Aliases for IL18 Gene
External Ids for IL18 Gene
Previous GeneCards Identifiers for IL18 Gene
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
GeneCards Summary for IL18 Gene
IL18 (Interleukin 18) is a Protein Coding gene. Diseases associated with IL18 include Adult-Onset Still's Disease and Shigellosis. Among its related pathways are ERK Signaling and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot Summary for IL18 Gene
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).