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Aliases for IL18 Gene

Aliases for IL18 Gene

  • Interleukin 18 2 3 5
  • Interleukin 18 (Interferon-Gamma-Inducing Factor) 2 3
  • IFN-Gamma-Inducing Factor 3 4
  • Interleukin-1 Gamma 3 4
  • Iboctadekin 3 4
  • IL-1 Gamma 3 4
  • IL-18 3 4
  • IL1F4 3 4
  • IGIF 3 4
  • Interferon Gamma-Inducing Factor 4
  • Interferon-Gamma-Inducing Factor 2
  • Interleukin-18 3
  • IL-1g 3

External Ids for IL18 Gene

Previous GeneCards Identifiers for IL18 Gene

  • GC11M114366
  • GC11M113526
  • GC11M112047
  • GC11M111551
  • GC11M111519
  • GC11M107938
  • GC11M112013

Summaries for IL18 Gene

Entrez Gene Summary for IL18 Gene

  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for IL18 Gene

IL18 (Interleukin 18) is a Protein Coding gene. Diseases associated with IL18 include Adult-Onset Still's Disease and Pleural Tuberculosis. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL18 Gene

  • Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Gene Wiki entry for IL18 Gene

Additional gene information for IL18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18 Gene

Genomics for IL18 Gene

GeneHancer (GH) Regulatory Elements for IL18 Gene

Promoters and enhancers for IL18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J112155 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 676.7 +2.6 2575 11.5 FOXA2 SIN3A FEZF1 BRCA1 ETS1 YY1 ZFP91 ATF7 FOS RXRA IL18 BCO2 TIMM8B ENSG00000255292 SDHD C11orf88 ENSG00000254638
GH11J112119 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.3 +43.2 43246 3.1 PKNOX1 JUN JUNB CEBPB EP300 JUND MAFF POLR2A EED FOS IL18 TIMM8B ENSG00000255292 SDHD TEX12 BCO2 LOC101928847 ALG9
GH11J112023 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +139.0 138985 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DLAT PPP2R1B FDXACB1 ALG9 NKAPD1 PIH1D2 DIXDC1 IL18 CRYAB C11orf52
GH11J112128 Enhancer 0.9 Ensembl ENCODE 11.4 +35.0 35035 2.2 KLF1 NFIB JUN KLF17 FOSL1 GATA3 ZBTB48 PRDM10 FOSL2 FOS BCO2 IL18 TEX12 ENSG00000255292 ENSG00000254638 SDHD TIMM8B NKAPD1 PIH1D2 CRYAB
GH11J112131 Enhancer 0.4 ENCODE 11.4 +32.3 32256 1.3 SCRT1 JUND SCRT2 IL18 TEX12 ENSG00000255292 BCO2 ENSG00000254638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL18 gene promoter:
  • TBP
  • AP-1
  • NF-kappaB1
  • NF-kappaB
  • ATF-2

Genomic Locations for IL18 Gene

Genomic Locations for IL18 Gene
20,867 bases
Minus strand
20,867 bases
Minus strand

Genomic View for IL18 Gene

Genes around IL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18 Gene

Proteins for IL18 Gene

  • Protein details for IL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O75599
    • Q6FGY3
    • Q6WWJ7

    Protein attributes for IL18 Gene

    193 amino acids
    Molecular mass:
    22326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL18 Gene

    Alternative splice isoforms for IL18 Gene


neXtProt entry for IL18 Gene

Post-translational modifications for IL18 Gene

  • The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL18 Gene

No data available for DME Specific Peptides for IL18 Gene

Domains & Families for IL18 Gene

Gene Families for IL18 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IL18 Gene

Suggested Antigen Peptide Sequences for IL18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-1 family.
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL18: view

Function for IL18 Gene

Molecular function for IL18 Gene

UniProtKB/Swiss-Prot Function:
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
UniProtKB/Swiss-Prot Induction:
In macrophages, release is increased by endocannabinoid anandamide/AEA.
GENATLAS Biochemistry:
interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity

Phenotypes From GWAS Catalog for IL18 Gene

Gene Ontology (GO) - Molecular Function for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity ISS,TAS 11598150
GO:0005515 protein binding IPI 19104048
genes like me logo Genes that share ontologies with IL18: view
genes like me logo Genes that share phenotypes with IL18: view

Animal Models for IL18 Gene

MGI Knock Outs for IL18:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL18 Gene

Localization for IL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL18 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
lysosome 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11598150
GO:0005615 extracellular space IDA 21323571
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with IL18: view

Pathways & Interactions for IL18 Gene

genes like me logo Genes that share pathways with IL18: view

SIGNOR curated interactions for IL18 Gene


Gene Ontology (GO) - Biological Process for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001525 angiogenesis IDA 11466388
GO:0006954 inflammatory response IDA 21147091
GO:0006955 immune response TAS 8999896
GO:0007267 cell-cell signaling TAS 9792649
genes like me logo Genes that share ontologies with IL18: view

Drugs & Compounds for IL18 Gene

(78) Drugs for IL18 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ribavirin Approved Pharma 1017
Tacrolimus Approved, Investigational Pharma 1151
interferons Pharma 2249

(59) Additional Compounds for IL18 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL18: view

Transcripts for IL18 Gene

Unigene Clusters for IL18 Gene

Interleukin 18 (interferon-gamma-inducing factor):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for IL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.1), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for IL18 Gene

This gene is overexpressed in Lymph node (11.0), Oral epithelium (10.0), and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL18 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL18 Gene:


SOURCE GeneReport for Unigene cluster for IL18 Gene:


Evidence on tissue expression from TISSUES for IL18 Gene

  • Blood(4.7)
  • Liver(4.5)
  • Skin(3.3)
  • Spleen(3.3)
  • Lymph node(3.2)
  • Kidney(2.9)
  • Lung(2.9)
  • Intestine(2.8)
  • Bone marrow(2.6)
  • Nervous system(2.4)
  • Heart(2.2)
  • Urine(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with IL18: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL18 Gene

Orthologs for IL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL18 34 33
  • 99.48 (n)
(Bos Taurus)
Mammalia IL18 34 33
  • 86.36 (n)
(Canis familiaris)
Mammalia IL18 34 33
  • 84.55 (n)
(Mus musculus)
Mammalia Il18 16 34 33
  • 75.53 (n)
(Rattus norvegicus)
Mammalia Il18 33
  • 74.39 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 43 (a)
-- 34
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia IL18 34
  • 36 (a)
(Gallus gallus)
Aves IL18 34
  • 33 (a)
(Anolis carolinensis)
Reptilia IL18 34
  • 29 (a)
Species where no ortholog for IL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18 Gene

Gene Tree for IL18 (if available)
Gene Tree for IL18 (if available)
Evolutionary constrained regions (ECRs) for IL18: view image

Paralogs for IL18 Gene

(1) SIMAP similar genes for IL18 Gene using alignment to 2 proteins:

  • IL18_HUMAN
  • B0YJ28_HUMAN
genes like me logo Genes that share paralogs with IL18: view

No data available for Paralogs for IL18 Gene

Variants for IL18 Gene

Sequence variations from dbSNP and Humsavar for IL18 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000120984 -- 112,145,765(-) A/G intron_variant
rs1000157208 -- 112,151,016(-) T/G intron_variant
rs1000352535 -- 112,160,072(-) C/T intron_variant
rs1000372405 -- 112,144,531(-) G/A intron_variant
rs1000722644 -- 112,144,350(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL18 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073
nsv1134175 CNV deletion 24896259
nsv519192 CNV gain 19592680

Variation tolerance for IL18 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL18 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18 Gene

Disorders for IL18 Gene

MalaCards: The human disease database

(65) MalaCards diseases for IL18 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adult-onset still's disease
  • adult onset still's disease
pleural tuberculosis
  • pearly disease
stachybotrys chartarum
  • stachybotrys atra
uremic pruritus
gillessen-kaesbach-nishimura syndrome
  • gikanis
- elite association - COSMIC cancer census association via MalaCards
Search IL18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18 Gene

Publications for IL18 Gene

  1. Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. (PMID: 20418295) Monitto CL … Brown RH (Anesthesia and analgesia 2010) 3 22 44 58
  2. [Correlations between serum interleukin-18 (IL-18) level, IL-18 gene promoter polymorphisms and the development of sepsis in children]. (PMID: 20441695) Cai LL … Zeng X (Zhonghua er ke za zhi = Chinese journal of pediatrics 2010) 3 22 44 58
  3. Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E … Petridou ET (European journal of haematology 2009) 3 22 44 58
  4. Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. (PMID: 19347053) Steinbrugger I … Weger M (Molecular vision 2009) 3 22 44 58
  5. Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans. (PMID: 18307517) Taudorf S … Bruunsgaard H (Clinical and experimental immunology 2008) 3 22 44 58

Products for IL18 Gene

Sources for IL18 Gene

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