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Aliases for IL17RB Gene

Aliases for IL17RB Gene

  • Interleukin 17 Receptor B 2 3 5
  • Cytokine Receptor-Like 4 3 4
  • Interleukin-17B Receptor 3 4
  • IL-17 Receptor Homolog 1 3 4
  • IL-17 Receptor B 3 4
  • IL-17B Receptor 3 4
  • IL-17Rh1 3 4
  • IL-17RB 3 4
  • IL17BR 3 4
  • EVI27 3 4
  • CRL4 3 4
  • Interleukin 17 Receptor Homolog 1 3
  • Interleukin-17 Receptor B 3
  • Interleukin 17B Receptor 2
  • Cytokine Receptor CRL4 3
  • IL17RH1 3
  • IL17Rh1 4

External Ids for IL17RB Gene

Previous HGNC Symbols for IL17RB Gene

  • IL17BR

Previous GeneCards Identifiers for IL17RB Gene

  • GC03P053735
  • GC03P053837

Summaries for IL17RB Gene

Entrez Gene Summary for IL17RB Gene

  • The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17RB Gene

IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis. Among its related pathways are IL-17 Family Signaling Pathways and Th2 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-17 receptor activity. An important paralog of this gene is IL17RA.

UniProtKB/Swiss-Prot for IL17RB Gene

  • Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Gene Wiki entry for IL17RB Gene

Additional gene information for IL17RB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RB Gene

Genomics for IL17RB Gene

GeneHancer (GH) Regulatory Elements for IL17RB Gene

Promoters and enhancers for IL17RB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J053841 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 680.3 -2.4 -2423 6 HDGF CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 IL17RB CHDH RFT1 STIMATE ENSG00000271916
GH03J053820 Enhancer 0.5 ENCODE dbSUPER 26.7 -24.9 -24878 1.5 EBF1 IL17RB CHDH ENSG00000271916
GH03J053747 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.1 -97.2 -97150 2.9 BACH1 EBF1 IRF4 RELA ETS1 EED ATF7 ETV6 IKZF2 SMARCA5 IL17RB SELENOK DCP1A GC03P053782 PIR47826 CACNA1D
GH03J053772 Enhancer 1.2 Ensembl ENCODE dbSUPER 7.9 -73.0 -73038 1.8 HDGF PKNOX1 SMAD1 YBX1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 IL17RB GC03P053782 PIR47826 CACNA1D
GH03J053776 Enhancer 0.4 dbSUPER 17.8 -69.1 -69125 1 ATF3 EGR1 HNF4A IL17RB CHDH GC03P053782 PIR47826 CACNA1D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17RB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17RB gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • GATA-2
  • YY1
  • ITF-2
  • Tal-1beta
  • S8
  • POU2F1

Genomic Locations for IL17RB Gene

Genomic Locations for IL17RB Gene
19,251 bases
Plus strand
19,251 bases
Plus strand

Genomic View for IL17RB Gene

Genes around IL17RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RB Gene

Proteins for IL17RB Gene

  • Protein details for IL17RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-17 receptor B
    Protein Accession:
    Secondary Accessions:
    • Q9BPZ0
    • Q9NRL4
    • Q9NRM5

    Protein attributes for IL17RB Gene

    502 amino acids
    Molecular mass:
    55885 Da
    Quaternary structure:
    • Interacts with DAZAP2.

    Alternative splice isoforms for IL17RB Gene


neXtProt entry for IL17RB Gene

Post-translational modifications for IL17RB Gene

  • Glycosylation at Asn283, isoforms=2197, isoforms=2183, Asn156, Asn103, and Asn67
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL17RB Gene

Domains & Families for IL17RB Gene

Gene Families for IL17RB Gene

Protein Domains for IL17RB Gene

Suggested Antigen Peptide Sequences for IL17RB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17RB: view

No data available for UniProtKB/Swiss-Prot for IL17RB Gene

Function for IL17RB Gene

Molecular function for IL17RB Gene

UniProtKB/Swiss-Prot Function:
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Phenotypes From GWAS Catalog for IL17RB Gene

Gene Ontology (GO) - Molecular Function for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity NAS 10815801
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17RB: view
genes like me logo Genes that share phenotypes with IL17RB: view

Animal Models for IL17RB Gene

MGI Knock Outs for IL17RB:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17RB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17RB Gene

Localization for IL17RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RB Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RB gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10749887
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with IL17RB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17RB Gene

Pathways & Interactions for IL17RB Gene

genes like me logo Genes that share pathways with IL17RB: view

Pathways by source for IL17RB Gene

SIGNOR curated interactions for IL17RB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10815801
GO:0006952 defense response TAS 10749887
GO:0050729 positive regulation of inflammatory response IEA --
GO:0097400 interleukin-17-mediated signaling pathway TAS --
GO:2000664 positive regulation of interleukin-5 secretion IEA --
genes like me logo Genes that share ontologies with IL17RB: view

Drugs & Compounds for IL17RB Gene

No Compound Related Data Available

Transcripts for IL17RB Gene

mRNA/cDNA for IL17RB Gene

Unigene Clusters for IL17RB Gene

Interleukin 17 receptor B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP3: -
SP4: -

Relevant External Links for IL17RB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL17RB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RB Gene

This gene is overexpressed in Kidney - Cortex (x11.0).

Protein differential expression in normal tissues from HIPED for IL17RB Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL17RB Gene

Protein tissue co-expression partners for IL17RB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL17RB Gene:


SOURCE GeneReport for Unigene cluster for IL17RB Gene:


mRNA Expression by UniProt/SwissProt for IL17RB Gene:

Tissue specificity: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Evidence on tissue expression from TISSUES for IL17RB Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with IL17RB: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RB Gene

Orthologs for IL17RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL17RB 34 33
  • 99.12 (n)
(Bos Taurus)
Mammalia IL17RB 34 33
  • 85.08 (n)
(Canis familiaris)
Mammalia IL17RB 34 33
  • 84.34 (n)
(Mus musculus)
Mammalia Il17rb 16 34 33
  • 79.12 (n)
(Rattus norvegicus)
Mammalia Il17rb 33
  • 77.05 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 60 (a)
(Monodelphis domestica)
Mammalia IL17RB 34
  • 50 (a)
(Anolis carolinensis)
Reptilia IL17RB 34
  • 39 (a)
(Danio rerio)
Actinopterygii il17ra1 34
  • 12 (a)
Species where no ortholog for IL17RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RB Gene

Gene Tree for IL17RB (if available)
Gene Tree for IL17RB (if available)
Evolutionary constrained regions (ECRs) for IL17RB: view image

Paralogs for IL17RB Gene

Paralogs for IL17RB Gene

genes like me logo Genes that share paralogs with IL17RB: view

Variants for IL17RB Gene

Sequence variations from dbSNP and Humsavar for IL17RB Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007560 -- 53,866,229(+) AAAAAA/AAAAAAA 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000093602 -- 53,856,803(+) A/G intron_variant
rs1000499577 -- 53,858,135(+) C/T intron_variant
rs1000552042 -- 53,857,914(+) C/T intron_variant
rs1000648905 -- 53,846,022(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RB Gene

Variant ID Type Subtype PubMed ID
dgv1376e212 CNV loss 25503493
dgv283n21 CNV loss 19592680
dgv4747n100 CNV gain 25217958
esv3575570 CNV gain 25503493
esv3596173 CNV loss 21293372
nsv1003621 CNV loss 25217958
nsv1006990 CNV gain 25217958
nsv1013783 CNV gain 25217958

Variation tolerance for IL17RB Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RB Gene

Disorders for IL17RB Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL17RB Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
chronic mucocutaneous candidiasis
  • cmc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL17RB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17RB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17RB Gene

Publications for IL17RB Gene

  1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. (PMID: 10815801) Tian E … Shaughnessy JD (Oncogene 2000) 2 3 4 22 58
  2. Association of IL-17RB gene polymorphism with asthma. (PMID: 19118269) Jung JS … Shin HD (Chest 2009) 3 22 44 58
  3. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PMID: 18794098) Goetz MP … Ingle JN (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 22 44 58
  4. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PMID: 10749887) Shi Y … Ebner R (The Journal of biological chemistry 2000) 2 3 4 58
  5. Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PMID: 22070932) Popova A … Gratchev A (Immunobiology 2012) 3 4 58

Products for IL17RB Gene

Sources for IL17RB Gene

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