The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alp... See more...

Aliases for IL19 Gene

Aliases for IL19 Gene

  • Interleukin 19 2 3 5
  • ZMDA1 2 3 4
  • NG.1 2 3 4
  • Melanoma Differentiation Associated Protein-Like Protein 2 3
  • Interleukin-19 3 4
  • IL-10C 2 3
  • IL-19 2 4
  • MDA1 2 3
  • Melanoma Differentiation-Associated Protein-Like Protein 4
  • IL19 5

External Ids for IL19 Gene

Previous GeneCards Identifiers for IL19 Gene

  • GC01P205632
  • GC01P202682
  • GC01P203615
  • GC01P204055
  • GC01P203360
  • GC01P205038
  • GC01P206972
  • GC01P177670
  • GC01P206798

Summaries for IL19 Gene

Entrez Gene Summary for IL19 Gene

  • The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL19 Gene

IL19 (Interleukin 19) is a Protein Coding gene. Diseases associated with IL19 include Inflammatory Bowel Disease and Psoriasis. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot Summary for IL19 Gene

  • May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL19 Gene

Genomics for IL19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206768 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +0.2 156 4.5 SP1 IKZF1 POLR2A BACH1 ZNF143 RELA TCF12 IKZF2 TRIM22 HDAC1 IL10 IL19 lnc-IL10-5 MAPKAPK2 IL24 IL20 C4BPB RASSF5
GH01J206830 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 620.1 +61.8 61837 8.4 REST IKZF2 MNT CTCF RUNX3 CEBPB ZNF316 JUN JUND MAFG IL19 IL20 IL24 FCMR PIGR FCAMR IL10 MAPKAPK2 C1orf147 CD46
GH01J206633 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -135.3 -135311 4.3 SP1 CREB1 CTCF HNRNPL TEAD4 PRDM10 TFE3 ZNF512 RFX1 LEF1 DYRK3 DYRK3-AS1 EIF2D MAPKAPK2 IL19 IKBKE
GH01J206917 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +152.3 152307 12 ARHGAP35 SP1 CREB1 ZBTB33 YBX1 RFX1 IKZF1 POLR2A BACH1 TARDBP FCMR MN308852 lnc-PIGR-3 lnc-FCMR-1 MAPKAPK2 CDCA4P4 EIF2D ENSG00000271680 PIGR FCAMR
GH01J206864 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 16.1 +94.4 94434 1.2 CTCF JUND ZNF143 ZNF24 REST RAD21 TRIM22 SOX6 NONO MTA3 IL20 IL19 IL24 FCMR PIGR FCAMR IL10 LOC105372878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL19

Top Transcription factor binding sites by QIAGEN in the IL19 gene promoter:
  • CREB
  • CUTL1
  • deltaCREB
  • GCNF
  • GR
  • GR-alpha
  • GR-beta
  • STAT3

Genomic Locations for IL19 Gene

Genomic Locations for IL19 Gene
chr1:206,770,764-206,842,981
(GRCh38/hg38)
Size:
72,218 bases
Orientation:
Plus strand
chr1:206,972,215-207,016,326
(GRCh37/hg19)
Size:
44,112 bases
Orientation:
Plus strand

Genomic View for IL19 Gene

Genes around IL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL19 Gene

Proteins for IL19 Gene

  • Protein details for IL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD0-IL19_HUMAN
    Recommended name:
    Interleukin-19
    Protein Accession:
    Q9UHD0
    Secondary Accessions:
    • B6VEV9
    • Q5VUT3
    • Q96QR4
    • Q9NUA0

    Protein attributes for IL19 Gene

    Size:
    177 amino acids
    Molecular mass:
    20452 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL19 Gene

    Alternative splice isoforms for IL19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL19 Gene

Post-translational modifications for IL19 Gene

  • Glycosylation at Asn56 and Asn135

Other Protein References for IL19 Gene

No data available for DME Specific Peptides for IL19 Gene

Domains & Families for IL19 Gene

Gene Families for IL19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL19 Gene

InterPro:
Blocks:
  • Interleukin-10
ProtoNet:

Suggested Antigen Peptide Sequences for IL19 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 19 isoform 3 (B6VEV9_HUMAN)
  • NG.1 (IL19_HUMAN)
  • Interleukin 19 (Q5VUT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHD0

UniProtKB/Swiss-Prot:

IL19_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL19: view

Function for IL19 Gene

Molecular function for IL19 Gene

UniProtKB/Swiss-Prot Function:
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).

Phenotypes From GWAS Catalog for IL19 Gene

Gene Ontology (GO) - Molecular Function for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 11196675
genes like me logo Genes that share ontologies with IL19: view
genes like me logo Genes that share phenotypes with IL19: view

Animal Models for IL19 Gene

MGI Knock Outs for IL19:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL19

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL19 Gene

Localization for IL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL19 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL19 Gene

Pathways & Interactions for IL19 Gene

PathCards logo

SuperPathways for IL19 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.41
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 JAK-STAT signaling pathway
genes like me logo Genes that share pathways with IL19: view

Pathways by source for IL19 Gene

24 Qiagen pathways for IL19 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

SIGNOR curated interactions for IL19 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006955 immune response NAS 11196675
GO:0007165 signal transduction NAS 11196675
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL19: view

Drugs & Compounds for IL19 Gene

(2) Drugs for IL19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL19: view

Transcripts for IL19 Gene

mRNA/cDNA for IL19 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL19

Alternative Splicing Database (ASD) splice patterns (SP) for IL19 Gene

No ASD Table

Relevant External Links for IL19 Gene

GeneLoc Exon Structure for
IL19

Expression for IL19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL19 Gene

mRNA differential expression in normal tissues according to GTEx for IL19 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.8), Minor Salivary Gland (x13.2), and Stomach (x9.7).

Protein differential expression in normal tissues from HIPED for IL19 Gene

This gene is overexpressed in Milk (53.4) and Cervix (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL19 Gene



Protein tissue co-expression partners for IL19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL19

SOURCE GeneReport for Unigene cluster for IL19 Gene:

Hs.661017

Evidence on tissue expression from TISSUES for IL19 Gene

  • Blood(2.4)
  • Skin(2.2)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with IL19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL19 Gene

Orthologs for IL19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL19 30 31
  • 97.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL19 30 31
  • 84.88 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL19 30 31
  • 83.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il19 30 17 31
  • 78.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il19 30
  • 77.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL19 31
  • 55 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL19 31
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL19 31
  • 42 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii il19l 31
  • 24 (a)
OneToMany
Species where no ortholog for IL19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL19 Gene

ENSEMBL:
Gene Tree for IL19 (if available)
TreeFam:
Gene Tree for IL19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL19: view image

Paralogs for IL19 Gene

Paralogs for IL19 Gene

(1) SIMAP similar genes for IL19 Gene using alignment to 2 proteins:

  • IL19_HUMAN
  • B6VEV9_HUMAN
genes like me logo Genes that share paralogs with IL19: view

Variants for IL19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL19 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
726782 Likely Benign: not provided 206,772,388(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
729261 Likely Benign: Inflammatory bowel disease 206,772,380(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
729486 Benign: Inflammatory bowel disease 206,772,263(+) A/G INTRON_VARIANT
745482 Likely Benign: Inflammatory bowel disease 206,770,940(+) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
756187 Likely Benign: Inflammatory bowel disease 206,771,057(+) A/G SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for IL19 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL19 Gene

Variant ID Type Subtype PubMed ID
esv1601718 CNV insertion 17803354
esv3407405 CNV insertion 20981092
esv997006 CNV deletion 20482838

Variation tolerance for IL19 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL19 Gene

Human Gene Mutation Database (HGMD)
IL19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL19 Gene

Disorders for IL19 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IL19 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease
  • inflammatory bowel diseases
psoriasis
psoriasis 12
  • psoriasis 12, susceptibility to
rheumatoid arthritis
  • ra
skin disease
  • genodermatosis
- elite association - COSMIC cancer census association via MalaCards
Search IL19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL19 Gene

Publications for IL19 Gene

  1. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). (PMID: 11196675) Gallagher G … Kotenko SV (Genes and immunity 2000) 2 3 4 23
  2. Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder. (PMID: 19087313) Traks T … Kõks S (BMC medical genetics 2008) 3 23 41
  3. Association of interleukin-19 gene polymorphisms with age. (PMID: 17522354) Okayama N … Hinoda Y (The journals of gerontology. Series A, Biological sciences and medical sciences 2007) 3 23 41
  4. Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. (PMID: 17263806) Kingo K … Silm H (The British journal of dermatology 2007) 3 23 41
  5. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. (PMID: 15815689) Oleksyk TK … Smith MW (Genes and immunity 2005) 3 23 41

Products for IL19 Gene

  • Boster Bio Antibodies for IL19
  • Boster Bio ELISA Kits for IL19

Sources for IL19 Gene