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This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018]
IL1RAP (Interleukin 1 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL1RAP include Marginal Corneal Ulcer and Indolent Myeloma. Among its related pathways are Bacterial infections in CF airways and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and interleukin-1 receptor activity. An important paralog of this gene is IL1RAPL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002114 | interleukin-33 receptor activity | IEA | -- |
GO:0004908 | interleukin-1 receptor activity | IBA | 21873635 |
GO:0005149 | interleukin-1 receptor binding | IBA | 21873635 |
GO:0005515 | protein binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 7775431 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Toll-Like receptor Signaling Pathways |
Immune response IL-1 signaling pathway
.41
|
|
2 | IL-1 signaling pathway | ||
3 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
IL-1 beta-dependent CFTR expression
.43
|
4 | Cytokine Signaling in Immune system | ||
5 | PEDF Induced Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006954 | inflammatory response | TAS,IEA | -- |
GO:0006955 | immune response | TAS | 9065432 |
GO:0007165 | signal transduction | IEA | -- |
GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | ||
Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2451 | ||
Paclitaxel | Approved, Vet_approved | Pharma | Tubulin and Bcl2 inhibitor, Taxanes | 3701 | ||
Albumin-Bound Paclitaxel | Pharma | 3701 | ||||
Antibodies | Pharma | 7499 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL1RAP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL1RAP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL1RAP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il1rap 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il1rap 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1RAP 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL1RAP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL1RAP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL1RAP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il1rap 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01068246.1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712519 | Benign: not provided | 190,656,067(+) | G/A | SYNONYMOUS_VARIANT | |
728616 | Benign: not provided | 190,604,213(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
753656 | Likely Benign: not provided | 190,604,288(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
778293 | Benign: not provided | 190,627,396(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
790445 | Benign: not provided | 190,629,458(+) | C/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv131n6 | CNV | deletion | 16902084 |
dgv2661n106 | CNV | deletion | 24896259 |
esv1000745 | CNV | deletion | 20482838 |
esv1433093 | CNV | deletion | 17803354 |
esv1980229 | CNV | deletion | 18987734 |
esv2440806 | CNV | deletion | 19546169 |
esv2667728 | CNV | deletion | 23128226 |
esv2677697 | CNV | deletion | 23128226 |
esv2726382 | CNV | deletion | 23290073 |
esv2726383 | CNV | deletion | 23290073 |
esv3302996 | CNV | tandem duplication | 20981092 |
esv34194 | CNV | loss | 18971310 |
esv3563082 | CNV | deletion | 23714750 |
esv3893843 | CNV | gain | 25118596 |
esv4162 | CNV | loss | 18987735 |
esv4944 | CNV | loss | 18987735 |
esv6677 | CNV | gain | 19470904 |
nsv1149600 | CNV | deletion | 26484159 |
nsv829820 | CNV | gain | 17160897 |
nsv956268 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
marginal corneal ulcer |
|
|
indolent myeloma |
|
|
chromosome xp21 deletion syndrome |
|
|
muckle-wells syndrome |
|
|