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The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/T... See more...
Aliases for IL17F Gene
Aliases for IL17F Gene
External Ids for IL17F Gene
- HGNC: 16404
- Entrez Gene: 112744
- Ensembl: ENSG00000112116
- OMIM: 606496
- UniProtKB: Q96PD4
Previous GeneCards Identifiers for IL17F Gene
- GC06M052103
- GC06M052148
- GC06M051932
- GC06M052101
Summaries for IL17F Gene
-
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17F Gene
IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include Candidiasis, Familial, 6 and Chronic Mucocutaneous Candidiasis. Among its related pathways are Immune response IL-23 signaling pathway and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine receptor binding. An important paralog of this gene is IL17A.
UniProtKB/Swiss-Prot Summary for IL17F Gene
-
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Additional gene information for IL17F Gene
- HGNC(16404)
- Entrez Gene(112744)
- Ensembl(ENSG00000112116)
- OMIM(606496)
- UniProtKB(Q96PD4)
- Open Targets Platform(ENSG00000112116)
- Monarch Initiative
- Search for IL17F at DataMed
- Search for IL17F at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17F Gene
Genomics for IL17F Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL17F Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL17F on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17F
- Top Transcription factor binding sites by QIAGEN in the IL17F gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- CREB
- deltaCREB
- GATA-1
- GATA-2
- GATA-3
- STAT3
Genomic Locations for IL17F Gene
Genomic Locations for IL17F Gene
- chr6:52,236,681-52,245,689
- (GRCh38/hg38)
- Size:
- 9,009 bases
- Orientation:
- Minus strand
- chr6:52,101,479-52,109,335
- (GRCh37/hg19)
- Size:
- 7,857 bases
- Orientation:
- Minus strand
Genomic View for IL17F Gene
Genes around IL17F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by HGNC
- 6p12.2 by Entrez Gene
- 6p12.2 by Ensembl
IL17F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL17F Gene
Proteins for IL17F Gene
-
Protein details for IL17F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PD4-IL17F_HUMAN
- Recommended name:
- Interleukin-17F
- Protein Accession:
- Q96PD4
- Q6NSI0
- Q7Z6P4
- Q96PI8
- Q9NUE6
Protein attributes for IL17F Gene
- Size:
- 163 amino acids
- Molecular mass:
- 18045 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:19838198). Heterodimer with IL17A (PubMed:17355969).
- SequenceCaution:
-
- Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Post-translational modifications for IL17F Gene
Other Protein References for IL17F Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IL17F Antibody
- NSJ Bioreagents IL17F Antibody
- BioLegend IL-17F Antibody (516604), IL-17F Antibody (516603), and Purified anti-IL-17F
-
Custom Antibody ServicesOriGene Antibodies for IL17F
- Novus Biologicals Antibodies for IL17F
-
Abcam antibodies for IL17F
- Invitrogen Antibodies for IL17F (AFLGC-IL17F)
- antibodies-online: Show 191 available IL17F Antibodies ranked by validation data
- Compare Top IL17F Antibodies
-
Recommended
- 151 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 30 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL17F
- Sino Biological Antibodies for IL17F
Protein Products
- BioLegend Recombinant Human IL-17F (carrier-free)
- Search Origene for MassSpec and Protein Over-expression Lysates for IL17F
- Origene Custom Protein Services for IL17F
- Sino Biological Recombinant Proteins for IL17F
- Sino Biological Cell Lysates for IL17F
- ProSpec Recombinant Proteins for IL17F
-
Abcam proteins for IL17F
Assay Products
- G Biosciences Immunotag™ Interleukin-17F ELISA Kit
- RayBiotech Human IL-17F ELISA
-
Custom Assay ServicesOriGene ELISA Kits for IL17F
- Novus Biologicals ELISA Kits for IL17F
- antibodies-online: Show 89 available IL17F Elisa Kits ranked by validation data
- Compare Top IL17F Elisa Kits
-
Quality Products:
- ABIN6574295
- ABIN6720542
- ABIN625014
- ABIN416867
- ABIN857591
- ABIN1028972
- ABIN4993120
- ABIN1081664
- ABIN924774
- ABIN3199225
- ABIN1672799
- ABIN841967
- ABIN425212
- ABIN1570646
- ABIN1380001
- ABIN3198454
- ABIN2708544
- ABIN6720198
- ABIN4885567
- ABIN1081665
- ABIN432432
- ABIN841968
- ABIN1706083
- ABIN5676197
- ABIN2708657
- ABIN2684610
- ABIN1081666
- ABIN1570647
- ABIN2748228
- ABIN6384731
- ABIN2748227
- ABIN6384728
-
Abcam assays for IL17F
No data available for DME Specific Peptides for IL17F Gene
Domains & Families for IL17F Gene
Gene Families for IL17F Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted secreted proteins
Protein Domains for IL17F Gene
- InterPro:
- Blocks:
-
- Interleukin-17
- ProtoNet:
Suggested Antigen Peptide Sequences for IL17F Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin-24 (IL17F_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96PD4- Family:
-
- Belongs to the IL-17 family.
Function for IL17F Gene
Molecular function for IL17F Gene
- UniProtKB/Swiss-Prot Function:
- Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Phenotypes From GWAS Catalog for IL17F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 11591732 |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0019955 | cytokine binding | IDA | 11574464 |
| GO:0042803 | protein homodimerization activity | IDA | 11574464 |
Phenotypes for IL17F Gene
- MGI mutant phenotypes for IL17F:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for IL17F:
Animal Models for IL17F Gene
- MGI Knock Outs for IL17F:
-
- Il17a/Il17f Il17a/Il17f<tm1.1Impr>
- Il17f Il17f<tm1Awai>
- Il17f Il17f<tm1Cdon>
- Il17f Il17f<tm1Yiw>
- Il17f Il17f<tm2Yiw>
Animal Model Products
-
Taconic Biosciences Mouse Models for IL17F
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL17F - Select products 50% OFF >
- * IL17F CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL17F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL17F
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL17F
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL17F
- Browse OriGene Inhibitory RNA Products For IL17F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17F
Clone Products
- Applied Biological Materials (abm): Clones for IL17F - Select products 50% OFF >
- * IL17F as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL17F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL17F
Cell Line Products
-
Horizon Cell Lines for IL17F
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IL17F Gene
Localization for IL17F Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL17F Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17F Gene
Pathways & Interactions for IL17F Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
| 2 | Th17 cell differentiation | ||
| 3 | Th17 Differentiation | ||
| 4 | Cytokine Signaling in Immune system | ||
| 5 | Cytokine production by Th17 cells in CF (Mouse model) |
Cytokine production by Th17 cells in CF
.72
|
Cytokine production by Th17 cells in CF (Mouse model)
.72
|
Pathways by source for IL17F Gene
2 Sino Biological pathways for IL17F Gene
2 BioSystems pathways for IL17F Gene
5 Reactome pathways for IL17F Gene
4 KEGG pathways for IL17F Gene
4 GeneGo (Thomson Reuters) pathways for IL17F Gene
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Immune response IL-23 signaling pathway
- Mucin expression in CF via IL-6, IL-17 signaling pathways
3 R&D Systems pathways for IL17F Gene
Interacting Proteins for IL17F Gene
Selected Interacting proteins:
Q96PD4-IL17F_HUMAN
ENSP00000337432
for IL17F Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL17F
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0016525 | negative regulation of angiogenesis | IDA | 11591732 |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | IDA | 11591732 |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
| GO:0042089 | cytokine biosynthetic process | IDA | 11591732 |
No data available for SIGNOR curated interactions for IL17F Gene
Drugs & Compounds for IL17F Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Y-320 | Pharma | 0 |
(1) ApexBio Compounds for IL17F Gene
| Compound | Action | Cas Number |
|---|---|---|
| Y-320 | 288250-47-5 |
Transcripts for IL17F Gene
mRNA/cDNA for IL17F Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336123 813 nts (view in UCSC)
- ENST00000478427 926 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL17F - Select products 50% OFF >
- * IL17F CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL17F
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL17F
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL17F
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL17F
- Browse OriGene Inhibitory RNA Products For IL17F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17F
Clone Products
- Applied Biological Materials (abm): Clones for IL17F - Select products 50% OFF >
- * IL17F as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL17F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL17F
Relevant External Links for IL17F Gene
- GeneLoc Exon Structure for
- IL17F
Expression for IL17F Gene
mRNA differential expression in normal tissues according to GTEx for IL17F Gene
This gene is overexpressed in Testis (x17.9), Esophagus - Mucosa (x7.6), and Small Intestine - Terminal Ileum (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17F
SOURCE GeneReport for Unigene cluster for IL17F Gene:
Hs.272295mRNA Expression by UniProt/SwissProt for IL17F Gene:
Q96PD4-IL17F_HUMAN
Tissue specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Evidence on tissue expression from TISSUES for IL17F Gene
- Blood(4.6)
- Spleen(2.8)
- Lymph node(2.8)
- Intestine(2.5)
- Skin(2.4)
- Lung(2.3)
- Bone marrow(2.3)
- Heart(2.2)
- Nervous system(2.1)
- Liver(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17F Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- eye
- eyelid
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- pharynx
- skull
- tongue
- tooth
Thorax:
- esophagus
- thymus
Abdomen:
- liver
- spleen
Pelvis:
- vagina
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IL17F
-
OriGene qPCR primer pairs and template standards for IL17F
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17F Gene
Orthologs for IL17F Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL17F 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL17F 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il17f 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Il17f 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL17F 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL17F 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL17F 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL17F 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101734106 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | il17a/f3 31 |
|
ManyToMany | |
| il17a/f1 31 |
|
ManyToMany |
- Species where no ortholog for IL17F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL17F Gene
- ENSEMBL:
- Gene Tree for IL17F (if available)
- TreeFam:
- Gene Tree for IL17F (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL17F: view image
Paralogs for IL17F Gene
Variants for IL17F Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17F Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 646441 | Uncertain Significance: Candidiasis, familial, 6 | 52,238,844(-) | C/A | MISSENSE_VARIANT | |
| 648005 | Uncertain Significance: Candidiasis, familial, 6 | 52,238,861(-) | G/C | MISSENSE_VARIANT | |
| 660654 | Uncertain Significance: Candidiasis, familial, 6 | 52,237,032(-) | G/A | MISSENSE_VARIANT | |
| 740268 | Likely Benign: not provided | 52,238,930(-) | C/T | SYNONYMOUS_VARIANT | |
| 760136 | Likely Benign: not provided | 52,237,173(-) | A/G | INTRON_VARIANT |
Residual Variation Intolerance Score:
71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.73;
66.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL17F Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17F Gene
Disorders for IL17F Gene
(31) MalaCards diseases for IL17F Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| candidiasis, familial, 6 |
|
|
| chronic mucocutaneous candidiasis |
|
|
| candidiasis |
|
|
| acute generalized exanthematous pustulosis |
|
|
| nail disease |
|
|
Search IL17F in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL17F_HUMAN- Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IL17F
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for IL17F Gene
Publications for IL17F Gene
- Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PMID: 11591732) Starnes T … Hromas R (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23
- Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PMID: 11591768) Kawaguchi M … Huang SK (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 23
- Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PMID: 19904747) Wu X … Hu P (International journal of cancer 2010) 3 23 41
- Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PMID: 19414056) Shibata T … Arisawa T (Human immunology 2009) 3 23 41
- Interleukin-17F gene polymorphisms in Korean patients with Behçet's disease. (PMID: 18769923) Jang WC … Kim SK (Rheumatology international 2008) 3 23 41
ExternalLinks
Products for IL17F Gene
- View all 38 R&D Systems IL17F (IL-17F) Products
- View all 2 R&D Systems IL17F (IL-17F) Proteins and Enzymes
- View all 33 R&D Systems IL17F (IL-17F) Primary Antibodies
- View all 2 R&D Systems IL17F (IL-17F) ELISAs
- View all R&D Systems IL17F (IL-17F) Luminex Assays
- Learn more about R&D Systems custom IL17F antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IL17F
- Custom Assay ServicesOriGene ELISA Kits for IL17F
- Search Origene for MassSpec and Protein Over-expression Lysates for IL17F
- Origene Custom Protein Services for IL17F
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL17F
- Browse OriGene Inhibitory RNA Products For IL17F
- OriGene qPCR primer pairs for IL17F
- OriGene qPCR primer pairs and template standards for IL17F
- OriGene CRISPR knockouts for IL17F
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL17F
- Sino Biological Human cDNA Clone for IL17F
- Sino Biological Recombinant Proteins for IL17F
- Sino Biological Cell Lysates for IL17F
- Sino Biological Antibodies for IL17F
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL17F
- Novus Biologicals proteins and lysates for IL17F
- Novus Biologicals ELISA Kits for IL17F
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- Abcam antibodies for IL17F
- Abcam proteins for IL17F
- Abcam assays for IL17F
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for IL17F
- Taconic Biosciences Mouse Models for IL17F
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IL17F (AFLGC-IL17F)
- ApexBio compounds for IL17F
- VectorBuilder Custom and pre-made DNA vectors for IL17F (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL17F (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IL17F (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IL17F CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IL17F
- antibodies-online: Show 191 available IL17F Antibodies ranked by validation data
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- Recommended
- 151 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 30 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 18 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 89 available IL17F Elisa Kits ranked by validation data
- Compare Top IL17F Elisa Kits
- Quality Products:
- ABIN6574295
- ABIN6720542
- ABIN625014
- ABIN416867
- ABIN857591
- ABIN1028972
- ABIN4993120
- ABIN1081664
- ABIN924774
- ABIN3199225
- ABIN1672799
- ABIN841967
- ABIN425212
- ABIN1570646
- ABIN1380001
- ABIN3198454
- ABIN2708544
- ABIN6720198
- ABIN4885567
- ABIN1081665
- ABIN432432
- ABIN841968
- ABIN1706083
- ABIN5676197
- ABIN2708657
- ABIN2684610
- ABIN1081666
- ABIN1570647
- ABIN2748228
- ABIN6384731
- ABIN2748227
- ABIN6384728
- antibodies-online: Show 80 available IL17F Proteins ranked by validation data
- Compare Top IL17F Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IL17F
- Search Santa Cruz Biotechnology (SCBT) for IL17F siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL17F
- Horizon Cell Lines for IL17F
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL17F
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL17F
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IL17F
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17F
Sources for IL17F Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB