promoter:
-
- AML1a
- Egr-4
- FOXJ2
- FOXJ2 (long isoform)
- FOXO1a
- ITF-2
- Lhx3a
- LHX3b
- MRF-2
- Tal-1beta
Genomic Locations for IL1RAP Gene
Latest Assembly
- chr3:190,514,051-190,659,750
- (GRCh38/hg38)
- Size:
- 145,700 bases
- Orientation:
- Plus strand
Previous Assembly
- chr3:190,231,874-190,377,539
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 145,666 bases
- Orientation:
- Plus strand
Genomic View for IL1RAP Gene
Genes around IL1RAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q28 by HGNC
- 3q28 by Entrez Gene
- 3q28 by Ensembl
IL1RAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1RAP Gene
Proteins for IL1RAP Gene
-
Protein details for IL1RAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPH3-IL1AP_HUMAN
- Recommended name:
- Interleukin-1 receptor accessory protein
- Protein Accession:
- Q9NPH3
- B1NLD0
- D3DNW0
- O14915
- Q86WJ7
Protein attributes for IL1RAP Gene
- Size:
- 570 amino acids
- Molecular mass:
- 65418 Da
- Quaternary structure:
-
- The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex. Isoform 4 interacts with IL1R1 in an interleukin-1-dependent manner. Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).
- Miscellaneous:
-
- [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for IL1RAP Gene
Post-translational modifications for IL1RAP Gene
Other Protein References for IL1RAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IL1RAP Antibody
- GeneTex Anti-IL1RAP antibody and Anti-IL1RAP antibody [N1N3]
- Novus Biologicals Antibodies for IL1RAP
- Invitrogen Antibodies for IL1RAP (AFLGC-IL1RAP)
-
Biorbyt antibodies for IL1RAP
-
Boster Bio Antibodies for IL1RAP
-
Custom Antibody ServicesProSci Antibodies for IL1RAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1RAP
- Sino Biological Antibodies for IL1RAP
Protein products for research
- G Biosciences Human IL-1RAP/IL1R3, Lyophilized and Human IL-1RAcP/IL1R3, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1RAP
- Origene Custom Protein Services for IL1RAP
- Sino Biological Recombinant Proteins for IL1RAP
- Sino Biological Cell Lysates for IL1RAP
-
Abcam proteins for IL1RAP
Assay products for research
- RayBiotech Human IL-1 R3/IL-1 R Acp ELISA
-
Custom Assay ServicesOriGene ELISA Kits for IL1RAP
-
Boster Bio ELISA Kits for IL1RAP
No data available for DME Specific Peptides for IL1RAP Gene
Domains & Families for IL1RAP Gene
Gene Families for IL1RAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL1RAP Gene
- InterPro:
- Blocks:
-
- Interleukin-1 receptor type I and type II family signature
- Interleukin-1 receptor type I family signature
Suggested Antigen Peptide Sequences for IL1RAP Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin-1 receptor 3 (IL1AP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NPH3UniProtKB/Swiss-Prot:
IL1AP_HUMAN :- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Belongs to the interleukin-1 receptor family.
- Domain:
-
- The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
- Family:
-
- Belongs to the interleukin-1 receptor family.
Function for IL1RAP Gene
Molecular function for IL1RAP Gene
- UniProtKB/Swiss-Prot Function:
- Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).
- UniProtKB/Swiss-Prot Function:
- [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};.
- UniProtKB/Swiss-Prot Induction:
- Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.
- GENATLAS Biochemistry:
- interleukin 1,receptor accessory protein,required for the recruitment of IRAK(1) to the interleukin 1 receptor complex,after induction by IL1A or IL1B
Enzyme Numbers (IUBMB) for IL1RAP Gene
Phenotypes From GWAS Catalog for IL1RAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002114 | interleukin-33 receptor activity | IEA | -- |
| GO:0004908 | interleukin-1 receptor activity | IBA | 21873635 |
| GO:0005149 | interleukin-1 receptor binding | IBA | 21873635 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for IL1RAP Gene
- MGI mutant phenotypes for IL1RAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL1RAP:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased shRNA abundance
- Increased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with Ras
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance (Z-score < -2)
- Decreased caspase 3/7 activity
Animal Models for IL1RAP Gene
- MGI Knock Outs for IL1RAP:
-
- Il1rap Il1rap<tm1Roml>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RAP - Starting at $85 >
- * IL1RAP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RAP
miRNA for IL1RAP Gene
- miRTarBase miRNAs that target IL1RAP
-
- hsa-miR-204-5p (MIRT005831)
- mmu-miR-149-5p (MIRT014477)
- mmu-miR-9-5p (MIRT015183)
- hsa-miR-375 (MIRT020058)
- hsa-miR-215-5p (MIRT024630)
- hsa-miR-192-5p (MIRT026944)
- hsa-miR-1228-3p (MIRT036392)
- hsa-miR-146a-5p (MIRT437619)
- hsa-miR-146b-5p (MIRT437625)
- hsa-miR-510-3p (MIRT448176)
- hsa-miR-494-3p (MIRT448177)
- hsa-miR-4635 (MIRT448178)
- hsa-miR-548c-3p (MIRT448179)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RAP
- Browse OriGene Inhibitory RNA Products For IL1RAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RAP
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RAP - Starting at $45 >
- * IL1RAP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205511
- MG223729
- MG223733
- MG224562
- MR205511
- MR205511L3
- MR205511L4
- MR223729
- MR223729L3
- MR223729L4
- MR223733
- MR223733L3
- MR223733L4
- MR224562
- MR224562L3
- MR224562L4
- RC208786
- RC208786L3
- RC208786L4
- RC211970
- RC211970L1
- RC211970L2
- RC211970L3
- RC211970L4
- RC229933
- RC229933L3
- RC229933L4
- RC230294
- RC230294L3
- RC230294L4
- RC230295
- RC230295L3
- RC230295L4
- RC230427
- RC230427L3
- RC230427L4
- RG208786
- RG211970
- RG229933
- RG230294
- RG230295
- RG230427
- RR213032
- RR213032L3
- RR213032L4
- RR217103
- MR205511L3V
- MR205511L4V
- MR223729L3V
- MR223729L4V
- MR223733L3V
- MR223733L4V
- MR224562L3V
- MR224562L4V
- RC208786L3V
- RC208786L4V
- RC211970L1V
- RC211970L2V
- RC211970L3V
- RC211970L4V
- RC229933L3V
- RC229933L4V
- RC230294L3V
- RC230294L4V
- RC230295L3V
- RC230295L4V
- RC230427L3V
- RC230427L4V
- RR213032L3V
- RR213032L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RAP
Cell Lines for research
-
Horizon Cell Lines for IL1RAP
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1RAP Gene
Localization for IL1RAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1RAP Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
- [Isoform 3]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 7775431 |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for IL1RAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways |
Immune response IL-1 signaling pathway
.41
|
|
| 2 | IL-1 signaling pathway | ||
| 3 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
IL-1 beta-dependent CFTR expression
.43
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | PEDF Induced Signaling | ||
Pathways by source for IL1RAP Gene
2 BioSystems pathways for IL1RAP Gene
4 Reactome pathways for IL1RAP Gene
4 KEGG pathways for IL1RAP Gene
5 GeneGo (Thomson Reuters) pathways for IL1RAP Gene
- Bacterial infections in CF airways
- IL-1 beta-dependent CFTR expression
- Immune response Bacterial infections in normal airways
- Immune response IL-1 signaling pathway
- Transcription_NF-kB signaling pathway
3 R&D Systems pathways for IL1RAP Gene
1 Qiagen pathway for IL1RAP Gene
- IL-1 Pathway
Interacting Proteins for IL1RAP Gene
Selected Interacting proteins:
Q9NPH3-IL1AP_HUMAN
ENSP00000314807
for IL1RAP Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for IL1RAP
SIGNOR curated interactions for IL1RAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0006954 | inflammatory response | TAS,IEA | -- |
| GO:0006955 | immune response | TAS | 9065432 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Drugs & Compounds for IL1RAP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3624 | ||
| Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2590 | ||
| Paclitaxel | Approved, Vet_approved | Pharma | Tubulin and Bcl2 inhibitor, Taxanes | 3989 | ||
| Albumin-Bound Paclitaxel | Pharma | 3989 | ||||
| Antibodies | Pharma | 8474 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human IL-1RAP/IL1R3, Lyophilized and Human IL-1RAcP/IL1R3, Lyophilized
Transcripts for IL1RAP Gene
mRNA/cDNA for IL1RAP Gene
- 9 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000072516 4697 nts (view in UCSC)
- ENST00000317757 5413 nts (view in UCSC)
- ENST00000342550 4490 nts (view in UCSC)
- ENST00000412080 795 nts (view in UCSC)
- ENST00000412504 4875 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL1RAP - Starting at $85 >
- * IL1RAP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL1RAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1RAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1RAP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1RAP
- Browse OriGene Inhibitory RNA Products For IL1RAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1RAP
Clone products for research
- Applied Biological Materials (abm): Clones for IL1RAP - Starting at $45 >
- * IL1RAP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205511
- MG223729
- MG223733
- MG224562
- MR205511
- MR205511L3
- MR205511L4
- MR223729
- MR223729L3
- MR223729L4
- MR223733
- MR223733L3
- MR223733L4
- MR224562
- MR224562L3
- MR224562L4
- RC208786
- RC208786L3
- RC208786L4
- RC211970
- RC211970L1
- RC211970L2
- RC211970L3
- RC211970L4
- RC229933
- RC229933L3
- RC229933L4
- RC230294
- RC230294L3
- RC230294L4
- RC230295
- RC230295L3
- RC230295L4
- RC230427
- RC230427L3
- RC230427L4
- RG208786
- RG211970
- RG229933
- RG230294
- RG230295
- RG230427
- RR213032
- RR213032L3
- RR213032L4
- RR217103
- MR205511L3V
- MR205511L4V
- MR223729L3V
- MR223729L4V
- MR223733L3V
- MR223733L4V
- MR224562L3V
- MR224562L4V
- RC208786L3V
- RC208786L4V
- RC211970L1V
- RC211970L2V
- RC211970L3V
- RC211970L4V
- RC229933L3V
- RC229933L4V
- RC230294L3V
- RC230294L4V
- RC230295L3V
- RC230295L4V
- RC230427L3V
- RC230427L4V
- RR213032L3V
- RR213032L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL1RAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1RAP
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Relevant External Links for IL1RAP Gene
- GeneLoc Exon Structure for
- IL1RAP
Expression for IL1RAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Oligodendrocyte progenitor cells(Najm FJ et. al. 2011)
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
- Spinal Cord (Nervous System)
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
- NULL (Integumentary System)
- Uncategorized
- Oligodendrocytes (Nervous System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for IL1RAP Gene
This gene is overexpressed in Whole Blood (x10.3) and Liver (x8.4).
This gene is overexpressed in Serum (57.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL1RAP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1RAP
SOURCE GeneReport for Unigene cluster for IL1RAP Gene:
Hs.478673mRNA Expression by UniProt/SwissProt for IL1RAP Gene:
Q9NPH3-IL1AP_HUMAN
Tissue specificity:
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
Evidence on tissue expression from TISSUES for IL1RAP Gene
- Liver(4.6)
- Nervous system(4.5)
- Skin(4.4)
- Spleen(2.6)
- Heart(2.3)
- Blood(2.3)
- Lung(2.3)
- Lymph node(2.1)
- Bone marrow(2.1)
- Intestine(2)
Primer products for research
-
OriGene qPCR primer pairs for IL1RAP
-
OriGene qPCR primer pairs and template standards for IL1RAP
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1RAP Gene
Orthologs for IL1RAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL1RAP 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL1RAP 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL1RAP 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il1rap 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il1rap 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1RAP 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL1RAP 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL1RAP 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IL1RAP 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il1rap 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CABZ01068246.1 30 |
|
OneToOne |
- Species where no ortholog for IL1RAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL1RAP Gene
- ENSEMBL:
- Gene Tree for IL1RAP (if available)
- TreeFam:
- Gene Tree for IL1RAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1RAP: view image
- Alliance of Genome Resources:
- Additional Orthologs for IL1RAP
Paralogs for IL1RAP Gene
Paralogs for IL1RAP Gene
(2) SIMAP similar genes for IL1RAP Gene using alignment to 5 proteins:
- IL1AP_HUMAN
- C9J1D9_HUMAN
- C9J9W1_HUMAN
- C9JT28_HUMAN
- H7C3W4_HUMAN
Variants for IL1RAP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1RAP Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116127803 | Benign: not provided | 190,656,067(+) |
G/A NM_001167931.2(IL1RAP):c.1524G>A (p.Pro508=) |
SYNONYMOUS | |
| rs142665925 | Benign: not provided | 190,627,396(+) |
C/T NM_002182.4(IL1RAP):c.849C>T (p.Thr283=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs145613403 | Uncertain Significance: Severe Myopia | 190,648,599(+) |
G/C NM_002182.4(IL1RAP):c.1607G>C (p.Gly536Ala) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON | |
| rs146492458 | Benign: not provided | 190,604,213(+) |
T/C NM_002182.4(IL1RAP):c.150T>C (p.Phe50=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs148996090 | Benign: not provided | 190,629,458(+) |
C/A NM_002182.4(IL1RAP):c.1011C>A (p.Ala337=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv131n6 | CNV | deletion | 16902084 |
| dgv2661n106 | CNV | deletion | 24896259 |
| esv1000745 | CNV | deletion | 20482838 |
| esv1433093 | CNV | deletion | 17803354 |
| esv1980229 | CNV | deletion | 18987734 |
| esv2440806 | CNV | deletion | 19546169 |
| esv2667728 | CNV | deletion | 23128226 |
| esv2677697 | CNV | deletion | 23128226 |
| esv2726382 | CNV | deletion | 23290073 |
| esv2726383 | CNV | deletion | 23290073 |
| esv3302996 | CNV | tandem duplication | 20981092 |
| esv34194 | CNV | loss | 18971310 |
| esv3563082 | CNV | deletion | 23714750 |
| esv3893843 | CNV | gain | 25118596 |
| esv4162 | CNV | loss | 18987735 |
| esv4944 | CNV | loss | 18987735 |
| esv6677 | CNV | gain | 19470904 |
| nsv1149600 | CNV | deletion | 26484159 |
| nsv829820 | CNV | gain | 17160897 |
| nsv956268 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.81;
47.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1RAP Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RAP Gene
Disorders for IL1RAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| marginal corneal ulcer |
|
|
| indolent plasma cell myeloma |
|
|
| chromosome xp21 deletion syndrome |
|
|
| psoriasis 14, pustular |
|
|
| familial cold autoinflammatory syndrome |
|
|
Search IL1RAP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1RAP
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1RAP Gene
Publications for IL1RAP Gene
- The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. (PMID: 9479509) Dale M … Nicklin MJ (Genomics 1998) 2 3 4 22
- A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687. (PMID: 17949817) Lu HL … Ting LP (Molecular immunology 2008) 3 4 22
- The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. (PMID: 12530978) Smith DE … Sims JE (Immunity 2003) 3 4 22
- Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. (PMID: 12781872) Jensen LE … Whitehead AS (Cellular signalling 2003) 3 4 22
- IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. (PMID: 10799889) Jensen LE … Whitehead AS (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22
ExternalLinks
Products for IL1RAP Gene
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- Biorbyt antibodies for IL1RAP
Sources for IL1RAP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
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- (21) IntAct
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- (24) DrugBank
- (25) HMDB
- (26) ASD
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
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- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
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- (78) MaxQB
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- (95) GTEx
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