Aliases for IL17F Gene
External Ids for IL17F Gene
Previous GeneCards Identifiers for IL17F Gene
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17F Gene
IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include Candidiasis, Familial, 6 and Chronic Mucocutaneous Candidiasis. Among its related pathways are Th1 Differentiation Pathway and IL-17 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine receptor binding. An important paralog of this gene is IL17A.
UniProtKB/Swiss-Prot Summary for IL17F Gene
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).