Aliases for IL1A Gene
External Ids for IL1A Gene
Previous HGNC Symbols for IL1A Gene
Previous GeneCards Identifiers for IL1A Gene
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL1A Gene
IL1A (Interleukin 1 Alpha) is a Protein Coding gene. Diseases associated with IL1A include Cholesteatoma Of Middle Ear and Irritant Dermatitis. Among its related pathways are Cellular Senescence (REACTOME) and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding.
UniProtKB/Swiss-Prot Summary for IL1A Gene
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.