The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel dise... See more...

Aliases for IL18RAP Gene

Aliases for IL18RAP Gene

  • Interleukin 18 Receptor Accessory Protein 2 3 5
  • Interleukin-18 Receptor Accessory Protein 3 4
  • CD218 Antigen-Like Family Member B 3 4
  • IL-18 Receptor Accessory Protein 3 4
  • Interleukin-18 Receptor Beta 3 4
  • Interleukin-1 Receptor 7 3 4
  • IL-18R-Beta 3 4
  • IL-18Rbeta 3 4
  • IL-18RAcP 3 4
  • IL-1RAcPL 3 4
  • CDw218b 3 4
  • IL-1R-7 3 4
  • IL-1R7 3 4
  • Interleukin-18 Receptor Accessory Protein-Like 4
  • Cluster Of Differentiation W218b 3
  • IL-1R Accessory Protein-Like 4
  • Accessory Protein-Like 4
  • IL-18 Receptor Beta 3
  • CD218b Antigen 4
  • CD218b 3
  • IL18RB 3
  • IL1R7 4
  • ACPL 3
  • AcPL 4

External Ids for IL18RAP Gene

Previous GeneCards Identifiers for IL18RAP Gene

  • GC02P100899
  • GC02P101487
  • GC02P102639
  • GC02P102656
  • GC02P102493
  • GC02P102401
  • GC02P103035
  • GC02P096799

Summaries for IL18RAP Gene

Entrez Gene Summary for IL18RAP Gene

  • The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL18RAP Gene

IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include Crohn's Disease and Inflammatory Bowel Disease. Among its related pathways are IL-1 Family Signaling Pathways and Cytokine Signaling in Immune system. An important paralog of this gene is IL1RAPL2.

UniProtKB/Swiss-Prot Summary for IL18RAP Gene

  • Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

Gene Wiki entry for IL18RAP Gene

Additional gene information for IL18RAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL18RAP Gene

Genomics for IL18RAP Gene

GeneHancer (GH) Regulatory Elements for IL18RAP Gene

Promoters and enhancers for IL18RAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102416 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 793.7 +1.1 1102 6.2 SMARCE1 RUNX1 CC2D1A ELF1 L3MBTL2 TEAD4 ZKSCAN8 BACH1 MLLT1 CBFA2T2 IL18RAP ENSG00000234389 IL1R2 IL1R1 IL18R1 MIR4772
GH02J102425 Promoter 0.6 EPDnew 780.3 +4.6 4583 0.1 GTF2E2 ZBTB11 LEF1 IL18RAP MIR4772
GH02J102355 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 28.9 -61.6 -61573 3.6 ZNF24 CTCF RBPJ ELF1 L3MBTL2 RAD21 NKRF ELF3 ZFX AHR IL18RAP ENSG00000234389 IL1RL1 lnc-IL1RL1-1 lnc-IL1RL1-3 IL18R1
GH02J102487 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 38.4 +70.2 70243 4.8 ZNF217 HLF MNT CREB1 CTBP1 ESRRA DPF2 GATA3 ELF1 ZNF687 IL1R2 IL18RAP SLC9A2 ENSG00000234389 IL18R1 IL1R1 SLC9A4 piR-32023-112 lnc-MFSD9-8
GH02J102311 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 27.3 -106.2 -106204 4.3 FOS GABPA FOSL1 JUN IKZF1 IL1RL1 IL18R1 IL18RAP ENSG00000234389 IL1RL2 piR-48553-160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL18RAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL18RAP gene promoter:
  • AML1a
  • AREB6
  • Evi-1
  • GATA-1
  • ISGF-3
  • NF-1
  • NF-1/L
  • RelA

Genomic Locations for IL18RAP Gene

Genomic Locations for IL18RAP Gene
chr2:102,418,558-102,452,568
(GRCh38/hg38)
Size:
34,011 bases
Orientation:
Plus strand
chr2:103,035,149-103,069,025
(GRCh37/hg19)
Size:
33,877 bases
Orientation:
Plus strand

Genomic View for IL18RAP Gene

Genes around IL18RAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18RAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18RAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18RAP Gene

Proteins for IL18RAP Gene

  • Protein details for IL18RAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95256-I18RA_HUMAN
    Recommended name:
    Interleukin-18 receptor accessory protein
    Protein Accession:
    O95256
    Secondary Accessions:
    • B2RPJ3
    • Q2QDE5
    • Q3KPE7
    • Q3KPE8
    • Q53TT4
    • Q53TU5

    Protein attributes for IL18RAP Gene

    Size:
    599 amino acids
    Molecular mass:
    68310 Da
    Quaternary structure:
    • Forms a ternary complex with IL18 and IL18R1 (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable).

    Three dimensional structures from OCA and Proteopedia for IL18RAP Gene

    Alternative splice isoforms for IL18RAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL18RAP Gene

Post-translational modifications for IL18RAP Gene

No data available for DME Specific Peptides for IL18RAP Gene

Domains & Families for IL18RAP Gene

Gene Families for IL18RAP Gene

Suggested Antigen Peptide Sequences for IL18RAP Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-18 receptor beta (I18RA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95256

UniProtKB/Swiss-Prot:

I18RA_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18RAP: view

Function for IL18RAP Gene

Molecular function for IL18RAP Gene

UniProtKB/Swiss-Prot Function:
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
UniProtKB/Swiss-Prot Induction:
Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells.

Phenotypes From GWAS Catalog for IL18RAP Gene

Gene Ontology (GO) - Molecular Function for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042008 interleukin-18 receptor activity IDA 25500532
genes like me logo Genes that share ontologies with IL18RAP: view
genes like me logo Genes that share phenotypes with IL18RAP: view

Animal Models for IL18RAP Gene

MGI Knock Outs for IL18RAP:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL18RAP

CRISPR Products

miRNA for IL18RAP Gene

miRTarBase miRNAs that target IL18RAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18RAP Gene

Localization for IL18RAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18RAP Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL18RAP gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
mitochondrion 0
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0045092 interleukin-18 receptor complex IDA 25500532
genes like me logo Genes that share ontologies with IL18RAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL18RAP Gene

Pathways & Interactions for IL18RAP Gene

genes like me logo Genes that share pathways with IL18RAP: view

Gene Ontology (GO) - Biological Process for IL18RAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS,IEA --
GO:0006955 immune response TAS 9792649
GO:0007165 signal transduction IEA --
GO:0008283 cell proliferation IEA --
GO:0032609 interferon-gamma production IEA --
genes like me logo Genes that share ontologies with IL18RAP: view

No data available for SIGNOR curated interactions for IL18RAP Gene

Drugs & Compounds for IL18RAP Gene

No Compound Related Data Available

Transcripts for IL18RAP Gene

mRNA/cDNA for IL18RAP Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18RAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for IL18RAP Gene

GeneLoc Exon Structure for
IL18RAP
ECgene alternative splicing isoforms for
IL18RAP

Expression for IL18RAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL18RAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18RAP Gene

This gene is overexpressed in Whole Blood (x43.5).

NURSA nuclear receptor signaling pathways regulating expression of IL18RAP Gene:

IL18RAP

SOURCE GeneReport for Unigene cluster for IL18RAP Gene:

Hs.158315

mRNA Expression by UniProt/SwissProt for IL18RAP Gene:

O95256-I18RA_HUMAN
Tissue specificity: Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).

Evidence on tissue expression from TISSUES for IL18RAP Gene

  • Nervous system(4.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with IL18RAP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL18RAP Gene

Orthologs for IL18RAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18RAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL18RAP 33 32
  • 99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL18RAP 33 32
  • 82.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL18RAP 33 32
  • 81.16 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il18rap 17 33 32
  • 76.49 (n)
rat
(Rattus norvegicus)
Mammalia Il18rap 32
  • 76.37 (n)
oppossum
(Monodelphis domestica)
Mammalia IL18RAP 33
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL18RAP 33
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL18RAP 33 32
  • 56.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL18RAP 33
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il18rap 32
  • 54.4 (n)
Species where no ortholog for IL18RAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18RAP Gene

ENSEMBL:
Gene Tree for IL18RAP (if available)
TreeFam:
Gene Tree for IL18RAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL18RAP: view image

Paralogs for IL18RAP Gene

Paralogs for IL18RAP Gene

genes like me logo Genes that share paralogs with IL18RAP: view

Variants for IL18RAP Gene

Sequence variations from dbSNP and Humsavar for IL18RAP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000037389 -- 102,451,667(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000038844 -- 102,424,596(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000166264 -- 102,421,465(+) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000208207 -- 102,435,424(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000362453 -- 102,441,436(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL18RAP Gene

Variant ID Type Subtype PubMed ID
nsv953499 CNV duplication 24416366

Variation tolerance for IL18RAP Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL18RAP Gene

Human Gene Mutation Database (HGMD)
IL18RAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL18RAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18RAP Gene

Disorders for IL18RAP Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL18RAP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
crohn's disease
  • ileitis
inflammatory bowel disease
  • inflammatory bowel diseases
celiac disease 1
  • celiac disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL18RAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL18RAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18RAP Gene

Publications for IL18RAP Gene

  1. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. (PMID: 9792649) Born TL … Sims JE (The Journal of biological chemistry 1998) 2 3 4 23 56
  2. Association study of the IL18RAP locus in three European populations with coeliac disease. (PMID: 19103669) Koskinen LL … Saavalainen P (Human molecular genetics 2009) 3 23 43 56
  3. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PMID: 19473509) Grisoni ML … Tregouet DA (BMC medical genetics 2009) 3 23 43 56
  4. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. (PMID: 18774397) Reijmerink NE … Koppelman GH (The Journal of allergy and clinical immunology 2008) 3 23 43 56
  5. Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues. (PMID: 17897836) Fiszer D … Kurpisz M (Cytokine 2007) 3 4 23 56

Products for IL18RAP Gene

Sources for IL18RAP Gene