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IL17D Gene(Protein Coding)

Interleukin 17D

GCID:
GC13P020702
GIFtS:
48
Genes Participants
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Aliases for IL17D Gene

Aliases for IL17D Gene

  • Interleukin 17D 2 3 5
  • IL-17D 3 4
  • Interleukin-17D 3
  • Interleukin 27 2
  • Interleukin-27 4
  • IL-27 4

External Ids for IL17D Gene

Previous GeneCards Identifiers for IL17D Gene

  • GC13P019257
  • GC13P015257
  • GC13P020207
  • GC13P019075
  • GC13P020175
  • GC13P021276
  • GC13P002080

Summaries for IL17D Gene

Entrez Gene Summary for IL17D Gene

  • The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17D Gene

IL17D (Interleukin 17D) is a Protein Coding gene. Diseases associated with IL17D include Psoriasis. Among its related pathways are Th17 cell differentiation and Jak-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17B.

UniProtKB/Swiss-Prot for IL17D Gene

  • Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.

Additional gene information for IL17D Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17D Gene

Genomics for IL17D Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IL17D Gene

Promoters and enhancers for IL17D Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13I020702 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +1.3 1275 2.8 PKNOX1 RB1 ARID4B SIN3A BMI1 ZNF48 RFX5 ZNF335 ZNF121 ELK1 ENSG00000278291 GC13M020702 IL17D IFT88 EEF1AKMT1 CRYL1
GH13I020565 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.9 -134.8 -134835 2.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS SP3 IFT88 LOC105370103 PIR57097 SLC35E1P1 ZMYM2 XPO4 ZMYM5 CRYL1 IL17D
GH13I020552 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 6.3 -148.3 -148299 2.2 ELF3 FOXA2 MLX ARID4B RAD21 RARA YY1 ZSCAN5C THAP11 MIXL1 IFT88 CRYL1 SLC35E1P1 EEF1AKMT1 IL17D LOC105370103
GH13I020822 Enhancer 0.7 FANTOM5 ENCODE 10.2 +122.5 122511 3.4 JUND POLR2A HLF EEF1AKMT1 CRYL1 SLC35E1P1 IFT88 IL17D GC13P020892 XPO4
GH13I020720 Enhancer 0.7 Ensembl ENCODE 7.7 +19.5 19535 1.6 OSR2 FOSL1 CTCF JUND NFIC FOS EZH2 GC13M020722 IFT88 EEF1AKMT1 CRYL1 IL17D ENSG00000279135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL17D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17D gene promoter:

Genomic Locations for IL17D Gene

Genomic Locations for IL17D Gene
chr13:20,702,127-20,723,100
(GRCh38/hg38)
Size:
20,974 bases
Orientation:
Plus strand
chr13:21,276,266-21,297,237
(GRCh37/hg19)

Genomic View for IL17D Gene

Genes around IL17D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17D Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL17D Gene

Proteins for IL17D Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL17D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAD2-IL17D_HUMAN
    Recommended name:
    Interleukin-17D
    Protein Accession:
    Q8TAD2
    Secondary Accessions:
    • B1AM69

    Protein attributes for IL17D Gene

    Size:
    202 amino acids
    Molecular mass:
    21893 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17D Gene

Protein Expression for IL17D Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL17D Gene

  • Glycosylation at isoforms=68 and posLast=181181

Other Protein References for IL17D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17D Gene

Domains & Families for IL17D Gene

Gene Families for IL17D Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL17D Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAD2

UniProtKB/Swiss-Prot:

IL17D_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17D: view

Function for IL17D Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IL17D Gene

UniProtKB/Swiss-Prot Function:
Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.

Phenotypes From GWAS Catalog for IL17D Gene

Gene Ontology (GO) - Molecular Function for IL17D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 12097364
GO:0042803 protein homodimerization activity IDA 12097364
GO:0048018 receptor ligand activity IDA 12097364
genes like me logo Genes that share ontologies with IL17D: view
genes like me logo Genes that share phenotypes with IL17D: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IL17D Gene

Localization for IL17D Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17D gene
Compartment Confidence
extracellular 5
nucleus 3

Gene Ontology (GO) - Cellular Components for IL17D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 12097364
genes like me logo Genes that share ontologies with IL17D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17D Gene

Pathways & Interactions for IL17D Gene

genes like me logo Genes that share pathways with IL17D: view

Pathways by source for IL17D Gene

1 BioSystems pathway for IL17D Gene
1 R&D Systems pathway for IL17D Gene

Interacting Proteins for IL17D Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000302924%0d%0a9606.ENSP00000363318%0d%0a9606.ENSP00000230882%0d%0a9606.ENSP00000296980%0d%0a9606.ENSP00000242338%0d%0a9606.ENSP00000327824%0d%0a
Selected Interacting proteins: ENSP00000302924 for IL17D Gene via STRING

Gene Ontology (GO) - Biological Process for IL17D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IDA 12097364
GO:0010469 regulation of receptor activity IEA --
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA 12097364
GO:0032755 positive regulation of interleukin-6 production IDA 12097364
GO:0032757 positive regulation of interleukin-8 production IDA 12097364
genes like me logo Genes that share ontologies with IL17D: view

No data available for SIGNOR curated interactions for IL17D Gene

Drugs & Compounds for IL17D Gene

Products:

  1. Drug

(1) Drugs for IL17D Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Y-320 Pharma 0

(1) ApexBio Compounds for IL17D Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17D: view

Drug Products

Transcripts for IL17D Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL17D Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17D Gene

Interleukin 17D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17D Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - -

Relevant External Links for IL17D Gene

GeneLoc Exon Structure for
IL17D
ECgene alternative splicing isoforms for
IL17D

Expression for IL17D Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17D Gene

mRNA expression in normal human tissues for IL17D Gene
mRNA expression by GTEx for IL17D GenemRNA expression by BioGPS for IL17D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17D Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.5), Brain - Putamen (basal ganglia) (x4.2), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for IL17D Gene

This gene is overexpressed in Heart (59.4) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL17D Gene



Protein tissue co-expression partners for IL17D Gene

NURSA nuclear receptor signaling pathways regulating expression of IL17D Gene:

IL17D

SOURCE GeneReport for Unigene cluster for IL17D Gene:

Hs.655142

mRNA Expression by UniProt/SwissProt for IL17D Gene:

Q8TAD2-IL17D_HUMAN
Tissue specificity: Expressed preferentially in adipose, skeletal muscle and CNS.

Evidence on tissue expression from TISSUES for IL17D Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with IL17D: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17D Gene

Orthologs for IL17D Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL17D 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia IL17D 33 34
  • 86.2 (n)
mouse
(Mus musculus)
 Mammalia Il17d 33 16 34
  • 84.94 (n)
dog
(Canis familiaris)
 Mammalia IL17D 34
  • 76 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia IL17D 34
  • 68 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IL17D 34
  • 67 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IL17D 34
  • 63 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia il17d 33
  • 70.24 (n)
zebrafish
(Danio rerio)
 Actinopterygii il17d 33 34
  • 66.44 (n)
Species where no ortholog for IL17D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17D Gene

ENSEMBL:
Gene Tree for IL17D (if available)
TreeFam:
Gene Tree for IL17D (if available)

Paralogs for IL17D Gene

Paralogs for IL17D Gene

genes like me logo Genes that share paralogs with IL17D: view

Variants for IL17D Gene

Sequence variations from dbSNP and Humsavar for IL17D Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000010430 -- 20,713,673(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000238343 -- 20,707,347(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000275110 -- 20,722,085(+) /TT 3_prime_UTR_variant
rs1000297552 -- 20,719,785(+) C/A intron_variant
rs1000536640 -- 20,703,955(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17D Gene

Variant ID Type Subtype PubMed ID
dgv922n106 CNV deletion 24896259
esv3550134 CNV deletion 23714750
nsv1069733 CNV deletion 25765185
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv832558 CNV loss 17160897
nsv952524 CNV deletion 24416366

Variation tolerance for IL17D Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17D Gene

Disorders for IL17D Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL17D Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search IL17D in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17D

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17D Gene

Publications for IL17D Gene

  1. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. (PMID: 12097364) Starnes T … Hromas R (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation. (PMID: 28685546) Tang YJ … Yang XS (Journal of biological regulators and homeostatic agents 2017) 3 58
  4. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. (PMID: 27545889) Saddawi-Konefka R … Bui JD (Cell reports 2016) 3 58
  5. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. (PMID: 24794441) O'Sullivan T … Bui JD (Cell reports 2014) 3 58

Products for IL17D Gene

Sources for IL17D Gene

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