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Aliases for IL1F10 Gene

Aliases for IL1F10 Gene

  • Interleukin 1 Family Member 10 2 3 5
  • Interleukin-1 Receptor Antagonist FKSG75 2 3
  • Family Of Interleukin 1-Theta 3 4
  • Interleukin-1 HY2 3 4
  • Interleukin-38 3 4
  • FIL1 Theta 3 4
  • IL-1 Theta 3 4
  • IL-1HY2 3 4
  • IL1HY2 3 4
  • IL-38 3 4
  • Interleukin-1 Receptor Antagonist-Like FIL1 Theta 3
  • Interleukin 1 Family, Member 10 (Theta) 2
  • Interleukin 1 Family Member 10 (Theta) 3
  • IL-1F10 (Canonical Form IL-1F10a) 3
  • Interleukin-1 Family Member 10 3
  • Interleukin-1 Theta 4
  • FIL1- Theta 2
  • FIL1-Theta 3
  • IL1-Theta 3
  • IL-1F10 4
  • FKSG75 3
  • FIL1T 4
  • IL38 4

External Ids for IL1F10 Gene

Previous GeneCards Identifiers for IL1F10 Gene

  • GC02P111031
  • GC02P111746
  • GC02P113732
  • GC02P113920
  • GC02P113541
  • GC02P113825
  • GC02P106280

Summaries for IL1F10 Gene

Entrez Gene Summary for IL1F10 Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1F10 Gene

IL1F10 (Interleukin 1 Family Member 10) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36RN.

UniProtKB/Swiss-Prot for IL1F10 Gene

  • Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.

Gene Wiki entry for IL1F10 Gene

Additional gene information for IL1F10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1F10 Gene

Genomics for IL1F10 Gene

GeneHancer (GH) Regulatory Elements for IL1F10 Gene

Promoters and enhancers for IL1F10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J113071 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 +4.7 4652 2.2 ZNF316 BACH1 MAFG ZMYM3 EMSY MAFK IL1F10 IL36B IL1RN PSD4 IL36RN IL36A IL37 NDUFB4P6 CDK8P2 GC02P113676
GH02J113069 Enhancer 0.8 ENCODE dbSUPER 650.7 +1.3 1289 0.1 SCRT1 PKNOX1 RFX1 DPF2 ZNF217 GATA3 CTBP1 CREB1 IL1F10 IL36B GC02P113676
GH02J113067 Promoter 0.5 EPDnew 650.7 0.0 -19 0.1 IL1F10 IL36RN
GH02J113126 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 9.9 +61.3 61283 5.1 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 NFKBIZ PAF1 IL1RN PSD4 PAX8-AS1 RNU6-1180P ENSG00000270019 WASH2P PAX8 IL1F10 IL36RN LINC01191
GH02J113123 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +57.0 57014 3.2 PKNOX1 MLX FOS RUNX3 JUNB REST KAT8 SREBF1 NFIL3 SSRP1 IL1RN IL36B PSD4 IL1B RNU6-1180P PAX8-AS1 PAX8 IL1F10 IL36G IL1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL1F10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL1F10 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for IL1F10 Gene

Genomic Locations for IL1F10 Gene
chr2:113,067,970-113,075,850
(GRCh38/hg38)
Size:
7,881 bases
Orientation:
Plus strand
chr2:113,825,547-113,833,427
(GRCh37/hg19)
Size:
7,881 bases
Orientation:
Plus strand

Genomic View for IL1F10 Gene

Genes around IL1F10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1F10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1F10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1F10 Gene

Proteins for IL1F10 Gene

  • Protein details for IL1F10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWZ1-IL1FA_HUMAN
    Recommended name:
    Interleukin-1 family member 10
    Protein Accession:
    Q8WWZ1
    Secondary Accessions:
    • Q53SR9
    • Q56AT8
    • Q7RTZ5
    • Q969H5
    • Q9BYX1

    Protein attributes for IL1F10 Gene

    Size:
    152 amino acids
    Molecular mass:
    16943 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL1F10 Gene

    Alternative splice isoforms for IL1F10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1F10 Gene

Post-translational modifications for IL1F10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL1F10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL1F10 Gene

Domains & Families for IL1F10 Gene

Gene Families for IL1F10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IL1F10 Gene

Suggested Antigen Peptide Sequences for IL1F10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWZ1

UniProtKB/Swiss-Prot:

IL1FA_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1F10: view

Function for IL1F10 Gene

Molecular function for IL1F10 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.

Phenotypes From GWAS Catalog for IL1F10 Gene

Gene Ontology (GO) - Molecular Function for IL1F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding IBA --
genes like me logo Genes that share ontologies with IL1F10: view
genes like me logo Genes that share phenotypes with IL1F10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL1F10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL1F10 Gene

Localization for IL1F10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1F10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1F10 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for IL1F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IL1F10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1F10 Gene

Pathways & Interactions for IL1F10 Gene

genes like me logo Genes that share pathways with IL1F10: view

Pathways by source for IL1F10 Gene

1 R&D Systems pathway for IL1F10 Gene

Interacting Proteins for IL1F10 Gene

Gene Ontology (GO) - Biological Process for IL1F10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0071345 cellular response to cytokine stimulus TAS --
genes like me logo Genes that share ontologies with IL1F10: view

No data available for SIGNOR curated interactions for IL1F10 Gene

Drugs & Compounds for IL1F10 Gene

No Compound Related Data Available

Transcripts for IL1F10 Gene

mRNA/cDNA for IL1F10 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1F10 Gene

Interleukin 1 family, member 10 (theta):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL1F10 Gene

No ASD Table

Relevant External Links for IL1F10 Gene

GeneLoc Exon Structure for
IL1F10
ECgene alternative splicing isoforms for
IL1F10

Expression for IL1F10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL1F10 Gene

mRNA differential expression in normal tissues according to GTEx for IL1F10 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.3) and Skin - Not Sun Exposed (Suprapubic) (x24.9).

Protein differential expression in normal tissues from HIPED for IL1F10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1F10 Gene



Protein tissue co-expression partners for IL1F10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL1F10 Gene:

IL1F10

SOURCE GeneReport for Unigene cluster for IL1F10 Gene:

Hs.306974

mRNA Expression by UniProt/SwissProt for IL1F10 Gene:

Q8WWZ1-IL1FA_HUMAN
Tissue specificity: Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.

Evidence on tissue expression from TISSUES for IL1F10 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with IL1F10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1F10 Gene

Orthologs for IL1F10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL1F10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1F10 34 33
  • 99.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL1F10 34 33
  • 85.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL1F10 34 33
  • 84.56 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1f10 33
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Il1f10 16 34 33
  • 82.34 (n)
oppossum
(Monodelphis domestica)
Mammalia IL1F10 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1F10 34
  • 68 (a)
OneToOne
Species where no ortholog for IL1F10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL1F10 Gene

ENSEMBL:
Gene Tree for IL1F10 (if available)
TreeFam:
Gene Tree for IL1F10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL1F10: view image

Paralogs for IL1F10 Gene

Paralogs for IL1F10 Gene

(3) SIMAP similar genes for IL1F10 Gene using alignment to 2 proteins:

  • IL1FA_HUMAN
  • H7BXV3_HUMAN
genes like me logo Genes that share paralogs with IL1F10: view

Variants for IL1F10 Gene

Sequence variations from dbSNP and Humsavar for IL1F10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000241950 -- 113,071,816(+) TTTTTT/TTTTTTT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000951100 -- 113,066,398(+) CC/C upstream_transcript_variant
rs1001509585 -- 113,070,508(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001677746 -- 113,075,585(+) T/C 3_prime_UTR_variant
rs1001980126 -- 113,070,318(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL1F10 Gene

Variant ID Type Subtype PubMed ID
nsv2881 CNV deletion 18451855
nsv582710 CNV gain 21841781

Variation tolerance for IL1F10 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL1F10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1F10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1F10 Gene

Disorders for IL1F10 Gene

Additional Disease Information for IL1F10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IL1F10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL1F10 Gene

Publications for IL1F10 Gene

  1. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. (PMID: 11747621) Bensen JT … Bowden DW (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001) 2 3 4 22 58
  2. The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis. (PMID: 20141484) Jung MY … Chung JH (Scandinavian journal of rheumatology 2010) 3 22 44 58
  3. A sequence-based map of the nine genes of the human interleukin-1 cluster. (PMID: 11991722) Nicklin MJ … Kornman K (Genomics 2002) 2 3 4 58
  4. Genomic organization of the interleukin-1 locus. (PMID: 11991723) Taylor SL … Sims JE (Genomics 2002) 2 3 4 58
  5. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. (PMID: 11278614) Lin H … Ford JE (The Journal of biological chemistry 2001) 3 4 22 58

Products for IL1F10 Gene

Sources for IL1F10 Gene

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