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Aliases for IL17RC Gene

Aliases for IL17RC Gene

  • Interleukin 17 Receptor C 2 3 5
  • Interleukin-17 Receptor-Like Protein 3 4
  • Interleukin-17 Receptor Homolog 3 4
  • IL-17 Receptor C 3 4
  • ZcytoR14 3 4
  • IL17Rhom 3 4
  • IL-17RL 3 4
  • Interleukin-17 Receptor C 3
  • IL17F Receptor 3
  • IL17-RL 3
  • IL-17RC 4
  • CANDF9 3
  • IL17RL 3

External Ids for IL17RC Gene

Previous GeneCards Identifiers for IL17RC Gene

  • GC03P009950
  • GC03P009933
  • GC03P009958
  • GC03P009895

Summaries for IL17RC Gene

Entrez Gene Summary for IL17RC Gene

  • This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL17RC Gene

IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. Diseases associated with IL17RC include Candidiasis, Familial, 9 and Chronic Mucocutaneous Candidiasis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include interleukin-17 receptor activity.

UniProtKB/Swiss-Prot for IL17RC Gene

  • Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).

  • Isoform 5: Receptor for both IL17A and IL17F.

  • Isoform 6: Does not bind IL17A or IL17F.

  • Isoform 7: Does not bind IL17A or IL17F.

  • Isoform 8: Receptor for both IL17A and IL17F.

Gene Wiki entry for IL17RC Gene

Additional gene information for IL17RC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RC Gene

Genomics for IL17RC Gene

GeneHancer (GH) Regulatory Elements for IL17RC Gene

Promoters and enhancers for IL17RC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I009914 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 578.8 -0.7 -685 4.1 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 IL17RC GC03M009835 IL17RE
GH03I009861 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37.3 -53.4 -53448 4.9 HDGF PKNOX1 SMAD1 ATF1 ARID4B FEZF1 DMAP1 ZNF48 POLR2B ZNF766 IL17RC JAGN1 CIDEC TADA3 IL17RE FANCD2 ARPC4 RNU6-882P THUMPD3 TTLL3
GH03I009883 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34 -32.7 -32683 2.2 PKNOX1 ARNT GTF3C2 TCF12 ZNF766 GATA2 ATF7 FOS ZNF263 ZNF592 CIDEC IL17RC JAGN1 TADA3 IL17RE RPUSD3 ARPC4 GC03M009835
GH03I009896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 26.2 -16.9 -16866 8.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 YY1 IL17RE GC03P009923 GC03P009922 IL17RC JAGN1 FANCD2 CRELD1 PRRT3-AS1 RPUSD3 PRRT3
GH03I009889 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.3 -26.3 -26256 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B JAGN1 BRPF1 RAD18 SETD5 FANCD2 TTLL3 GHRLOS BRK1 PRRT3 LINC00852
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL17RC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17RC gene promoter:

Genomic Locations for IL17RC Gene

Genomic Locations for IL17RC Gene
chr3:9,917,074-9,933,630
(GRCh38/hg38)
Size:
16,557 bases
Orientation:
Plus strand
chr3:9,958,758-9,975,314
(GRCh37/hg19)

Genomic View for IL17RC Gene

Genes around IL17RC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RC Gene

Proteins for IL17RC Gene

  • Protein details for IL17RC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAC3-I17RC_HUMAN
    Recommended name:
    Interleukin-17 receptor C
    Protein Accession:
    Q8NAC3
    Secondary Accessions:
    • A8BWC1
    • A8BWC9
    • A8BWD5
    • E9PHG1
    • E9PHJ6
    • Q6UVY3
    • Q6UWD4
    • Q8NFS1
    • Q9BR97

    Protein attributes for IL17RC Gene

    Size:
    791 amino acids
    Molecular mass:
    86240 Da
    Quaternary structure:
    • Heterodimer with IL17RA (PubMed:16785495, PubMed:18684971). Heterodimerization with IL17RA is independent of the cytoplasmic tail (By similarity). Associates with non-glycosylated IL17RA constitutively (By similarity). Binding of IL17A and IL17F induces association with glycosylated IL17RA (By similarity). Interacts (via SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (By similarity).

    Alternative splice isoforms for IL17RC Gene

neXtProt entry for IL17RC Gene

Post-translational modifications for IL17RC Gene

  • Ubiquitination at isoforms=2, 3, 4, 6572
  • Glycosylation at isoforms=2, 3, 4, 5, 6189, isoforms=2, 3, 4, 5, 6257, isoforms=2, 3, 4, 5, 6284, posLast=297297, isoforms=2, 3, 4, 5, 6324, posLast=334334, posLast=420420, posLast=443443, and posLast=477477

No data available for DME Specific Peptides for IL17RC Gene

Domains & Families for IL17RC Gene

Gene Families for IL17RC Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL17RC Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17RC: view

No data available for UniProtKB/Swiss-Prot for IL17RC Gene

Function for IL17RC Gene

Molecular function for IL17RC Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).
UniProtKB/Swiss-Prot Function:
Isoform 5: Receptor for both IL17A and IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 6: Does not bind IL17A or IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 7: Does not bind IL17A or IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 8: Receptor for both IL17A and IL17F.
UniProtKB/Swiss-Prot Induction:
By HGF and VEGF.

Gene Ontology (GO) - Molecular Function for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0030368 interleukin-17 receptor activity IDA 17911633
genes like me logo Genes that share ontologies with IL17RC: view

Phenotypes for IL17RC Gene

genes like me logo Genes that share phenotypes with IL17RC: view

Human Phenotype Ontology for IL17RC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RC Gene

MGI Knock Outs for IL17RC:

Animal Model Products

CRISPR Products

miRNA for IL17RC Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for IL17RC Gene

Localization for IL17RC Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RC Gene

Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RC gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17RC Gene

Pathways & Interactions for IL17RC Gene

genes like me logo Genes that share pathways with IL17RC: view

Gene Ontology (GO) - Biological Process for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0050832 defense response to fungus IEA --
GO:0071621 granulocyte chemotaxis IEA --
GO:0097398 cellular response to interleukin-17 TAS --
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17RC: view

No data available for SIGNOR curated interactions for IL17RC Gene

Drugs & Compounds for IL17RC Gene

No Compound Related Data Available

Transcripts for IL17RC Gene

Unigene Clusters for IL17RC Gene

Interleukin 17 receptor C:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -
SP10: - - -
SP11: - - - -
SP12:
SP13: -

ExUns: 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for IL17RC Gene

GeneLoc Exon Structure for
IL17RC
ECgene alternative splicing isoforms for
IL17RC

Expression for IL17RC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17RC Gene

NURSA nuclear receptor signaling pathways regulating expression of IL17RC Gene:

IL17RC

SOURCE GeneReport for Unigene cluster for IL17RC Gene:

Hs.129959

mRNA Expression by UniProt/SwissProt for IL17RC Gene:

Q8NAC3-I17RC_HUMAN
Tissue specificity: Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037).

Evidence on tissue expression from TISSUES for IL17RC Gene

  • Spleen(4.2)
  • Nervous system(3.9)
  • Skin(2.8)
  • Lung(2.2)
  • Pancreas(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL17RC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17RC Gene

Orthologs for IL17RC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RC 33 34
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia IL17RC 33 34
  • 84.47 (n)
cow
(Bos Taurus)
Mammalia IL17RC 33 34
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Il17rc 33
  • 77.42 (n)
mouse
(Mus musculus)
Mammalia Il17rc 33 16 34
  • 77.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RC 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RC 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750586 33
  • 53.95 (n)
IL17RC 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RC 34
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486154 33
  • 44.94 (n)
Species where no ortholog for IL17RC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RC Gene

ENSEMBL:
Gene Tree for IL17RC (if available)
TreeFam:
Gene Tree for IL17RC (if available)

Paralogs for IL17RC Gene

No data available for Paralogs for IL17RC Gene

Variants for IL17RC Gene

Sequence variations from dbSNP and Humsavar for IL17RC Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1057518751 pathogenic, Candidiasis, familial, 9 9,917,994(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs115419420 benign, Candidiasis, familial, 9 9,928,437(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs115461448 benign, Candidiasis, familial, 9 9,928,397(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs115949142 benign, Candidiasis, familial, 9 9,924,029(+) T/A intron_variant, non_coding_transcript_variant
rs138063632 likely-benign, Candidiasis, familial, 9 9,930,074(+) A/G coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RC Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV loss 17160897
nsv589648 CNV loss 21841781

Variation tolerance for IL17RC Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RC Gene

Human Gene Mutation Database (HGMD)
IL17RC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RC Gene

Disorders for IL17RC Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL17RC Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 9
  • candf9
chronic mucocutaneous candidiasis
  • cmc
candidiasis
  • disseminated candidiasis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RC_HUMAN
  • Candidiasis, familial, 9 (CANDF9) [MIM:616445]: A disorder characterized by altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:25918342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL17RC

genes like me logo Genes that share disorders with IL17RC: view

No data available for Genatlas for IL17RC Gene

Publications for IL17RC Gene

  1. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. (PMID: 11706037) Haudenschild D … Reddi AH (The Journal of biological chemistry 2002) 2 3 4 58
  2. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. (PMID: 25918342) Ling Y … Puel A (The Journal of experimental medicine 2015) 3 4 58
  3. IL-17 contributes to angiogenesis in rheumatoid arthritis. (PMID: 20173024) Pickens SR … Shahrara S (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22 58
  4. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. (PMID: 18684971) Wright JF … Carreno BM (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 4 58
  5. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. (PMID: 17911633) Kuestner RE … Levin SD (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 58

Products for IL17RC Gene

Sources for IL17RC Gene

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