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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferatio... See more...
Aliases for IL1B Gene
Aliases for IL1B Gene
External Ids for IL1B Gene
- HGNC: 5992
- Entrez Gene: 3553
- Ensembl: ENSG00000125538
- OMIM: 147720
- UniProtKB: P01584
Previous GeneCards Identifiers for IL1B Gene
- GC02M110793
- GC02M111508
- GC02M113494
- GC02M113682
- GC02M113303
- GC02M106041
- GC02M113587
Summaries for IL1B Gene
-
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1B Gene
IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer, Hereditary Diffuse and Toxic Shock Syndrome. Among its related pathways are Monoamine Transport and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and interleukin-1 receptor binding. An important paralog of this gene is IL36RN.
UniProtKB/Swiss-Prot Summary for IL1B Gene
-
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL1B Gene
- HGNC(5992)
- Entrez Gene(3553)
- Ensembl(ENSG00000125538)
- OMIM(147720)
- UniProtKB(P01584)
- Open Targets Platform(ENSG00000125538)
- Monarch Initiative
- Search for IL1B at DataMed
- Search for IL1B at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1B Gene
Genomics for IL1B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1B
- Top Transcription factor binding sites by QIAGEN in the IL1B gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- COUP
- COUP-TF
- COUP-TF1
- GR-alpha
- HNF-4alpha1
- HNF-4alpha2
- STAT3
Genomic Locations for IL1B Gene
Genomic Locations for IL1B Gene
- chr2:112,829,751-112,836,843
- (GRCh38/hg38)
- Size:
- 7,093 bases
- Orientation:
- Minus strand
- chr2:113,587,328-113,594,480
- (GRCh37/hg19)
- Size:
- 7,153 bases
- Orientation:
- Minus strand
Genomic View for IL1B Gene
Genes around IL1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q14.1 by HGNC
- 2q14.1 by Entrez Gene
- 2q14.1 by Ensembl
IL1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1B Gene
Proteins for IL1B Gene
-
Protein details for IL1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01584-IL1B_HUMAN
- Recommended name:
- Interleukin-1 beta
- Protein Accession:
- P01584
- Q53X59
- Q53XX2
- Q7M4S7
- Q7RU01
- Q96HE5
- Q9UCT6
Protein attributes for IL1B Gene
- Size:
- 269 amino acids
- Molecular mass:
- 30748 Da
- Quaternary structure:
-
- Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422). Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430).
- Miscellaneous:
-
- The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
Protein Expression for IL1B Gene
Post-translational modifications for IL1B Gene
- Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IL1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Interleukin 1ß Antibody and Immunotag™ IL1B Antibody
- NSJ Bioreagents IL1 beta Antibody
-
BioLegend
- IL-1beta Antibody (508304)
- IL-1beta Antibody (508301)
- IL-1beta Antibody (508202)
- IL-1beta Antibody (508302)
- IL-1beta Antibody (508201)
- IL-1beta Antibody (508206)
- IL-1beta Antibody (508208)
- IL-1beta Antibody (508207)
- IL-1beta Antibody (511705)
- IL-1beta Antibody (511704)
- IL-1beta Antibody (511602)
- IL-1beta Antibody (511703)
- IL-1beta Antibody (511707)
- IL-1beta Antibody (511601)
- IL-1beta Antibody (511709)
- IL-1beta Antibody (511710)
- IL-1beta Antibody (515801)
- IL-1beta Antibody (517403)
-
Custom Antibody ServicesOriGene Antibodies for IL1B
- 4IL12-11E5
- 4IL12-6E10
- AM06692SU-N
- AM26380PU-L
- AM26747PU-N
- AM31259AF-N
- AM31259RP-N
- AP02107SU-N
- AP02107SU-S
- AP05799SU-N
- AP18071PU-N
- AP20628PU-N
- CF506440
- CF506443
- DM1019
- DM1021
- DM1024
- PP006B1
- PP006B2
- PP006P1
- PP006P2
- R1130
- SM480
- SP2112A
- SP2112B
- SP2127A
- TA319141
- TA319453
- TA319454
- TA320365
- TA320366
- TA321162
- TA326933
- TA328478
- TA328479
- TA328564
- TA328565
- TA334185
- TA336742
- TA347865
- TA352734
- TA506440
- TA506440S
- TA506443
- TA506443S
- Novus Biologicals Antibodies for IL1B
-
Abcam antibodies for IL1B
- Invitrogen Antibodies for IL1B (AFLGC-IL1B)
- antibodies-online: Show 234 available IL1B Antibodies ranked by validation data
- Compare Top IL1B Antibodies
-
Recommended
- 145 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 7 FACS Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 115 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IP Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 1 Inhibition Antibody (anti-rat)
- 317 WB Antibodies (anti-human)
- 52 FACS Antibodies (anti-human)
- 30 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 6 Neut Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IL Antibody (anti-human)
- 1 ICS Antibody (anti-human)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1B
- Sino Biological Antibodies for IL1B
Protein Products
- BioLegend Recombinant Human IL-1beta (ELISA Std.)
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1B
- Origene Custom Protein Services for IL1B
- Sino Biological Recombinant Proteins for IL1B
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IL1B
-
ProSci Proteins for IL1B
- interleukin 1 beta [90-462]
- interleukin 1 beta [90-463]
- interleukin 1 beta [91-032]
- interleukin 1 beta [40-598]
- interleukin 1, beta [96-461]
- interleukin 1 beta [92-219]
- interleukin 1 beta [40-101]
- interleukin 1 beta [40-110]
- interleukin 1, beta [90-234]
- interleukin 1, beta [90-270]
- interleukin 1, beta [40-241]
-
Abcam proteins for IL1B
Assay Products
- G Biosciences Immunotag™ Interleukin-1 beta ELISA Kit
- RayBiotech Human IL-1 beta ELISA
-
BioLegend
- Human IL-1beta ELISA MAX(TM) Deluxe
- LEGEND MAX(TM) Human IL-1beta ELISA Kit with Pre-coated Plates
- LEGENDplex(TM) Human IL-1beta Capture Bead A6, 13X
- LEGENDplex(TM) Human IL-1beta Capture Bead A4, 13X (740119)
- LEGENDplex(TM) Human IL-1beta Capture Bead A8, 13X
- LEGENDplex(TM) Human IL-1beta Capture Beads A10, 13X
- LEGENDplex(TM) Human IL-1beta Capture Bead A4, 13X (740812)
-
Custom Assay ServicesOriGene ELISA Kits for IL1B
- Novus Biologicals ELISA Kits for IL1B
- antibodies-online: Show 322 available IL1B Elisa Kits ranked by validation data
- Compare Top IL1B Elisa Kits
-
Quality Products:
- ABIN411293
- ABIN6574165
- ABIN1115635
- ABIN625019
- ABIN415066
- ABIN365160
- ABIN2506948
- ABIN5520913
- ABIN2684632
- ABIN2690563
- ABIN6574166
- ABIN1115634
- ABIN411294
- ABIN625141
- ABIN365172
- ABIN415642
- ABIN625142
- ABIN2506960
- ABIN492075
- ABIN5520914
- ABIN6574167
- ABIN1115639
- ABIN921061
- ABIN416397
- ABIN625200
- ABIN365189
- ABIN578836
- ABIN625201
- ABIN5520917
- ABIN2472108
- ABIN5696366
- ABIN1563436
- ABIN1055205
- ABIN2948694
- ABIN6205272
- ABIN6205273
- ABIN1055215
-
Abcam assays for IL1B
- Sino Biological Assays for IL1B
No data available for DME Specific Peptides for IL1B Gene
Domains & Families for IL1B Gene
Gene Families for IL1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for IL1B Gene
Suggested Antigen Peptide Sequences for IL1B Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin-1 beta (B5BUQ8_HUMAN)
- Catabolin (IL1B_HUMAN)
- Interleukin 1 beta (O43645_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01584- Family:
-
- Belongs to the IL-1 family.
Function for IL1B Gene
Molecular function for IL1B Gene
- UniProtKB/Swiss-Prot Function:
- Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
- UniProtKB/Swiss-Prot Induction:
- By LPS (PubMed:15192144). Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components in macrophages; EsxA is the most potent activator tested (at protein level) (PubMed:20148899). In pancreatic islets, release is increased by high glucose treatment. In pancreatic islets and macrophages, release is also increased by endocannabinoid anandamide/AEA (PubMed:23955712).
- GENATLAS Biochemistry:
- interleukin 1,17.3kDa,beta polypeptide,mainly expressed by macrophages osteoblastic cells and putatively stimulating osteoclastogenesis,inducing the association of TRAF6 with IRAK1,involved in the inflammatory response,susceptibility factor for inflammatory bowel diseaes
LifeMap Function Summary for IL1B Gene
IL1B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Blood
Phenotypes From GWAS Catalog for IL1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA,IMP | 2989698 |
| GO:0005149 | interleukin-1 receptor binding | IEA,NAS | 1919436 |
| GO:0005178 | integrin binding | IDA | 29030430 |
| GO:0005515 | protein binding | IPI | 15817483 |
| GO:0019904 | protein domain specific binding | IPI | 16575408 |
Phenotypes for IL1B Gene
- MGI mutant phenotypes for IL1B:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for IL1B:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased viability ratio
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for IL1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL1B - Select products 50% OFF >
- * IL1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1B
miRNA for IL1B Gene
- miRTarBase miRNAs that target IL1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1B
- Browse OriGene Inhibitory RNA Products For IL1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1B
Clone Products
- Applied Biological Materials (abm): Clones for IL1B - Select products 50% OFF >
- * IL1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL1B
- Addgene plasmids for IL1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1B
Cell Line Products
-
Horizon Cell Lines for IL1B
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL1B Gene
Localization for IL1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1B Gene
- Cytoplasm, cytosol. Lysosome. Secreted, extracellular exosome. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood (PubMed:24201029). On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (PubMed:24201029). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (By similarity). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (PubMed:11728343). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (By similarity). These mechanisms may not be not mutually exclusive. {ECO:0000250 UniProtKB:P10749, ECO:0000269 PubMed:11728343, ECO:0000269 PubMed:15192144, ECO:0000305 PubMed:24201029}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| lysosome | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IMP | 3493774 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005776 | autophagosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1B Gene
Pathways & Interactions for IL1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | Toll-Like receptor Signaling Pathways |
Immune response IL-1 signaling pathway
.41
|
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 4 | Toll-like Receptor Signaling Pathway | ||
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
Pathways by source for IL1B Gene
32 BioSystems pathways for IL1B Gene
11 Reactome pathways for IL1B Gene
40 KEGG pathways for IL1B Gene
6 GeneGo (Thomson Reuters) pathways for IL1B Gene
- Bacterial infections in CF airways
- IL-1 beta-dependent CFTR expression
- Immune response Bacterial infections in normal airways
- Immune response IL-1 signaling pathway
- Immune response MIF in innate immunity response
9 R&D Systems pathways for IL1B Gene
3 Tocris pathways for IL1B Gene
38 Qiagen pathways for IL1B Gene
- 14-3-3 Induced Apoptosis
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Cytokine Network
1 Cell Signaling Technology pathway for IL1B Gene
1 GeneTex pathway for IL1B Gene
Interacting Proteins for IL1B Gene
GPS-Prot Interaction Network for IL1B
SIGNOR curated interactions for IL1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IMP | 21147091 |
| GO:0000187 | activation of MAPK activity | IDA | 10748004 |
| GO:0001660 | fever generation | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | NAS | 16477012 |
| GO:0002437 | inflammatory response to antigenic stimulus | IBA | -- |
Drugs & Compounds for IL1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| canakinumab | Approved, Investigational | Pharma | Target, binder, immunotherapy, antibody | Immunotherapies | 0 | |
| Rilonacept | Approved, Investigational | Pharma | Target, binder | 25 | ||
| Minocycline | Approved, Investigational | Pharma | Target, modulator | 229 | ||
| Clodronate | Approved, Investigational, Vet_approved | Pharma | 12 | |||
| Infliximab | Approved | Pharma | 469 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AS 101 |
|
106566-58-9 |
|
|
||
| GIT 27 |
|
6501-72-0 |
|
|
(4) Tocris Compounds for IL1B Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
(1) ApexBio Compounds for IL1B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Diacerein | 13739-02-1 |
Transcripts for IL1B Gene
mRNA/cDNA for IL1B Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263341 1507 nts (view in UCSC)
- ENST00000416750 580 nts (view in UCSC)
- ENST00000418817 581 nts (view in UCSC)
- ENST00000432018 581 nts (view in UCSC)
- ENST00000477398 571 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL1B - Select products 50% OFF >
- * IL1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1B
- Browse OriGene Inhibitory RNA Products For IL1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1B
Clone Products
- Applied Biological Materials (abm): Clones for IL1B - Select products 50% OFF >
- * IL1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL1B
- Addgene plasmids for IL1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1B
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | - |
Relevant External Links for IL1B Gene
- GeneLoc Exon Structure for
- IL1B
Expression for IL1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Placenta (Extraembryonic Tissues)
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- Villous Cytotrophoblast Cells Chorionic Villus
- Umbilical Cord (Extraembryonic Tissues)
- Epithelial Cells (Uncategorized)
- Mesenchymal Stem Cells (Uncategorized)
- Adipose (Muscoskeletal System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Esophagus
- Eye (Sensory Organs)
- Epidermis (Integumentary System)
- Hair
-
Smooth Muscle (Muscoskeletal System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for IL1B Gene
This gene is overexpressed in Whole Blood (x17.8) and Stomach (x4.1).
This gene is overexpressed in Pancreas (44.9) and Bone (24.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1B
SOURCE GeneReport for Unigene cluster for IL1B Gene:
Hs.126256mRNA Expression by UniProt/SwissProt for IL1B Gene:
P01584-IL1B_HUMAN
Tissue specificity:
Expressed in activated monocytes/macrophages (at protein level).
Evidence on tissue expression from TISSUES for IL1B Gene
- Blood(4.9)
- Lung(4.8)
- Skin(4.7)
- Nervous system(4.1)
- Intestine(4)
- Spleen(4)
- Bone marrow(4)
- Liver(3.9)
- Lymph node(3.9)
- Heart(3.7)
- Kidney(3.5)
- Muscle(3.5)
- Bone(3.3)
- Stomach(3.2)
- Adrenal gland(3.2)
- Pancreas(3.2)
- Eye(3)
- Urine(2.8)
- Saliva(2.6)
- Thyroid gland(2.5)
- Gall bladder(2.5)
Primer Products
-
OriGene qPCR primer pairs for IL1B
-
OriGene qPCR primer pairs and template standards for IL1B
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1B Gene
Orthologs for IL1B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il1b 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il1b 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | IL1B 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL1B 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL1B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL-1BETA 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il1b 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | il1b 31 |
|
OneToOne |
- Species where no ortholog for IL1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL1B Gene
- ENSEMBL:
- Gene Tree for IL1B (if available)
- TreeFam:
- Gene Tree for IL1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1B: view image
Paralogs for IL1B Gene
Variants for IL1B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1B Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 772847 | Benign: not provided | 112,833,585(-) | G/A | INTRON_VARIANT | |
| 779077 | Benign: not provided | 112,833,504(-) | G/A | SYNONYMOUS_VARIANT | |
| 780097 | Benign: not provided | 112,833,537(-) | G/A | SYNONYMOUS_VARIANT | |
| 869137 | Association: Antisynthetase syndrome | 112,832,813(-) | G/A | SYNONYMOUS_VARIANT | |
| 869138 | Association: Antisynthetase syndrome | 112,837,290(-) | A/G |
Residual Variation Intolerance Score:
28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.36;
7.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL1B Gene
Disorders for IL1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cancer, hereditary diffuse |
|
|
| toxic shock syndrome |
|
|
| gingivitis |
|
|
| bacterial meningitis |
|
|
| muckle-wells syndrome |
|
Search IL1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1B Gene
Publications for IL1B Gene
- Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PMID: 20486195) Chou IC … Tsai FJ (Journal of clinical laboratory analysis 2010) 3 23 41
- Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. (PMID: 19904560) Qian N … Hu Z (Journal of cancer research and clinical oncology 2010) 3 23 41
- Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 20188863) Taype CA … Shaw MA (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2010) 3 23 41
- The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women. (PMID: 20060205) Czerny B … Pawlik A (European journal of obstetrics, gynecology, and reproductive biology 2010) 3 23 41
- The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma. (PMID: 20467172) Okamoto K … Yuasa I (Internal medicine (Tokyo, Japan) 2010) 3 23 41
ExternalLinks
Products for IL1B Gene
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- 4IL12-11E5
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- antibodies-online: Show 234 available IL1B Antibodies ranked by validation data
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- 2 RIA Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
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- 115 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
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- 317 WB Antibodies (anti-human)
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- 5 EIA Antibodies (anti-human)
- 5 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IL Antibody (anti-human)
- 1 ICS Antibody (anti-human)
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- ABIN6205273
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- antibodies-online: Show 212 available IL1B Proteins ranked by validation data
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- Search Santa Cruz Biotechnology (SCBT) for IL1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL1B