Aliases for IL19 Gene
External Ids for IL19 Gene
Previous GeneCards Identifiers for IL19 Gene
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL19 Gene
IL19 (Interleukin 19) is a Protein Coding gene. Diseases associated with IL19 include Psoriasis and Inflammatory Bowel Disease. Among its related pathways are ERK Signaling and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.
UniProtKB/Swiss-Prot Summary for IL19 Gene
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).