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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. ... See more...
Aliases for IL1A Gene
Aliases for IL1A Gene
External Ids for IL1A Gene
- HGNC: 5991
- Entrez Gene: 3552
- Ensembl: ENSG00000115008
- OMIM: 147760
- UniProtKB: P01583
Previous HGNC Symbols for IL1A Gene
- IL1
Previous GeneCards Identifiers for IL1A Gene
- GC02M110737
- GC02M111452
- GC02M113438
- GC02M113626
- GC02M113247
- GC02M105986
- GC02M113531
Summaries for IL1A Gene
-
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1A Gene
IL1A (Interleukin 1 Alpha) is a Protein Coding gene. Diseases associated with IL1A include Arthritis and Cholesteatoma Of Middle Ear. Among its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding.
UniProtKB/Swiss-Prot Summary for IL1A Gene
-
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
-
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Additional gene information for IL1A Gene
- HGNC(5991)
- Entrez Gene(3552)
- Ensembl(ENSG00000115008)
- OMIM(147760)
- UniProtKB(P01583)
- Open Targets Platform(ENSG00000115008)
- Monarch Initiative
- Search for IL1A at DataMed
- Search for IL1A at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL1A Gene
Genomics for IL1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL1A
- Top Transcription factor binding sites by QIAGEN in the IL1A gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
Genomic Locations for IL1A Gene
Genomic Locations for IL1A Gene
- chr2:112,773,925-112,784,493
- (GRCh38/hg38)
- Size:
- 10,569 bases
- Orientation:
- Minus strand
- chr2:113,531,492-113,542,971
- (GRCh37/hg19)
- Size:
- 11,480 bases
- Orientation:
- Minus strand
Genomic View for IL1A Gene
Genes around IL1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q14.1 by HGNC
- 2q14.1 by Entrez Gene
- 2q14.1 by Ensembl
IL1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL1A Gene
Proteins for IL1A Gene
-
Protein details for IL1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01583-IL1A_HUMAN
- Recommended name:
- Interleukin-1 alpha
- Protein Accession:
- P01583
- Q53QF9
- Q7RU02
Protein attributes for IL1A Gene
- Size:
- 271 amino acids
- Molecular mass:
- 30607 Da
- Quaternary structure:
-
- Monomer.
Protein Expression for IL1A Gene
Post-translational modifications for IL1A Gene
Other Protein References for IL1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences IL1A / IL-1 Alpha Monoclonal Antibody (LS-B1581) and IL1A / IL-1 Alpha Monoclonal Antibody (LS-B14239)
- G Biosciences Immunotag™ IL1A Antibody
- NSJ Bioreagents IL1 alpha Antibody
- Creative Diagnostics Anti-IL1A monoclonal antibody, clone Qpmz6045 [Biotin]
-
Creative Biolabs
- Recombinant Anti-Human IL1A Antibody
- Anti-Human IL-1a (Interleukin 1 alpha) Therapeutic Antibody (3D12)
- Anti-Human IL1A Therapeutic Antibody (MABp1)
- Anti-Human IL-1a (Interleukin 1 alpha) Therapeutic Antibody scFv Fragment (3D12.6)
- Mouse Anti-ITGA6 Recombinant Antibody (CBYY-I0543)
- Recombinant Mouse Anti-IL1A Antibody (9F46)
- Mouse Anti-CXCL8 Recombinant Antibody (CBYY-I1113)
- Mouse Anti-ITGA2B/ITGB3 Recombinant Antibody (CBYY-I1641)
-
Custom Antibody ServicesOriGene Antibodies for IL1A
- AM05675AF-N
- AM06011PU-N
- AM06080SU-N
- AP17498PU-N
- CF506846
- CF506847
- CF506848
- CF506849
- CF506850
- CF506851
- CF506852
- CF506853
- DDX0710A488-100
- DDX0710A546-100
- DDX0710A647-100
- DDX0710B-100
- DDX0710P-100
- PP005B1
- PP005B2
- PP005P1
- PP005P2
- PP1022B1
- PP1022B2
- PP1022P1
- PP1022P2
- PP1133B1
- PP1133B2
- PP1133P1
- PP1133P2
- R1131
- TA320363
- TA320364
- TA327311
- TA328201
- TA328476
- TA328477
- TA328562
- TA328563
- TA349352
- TA506846
- TA506846S
- TA506847
- TA506847S
- TA506848
- TA506848S
- TA506849
- TA506849S
- TA506850
- TA506850S
- TA506851
- TA506851S
- TA506852
- TA506852S
- TA506853
- TA506853S
- TA590791
- Novus Biologicals Antibodies for IL1A
-
Abcam antibodies for IL1A
- Invitrogen Antibodies for IL1A (AFLGC-Il1a)
- antibodies-online: Show 151 available IL1A Antibodies ranked by validation data
- Compare Top IL1A Antibodies
-
Recommended
- 193 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 56 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL1A
- Sino Biological Antibodies for IL1A
Protein Products
- RayBiotech Recombinant Human IL-1 alpha
- Search Origene for MassSpec and Protein Over-expression Lysates for IL1A
- Origene Custom Protein Services for IL1A
- Sino Biological Recombinant Proteins for IL1A
- Sino Biological Cell Lysates for IL1A
- ProSpec Recombinant Proteins for IL1A
-
Abcam proteins for IL1A
Assay Products
- G Biosciences Immunotag™ Interleukin-1 alpha ELISA Kit
- RayBiotech Human IL-1 alpha ELISA (For Lysates) and Human IL-1 alpha ELISA
-
Creative Diagnostics
- Human IL1A ELISA Matched Antibody Pair (ABPR-0484)
- IL1 alpha Human ELISA Kit
- Human Interleukin 1, Alpha, IL1A ELISA Kit
- Mouse Interleukin 1 Alpha, Il1a ELISA Kit (DEIA109)
- Human IL1A ELISA Matched Antibody Pair (ABPR-0482)
- Mouse Interleukin 1 Alpha, Il1a ELISA Kit (DEIA190)
- Human IL-1a ELISA Kit
- Human Interleukin 1, alpha, IL1A ELISA Kit
- Bovine Interleukin 1 ELISA Kit
- Human IL1A ELISA Matched Antibody Pair (ABPR-0483)
- Interleukin-1 alpha Rat ELISA Kit
- Novus Biologicals ELISA Kits for IL1A
- antibodies-online: Show 241 available IL1A Elisa Kits ranked by validation data
- Compare Top IL1A Elisa Kits
-
Quality Products:
- ABIN6730878
- ABIN411291
- ABIN625017
- ABIN1115633
- ABIN612717
- ABIN414881
- ABIN365159
- ABIN2472115
- ABIN924776
- ABIN625018
- ABIN6730924
- ABIN921060
- ABIN1115631
- ABIN365176
- ABIN415509
- ABIN924814
- ABIN625140
- ABIN1873500
- ABIN3032809
- ABIN1570664
- ABIN6730939
- ABIN411292
- ABIN1115632
- ABIN365193
- ABIN416246
- ABIN625199
- ABIN1873503
- ABIN3032871
- ABIN924835
- ABIN1570666
- ABIN366457
- ABIN415825
- ABIN1570665
- ABIN5522122
- ABIN5592992
- ABIN579021
- ABIN779190
- ABIN1563431
- ABIN2748204
- ABIN6385157
-
Abcam assays for IL1A
- Sino Biological Assays for IL1A
No data available for DME Specific Peptides for IL1A Gene
Domains & Families for IL1A Gene
Gene Families for IL1A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for IL1A Gene
- InterPro:
- Blocks:
-
- IL1/HBGF family signature
- Interleukin-1 precursor family signature
- Interleukin-1 alpha/beta precursor family signature
- Interleukin-1 alpha precursor signature
- Interleukin-1 propeptide
- ProtoNet:
Suggested Antigen Peptide Sequences for IL1A Gene
- GenScript: Design optimal peptide antigens:
-
- Hematopoietin-1 (IL1A_HUMAN)
- cDNA, FLJ95747, Homo sapiens interleukin 1, alpha (IL1A), mRNA (Q53QF9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01583UniProtKB/Swiss-Prot:
IL1A_HUMAN :- The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
- Belongs to the IL-1 family.
- Domain:
-
- The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
- Family:
-
- Belongs to the IL-1 family.
Function for IL1A Gene
Molecular function for IL1A Gene
- UniProtKB/Swiss-Prot Function:
- Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
- GENATLAS Biochemistry:
- interleukin 1,alpha polypeptide,mainly expressed by macrophage,involved in the inflammatory response
Phenotypes From GWAS Catalog for IL1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IMP | 2989698 |
| GO:0005149 | interleukin-1 receptor binding | IEA | -- |
| GO:0005507 | copper ion binding | IDA | 12746488 |
| GO:0005515 | protein binding | IPI | 12746488 |
Phenotypes for IL1A Gene
- MGI mutant phenotypes for IL1A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IL1A:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability
- Decreased Salmonella enterica Typhimurium invasion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Models for IL1A Gene
- MGI Knock Outs for IL1A:
-
- Il1a Il1a<tm1Yiw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL1A - Select products 50% OFF >
- * IL1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1A
miRNA for IL1A Gene
- miRTarBase miRNAs that target IL1A
-
- hsa-miR-191-5p (MIRT004689)
- hsa-miR-335-5p (MIRT017051)
- mmu-miR-181a-5p (MIRT054235)
- hsa-miR-142-3p (MIRT054374)
- hsa-miR-30d-5p (MIRT727451)
- hsa-miR-30e-5p (MIRT727452)
- hsa-miR-30c-5p (MIRT727453)
- hsa-miR-30b-5p (MIRT727454)
- hsa-miR-30a-5p (MIRT727455)
- hsa-miR-181c-5p (MIRT727456)
- hsa-miR-181d-5p (MIRT727457)
- hsa-miR-181b-5p (MIRT727458)
- hsa-miR-181a-5p (MIRT727459)
- hsa-miR-92a-1-5p (MIRT733328)
- hsa-miR-122-5p (MIRT734220)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1A
- Browse OriGene Inhibitory RNA Products For IL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1A
Clone Products
- Applied Biological Materials (abm): Clones for IL1A - Select products 50% OFF >
- * IL1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1A
Cell Line Products
-
Horizon Cell Lines for IL1A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL1A Gene
Localization for IL1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL1A Gene
- Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,IMP | 3493774 |
| GO:0005829 | cytosol | IDA | 12746488 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL1A Gene
Pathways & Interactions for IL1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
|
| 4 | IL-1 signaling pathway | ||
| 5 | Allograft rejection | ||
Pathways by source for IL1A Gene
17 BioSystems pathways for IL1A Gene
10 Reactome pathways for IL1A Gene
20 KEGG pathways for IL1A Gene
4 GeneGo (Thomson Reuters) pathways for IL1A Gene
- Development NOTCH1-mediated pathway for NF-KB activity modulation
- Immune response IL-1 signaling pathway
- Transcription_NF-kB signaling pathway
- Transcription_Role of VDR in regulation of genes involved in osteoporosis
1 R&D Systems pathway for IL1A Gene
3 Tocris pathways for IL1A Gene
35 Qiagen pathways for IL1A Gene
- 14-3-3 Induced Apoptosis
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Cytokine Network
Interacting Proteins for IL1A Gene
Selected Interacting proteins:
P01583-IL1A_HUMAN
ENSP00000263339
for IL1A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL1A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001660 | fever generation | IEA | -- |
| GO:0002248 | connective tissue replacement involved in inflammatory response wound healing | IEA | -- |
| GO:0002437 | inflammatory response to antigenic stimulus | IBA | -- |
| GO:0006915 | apoptotic process | TAS | 1924307 |
| GO:0006954 | inflammatory response | IBA | 21873635 |
Drugs & Compounds for IL1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rilonacept | Approved, Investigational | Pharma | Target, binder | 25 | ||
| Olanzapine | Approved, Investigational | Pharma | Antagonist, Agonist, Full agonist, Inverse agonist | 442 | ||
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 86 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 429 | ||
| AMG-108 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AS 101 |
|
106566-58-9 |
|
|||
| GIT 27 |
|
6501-72-0 |
|
|
(4) Tocris Compounds for IL1A Gene
| Compound | Action | Cas Number |
|---|---|---|
| AS 101 | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release | 106566-58-9 |
| GIT 27 | Immunomodulator; reduces production of pro-inflammatory cytokines | 6501-72-0 |
| Pirfenidone | Antifibrotic agent; regulates cytokine levels in vivo | 53179-13-8 |
| Thalidomide | TNF-alpha synthesis inhibitor | 50-35-1 |
Transcripts for IL1A Gene
mRNA/cDNA for IL1A Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263339 2017 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL1A - Select products 50% OFF >
- * IL1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL1A
- Browse OriGene Inhibitory RNA Products For IL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1A
Clone Products
- Applied Biological Materials (abm): Clones for IL1A - Select products 50% OFF >
- * IL1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1A
Relevant External Links for IL1A Gene
- GeneLoc Exon Structure for
- IL1A
Expression for IL1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Umbilical Cord (Extraembryonic Tissues)
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
- Mesenchymal Stem Cells (Uncategorized)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Placenta (Extraembryonic Tissues)
- Villous Cytotrophoblast Cells Chorionic Villus
- Epidermis (Integumentary System)
- Hair
- Endothelium (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for IL1A Gene
This gene is overexpressed in Esophagus - Mucosa (x20.4), Testis (x7.4), and Minor Salivary Gland (x4.1).
This gene is overexpressed in Serum (67.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL1A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL1A
SOURCE GeneReport for Unigene cluster for IL1A Gene:
Hs.1722Evidence on tissue expression from TISSUES for IL1A Gene
- Lung(4.7)
- Blood(3.6)
- Skin(3.5)
- Spleen(3.3)
- Heart(3.2)
- Nervous system(3.2)
- Lymph node(3.2)
- Kidney(3.1)
- Bone marrow(3.1)
- Liver(3.1)
- Intestine(3)
- Muscle(3)
- Bone(2.7)
- Eye(2.5)
- Stomach(2.4)
- Pancreas(2.3)
- Thyroid gland(2.3)
- Adrenal gland(2.3)
- Urine(2.1)
- Saliva(2.1)
Primer Products
-
OriGene qPCR primer pairs for IL1A
-
OriGene qPCR primer pairs and template standards for IL1A
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL1A Gene
Orthologs for IL1A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL1A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL1A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL1A 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il1a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Il1a 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL1A 31 |
|
OneToOne |
- Species where no ortholog for IL1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL1A Gene
- ENSEMBL:
- Gene Tree for IL1A (if available)
- TreeFam:
- Gene Tree for IL1A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL1A: view image
Paralogs for IL1A Gene
No data available for Paralogs for IL1A Gene
Variants for IL1A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL1A Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 740365 | Likely Benign: not provided | 112,779,527(-) | C/T | SYNONYMOUS_VARIANT | |
| 775754 | Benign: not provided | 112,781,647(-) | G/A | SYNONYMOUS_VARIANT | |
| 780832 | Likely Benign: not provided | 112,779,613(-) | T/C | MISSENSE_VARIANT | |
| 791867 | Benign: not provided | 112,779,574(-) | C/T | MISSENSE_VARIANT | |
| rs17561 | - | p.Ala114Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2518569 | CNV | deletion | 19546169 |
| esv2720538 | CNV | deletion | 23290073 |
| esv2720540 | CNV | deletion | 23290073 |
| esv2720541 | CNV | deletion | 23290073 |
| esv2720542 | CNV | deletion | 23290073 |
| esv2720543 | CNV | deletion | 23290073 |
| esv2720544 | CNV | deletion | 23290073 |
| nsv1072437 | CNV | deletion | 25765185 |
| nsv1144910 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.91;
74.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL1A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1A Gene
Disorders for IL1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arthritis |
|
|
| cholesteatoma of middle ear |
|
|
| irritant dermatitis |
|
|
| bacterial vaginosis |
|
|
| rheumatoid arthritis |
|
Search IL1A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL1A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL1A Gene
Publications for IL1A Gene
- Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhage. (PMID: 20495422) Fontanella M … Pinessi L (Neurosurgery 2010) 3 23 41
- Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases. (PMID: 19117745) Vasakova M … Striz I (Respiratory medicine 2009) 3 23 41
- Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist. (PMID: 19702713) Khalilzadeh O … Amirzargar A (Clinical & experimental ophthalmology 2009) 3 23 41
- Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism. (PMID: 19332120) Lobashevsky AL … Turrentine MW (Transplant immunology 2009) 3 23 41
- Proinflammatory cytokine gene single nucleotide polymorphisms in common variable immunodeficiency. (PMID: 19076825) Rezaei N … Aghamohammadi A (Clinical and experimental immunology 2009) 3 23 41
ExternalLinks
Products for IL1A Gene
- View all 43 R&D Systems IL1A (IL-1 alpha/IL-1F1) Products
- View all R&D Systems IL1A (IL-1 alpha/IL-1F1) Proteins and Enzymes
- View all 32 R&D Systems IL1A (IL-1 alpha/IL-1F1) Primary Antibodies
- View all 2 R&D Systems IL1A (IL-1 alpha/IL-1F1) ELISAs
- View all R&D Systems IL1A (IL-1 alpha/IL-1F1) Simple Plex Assays
- View all 5 R&D Systems IL1A (IL-1 alpha/IL-1F1) Luminex Assays
- View all 2 R&D Systems IL1A (IL-1 alpha/IL-1F1) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom IL1A antibody, protein, and immunoassay development services
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- Sino Biological Human cDNA Clone for IL1A
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- Browse Recombinant Proteins
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL1A
- Novus Biologicals proteins and lysates for IL1A
- Novus Biologicals ELISA Kits for IL1A
- Browse Antibodies
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- Abcam antibodies for IL1A
- Abcam proteins for IL1A
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- VectorBuilder Custom and pre-made DNA vectors for IL1A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL1A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IL1A (ie. knockout, knockin, CRISPRa, CRISPRi)
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- antibodies-online: Show 151 available IL1A Antibodies ranked by validation data
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- 193 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 ICFC Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 56 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 241 available IL1A Elisa Kits ranked by validation data
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- ABIN6730878
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- ABIN6730924
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- ABIN1873500
- ABIN3032809
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- ABIN365193
- ABIN416246
- ABIN625199
- ABIN1873503
- ABIN3032871
- ABIN924835
- ABIN1570666
- ABIN366457
- ABIN415825
- ABIN1570665
- ABIN5522122
- ABIN5592992
- ABIN579021
- ABIN779190
- ABIN1563431
- ABIN2748204
- ABIN6385157
- antibodies-online: Show 152 available IL1A Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL1A
- Search Santa Cruz Biotechnology (SCBT) for IL1A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL1A
- Horizon Cell Lines for IL1A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL1A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL1A
Sources for IL1A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (112) MedlinePlus
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- (115) NCBI Bookshelf
- (116) ClinVar
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB