Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin ... See more...

Aliases for IL17RA Gene

Aliases for IL17RA Gene

  • Interleukin 17 Receptor A 2 3 5
  • IL-17RA 2 3 4
  • CDw217 2 3 4
  • Interleukin-17 Receptor A 3 4
  • IL-17 Receptor A 3 4
  • HIL-17R 2 3
  • CD217 2 3
  • IL17R 3 4
  • Interleukin 17 Receptor 2
  • CD217 Antigen 4
  • CANDF5 3
  • IL17RA 5
  • IMD51 3

External Ids for IL17RA Gene

Previous HGNC Symbols for IL17RA Gene

  • IL17R

Previous GeneCards Identifiers for IL17RA Gene

  • GC22P015947
  • GC22P017565
  • GC22P001385
  • GC22P017086
  • GC22P017092

Summaries for IL17RA Gene

Entrez Gene Summary for IL17RA Gene

  • Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL17RA Gene

IL17RA (Interleukin 17 Receptor A) is a Protein Coding gene. Diseases associated with IL17RA include Immunodeficiency 51 and Chronic Mucocutaneous Candidiasis. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine production by Th17 cells in CF (Mouse model). Gene Ontology (GO) annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RD.

UniProtKB/Swiss-Prot Summary for IL17RA Gene

  • Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848).

Gene Wiki entry for IL17RA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17RA Gene

Genomics for IL17RA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL17RA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J017084 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 258 +1.3 1347 4.6 ZNF600 IKZF1 ZNF592 POLR2A NFIC ZIC2 ZBTB10 NONO BCL11A CTCF IL17RA CECR7 ENSG00000273203 ADA2 CECR2 HSALNG0133863 TMEM121B
GH22J017036 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.3 -47.3 -47254 3.4 ZNF592 NFIC ZNF316 NFE2 SKIL ZFP91 PRDM10 BHLHE40 CTCF SMARCA4 CECR7 IL17RA piR-51863 GAB4
GH22J017115 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.5 +33.9 33917 6.7 SP1 POLR2A ZIC2 ZBTB10 CTCF REST SIN3A ZNF513 KLF9 SP2 LINC01664 IL17RA TMEM121B HDHD5 lnc-TMEM121B-1 lnc-CECR2-1
GH22J017157 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 +72.7 72749 5.4 SP1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SIX5 ZNF223 ZSCAN16 POLR2A HDHD5 HDHD5-AS1 HSALNG0133878 lnc-ADA2-2 TMEM121B LINC01664 IL17RA lnc-TMEM121B-3
GH22J017170 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 7.5 +87.0 86970 2.3 BCLAF1 ZNF207 MYC IKZF1 ZNF580 POLR2A ZIC2 ZBTB10 YY1 NONO HSALNG0133879 IL17RA HDHD5 HDHD5-AS1 piR-32285-062 ADA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17RA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17RA

Top Transcription factor binding sites by QIAGEN in the IL17RA gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • GATA-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for IL17RA Gene

Latest Assembly
chr22:17,084,954-17,115,694
(GRCh38/hg38)
Size:
30,741 bases
Orientation:
Plus strand

Previous Assembly
chr22:17,565,890-17,596,583
(GRCh37/hg19 by Entrez Gene)
Size:
30,694 bases
Orientation:
Plus strand

chr22:17,565,844-17,596,583
(GRCh37/hg19 by Ensembl)
Size:
30,740 bases
Orientation:
Plus strand

Genomic View for IL17RA Gene

Genes around IL17RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RA Gene

Proteins for IL17RA Gene

  • Protein details for IL17RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F46-I17RA_HUMAN
    Recommended name:
    Interleukin-17 receptor A
    Protein Accession:
    Q96F46
    Secondary Accessions:
    • O43844
    • Q20WK1

    Protein attributes for IL17RA Gene

    Size:
    866 amino acids
    Molecular mass:
    96122 Da
    Quaternary structure:
    • Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971, PubMed:32187518). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (PubMed:32187518). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (PubMed:23695682). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RA chain can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:28827714). Interacts with TRAF3IP2 (PubMed:24120361). Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848, PubMed:16785495, PubMed:18684971).
    • (Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 virus protein ORF8.
    Miscellaneous:
    • [Isoform 2]: Soluble isoform lacking the transmembrane segment.

    Three dimensional structures from OCA and Proteopedia for IL17RA Gene

    Alternative splice isoforms for IL17RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RA Gene

Post-translational modifications for IL17RA Gene

  • Glycosylated.
  • Glycosylation at Asn49, Asn54, Asn67, Asn206, Asn225, Asn242, and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RA Gene

Assay products for research

  • Boster Bio ELISA Kits for IL17RA

No data available for DME Specific Peptides for IL17RA Gene

Domains & Families for IL17RA Gene

Gene Families for IL17RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL17RA Gene

Suggested Antigen Peptide Sequences for IL17RA Gene

GenScript: Design optimal peptide antigens:
  • CDw217 (I17RA_HUMAN)
genes like me logo Genes that share domains with IL17RA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL17RA Gene

Function for IL17RA Gene

Molecular function for IL17RA Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848).

Phenotypes From GWAS Catalog for IL17RA Gene

Gene Ontology (GO) - Molecular Function for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity NAS 9367539
genes like me logo Genes that share ontologies with IL17RA: view
genes like me logo Genes that share phenotypes with IL17RA: view

Human Phenotype Ontology for IL17RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RA Gene

MGI Knock Outs for IL17RA:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17RA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17RA Gene

Localization for IL17RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RA Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RA gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9367539
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RA: view

Pathways & Interactions for IL17RA Gene

PathCards logo

SuperPathways for IL17RA Gene

SuperPathway Contained pathways
1 IL-17 Family Signaling Pathways
.48
2 Akt Signaling
.60
.60
.55
3 PEDF Induced Signaling
.47
4 Cytokine Signaling in Immune system
5 Cytokine production by Th17 cells in CF (Mouse model)
.72
.72
genes like me logo Genes that share pathways with IL17RA: view

Pathways by source for IL17RA Gene

3 GeneGo (Thomson Reuters) pathways for IL17RA Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Mucin expression in CF via IL-6, IL-17 signaling pathways
6 Qiagen pathways for IL17RA Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • STAT3 Pathway

SIGNOR curated interactions for IL17RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway NAS 9367539
GO:0032747 positive regulation of interleukin-23 production IDA 21145111
genes like me logo Genes that share ontologies with IL17RA: view

Drugs & Compounds for IL17RA Gene

(1) Drugs for IL17RA Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(1) Additional Compounds for IL17RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL17RA: view

Transcripts for IL17RA Gene

mRNA/cDNA for IL17RA Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17RA

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IL17RA Gene

GeneLoc Exon Structure for
IL17RA

Expression for IL17RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RA Gene

This gene is overexpressed in Whole Blood (x17.9).

Protein differential expression in normal tissues from HIPED for IL17RA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), Testis (27.4), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL17RA Gene



Protein tissue co-expression partners for IL17RA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17RA

SOURCE GeneReport for Unigene cluster for IL17RA Gene:

Hs.48353

mRNA Expression by UniProt/SwissProt for IL17RA Gene:

Q96F46-I17RA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for IL17RA Gene

  • Blood(4.6)
  • Intestine(2.7)
  • Spleen(2.6)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Nervous system(2.5)
  • Lung(2.5)
  • Skin(2.3)
  • Liver(2.3)
  • Heart(2.1)
  • Kidney(2.1)
  • Pancreas(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL17RA: view

Primer products for research

Orthologs for IL17RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL17RA 29 30
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL17RA 29 30
  • 79.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL17RA 29 30
  • 77.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il17ra 29 16 30
  • 76.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il17ra 29
  • 75.68 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL17RA 30
  • 57 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL17RA 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL17RA 29 30
  • 57.65 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL17RA 30
  • 43 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC561494 29
  • 46.21 (n)
BX942819.1 30
  • 35 (a)
OneToMany
il17ra2 30
  • 31 (a)
OneToMany
IL17RA (1 of 4) 30
  • 31 (a)
OneToMany
IL17RA (3 of 4) 30
  • 30 (a)
OneToMany
Species where no ortholog for IL17RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL17RA Gene

ENSEMBL:
Gene Tree for IL17RA (if available)
TreeFam:
Gene Tree for IL17RA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17RA: view image
Alliance of Genome Resources:
Additional Orthologs for IL17RA

Paralogs for IL17RA Gene

Paralogs for IL17RA Gene

genes like me logo Genes that share paralogs with IL17RA: view

Variants for IL17RA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17RA Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
1002671 Uncertain Significance: Immunodeficiency 51 17,108,601(+) G/A
NM_014339.7(IL17RA):c.1382G>A (p.Arg461Gln)
MISSENSE
1002733 Uncertain Significance: Immunodeficiency 51 17,109,434(+) C/G
NM_014339.7(IL17RA):c.2215C>G (p.Leu739Val)
MISSENSE
1004250 Uncertain Significance: Immunodeficiency 51 17,108,598(+) G/A
NM_014339.7(IL17RA):c.1379G>A (p.Gly460Asp)
MISSENSE
1006539 Uncertain Significance: Immunodeficiency 51 17,105,905(+) GG/CT
NM_014339.7(IL17RA):c.996_997delinsCT (p.Val333Leu)
MISSENSE_VARIANT,INTRON
1007791 Uncertain Significance: Immunodeficiency 51 17,104,816(+) G/C
NM_014339.7(IL17RA):c.931+6G>C
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL17RA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL17RA Gene

Variant ID Type Subtype PubMed ID
dgv4460n100 CNV gain 25217958
dgv729e201 CNV deletion 23290073
esv2723938 CNV deletion 23290073
esv2723939 CNV deletion 23290073
esv3361550 CNV duplication 20981092
esv3647204 CNV gain 21293372
esv3647208 CNV gain 21293372
nsv1062859 CNV loss 25217958
nsv1064641 CNV gain 25217958
nsv1067241 CNV loss 25217958
nsv509805 CNV insertion 20534489
nsv518600 CNV loss 19592680
nsv519563 CNV loss 19592680
nsv521478 CNV loss 19592680
nsv828923 CNV gain 20364138

Variation tolerance for IL17RA Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RA Gene

Human Gene Mutation Database (HGMD)
IL17RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RA
Leiden Open Variation Database (LOVD)
IL17RA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RA Gene

Disorders for IL17RA Gene

MalaCards: The human disease database

(20) MalaCards diseases for IL17RA Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
immunodeficiency 51
  • imd51
chronic mucocutaneous candidiasis
  • familiar chronic mucocutaneous candidiasis
candidiasis
  • disseminated candidiasis
rheumatoid arthritis
  • ra
arthritis
  • inflammatory disorder of joint
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RA_HUMAN
  • Immunodeficiency 51 (IMD51) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for IL17RA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL17RA: view

No data available for Genatlas for IL17RA Gene

Publications for IL17RA Gene

  1. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PMID: 21350122) Puel A … Casanova JL (Science (New York, N.Y.) 2011) 3 4 72
  2. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. (PMID: 16785495) Toy D … Peschon J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 22
  3. Molecular characterization of the human interleukin (IL)-17 receptor. (PMID: 9367539) Yao Z … Armitage RJ (Cytokine 1997) 2 3 4
  4. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3 4
  5. The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. (PMID: 28827714) Goepfert A … Rondeau JM (Scientific reports 2017) 3 4

Products for IL17RA Gene

  • Biorbyt antibodies for IL17RA

Sources for IL17RA Gene