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Aliases for IL18R1 Gene

Aliases for IL18R1 Gene

  • Interleukin 18 Receptor 1 2 3 5
  • CD218 Antigen-Like Family Member A 3 4
  • IL1 Receptor-Related Protein 3 4
  • IL-18R-1 3 4
  • CDw218a 3 4
  • IL-18R1 3 4
  • IL-1Rrp 3 4
  • IL1R-Rp 3 4
  • IL1RRP 3 4
  • Interleukin-18 Receptor 1 3
  • Cytokine Receptor 3
  • CD218a Antigen 4
  • IL18Ralpha2 3
  • CD218a 3
  • IL18RA 3

External Ids for IL18R1 Gene

Previous GeneCards Identifiers for IL18R1 Gene

  • GC02P100843
  • GC02P101431
  • GC02P102583
  • GC02P102600
  • GC02P102437
  • GC02P102928
  • GC02P096744

Summaries for IL18R1 Gene

Entrez Gene Summary for IL18R1 Gene

  • The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL18R1 Gene

IL18R1 (Interleukin 18 Receptor 1) is a Protein Coding gene. Diseases associated with IL18R1 include Smallpox and Laron Syndrome. Among its related pathways are Akt Signaling and Immune response_IL-12 signaling pathway. Gene Ontology (GO) annotations related to this gene include interleukin-18 receptor activity. An important paralog of this gene is IL1RAPL2.

UniProtKB/Swiss-Prot for IL18R1 Gene

  • Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

Gene Wiki entry for IL18R1 Gene

Additional gene information for IL18R1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18R1 Gene

Genomics for IL18R1 Gene

GeneHancer (GH) Regulatory Elements for IL18R1 Gene

Promoters and enhancers for IL18R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102311 Promoter 0.7 EPDnew 650.7 +0.0 15 0.1 HMBOX1 GABPA IL18R1 IL1RL1 SDR42E1P5 GC02P101903
GH02J102312 Enhancer 0.5 ENCODE 650.7 +1.9 1909 2.1 FOSL1 IKZF1 JUN FOS SETDB1 IL1RL1 IL18R1 ENSG00000234389 SDR42E1P5 GC02P101903
GH02J102362 Promoter 0.5 EPDnew 650.2 +51.2 51172 0.1 IL18R1 IL18RAP SDR42E1P5 GC02P101903
GH02J102335 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 20.5 +25.3 25250 2.6 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 CBX5 GATA2 ATF7 IL1RL1 IL18R1 IL18RAP ENSG00000234389 SDR42E1P5 GC02P101903
GH02J102040 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -270.0 -270016 2.2 HDGF YBX1 BATF IRF4 ZSCAN9 RARA ZNF366 ATF7 RXRA CEBPB IL1R2 IL1R1 IL18R1 RNF149 IL1R1-AS1 IL1RL2 IL18RAP TBC1D8 MAP4K4 GC02P101903
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL18R1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL18R1 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • AP-4
  • AML1a
  • ZID
  • FOXL1
  • RORalpha2
  • TGIF
  • Cart-1

Genomic Locations for IL18R1 Gene

Genomic Locations for IL18R1 Gene
chr2:102,311,529-102,398,777
(GRCh38/hg38)
Size:
87,249 bases
Orientation:
Plus strand
chr2:102,927,989-103,015,218
(GRCh37/hg19)
Size:
87,230 bases
Orientation:
Plus strand

Genomic View for IL18R1 Gene

Genes around IL18R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18R1 Gene

Proteins for IL18R1 Gene

  • Protein details for IL18R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13478-IL18R_HUMAN
    Recommended name:
    Interleukin-18 receptor 1
    Protein Accession:
    Q13478
    Secondary Accessions:
    • B2R9Y5
    • Q52LC9

    Protein attributes for IL18R1 Gene

    Size:
    541 amino acids
    Molecular mass:
    62304 Da
    Quaternary structure:
    • Heterodimer with IL18RAP; within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).

    Three dimensional structures from OCA and Proteopedia for IL18R1 Gene

neXtProt entry for IL18R1 Gene

Post-translational modifications for IL18R1 Gene

  • Glycosylation at isoforms=297, Asn255, isoforms=236, Asn203, isoforms=197, isoforms=150, isoforms=102, and isoforms=91
  • Modification sites at PhosphoSitePlus

Assay Products

  • Boster Bio ELISA Kits for IL18R1
  • Abcam assays for IL18R1

No data available for DME Specific Peptides for IL18R1 Gene

Domains & Families for IL18R1 Gene

Gene Families for IL18R1 Gene

Suggested Antigen Peptide Sequences for IL18R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13478

UniProtKB/Swiss-Prot:

IL18R_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL18R1: view

Function for IL18R1 Gene

Molecular function for IL18R1 Gene

UniProtKB/Swiss-Prot Function:
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
GENATLAS Biochemistry:
interleukin 18 receptor 1,type 1

Phenotypes From GWAS Catalog for IL18R1 Gene

Gene Ontology (GO) - Molecular Function for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity IEA --
GO:0005515 protein binding IPI 25261253
GO:0038023 signaling receptor activity TAS 9325300
GO:0042008 interleukin-18 receptor activity IEA --
genes like me logo Genes that share ontologies with IL18R1: view
genes like me logo Genes that share phenotypes with IL18R1: view

Animal Models for IL18R1 Gene

MGI Knock Outs for IL18R1:

Animal Model Products

miRNA for IL18R1 Gene

miRTarBase miRNAs that target IL18R1

Clone Products

  • R&D Systems cDNA Clones for IL18R1 (IL-18 R alpha/IL-1 R5)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18R1 Gene

Localization for IL18R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18R1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL18R1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL18R1: view

Pathways & Interactions for IL18R1 Gene

genes like me logo Genes that share pathways with IL18R1: view

SIGNOR curated interactions for IL18R1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL18R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9325300
GO:0007165 signal transduction TAS 9325300
GO:0030101 natural killer cell activation IEA --
GO:0032729 positive regulation of interferon-gamma production IEA --
GO:0035655 interleukin-18-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL18R1: view

Drugs & Compounds for IL18R1 Gene

(43) Drugs for IL18R1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(28) Additional Compounds for IL18R1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18R1: view

Transcripts for IL18R1 Gene

Unigene Clusters for IL18R1 Gene

Interleukin 18 receptor 1:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for IL18R1 (IL-18 R alpha/IL-1 R5)

Alternative Splicing Database (ASD) splice patterns (SP) for IL18R1 Gene

No ASD Table

Relevant External Links for IL18R1 Gene

GeneLoc Exon Structure for
IL18R1
ECgene alternative splicing isoforms for
IL18R1

Expression for IL18R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL18R1 Gene

mRNA differential expression in normal tissues according to GTEx for IL18R1 Gene

This gene is overexpressed in Whole Blood (x20.4) and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for IL18R1 Gene

This gene is overexpressed in Adrenal (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL18R1 Gene



Protein tissue co-expression partners for IL18R1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL18R1 Gene:

IL18R1

SOURCE GeneReport for Unigene cluster for IL18R1 Gene:

Hs.469521

mRNA Expression by UniProt/SwissProt for IL18R1 Gene:

Q13478-IL18R_HUMAN
Tissue specificity: Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart.

Evidence on tissue expression from TISSUES for IL18R1 Gene

  • Lung(2.2)
genes like me logo Genes that share expression patterns with IL18R1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL18R1 Gene

Orthologs for IL18R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL18R1 34 33
  • 99.17 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL18R1 34 33
  • 83.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL18R1 34 33
  • 82.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il18r1 16 34 33
  • 72.67 (n)
rat
(Rattus norvegicus)
Mammalia Il18r1 33
  • 72.66 (n)
oppossum
(Monodelphis domestica)
Mammalia IL18R1 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 19 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IL18R1 34 33
  • 58.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL18R1 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732855 33
  • 54.33 (n)
Species where no ortholog for IL18R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18R1 Gene

ENSEMBL:
Gene Tree for IL18R1 (if available)
TreeFam:
Gene Tree for IL18R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL18R1: view image

Paralogs for IL18R1 Gene

Paralogs for IL18R1 Gene

(2) SIMAP similar genes for IL18R1 Gene using alignment to 3 proteins:

  • IL18R_HUMAN
  • B7ZKV7_HUMAN
  • Q86YL8_HUMAN
genes like me logo Genes that share paralogs with IL18R1: view

Variants for IL18R1 Gene

Sequence variations from dbSNP and Humsavar for IL18R1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000117409 -- 102,391,704(+) TTTTTT/TTTTTTT genic_downstream_transcript_variant, intron_variant
rs1000176930 -- 102,373,713(+) C/A intron_variant
rs1000183822 -- 102,380,176(+) A/G intron_variant
rs1000219085 -- 102,389,787(+) G/T intron_variant
rs1000257222 -- 102,380,475(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL18R1 Gene

Variant ID Type Subtype PubMed ID
esv3591790 CNV loss 21293372
nsv1160830 CNV deletion 26073780
nsv2856 CNV deletion 18451855

Variation tolerance for IL18R1 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL18R1 Gene

Human Gene Mutation Database (HGMD)
IL18R1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL18R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18R1 Gene

Disorders for IL18R1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IL18R1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
laron syndrome
  • growth hormone insensitivity syndrome
acute basophilic leukemia
human monocytic ehrlichiosis
  • ehrlichiosis chafeensis
anthracosis
  • pneumoconiosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL18R1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL18R1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18R1 Gene

Publications for IL18R1 Gene

  1. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (PMID: 19473509) Grisoni ML … Tregouet DA (BMC medical genetics 2009) 3 22 44 58
  2. IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (PMID: 16971411) Nadif R … Kleeberger SR (The European respiratory journal 2006) 3 22 44 58
  3. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M … Nicklin MJ (Genomics 1999) 2 3 22 58
  4. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. (PMID: 8626725) Parnet P … Sims JE (The Journal of biological chemistry 1996) 2 3 4 58
  5. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PMID: 19910030) Wu H … London SJ (The Journal of allergy and clinical immunology 2010) 3 44 58

Products for IL18R1 Gene

  • Boster Bio Antibodies for IL18R1
  • Boster Bio ELISA Kits for IL18R1

Sources for IL18R1 Gene

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