This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through... See more...

Aliases for IL17RD Gene

Aliases for IL17RD Gene

  • Interleukin 17 Receptor D 2 3 5
  • Interleukin-17 Receptor-Like Protein 3 4
  • Interleukin-17 Receptor D 3 4
  • IL-17 Receptor D 3 4
  • Sef Homolog 3 4
  • IL17Rhom 3 4
  • IL-17RD 3 4
  • IL17RLM 3 4
  • SEF 3 4
  • HH18 3
  • HSef 4

External Ids for IL17RD Gene

Previous GeneCards Identifiers for IL17RD Gene

  • GC03M056983
  • GC03M057085
  • GC03M057103
  • GC03M057124

Summaries for IL17RD Gene

Entrez Gene Summary for IL17RD Gene

  • This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for IL17RD Gene

IL17RD (Interleukin 17 Receptor D) is a Protein Coding gene. Diseases associated with IL17RD include Hypogonadotropic Hypogonadism 18 With Or Without Anosmia and Kallmann Syndrome. Among its related pathways are RET signaling and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RA.

UniProtKB/Swiss-Prot Summary for IL17RD Gene

  • Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Additional gene information for IL17RD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17RD Gene

Genomics for IL17RD Gene

GeneHancer (GH) Regulatory Elements for IL17RD Gene

Promoters and enhancers for IL17RD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J057158 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.4 +8.9 8930 8.8 ZSCAN5C NRF1 TEAD4 ZIC2 ZBTB26 ZEB1 MXI1 POLR2A OSR2 EZH2 IL17RD SPATA12 ARHGEF3 APPL1 HESX1 ASB14 DNAH12 SLMAP lnc-HESX1-2 LOC105377101
GH03J057169 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 116 0.8 CTCF NRF1 REST RFX1 RAD21 CTBP1 ZBTB7A SKI TRIM22 ZEB1 IL17RD APPL1 HESX1 PDE12 ASB14 DNAH12 DENND6A DENND6A-DT SLMAP lnc-HESX1-2
GH03J057170 Promoter 0.6 CraniofacialAtlas 500.7 +0.6 644 0.2 ZFHX2 ELF1 PKNOX1 IL17RD lnc-HESX1-2
GH03J057127 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 20 +40.2 40236 5.4 USF1 HDAC2 MXI1 POLR2A RXRA GATA3 REST NANOG TCF12 ETS1 IL17RD ARHGEF3 APPL1 HESX1 ASB14 DNAH12 SLMAP RPL19P2 piR-57133-427 lnc-HESX1-2
GH03J057141 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.2 +27.4 27431 2.6 MXI1 GATA3 TCF12 RCOR1 RAD21 ATF2 CTCF EP300 CHD2 GATA2 IL17RD APPL1 HESX1 SLMAP ENSG00000229863 LOC105377101 lnc-HESX1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17RD on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17RD

Top Transcription factor binding sites by QIAGEN in the IL17RD gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • C/EBPbeta
  • MEF-2A
  • Nkx2-5
  • p53
  • Pbx1a
  • POU6F1 (c2)

Genomic Locations for IL17RD Gene

Genomic Locations for IL17RD Gene
chr3:57,089,982-57,170,317
(GRCh38/hg38)
Size:
80,336 bases
Orientation:
Minus strand
chr3:57,124,010-57,204,334
(GRCh37/hg19)
Size:
80,325 bases
Orientation:
Minus strand

Genomic View for IL17RD Gene

Genes around IL17RD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RD Gene

Proteins for IL17RD Gene

  • Protein details for IL17RD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFM7-I17RD_HUMAN
    Recommended name:
    Interleukin-17 receptor D
    Protein Accession:
    Q8NFM7
    Secondary Accessions:
    • Q2NKP7
    • Q58EZ7
    • Q6RVF4
    • Q6UWI5
    • Q8N113
    • Q8NFS0
    • Q9UFA0

    Protein attributes for IL17RD Gene

    Size:
    739 amino acids
    Molecular mass:
    82411 Da
    Quaternary structure:
    • Interacts with MAP3K7 (By similarity). Self-associates. Interacts with FGFR1, FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex.

    Alternative splice isoforms for IL17RD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RD Gene

Post-translational modifications for IL17RD Gene

  • Glycosylation at Asn19, Asn55, Asn171, Asn62, Asn80, Asn206, Asn137, and Asn277
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RD Gene

No data available for DME Specific Peptides for IL17RD Gene

Domains & Families for IL17RD Gene

Gene Families for IL17RD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL17RD Gene

Suggested Antigen Peptide Sequences for IL17RD Gene

GenScript: Design optimal peptide antigens:
  • Sef homolog (I17RD_HUMAN)
genes like me logo Genes that share domains with IL17RD: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL17RD Gene

Function for IL17RD Gene

Molecular function for IL17RD Gene

UniProtKB/Swiss-Prot Function:
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Phenotypes From GWAS Catalog for IL17RD Gene

Gene Ontology (GO) - Molecular Function for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030368 interleukin-17 receptor activity IBA 21873635
genes like me logo Genes that share ontologies with IL17RD: view
genes like me logo Genes that share phenotypes with IL17RD: view

Human Phenotype Ontology for IL17RD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RD Gene

MGI Knock Outs for IL17RD:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17RD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17RD Gene

Localization for IL17RD Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RD Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
[Isoform 4]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RD gene
Compartment Confidence
nucleus 5
plasma membrane 4
golgi apparatus 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17RD: view

Pathways & Interactions for IL17RD Gene

PathCards logo

SuperPathways for IL17RD Gene

SuperPathway Contained pathways
1 RET signaling
2 IL-17 Family Signaling Pathways
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 Innate Immune System
genes like me logo Genes that share pathways with IL17RD: view

Gene Ontology (GO) - Biological Process for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL17RD: view

No data available for SIGNOR curated interactions for IL17RD Gene

Drugs & Compounds for IL17RD Gene

(1) Drugs for IL17RD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IL17RD: view

Transcripts for IL17RD Gene

mRNA/cDNA for IL17RD Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RD Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3:

Relevant External Links for IL17RD Gene

GeneLoc Exon Structure for
IL17RD

Expression for IL17RD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17RD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RD Gene

This gene is overexpressed in Uterus (x4.6).

Protein differential expression in normal tissues from HIPED for IL17RD Gene

This gene is overexpressed in Bone (62.9) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17RD Gene



Protein tissue co-expression partners for IL17RD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17RD

SOURCE GeneReport for Unigene cluster for IL17RD Gene:

Hs.150725

mRNA Expression by UniProt/SwissProt for IL17RD Gene:

Q8NFM7-I17RD_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
Pelvis:
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with IL17RD: view

No data available for Evidence on tissue expression from TISSUES for IL17RD Gene

Orthologs for IL17RD Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RD 31 30
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RD 31 30
  • 87.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RD 31 30
  • 87.44 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17rd 30
  • 85.66 (n)
mouse
(Mus musculus)
Mammalia Il17rd 17 31 30
  • 85.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IL17RD 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RD 31 30
  • 72.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RD 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17rd 30
  • 68.85 (n)
Str.19050 30
zebrafish
(Danio rerio)
Actinopterygii il17rd 31 30 30
  • 60.16 (n)
OneToMany
IL17RD (2 of 2) 31
  • 23 (a)
OneToMany
Species where no ortholog for IL17RD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RD Gene

ENSEMBL:
Gene Tree for IL17RD (if available)
TreeFam:
Gene Tree for IL17RD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17RD: view image

Paralogs for IL17RD Gene

Paralogs for IL17RD Gene

genes like me logo Genes that share paralogs with IL17RD: view

Variants for IL17RD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17RD Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
677804 Likely Benign: not provided 57,097,731(-) T/C MISSENSE_VARIANT
712436 Benign: not provided 57,098,158(-) G/A SYNONYMOUS_VARIANT
712460 Benign: not provided 57,097,779(-) C/G MISSENSE_VARIANT
718011 Likely Benign: not provided 57,101,275(-) C/T SYNONYMOUS_VARIANT
718248 Likely Benign: not provided 57,097,629(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IL17RD Gene

Structural Variations from Database of Genomic Variants (DGV) for IL17RD Gene

Variant ID Type Subtype PubMed ID
nsv3835 CNV deletion 18451855
nsv819583 CNV gain 19587683

Variation tolerance for IL17RD Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.88; 87.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RD Gene

Human Gene Mutation Database (HGMD)
IL17RD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RD Gene

Disorders for IL17RD Gene

MalaCards: The human disease database

(7) MalaCards diseases for IL17RD Gene - From: UniProtKB/Swiss-Prot, OMIM, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 18 with or without anosmia
  • hh18
kallmann syndrome
  • hypogonadotropic hypogonadism and anosmia
hypogonadotropic hypogonadism 7 with or without anosmia
  • hh7
hypogonadotropic hypogonadism
  • congenital idiopathic hypogonadotropic hypogonadism
hypogonadism
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RD_HUMAN
  • Hypogonadotropic hypogonadism 18 with or without anosmia (HH18) [MIM:615267]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in IL17RD also have a heterozygous mutation in another HH-associated gene including FGFR1 and KISS1R (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Additional Disease Information for IL17RD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17RD: view

No data available for Genatlas for IL17RD Gene

Publications for IL17RD Gene

  1. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. (PMID: 14742870) Preger E … Ron D (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 54
  2. hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. (PMID: 12958313) Xiong S … Chang Z (The Journal of biological chemistry 2003) 3 4 23 54
  3. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. (PMID: 23643382) Miraoui H … Pitteloud N (American journal of human genetics 2013) 3 4 54
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  5. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. (PMID: 19079364) Rong Z … Chang Z (Cell research 2009) 3 23 54

Products for IL17RD Gene

Sources for IL17RD Gene