IL1B Gene (Protein Coding)

Interleukin 1 Beta

GC02M112829
GIFtS:
49
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferatio... See more...

Aliases for IL1B Gene

Aliases for IL1B Gene

  • Interleukin 1 Beta 2 3 5
  • IL1F2 2 3 4
  • Interleukin-1 Beta 3 4
  • IL-1 Beta 3 4
  • Catabolin 3 4
  • IL1-BETA 2 3
  • Pro-Interleukin-1-Beta 3
  • Preinterleukin 1 Beta 3
  • Interleukin 1beta 3
  • IL1beta 3
  • IL-1B 2
  • IL-1 3
  • IL1B 5

External Ids for IL1B Gene

Previous GeneCards Identifiers for IL1B Gene

  • GC02M110793
  • GC02M111508
  • GC02M113494
  • GC02M113682
  • GC02M113303
  • GC02M106041
  • GC02M113587

Summaries for IL1B Gene

Entrez Gene Summary for IL1B Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]

GeneCards Summary for IL1B Gene

IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer, Hereditary Diffuse and Toxic Shock Syndrome. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and interleukin-1 receptor binding. An important paralog of this gene is IL37.

UniProtKB/Swiss-Prot Summary for IL1B Gene

  • Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).

Tocris Summary for IL1B Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL1B Gene

Additional gene information for IL1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1B Gene

Genomics for IL1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J112835 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 264.7 +1.0 980 3.7 NFIC YY1 CEBPB FEZF1 EP300 MAFF RXRA SAP130 DMAP1 ZNF316 IL1B lnc-IL1A-3 IL1A IL37 ENSG00000287937
GH02J112875 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 87.6 -44.1 -44072 11 BCLAF1 SP1 ZNF207 ZNF654 ZNF580 CEBPA NFIC ZIC2 CHD4 BCL11A lnc-IL1B-2 piR-47728 IL1B IL1RN IL1A IL36B IL37 IL36G CKAP2L CDK8P2
GH02J112811 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 75.3 +23.6 23608 4.5 BCLAF1 SP1 BCL11A TARDBP TRIM22 HOMEZ NR2C1 SMAD4 IRF4 ETV4 HSALNG0018001-002 IL1B IL1RN IL1A IL37 IL36B IL36G CKAP2L IL36RN HSALNG0018001-001
GH02J112792 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 58.9 +42.1 42076 4.4 NCOR1 MYC ZNF592 CEBPA ATF3 CEBPB REST HES1 BHLHE40 MNT lnc-IL1A-4 IL1B IL1RN ANAPC1 IL1A CKAP2L CBWD2 RGPD8 IL36G ZC3H6
GH02J112799 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 57.1 +37.8 37842 2.8 IKZF1 BCL11A TAL1 SPI1 BATF STAT5A TCF12 MTA2 MTA3 TEAD4 HSALNG0018000 lnc-IL1A-5 IL1B IL1RN CKAP2L IL36B IL1A IL36G IL37 ENSG00000237753
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1B

Top Transcription factor binding sites by QIAGEN in the IL1B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • GR-alpha
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT3

Genomic Locations for IL1B Gene

Latest Assembly
chr2:112,829,751-112,836,843
(GRCh38/hg38)
Size:
7,093 bases
Orientation:
Minus strand

Previous Assembly
chr2:113,587,328-113,594,356
(GRCh37/hg19 by Entrez Gene)
Size:
7,029 bases
Orientation:
Minus strand

chr2:113,587,328-113,594,480
(GRCh37/hg19 by Ensembl)
Size:
7,153 bases
Orientation:
Minus strand

Genomic View for IL1B Gene

Genes around IL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL1B Gene

Proteins for IL1B Gene

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  • Protein details for IL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01584-IL1B_HUMAN
    Recommended name:
    Interleukin-1 beta
    Protein Accession:
    P01584
    Secondary Accessions:
    • Q53X59
    • Q53XX2
    • Q7M4S7
    • Q7RU01
    • Q96HE5
    • Q9UCT6

    Protein attributes for IL1B Gene

    Size:
    269 amino acids
    Molecular mass:
    30748 Da
    Quaternary structure:
    • Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422). Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430). Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form (PubMed:32272059). Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059). Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059).
    Miscellaneous:
    • The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.

    Three dimensional structures from OCA and Proteopedia for IL1B Gene

neXtProt entry for IL1B Gene

Protein Expression for IL1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL1B Gene

  • Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Protein products for research

Assay products for research

No data available for DME Specific Peptides for IL1B Gene

Domains & Families for IL1B Gene

Gene Families for IL1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for IL1B Gene

InterPro:
Blocks:
  • IL1/HBGF family signature
  • Interleukin-1 precursor family signature
  • Interleukin-1 alpha/beta precursor family signature
  • Interleukin-1 propeptide
  • Interleukin-1 beta precursor signature

Suggested Antigen Peptide Sequences for IL1B Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-1 beta (B5BUQ8_HUMAN)
  • Catabolin (IL1B_HUMAN)
  • Interleukin 1 beta (O43645_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01584

UniProtKB/Swiss-Prot:

IL1B_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL1B: view

Function for IL1B Gene

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Molecular function for IL1B Gene

UniProtKB/Swiss-Prot Function:
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
UniProtKB/Swiss-Prot Induction:
By LPS (PubMed:15192144). Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components in macrophages; EsxA is the most potent activator tested (at protein level) (PubMed:20148899). In pancreatic islets, release is increased by high glucose treatment. In pancreatic islets and macrophages, release is also increased by endocannabinoid anandamide/AEA (PubMed:23955712).
GENATLAS Biochemistry:
interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility factor for inflammatory bowel diseaes

LifeMap Function Summary for IL1B Gene

IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IL1B Gene

Gene Ontology (GO) - Molecular Function for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,TAS 28720735
GO:0005149 interleukin-1 receptor binding IEA,NAS 1919436
GO:0005178 integrin binding IDA 29030430
GO:0005515 protein binding IPI 15817483
GO:0019904 protein domain specific binding IPI 16575408
genes like me logo Genes that share ontologies with IL1B: view
genes like me logo Genes that share phenotypes with IL1B: view

Human Phenotype Ontology for IL1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL1B Gene

MGI Knock Outs for IL1B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL1B Gene

Localization for IL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1B Gene

Cytoplasm, cytosol. Lysosome. Secreted, extracellular exosome. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood (PubMed:24201029). On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (PubMed:24201029). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (By similarity). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (PubMed:11728343). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (By similarity). 6. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion, and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 (PubMed:32272059). These mechanisms may not be mutually exclusive. {ECO:0000250 UniProtKB:P10749, ECO:0000269 PubMed:11728343, ECO:0000269 PubMed:15192144, ECO:0000269 PubMed:32272059, ECO:0000305 PubMed:24201029}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL1B gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
lysosome 4
cytoskeleton 3
mitochondrion 3
peroxisome 3
endoplasmic reticulum 3
endosome 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IMP 3493774
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with IL1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1B Gene

Pathways & Interactions for IL1B Gene

PathCards logo

SuperPathways for IL1B Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Lipid and atherosclerosis
.32
Chagas disease
.31
3 Toll-Like receptor Signaling Pathways
NOD-like Receptor Signaling Pathways
.59
Toll-Like receptor Signaling Pathways
.59
Inflammasome Activation Pathways
.51
IL-1 Family Signaling Pathways
.43
Immune response IL-1 signaling pathway
.41
4 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
5 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
genes like me logo Genes that share pathways with IL1B: view

Pathways by source for IL1B Gene

6 GeneGo (Thomson Reuters) pathways for IL1B Gene
  • Bacterial infections in CF airways
  • IL-1 beta-dependent CFTR expression
  • Immune response Bacterial infections in normal airways
  • Immune response IL-1 signaling pathway
  • Immune response MIF in innate immunity response
3 Tocris pathways for IL1B Gene
38 Qiagen pathways for IL1B Gene
  • 14-3-3 Induced Apoptosis
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Cytokine Network
1 Cell Signaling Technology pathway for IL1B Gene
1 GeneTex pathway for IL1B Gene

SIGNOR curated interactions for IL1B Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0000187 activation of MAPK activity IDA 10748004
GO:0001660 fever generation IEA --
GO:0001934 positive regulation of protein phosphorylation NAS 16477012
GO:0002711 positive regulation of T cell mediated immunity IC 1919436
genes like me logo Genes that share ontologies with IL1B: view

Drugs & Compounds for IL1B Gene

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(105) Drugs for IL1B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
canakinumab Approved, Investigational Pharma Target, binder, immunotherapy, antibody Immunotherapies 0
Rilonacept Approved, Investigational Pharma Target, binder 25
Minocycline Approved, Investigational Pharma Target, modulator 240
Clodronate Approved, Investigational, Vet_approved Pharma 12
Infliximab Approved Pharma 485

(66) Additional Compounds for IL1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AS 101
106566-58-9
GIT 27
6501-72-0

(4) Tocris Compounds for IL1B Gene

Compound Action Cas Number
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release 106566-58-9
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines 6501-72-0
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1

(1) ApexBio Compounds for IL1B Gene

Compound Action Cas Number
Diacerein 13739-02-1
genes like me logo Genes that share compounds with IL1B: view

Transcripts for IL1B Gene

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mRNA/cDNA for IL1B Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1B

Alternative Splicing Database (ASD) splice patterns (SP) for IL1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -

Relevant External Links for IL1B Gene

GeneLoc Exon Structure for
IL1B

Expression for IL1B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL1B Gene

mRNA expression in normal human tissues for IL1B Gene
mRNA expression by BioGPS for IL1B GenemRNA expression by GTEx for IL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1B Gene

This gene is overexpressed in Whole Blood (x17.8) and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for IL1B Gene

This gene is overexpressed in Pancreas (44.9) and Bone (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1B Gene



Protein tissue co-expression partners for IL1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1B

SOURCE GeneReport for Unigene cluster for IL1B Gene:

Hs.126256

mRNA Expression by UniProt/SwissProt for IL1B Gene:

P01584-IL1B_HUMAN
Tissue specificity: Expressed in activated monocytes/macrophages (at protein level).

Evidence on tissue expression from TISSUES for IL1B Gene

  • Blood(4.9)
  • Lung(4.8)
  • Skin(4.6)
  • Nervous system(3.8)
  • Intestine(3.7)
  • Bone marrow(3.7)
  • Spleen(3.7)
  • Liver(3.7)
  • Lymph node(3.6)
  • Heart(3.3)
  • Kidney(3.2)
  • Muscle(3.1)
  • Stomach(3)
  • Bone(2.9)
  • Adrenal gland(2.9)
  • Pancreas(2.8)
  • Eye(2.7)
  • Urine(2.5)
  • Saliva(2.4)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with IL1B: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1B Gene

Orthologs for IL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL1B 29 30
  • 99.5 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Il1b 29 16 30
  • 78.45 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL1B 29 30
  • 78.28 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il1b 29
  • 76.32 (n)
Cow
(Bos Taurus)
 Mammalia IL1B 29 30
  • 75.38 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia IL1B 30
  • 46 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia IL1B 30
  • 39 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves IL-1BETA 30
  • 25 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia il1b 29
  • 48.77 (n)
Zebrafish
(Danio rerio)
 Actinopterygii il1b 30
  • 21 (a)
 OneToOne
Species where no ortholog for IL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL1B Gene

ENSEMBL:
Gene Tree for IL1B (if available)
TreeFam:
Gene Tree for IL1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL1B: view image
Alliance of Genome Resources:
Additional Orthologs for IL1B

Paralogs for IL1B Gene

Paralogs for IL1B Gene

(1) SIMAP similar genes for IL1B Gene using alignment to 5 proteins:

  • IL1B_HUMAN
  • B5BUQ8_HUMAN
  • C9JSC2_HUMAN
  • C9JVK0_HUMAN
  • C9JWV2_HUMAN
genes like me logo Genes that share paralogs with IL1B: view

Variants for IL1B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
869137 Association: Antisynthetase syndrome 112,832,813(-) G/A
NM_000576.3(IL1B):c.315C>T (p.Phe105=) 		SYNONYMOUS
869138 Association: Antisynthetase syndrome 112,837,290(-) A/G
NC_000002.12:g.112837290A>G
869139 Association: Antisynthetase syndrome 112,838,252(-) C/G
NC_000002.12:g.112838252C>G
916339 Likely Benign: not provided 112,830,541(-) C/T
NM_000576.3(IL1B):c.630G>A (p.Lys210=) 		SYNONYMOUS
rs1143627 Risk Factor: Gastric cancer susceptibility after h. pylori infection 112,836,810(-) G/A
NM_000576.2(IL1B):c.-118C>T 		GENIC_UPSTREAM_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for IL1B Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL1B Gene

Human Gene Mutation Database (HGMD)
IL1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL1B
Leiden Open Variation Database (LOVD)
IL1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL1B Gene

Disorders for IL1B Gene

MalaCards: The human disease database

(521) MalaCards diseases for IL1B Gene - From: OMI, GTR, COP, and GCD

Disorder Aliases PubMed IDs
gastric cancer, hereditary diffuse
  • hdgc
toxic shock syndrome
  • toxic shock
gingivitis
  • acute gingivitis
covid-19
  • 2019 novel coronavirus
bacterial meningitis
  • meningitis, bacterial
- elite association - COSMIC cancer census association via MalaCards
Search IL1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL1B Gene

Publications for IL1B Gene

  1. Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 20188863) Taype CA … Shaw MA (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010) 3 22 40
  2. The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. (PMID: 20060205) Czerny B … Pawlik A (European journal of obstetrics, gynecology, and reproductive biology 2010) 3 22 40
  3. Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PMID: 20486195) Chou IC … Tsai FJ (Journal of clinical laboratory analysis 2010) 3 22 40
  4. The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma. (PMID: 20467172) Okamoto K … Yuasa I (Internal medicine (Tokyo, Japan) 2010) 3 22 40
  5. Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. (PMID: 19904560) Qian N … Hu Z (Journal of cancer research and clinical oncology 2010) 3 22 40

ExternalLinks

View latest publications for IL1B gene in Mastermind

Products for IL1B Gene

  • Addgene plasmids for IL1B