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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer, Hereditary Diffuse and Toxic Shock Syndrome. Among its related pathways are Monoamine Transport and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and interleukin-1 receptor binding. An important paralog of this gene is IL36RN.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA,IMP | 2989698 |
GO:0005149 | interleukin-1 receptor binding | IEA,NAS | 1919436 |
GO:0005178 | integrin binding | IDA | 29030430 |
GO:0005515 | protein binding | IPI | 15817483 |
GO:0019904 | protein domain specific binding | IPI | 16575408 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IMP | 3493774 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005764 | lysosome | IEA | -- |
GO:0005776 | autophagosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | Toll-Like receptor Signaling Pathways |
Immune response IL-1 signaling pathway
.41
|
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | Toll-like Receptor Signaling Pathway | ||
5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IMP | 21147091 |
GO:0000187 | activation of MAPK activity | IDA | 10748004 |
GO:0001660 | fever generation | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | NAS | 16477012 |
GO:0002437 | inflammatory response to antigenic stimulus | IBA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
canakinumab | Approved, Investigational | Pharma | Target, binder, immunotherapy, antibody | Immunotherapies | 0 | |
Rilonacept | Approved, Investigational | Pharma | Target, binder | 25 | ||
Minocycline | Approved, Investigational | Pharma | Target, modulator | 229 | ||
Clodronate | Approved, Investigational, Vet_approved | Pharma | 12 | |||
Infliximab | Approved | Pharma | 469 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
AS 101 |
|
106566-58-9 |
|
|
||
GIT 27 |
|
6501-72-0 |
|
|
Compound | Action | Cas Number |
---|---|---|
AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
Compound | Action | Cas Number |
---|---|---|
Diacerein | 13739-02-1 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||
SP6: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il1b 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il1b 30 |
|
||
Cow (Bos Taurus) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL1B 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL-1BETA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il1b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il1b 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
772847 | Benign: not provided | 112,833,585(-) | G/A | INTRON_VARIANT | |
779077 | Benign: not provided | 112,833,504(-) | G/A | SYNONYMOUS_VARIANT | |
780097 | Benign: not provided | 112,833,537(-) | G/A | SYNONYMOUS_VARIANT | |
869137 | Association: Antisynthetase syndrome | 112,832,813(-) | G/A | SYNONYMOUS_VARIANT | |
869138 | Association: Antisynthetase syndrome | 112,837,290(-) | A/G |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric cancer, hereditary diffuse |
|
|
toxic shock syndrome |
|
|
gingivitis |
|
|
bacterial meningitis |
|
|
muckle-wells syndrome |
|