Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin ... See more...

Aliases for IL17RA Gene

Aliases for IL17RA Gene

  • Interleukin 17 Receptor A 2 3 5
  • Interleukin-17 Receptor A 3 4
  • IL-17 Receptor A 3 4
  • IL-17RA 3 4
  • CDw217 3 4
  • IL17R 3 4
  • Interleukin 17 Receptor 2
  • CD217 Antigen 4
  • HIL-17R 3
  • CANDF5 3
  • CD217 3
  • IMD51 3

External Ids for IL17RA Gene

Previous HGNC Symbols for IL17RA Gene

  • IL17R

Previous GeneCards Identifiers for IL17RA Gene

  • GC22P015947
  • GC22P017565
  • GC22P001385

Summaries for IL17RA Gene

Entrez Gene Summary for IL17RA Gene

  • Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL17RA Gene

IL17RA (Interleukin 17 Receptor A) is a Protein Coding gene. Diseases associated with IL17RA include Immunodeficiency 51 and Chronic Mucocutaneous Candidiasis. Among its related pathways are Cytokine Signaling in Immune system and Cytokine production by Th17 cells in CF (Mouse model). Gene Ontology (GO) annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RD.

UniProtKB/Swiss-Prot Summary for IL17RA Gene

  • Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Gene Wiki entry for IL17RA Gene

Additional gene information for IL17RA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17RA Gene

Genomics for IL17RA Gene

GeneHancer (GH) Regulatory Elements for IL17RA Gene

Promoters and enhancers for IL17RA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J017084 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 758 +1.3 1347 4.6 ZBTB40 POLR2A ETV6 ELF1 RELA HLF L3MBTL2 MAX DACH1 HDGF IL17RA CECR7 ENSG00000273203 ADA2 CECR2 RPL31P62 lnc-TMEM121B-2
GH22J017036 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 750.2 -47.3 -47254 3.4 L3MBTL2 NKRF ZFX NCOA6 ZNF687 EGR1 IKZF1 ARID2 ZNF512 ATF1 CECR7 IL17RA piR-51863
GH22J017115 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.5 +33.9 33917 6.7 ZNF785 SP1 CTCF L3MBTL2 RAD21 ZNF280D AHR SP7 PRDM1 GLIS2 IL17RA TMEM121B HDHD5 LINC01664 lnc-TMEM121B-1 lnc-CECR2-1
GH22J017157 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.7 +72.7 72749 5.4 ZNF785 SP1 SIX5 ZBTB6 SMARCE1 POLR2A HCFC1 ZNF362 MYC ELF1 HDHD5 HDHD5-AS1 lnc-ADA2-2 TMEM121B LINC01664 IL17RA lnc-TMEM121B-3
GH22J017170 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 7.5 +87.0 86970 2.3 ZNF785 ZNF24 ZBTB40 CTCF ZBTB6 POLR2A CC2D1A ELF1 L3MBTL2 RAD21 HSALNG0133879 ENSG00000273442 HDHD5-AS1 ENSG00000273203 IL17RA HDHD5 piR-32285-062
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17RA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17RA gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • GATA-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for IL17RA Gene

Genomic Locations for IL17RA Gene
chr22:17,084,954-17,115,694
(GRCh38/hg38)
Size:
30,741 bases
Orientation:
Plus strand
chr22:17,565,844-17,596,584
(GRCh37/hg19)
Size:
30,741 bases
Orientation:
Plus strand

Genomic View for IL17RA Gene

Genes around IL17RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RA Gene

Proteins for IL17RA Gene

  • Protein details for IL17RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F46-I17RA_HUMAN
    Recommended name:
    Interleukin-17 receptor A
    Protein Accession:
    Q96F46
    Secondary Accessions:
    • O43844
    • Q20WK1

    Protein attributes for IL17RA Gene

    Size:
    866 amino acids
    Molecular mass:
    96122 Da
    Quaternary structure:
    • Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971).

    Three dimensional structures from OCA and Proteopedia for IL17RA Gene

    Alternative splice isoforms for IL17RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RA Gene

Post-translational modifications for IL17RA Gene

  • Glycosylated.
  • Glycosylation at Asn49, Asn54, Asn67, Asn206, Asn225, Asn242, and Asn265
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Biorbyt antibodies for IL17RA
  • Boster Bio Antibodies for IL17RA

No data available for DME Specific Peptides for IL17RA Gene

Domains & Families for IL17RA Gene

Gene Families for IL17RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL17RA Gene

Suggested Antigen Peptide Sequences for IL17RA Gene

GenScript: Design optimal peptide antigens:
  • CDw217 (I17RA_HUMAN)
genes like me logo Genes that share domains with IL17RA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL17RA Gene

Function for IL17RA Gene

Molecular function for IL17RA Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Phenotypes From GWAS Catalog for IL17RA Gene

Gene Ontology (GO) - Molecular Function for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity NAS 9367539
genes like me logo Genes that share ontologies with IL17RA: view
genes like me logo Genes that share phenotypes with IL17RA: view

Human Phenotype Ontology for IL17RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RA Gene

MGI Knock Outs for IL17RA:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17RA Gene

Localization for IL17RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RA Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RA gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9367539
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RA: view

Pathways & Interactions for IL17RA Gene

genes like me logo Genes that share pathways with IL17RA: view

Pathways by source for IL17RA Gene

6 Qiagen pathways for IL17RA Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • STAT3 Pathway

SIGNOR curated interactions for IL17RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway NAS 9367539
GO:0032747 positive regulation of interleukin-23 production IDA 21145111
GO:0050729 positive regulation of inflammatory response IEA --
GO:0050832 defense response to fungus IEA --
GO:0071345 cellular response to cytokine stimulus IEA --
genes like me logo Genes that share ontologies with IL17RA: view

Drugs & Compounds for IL17RA Gene

(1) Drugs for IL17RA Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(1) Additional Compounds for IL17RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL17RA: view

Transcripts for IL17RA Gene

mRNA/cDNA for IL17RA Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IL17RA Gene

GeneLoc Exon Structure for
IL17RA
ECgene alternative splicing isoforms for
IL17RA

Expression for IL17RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RA Gene

This gene is overexpressed in Whole Blood (x17.9).

Protein differential expression in normal tissues from HIPED for IL17RA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), Testis (27.4), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL17RA Gene



Protein tissue co-expression partners for IL17RA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL17RA Gene:

IL17RA

SOURCE GeneReport for Unigene cluster for IL17RA Gene:

Hs.48353

mRNA Expression by UniProt/SwissProt for IL17RA Gene:

Q96F46-I17RA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for IL17RA Gene

  • Blood(4.5)
  • Lung(2.2)
  • Intestine(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Regions:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL17RA: view

Orthologs for IL17RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RA 33 32
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RA 33 32
  • 79.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RA 33 32
  • 77.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il17ra 17 33 32
  • 76.51 (n)
rat
(Rattus norvegicus)
Mammalia Il17ra 32
  • 75.68 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17RA 33
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RA 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RA 33 32
  • 57.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RA 33
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC561494 32
  • 46.21 (n)
BX942819.1 33
  • 35 (a)
OneToMany
il17ra2 33
  • 31 (a)
OneToMany
IL17RA (1 of 4) 33
  • 31 (a)
OneToMany
IL17RA (3 of 4) 33
  • 30 (a)
OneToMany
Species where no ortholog for IL17RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RA Gene

ENSEMBL:
Gene Tree for IL17RA (if available)
TreeFam:
Gene Tree for IL17RA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17RA: view image

Paralogs for IL17RA Gene

Paralogs for IL17RA Gene

genes like me logo Genes that share paralogs with IL17RA: view

Variants for IL17RA Gene

Sequence variations from dbSNP and Humsavar for IL17RA Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1003943 likely-benign, Familial Candidiasis, Recessive 17,115,090(+) C/T 3_prime_UTR_variant
rs1003944 likely-benign, Familial Candidiasis, Recessive 17,115,076(+) C/T 3_prime_UTR_variant
rs1003945 likely-benign, Familial Candidiasis, Recessive 17,114,856(+) C/T 3_prime_UTR_variant
rs1006074686 uncertain-significance, Immunodeficiency 51 17,085,224(+) C/A coding_sequence_variant, missense_variant
rs1047929 benign, Familial Candidiasis, Recessive 17,115,339(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RA Gene

Variant ID Type Subtype PubMed ID
dgv4460n100 CNV gain 25217958
dgv729e201 CNV deletion 23290073
esv2723938 CNV deletion 23290073
esv2723939 CNV deletion 23290073
esv3361550 CNV duplication 20981092
esv3647204 CNV gain 21293372
esv3647208 CNV gain 21293372
nsv1062859 CNV loss 25217958
nsv1064641 CNV gain 25217958
nsv1067241 CNV loss 25217958
nsv509805 CNV insertion 20534489
nsv518600 CNV loss 19592680
nsv519563 CNV loss 19592680
nsv521478 CNV loss 19592680
nsv828923 CNV gain 20364138

Variation tolerance for IL17RA Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17RA Gene

Human Gene Mutation Database (HGMD)
IL17RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RA Gene

Disorders for IL17RA Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL17RA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 51
  • imd51
chronic mucocutaneous candidiasis
  • cmc
candidiasis
  • disseminated candidiasis
nasopharyngitis
  • chronic nasopharyngitis
stromal keratitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RA_HUMAN
  • Immunodeficiency 51 (IMD51) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL17RA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17RA: view

No data available for Genatlas for IL17RA Gene

Publications for IL17RA Gene

  1. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. (PMID: 16785495) Toy D … Peschon J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 23 56
  2. Molecular characterization of the human interleukin (IL)-17 receptor. (PMID: 9367539) Yao Z … Armitage RJ (Cytokine 1997) 2 3 4 56
  3. Identification of a soluble isoform of human IL-17RA generated by alternative splicing. (PMID: 24084331) Sohda M … Oda K (Cytokine 2013) 3 4 56
  4. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PMID: 21350122) Puel A … Casanova JL (Science (New York, N.Y.) 2011) 3 4 56
  5. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V … Pappu R (Nature immunology 2011) 3 4 56

Products for IL17RA Gene

  • Boster Bio Antibodies for IL17RA
  • Boster Bio ELISA Kits for IL17RA
  • Biorbyt antibodies for IL17RA

Sources for IL17RA Gene