This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chro... See more...

Aliases for IL1R1 Gene

Aliases for IL1R1 Gene

  • Interleukin 1 Receptor Type 1 2 3 5
  • CD121 Antigen-Like Family Member A 3 4
  • Interleukin-1 Receptor Type 1 3 4
  • Interleukin-1 Receptor Type I 3 4
  • Interleukin-1 Receptor Alpha 3 4
  • IL-1R-Alpha 3 4
  • IL-1RT-1 3 4
  • IL-1R-1 3 4
  • IL-1RT1 3 4
  • IL1RA 3 4
  • IL1R 3 4
  • P80 3 4
  • Interleukin 1 Receptor Alpha, Type I 3
  • Interleukin-1 Receptor, Type I 2
  • Interleukin 1 Receptor, Type I 2
  • CD121a Antigen 4
  • D2S1473 3
  • CD121A 3
  • IL1RT1 4

External Ids for IL1R1 Gene

Previous HGNC Symbols for IL1R1 Gene

  • IL1R
  • IL1RA

Previous GeneCards Identifiers for IL1R1 Gene

  • GC02P100634
  • GC02P101223
  • GC02P102285
  • GC02P102391
  • GC02P102228
  • GC02P102125
  • GC02P102053
  • GC02P102681
  • GC02P096534

Summaries for IL1R1 Gene

Entrez Gene Summary for IL1R1 Gene

  • This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

GeneCards Summary for IL1R1 Gene

IL1R1 (Interleukin 1 Receptor Type 1) is a Protein Coding gene. Diseases associated with IL1R1 include Schnitzler Syndrome and Aseptic Meningitis. Among its related pathways are Th1 Differentiation Pathway and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and protease binding. An important paralog of this gene is IL1RL2.

UniProtKB/Swiss-Prot Summary for IL1R1 Gene

  • Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).

Tocris Summary for IL1R1 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1R1 Gene

Additional gene information for IL1R1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1R1 Gene

Genomics for IL1R1 Gene

GeneHancer (GH) Regulatory Elements for IL1R1 Gene

Promoters and enhancers for IL1R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102139 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 507.9 +77.8 77827 5 NRF1 POLR2G POLR2A ZBTB26 REST ZBTB25 TGIF2 CTBP1 SKI ZSCAN9 IL1R1 piR-37824 IL1R1-AS1 CNOT11 IL1RL2 IL18R1 RF00017-3286
GH02J102060 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 503.2 -0.6 -573 6.2 EP300 TCF12 NRF1 POLR2G NCOR1 NONO JUND FOS KDM6A POLR2A IL1R1 HSALNG0017398 MAP4K4 IL1R1-AS1 IL1R2 IL18R1
GH02J102069 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 500.4 +5.6 5628 2 TCF12 NRF1 POLR2G PHF8 PHB2 ZBTB11 AFF1 TARDBP REST DNMT1 IL1R1 MAP4K4 RF00994-505
GH02J102103 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 524.3 +40.8 40804 3.7 TCF12 SIN3A JUND FOS EP300 KDM6A TCF7 ZBTB25 TEAD1 ZKSCAN8 IL1R1 IL1R1-AS1 IL1RL1 RF00994-505 piR-37824
GH02J102110 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 27.1 +49.9 49879 8.4 JUND FOS RELA TEAD1 ZKSCAN8 FOXA2 NR2F2 ZNF316 MAFF CEBPG IL1R1 IL1R1-AS1 IL1RL2 IL1RL1 MAP4K4 IL18R1 RF00994-505 piR-37824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL1R1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1R1

Top Transcription factor binding sites by QIAGEN in the IL1R1 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • GATA-1
  • GR
  • GR-alpha
  • IRF-7A
  • MyoD

Genomic Locations for IL1R1 Gene

Genomic Locations for IL1R1 Gene
chr2:102,064,544-102,179,874
(GRCh38/hg38)
Size:
115,331 bases
Orientation:
Plus strand
chr2:102,681,004-102,796,334
(GRCh37/hg19)
Size:
115,331 bases
Orientation:
Plus strand

Genomic View for IL1R1 Gene

Genes around IL1R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1R1 Gene

Proteins for IL1R1 Gene

  • Protein details for IL1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14778-IL1R1_HUMAN
    Recommended name:
    Interleukin-1 receptor type 1
    Protein Accession:
    P14778
    Secondary Accessions:
    • Q587I7

    Protein attributes for IL1R1 Gene

    Size:
    569 amino acids
    Molecular mass:
    65402 Da
    Quaternary structure:
    • The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.

    Three dimensional structures from OCA and Proteopedia for IL1R1 Gene

neXtProt entry for IL1R1 Gene

Post-translational modifications for IL1R1 Gene

  • A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
  • Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
  • Glycosylation at Asn100, Asn193, Asn233, Asn249, Asn263, and Asn297
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL1R1 Gene

Domains & Families for IL1R1 Gene

Gene Families for IL1R1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for IL1R1 Gene

Blocks:
  • Immunoglobulin subtype
  • Interleukin-1 receptor type I family signature
  • Interleukin-1 receptor type I and type II family signature
  • Interleukin-1 receptor type I precursor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL1R1 Gene

GenScript: Design optimal peptide antigens:
  • p80 (IL1R1_HUMAN)
  • Interleukin 1 receptor, type I (Q6NWP5_HUMAN)
  • Interleukin 1 receptor, type I (Q6NWP6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P14778

UniProtKB/Swiss-Prot:

IL1R1_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1R1: view

Function for IL1R1 Gene

Molecular function for IL1R1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
GENATLAS Biochemistry:
interleukin 1,receptor type 1,high affinity,expressed in T cell and fibroblast,with two alternatively spliced isoforms,secreted and cytoplasmic,forming a complex after induction of IL1 and recruitment of IRAK through its association with IL1RAP

Phenotypes From GWAS Catalog for IL1R1 Gene

Gene Ontology (GO) - Molecular Function for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004888 transmembrane signaling receptor activity TAS 2530587
GO:0004908 interleukin-1 receptor activity IDA,IEA 10383454
GO:0004909 interleukin-1, type I, activating receptor activity IEA --
GO:0005161 platelet-derived growth factor receptor binding IPI 16477012
genes like me logo Genes that share ontologies with IL1R1: view
genes like me logo Genes that share phenotypes with IL1R1: view

Animal Models for IL1R1 Gene

MGI Knock Outs for IL1R1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1R1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1R1 Gene

Localization for IL1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1R1 Gene

Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1R1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
endoplasmic reticulum 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2530587
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with IL1R1: view

Pathways & Interactions for IL1R1 Gene

PathCards logo

SuperPathways for IL1R1 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.51
.47
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
3 IL-1 signaling pathway
4 Akt Signaling
.60
.60
.55
5 Bacterial infections in CF airways
.78
.78
.43
genes like me logo Genes that share pathways with IL1R1: view

Pathways by source for IL1R1 Gene

6 GeneGo (Thomson Reuters) pathways for IL1R1 Gene
  • Bacterial infections in CF airways
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • IL-1 beta-dependent CFTR expression
  • Immune response Bacterial infections in normal airways
  • Immune response IL-1 signaling pathway
3 Tocris pathways for IL1R1 Gene
21 Qiagen pathways for IL1R1 Gene
  • 14-3-3 Induced Apoptosis
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Glucocorticoid Receptor Signaling
  • HMGB1 Pathway

SIGNOR curated interactions for IL1R1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 9120302
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 1833184
GO:0019221 cytokine-mediated signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with IL1R1: view

Drugs & Compounds for IL1R1 Gene

(86) Drugs for IL1R1 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anakinra Approved Pharma antagonist, Target IL-1 receptor antagonist 0
Foreskin fibroblast (neonatal) Approved Pharma Target, agonist 0
OMS-103HP Investigational Pharma Target 0
SD118 Investigational Pharma Target 0
AF 12198 Pharma Type I IL-1 receptor antagonist, Potent, selective human type I IL-1 receptor antagonist 0

(48) Additional Compounds for IL1R1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5

(5) Tocris Compounds for IL1R1 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8

(4) ApexBio Compounds for IL1R1 Gene

Compound Action Cas Number
AF 12198 Type I IL-1 receptor antagonist 185413-30-3
Dexamethasone Sodium Phosphate 55203-24-2
Ro 26-4550 trifluoroacetate reversible inhibitor of interleukin-2 (IL-2) binding to its receptor 1217448-66-2
YM 90709 163769-88-8
genes like me logo Genes that share compounds with IL1R1: view

Transcripts for IL1R1 Gene

mRNA/cDNA for IL1R1 Gene

10 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1R1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1R1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for IL1R1 Gene

GeneLoc Exon Structure for
IL1R1

Expression for IL1R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL1R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL1R1 Gene

This gene is overexpressed in Placenta (47.2), Liver (14.3), and Gallbladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1R1 Gene



Protein tissue co-expression partners for IL1R1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1R1

SOURCE GeneReport for Unigene cluster for IL1R1 Gene:

Hs.701982

mRNA Expression by UniProt/SwissProt for IL1R1 Gene:

P14778-IL1R1_HUMAN
Tissue specificity: Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.

Evidence on tissue expression from TISSUES for IL1R1 Gene

  • Blood(4.5)
  • Liver(4.5)
  • Nervous system(4.5)
  • Lung(3)
  • Spleen(3)
  • Lymph node(2.6)
  • Intestine(2.5)
  • Skin(2.5)
  • Heart(2.4)
  • Bone marrow(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with IL1R1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1R1 Gene

Orthologs for IL1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1R1 31 30
  • 98.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL1R1 31 30
  • 84.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL1R1 31 30
  • 79.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il1r1 17 31 30
  • 75.41 (n)
rat
(Rattus norvegicus)
Mammalia Il1r1 30
  • 75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL1R1 31
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1R1 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL1RL2 30
  • 57.94 (n)
IL1R1 31
  • 41 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il1r1 30
  • 53.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799204 30
  • 44.18 (n)
CABZ01054965.1 31
  • 25 (a)
ManyToMany
CABZ01054962.1 31
  • 25 (a)
ManyToMany
Species where no ortholog for IL1R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1R1 Gene

ENSEMBL:
Gene Tree for IL1R1 (if available)
TreeFam:
Gene Tree for IL1R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL1R1: view image

Paralogs for IL1R1 Gene

(3) SIMAP similar genes for IL1R1 Gene using alignment to 13 proteins:

  • IL1R1_HUMAN
  • B8ZZ73_HUMAN
  • B8ZZW4_HUMAN
  • B9A040_HUMAN
  • C9J3W8_HUMAN
  • C9J686_HUMAN
  • C9JQ36_HUMAN
  • C9JW84_HUMAN
  • C9JWB2_HUMAN
  • F8WF92_HUMAN
  • H7BZM5_HUMAN
  • Q6NWP5_HUMAN
  • Q6NWP6_HUMAN
genes like me logo Genes that share paralogs with IL1R1: view

Variants for IL1R1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1R1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs2228139 - p.Ala124Gly
rs28362304 - p.Thr344Met

Additional dbSNP identifiers (rs#s) for IL1R1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL1R1 Gene

Variant ID Type Subtype PubMed ID
dgv6981n54 CNV loss 21841781
esv2483943 CNV deletion 19546169
esv25260 CNV loss 19812545
esv3591781 CNV loss 21293372
esv3591783 CNV loss 21293372
nsv2852 CNV deletion 18451855
nsv458718 CNV loss 19166990
nsv518990 CNV gain 19592680

Variation tolerance for IL1R1 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL1R1 Gene

Human Gene Mutation Database (HGMD)
IL1R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1R1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1R1 Gene

Disorders for IL1R1 Gene

MalaCards: The human disease database

(70) MalaCards diseases for IL1R1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schnitzler syndrome
  • chronic urticaria with gammapathy
aseptic meningitis
  • acute aseptic meningitis
cinca syndrome
  • cinca
muckle-wells syndrome
  • mws
adult-onset still's disease
  • adult onset still's disease
- elite association - COSMIC cancer census association via MalaCards
Search IL1R1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL1R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL1R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1R1 Gene

Publications for IL1R1 Gene

  1. Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (PMID: 19117745) Vasakova M … Striz I (Respiratory medicine 2009) 3 23 41 54
  2. Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist. (PMID: 19702713) Khalilzadeh O … Amirzargar A (Clinical & experimental ophthalmology 2009) 3 23 41 54
  3. Retinopathy and nephropathy in type 1 diabetic patients--association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes. (PMID: 20120526) Bućan K … Znaor L (Collegium antropologicum 2009) 3 23 41 54
  4. Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population. (PMID: 17257312) Kaur G … Mehra NK (Tissue antigens 2007) 3 23 41 54
  5. FokI polymorphism, vitamin D receptor, and interleukin-1 receptor haplotypes are associated with type 1 diabetes in the Dalmatian population. (PMID: 16258158) Zemunik T … Terzic J (The Journal of molecular diagnostics : JMD 2005) 3 23 41 54

Products for IL1R1 Gene

Sources for IL1R1 Gene