Aliases for IL1R1 Gene
External Ids for IL1R1 Gene
Previous HGNC Symbols for IL1R1 Gene
Previous GeneCards Identifiers for IL1R1 Gene
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
GeneCards Summary for IL1R1 Gene
IL1R1 (Interleukin 1 Receptor Type 1) is a Protein Coding gene. Diseases associated with IL1R1 include Schnitzler Syndrome and Cinca Syndrome. Among its related pathways are Monoamine Transport and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and protease binding. An important paralog of this gene is IL1RL2.
UniProtKB/Swiss-Prot Summary for IL1R1 Gene
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.