Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL18BP Gene

Aliases for IL18BP Gene

  • Interleukin 18 Binding Protein 2 3 5
  • MC51L-53L-54L Homolog Gene Product 2 3
  • Tadekinig-Alfa 3 4
  • Interleukin-18-Binding Protein 3
  • IL18BPa 3
  • IL-18BP 4

External Ids for IL18BP Gene

Previous GeneCards Identifiers for IL18BP Gene

  • GC11P074042
  • GC11P073248
  • GC11P071931
  • GC11P071435
  • GC11P071436
  • GC11P071387
  • GC11P071709
  • GC11P068003

Summaries for IL18BP Gene

Entrez Gene Summary for IL18BP Gene

  • The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL18BP Gene

IL18BP (Interleukin 18 Binding Protein) is a Protein Coding gene. Diseases associated with IL18BP include Molluscum Contagiosum and Gillessen-Kaesbach-Nishimura Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor antagonist activity and interleukin-18 binding.

UniProtKB/Swiss-Prot for IL18BP Gene

  • Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Gene Wiki entry for IL18BP Gene

Additional gene information for IL18BP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18BP Gene

Genomics for IL18BP Gene

GeneHancer (GH) Regulatory Elements for IL18BP Gene

Promoters and enhancers for IL18BP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J071995 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.6 566 5.1 PKNOX1 ARNT TCF12 ZFP91 ATF7 NCOA1 REST ZNF592 MBD2 SMARCA4 IL18BP LRTOMT LOC100133315 RNF121 LAMTOR1 ANAPC15 FAM86C1 GC11P072002
GH11J072430 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.4 +435.0 434983 4.7 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ZNF610 ZNF585B CLPB NUMA1 LOC100128494 ZNF705E RNF121 IL18BP NADSYN1 FAM86C1 ENSG00000255672 ENSG00000256739
GH11J071927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.6 -68.1 -68110 5.5 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 RNF121 LOC100133315 NUMA1 LOC100128494 ZNF705E IL18BP NADSYN1 FAM86C1 LOC220077 KRTAP5-13P
GH11J071446 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.1 -546.9 -546888 8.5 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 NADSYN1 DHCR7 ENSG00000254682 NUMA1 LOC100128494 ZNF705E IL18BP ALG1L9P
GH11J072077 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.7 +82.9 82915 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 NUMA1 LRTOMT ENSG00000284922 LOC100128494 FAM86C1 NADSYN1 IL18BP OR7E128P ZNF705E RNF121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL18BP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL18BP gene promoter:
  • STAT3

Genomic Locations for IL18BP Gene

Genomic Locations for IL18BP Gene
chr11:71,997,944-72,005,715
(GRCh38/hg38)
Size:
7,772 bases
Orientation:
Plus strand
chr11:71,709,587-71,716,761
(GRCh37/hg19)
Size:
7,175 bases
Orientation:
Plus strand

Genomic View for IL18BP Gene

Genes around IL18BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18BP Gene

Proteins for IL18BP Gene

  • Protein details for IL18BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95998-I18BP_HUMAN
    Recommended name:
    Interleukin-18-binding protein
    Protein Accession:
    O95998
    Secondary Accessions:
    • B3KUZ0
    • B7WPK4
    • O95993
    • O96027
    • Q9NZA9
    • Q9UBR7

    Protein attributes for IL18BP Gene

    Size:
    194 amino acids
    Molecular mass:
    21099 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD17187.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17189.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAD17190.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD17192.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF31697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IL18BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL18BP Gene

Post-translational modifications for IL18BP Gene

  • N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.
  • Glycosylation at Asn147, isoforms=4103, Asn94, isoforms=479, Ser53, isoforms=3, 447, and isoforms=3, 446
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • I18BP_HUMAN (669)

Antibody Products

  • Boster Bio Antibodies for IL18BP

No data available for DME Specific Peptides for IL18BP Gene

Domains & Families for IL18BP Gene

Gene Families for IL18BP Gene

Protein Domains for IL18BP Gene

Suggested Antigen Peptide Sequences for IL18BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL18BP: view

No data available for UniProtKB/Swiss-Prot for IL18BP Gene

Function for IL18BP Gene

Molecular function for IL18BP Gene

UniProtKB/Swiss-Prot Function:
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
GENATLAS Biochemistry:
interleukin 18 binding protein homolog to several poxvirus proteins,expressed in the spleen inhibitor of the early Th1 cytokine response,abolishing IL18 induction of INF gamma

Phenotypes From GWAS Catalog for IL18BP Gene

Gene Ontology (GO) - Molecular Function for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042007 interleukin-18 binding IDA 10023777
GO:0048019 receptor antagonist activity TAS 11890646
genes like me logo Genes that share ontologies with IL18BP: view
genes like me logo Genes that share phenotypes with IL18BP: view

Animal Models for IL18BP Gene

MGI Knock Outs for IL18BP:
  • Il18bp Il18bp<tm1(KOMP)Vlcg>
  • Il18bp Il18bp<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for IL18BP

miRNA for IL18BP Gene

miRTarBase miRNAs that target IL18BP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18BP Gene

Localization for IL18BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18BP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL18BP gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10023777
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with IL18BP: view

Pathways & Interactions for IL18BP Gene

genes like me logo Genes that share pathways with IL18BP: view

Pathways by source for IL18BP Gene

1 R&D Systems pathway for IL18BP Gene

Gene Ontology (GO) - Biological Process for IL18BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032496 response to lipopolysaccharide IEA --
GO:0035655 interleukin-18-mediated signaling pathway TAS --
GO:0042088 T-helper 1 type immune response IDA 10023777
GO:0070301 cellular response to hydrogen peroxide IEA --
GO:0071345 cellular response to cytokine stimulus TAS --
genes like me logo Genes that share ontologies with IL18BP: view

No data available for SIGNOR curated interactions for IL18BP Gene

Drugs & Compounds for IL18BP Gene

(2) Drugs for IL18BP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL18BP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18BP: view

Transcripts for IL18BP Gene

Unigene Clusters for IL18BP Gene

Interleukin 18 binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18BP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: - - -
SP6:
SP7: -

Relevant External Links for IL18BP Gene

GeneLoc Exon Structure for
IL18BP
ECgene alternative splicing isoforms for
IL18BP

Expression for IL18BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL18BP Gene

Protein differential expression in normal tissues from HIPED for IL18BP Gene

This gene is overexpressed in Serum (42.2) and Urine (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL18BP Gene



Protein tissue co-expression partners for IL18BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL18BP Gene:

IL18BP

SOURCE GeneReport for Unigene cluster for IL18BP Gene:

Hs.591967

mRNA Expression by UniProt/SwissProt for IL18BP Gene:

O95998-I18BP_HUMAN
Tissue specificity: Strongly expressed in heart, lung, placenta and spleen.

Evidence on tissue expression from TISSUES for IL18BP Gene

  • Blood(4.4)
  • Intestine(2.6)
  • Spleen(2.3)
  • Kidney(2.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IL18BP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL18BP Gene

Orthologs for IL18BP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL18BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL18BP 34 33
  • 99.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL18BP 34 33
  • 80.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il18bp 16 34 33
  • 78.02 (n)
rat
(Rattus norvegicus)
Mammalia Il18bp 33
  • 75.09 (n)
dog
(Canis familiaris)
Mammalia IL18BP 34 33
  • 75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL18BP 34
  • 35 (a)
OneToOne
Species where no ortholog for IL18BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18BP Gene

ENSEMBL:
Gene Tree for IL18BP (if available)
TreeFam:
Gene Tree for IL18BP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL18BP: view image

Paralogs for IL18BP Gene

No data available for Paralogs for IL18BP Gene

Variants for IL18BP Gene

Sequence variations from dbSNP and Humsavar for IL18BP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000120970 -- 72,001,986(+) C/T 3_prime_UTR_variant
rs1000716402 -- 72,000,813(+) T/C intron_variant
rs1000969227 -- 72,002,719(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001266929 -- 71,998,995(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001373065 -- 71,997,103(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL18BP Gene

Variant ID Type Subtype PubMed ID
nsv951037 CNV deletion 24416366
nsv428262 CNV gain+loss 18775914

Variation tolerance for IL18BP Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL18BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL18BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18BP Gene

Disorders for IL18BP Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL18BP Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL18BP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL18BP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18BP Gene

Publications for IL18BP Gene

  1. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. (PMID: 10023777) Novick D … Rubinstein M (Immunity 1999) 2 3 4 22 58
  2. Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men. (PMID: 17951325) Thompson SR … Humphries SE (Arteriosclerosis, thrombosis, and vascular biology 2007) 3 22 44 58
  3. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. (PMID: 10655506) Kim SH … Dinarello CA (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 58
  4. Cloning and expression of interleukin-18 binding protein. (PMID: 10094485) Aizawa Y … Kurimoto M (FEBS letters 1999) 3 4 22 58
  5. Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients. (PMID: 19394601) Huang HY … Soong YK (Fertility and sterility 2010) 3 22 58

Products for IL18BP Gene

  • Boster Bio Antibodies for IL18BP
  • Boster Bio ELISA Kits for IL18BP

Sources for IL18BP Gene

Content
Loading form....