This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by Re... See more...

Aliases for IL17RE Gene

Aliases for IL17RE Gene

  • Interleukin 17 Receptor E 2 3 5
  • Interleukin-17 Receptor E 3 4
  • IL-17 Receptor E 3 4
  • IL-17RE 4

External Ids for IL17RE Gene

Previous GeneCards Identifiers for IL17RE Gene

  • GC03P009936
  • GC03P009919
  • GC03P009903
  • GC03P009944
  • GC03P009880
  • GC03P009904
  • GC03P009905
  • GC03P009924
  • GC03P009925
  • GC03P009927
  • GC03P009906
  • GC03P009914
  • GC03P009916
  • GC03P009918
  • GC03P009920
  • GC03P009921
  • GC03P009922
  • GC03P009923

Summaries for IL17RE Gene

Entrez Gene Summary for IL17RE Gene

  • This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL17RE Gene

IL17RE (Interleukin 17 Receptor E) is a Protein Coding gene. Diseases associated with IL17RE include Seborrheic Infantile Dermatitis and Cutaneous Candidiasis. Among its related pathways are IL-17 Family Signaling Pathways and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RC.

UniProtKB/Swiss-Prot Summary for IL17RE Gene

  • Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Additional gene information for IL17RE Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17RE Gene

Genomics for IL17RE Gene

GeneHancer (GH) Regulatory Elements for IL17RE Gene

Promoters and enhancers for IL17RE Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17RE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17RE

Top Transcription factor binding sites by QIAGEN in the IL17RE gene promoter:
  • AP-1
  • ATF-2

Genomic Locations for IL17RE Gene

Genomic Locations for IL17RE Gene
chr3:9,902,062-9,916,402
(GRCh38/hg38)
Size:
14,341 bases
Orientation:
Plus strand
chr3:9,944,296-9,958,086
(GRCh37/hg19)
Size:
13,791 bases
Orientation:
Plus strand

Genomic View for IL17RE Gene

Genes around IL17RE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RE Gene

Proteins for IL17RE Gene

  • Protein details for IL17RE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFR9-I17RE_HUMAN
    Recommended name:
    Interleukin-17 receptor E
    Protein Accession:
    Q8NFR9
    Secondary Accessions:
    • B2RB34
    • B2RNR1
    • B9EH65
    • Q6P532
    • Q8N8H7
    • Q8N8H8
    • Q8TEC2

    Protein attributes for IL17RE Gene

    Size:
    667 amino acids
    Molecular mass:
    74810 Da
    Quaternary structure:
    • Forms heterodimers with IL17RA; the heterodimer binds IL17C.
    SequenceCaution:

    Alternative splice isoforms for IL17RE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RE Gene

Post-translational modifications for IL17RE Gene

  • Glycosylation at Asn318, Asn347, and Asn364
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL17RE Gene

Domains & Families for IL17RE Gene

Gene Families for IL17RE Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL17RE Gene

Blocks:
  • SEFIR
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17RE Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57755, highly similar to Homo sapiens interleukin 17 receptor E (IL17RE), transcript variant 5, mRNA (A6NL85_HUMAN)
  • Interleukin-17 receptor E (I17RE_HUMAN)
genes like me logo Genes that share domains with IL17RE: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL17RE Gene

Function for IL17RE Gene

Molecular function for IL17RE Gene

UniProtKB/Swiss-Prot Function:
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Phenotypes From GWAS Catalog for IL17RE Gene

Gene Ontology (GO) - Molecular Function for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with IL17RE: view
genes like me logo Genes that share phenotypes with IL17RE: view

Animal Models for IL17RE Gene

MGI Knock Outs for IL17RE:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17RE

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17RE Gene

Localization for IL17RE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RE Gene

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
[Isoform 2]: Cytoplasm.
[Isoform 3]: Secreted.
[Isoform 4]: Cytoplasm.
[Isoform 5]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RE gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
nucleus 1
cytosol 1
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17RE Gene

Pathways & Interactions for IL17RE Gene

genes like me logo Genes that share pathways with IL17RE: view

Pathways by source for IL17RE Gene

1 R&D Systems pathway for IL17RE Gene

Gene Ontology (GO) - Biological Process for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0097400 interleukin-17-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL17RE: view

No data available for SIGNOR curated interactions for IL17RE Gene

Drugs & Compounds for IL17RE Gene

No Compound Related Data Available

Transcripts for IL17RE Gene

mRNA/cDNA for IL17RE Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RE Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for IL17RE Gene

GeneLoc Exon Structure for
IL17RE

Expression for IL17RE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17RE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RE Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.6), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for IL17RE Gene

This gene is overexpressed in Esophagus (35.2) and Stomach (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17RE Gene



Protein tissue co-expression partners for IL17RE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17RE

SOURCE GeneReport for Unigene cluster for IL17RE Gene:

Hs.390823

mRNA Expression by UniProt/SwissProt for IL17RE Gene:

Q8NFR9-I17RE_HUMAN
Tissue specificity: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

Evidence on tissue expression from TISSUES for IL17RE Gene

  • Skin(4.4)
  • Lung(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with IL17RE: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RE Gene

Orthologs for IL17RE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RE 31 30
  • 99.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RE 31 30
  • 84.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RE 31 30
  • 83.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il17re 17 31 30
  • 78.38 (n)
rat
(Rattus norvegicus)
Mammalia Il17re 30
  • 78.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RE 31
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RE 31
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RE 31
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RE 31
  • 45 (a)
OneToOne
Species where no ortholog for IL17RE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RE Gene

ENSEMBL:
Gene Tree for IL17RE (if available)
TreeFam:
Gene Tree for IL17RE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17RE: view image

Paralogs for IL17RE Gene

Paralogs for IL17RE Gene

genes like me logo Genes that share paralogs with IL17RE: view

Variants for IL17RE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17RE Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
712434 Benign: not provided 9,910,984(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
773438 Benign: not provided 9,902,952(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
791238 Benign: not provided 9,907,090(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
791239 Benign: not provided 9,910,875(+) C/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs7356031 - p.Tyr219Cys

Additional dbSNP identifiers (rs#s) for IL17RE Gene

Structural Variations from Database of Genomic Variants (DGV) for IL17RE Gene

Variant ID Type Subtype PubMed ID
nsv1073203 CNV deletion 25765185
nsv589648 CNV loss 21841781
nsv834615 CNV loss 17160897

Variation tolerance for IL17RE Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RE Gene

Disorders for IL17RE Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL17RE Gene - From: DISEASES

Disorder Aliases PubMed IDs
seborrheic infantile dermatitis
  • complement component 5 deficiency
cutaneous candidiasis
  • candidiasis, cutaneous
chronic mucocutaneous candidiasis
  • cmc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL17RE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17RE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17RE Gene

Publications for IL17RE Gene

  1. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V … Pappu R (Nature immunology 2011) 3 4 54
  2. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. (PMID: 21993849) Song X … Qian Y (Nature immunology 2011) 3 4 54
  3. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PMID: 20459687) Eid NA … Ibrahim ME (Malaria journal 2010) 3 41 54
  4. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway. (PMID: 16310341) Li TS … Liu L (Cellular signalling 2006) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for IL17RE Gene

Sources for IL17RE Gene